ライフサイエンスコーパス: retina

1 ents with RP by electrically stimulating the retina.

2 ericyte loss relative to nondiabetic control retina.

3 ve contributions of HC subtypes in the outer retina.

4 1 CNV on the RPE and overlying neurosensory retina.

5 l for the development and maintenance of the retina.

6 with the expected vasculopathy in the inner retina.

7 onophosphate dehydrogenase 1 (IMPDH1) in the retina.

8 the feedforward signals from the degenerated retina.

9 a rare self-limiting condition of the outer retina.

10 etention in the ONL in the injected superior retina.

11 on the excess VEGFA produced by the ischemic retina.

12 , mesencephalon, hindbrain, spinal cord, and retina.

13 nd Xbp1 mRNA splicing in TLR2 knockout mouse retina.

14 urons while also receiving synapses from the retina.

15 ing evolution to have resulted in the duplex retina.

16 one nuclei to the basal side of ONL in mouse retina.

17 ith the morphological expansion of the inner retina.

18 by damage to the small blood vessels in the retina.

19 oncurrent thinning in the outer layer of the retina.

20 rentiation and collagen secretion within the retina.

21 ity differences in the inferior and superior retina.

22 intermediate progenitor state exists in the retina.

23 t in the other eye that lies within affected retina.

24 l maturation, and survival in the cortex and retina.

25 y effective in centering the stimulus on the retina.

26 gher pyruvate kinase activity in db/db mouse retina.

27 he positioning of the electrode array on the retina.

28 ward pathways within the output layer of the retina.

29 sive scar tissue found throughout the neural retina.

30 ent epithelium and occasionally neurosensory retina.

31 ace the desired object image relative to the retina.

32 natural light stimuli projected onto healthy retina.

33 noblastoma is a rare childhood cancer of the retina.

34 l-ventral and central-peripheral axes of the retina.

35 es are active in discrete regions of the rat retina.

36 d prevented photoreceptor neuron loss in the retina.

37 harnessing the regenerative potential of the retina.

38 s expressing specific microRNAs in the mouse retina.

39 4, and rh1 were more prevalent in the dorsal retina.

40 hich may result in longer term damage to the retina.

41 lear how EPO functions to support the neural retina.

42 asol-magnocellular (M pathway) through human retina.

43 rmation of scar tissue on the surface of the retina.

44 as well as in other synapses of the chicken retina.

45 rectly toward the superior nasal paracentral retina.

46 e foveola, the high-resolution region of the retina.

47 rmation of rod photoreceptor synapses in the retina.

48 hat drive phototransduction in the mammalian retina.

49 to the underlying physiology of the primate retina.

50 and function of photoreceptor neurons in the retina.

51 mRNA expression in the developing zebrafish retina.

52 d for capturing the overall structure of the retina.

53 suppressed aberrant angiogenesis in ischemic retina.

54 ss accelerates degenerative processes in the retina.

55 y interact, extravasate and survey the mouse retina.

56 in fixing the number of RGC types in rabbit retina.

57 a uniformity in dendritic density across the retina.

58 n of microRNAs in tissue sections from mouse retinas.

59 in db/db mouse retina compared with control retinas.

60 n organoids and for targeted repair in human retinas.

61 transducing light stimuli to non-functioning retinas.

62 l cell adhesion, is mislocalized in Sac1(ts) retinas.

63 ninvasive monitoring of vascular function in retinas.

64 ajor issue in the field of stem cell-derived retinas.

65 e function of human versus non-human primate retinas.

66 enriched class of genes in Rbfox2-deficient retinas.

67 ity establishes direction selectivity in the retina(13-17).

68 In the cortex (e.g. [2-4]), and even the retina [5], of primates, cells are found that respond se

69 protein which was initially described in the retina, although it is also present in other tissues.

70 LTB(4), preventing structural damage to the retina and a significantly reducing effector T helper 17

71 rifts to precisely position the image on the retina and adjust its motion.

72 ng unique developmental responses within the retina and at central targets.

73 dered when studying visual processing in the retina and beyond.

74 ousands of unannotated isoforms expressed in retina and brain.

75 CHD7 expression in the developing inner ear, retina and brain.

76 , the pseudostratified neuroepithelia of the retina and cerebrocortical ventricular zones provide a p

77 hanges in both the peripapillary and macular retina and changes in vascular parameters have been iden

78 es as early as in the first synapse from the retina and even in retinal axons.

79 re weighted and combined at the level of the retina and how this combined signal is transformed into

80 timize vision and that are protective to the retina and infant.

81 (A) receptor is prominently expressed in the retina and is present at lower levels in several brain r

82 evelopment and regeneration mechanism of the retina and may offer a new way for maintaining and regen

83 l activation was more robust in the inferior retina and modulated across the boundary of light damage

84 The retina and optic nerve are among the metabolically most

85 ion of the vascularized and non-vascularized retina and optic nerve head.

86 pon change in numerousness; in contrast, the retina and optic tectum responded mainly to changes in s

87 om dorsotemporal to ventrolateral across the retina and overlapping with the mouse binocular field of

88 fore, the image projection occurring between retina and primary visual cortex can be mathematically d

89 identify an inhibitory RGC population in the retina and provide a circuit-level mechanism that contri

90 used to image the vascular structure of the retina and requires the insertion of an exogenous dye wi

91 ated fatty acid transport between the neural retina and retinal pigment epithelium.

92 er stage resulting in a more under-developed retina and severe phenotype.

93 on enhances Nrf2 DNA-binding activity in the retina and that the suppressive effect of diabetes on Nr

94 individual layers of microvasculature of the retina and the choroid by comparing consecutive B-scans.

95 dependent changes of the CV2 location in the retina and the existence of an endothelial population wi

96 equate contact between the anterior inferior retina and the gas bubble.

97 number and structure of synapses between the retina and the thalamus.

98 Both the retina and the visual cortex process object motion in la

99 ations for both signal processing within the retina and therapeutic interventions for blinding condit

100 nes of the skate eye and the location of the retina and this enabled us to reconstruct how photorecep

101 To study the organization of the retina and visual projections in these mice, we also est

102 tmortem samples of human cerebral cortex and retina and were able to identify transcripts, including

103 diameter determines how much light hits the retina and, thus, how much information is available for

104 d between 93.4% for "ORCC" and 100% for the "retina" and "avascular" slabs.

105 ciated genes was cell-type-specific in adult retina, and cell-type specificity was retained in organo

106 r, ECS alpha has never been measured in live retina, and little is known about how ECS alpha varies f

107 acrine cells during development and in adult retinas, and it is present in both GABAergic and glycine

108 Overall, rat retina appeared slightly more sensitive to HG levels com

109 Amacrine cells of the retina are conspicuously variable in their morphologies,

110 clarify whether visual inputs to the intact retina are necessary for the LPZ responses, here, we mea

111 Rod and cone photoreceptors of the retina are responsible for the initial stages in vision

112 ve ganglion cells (ooDSGCs) in the mammalian retina are typically thought to signal local motion to t

113 tively using an ex vivo configuration, where retinas are isolated and transretinal photovoltages are

114 d transmit photoreceptor output to the inner retina, are among the first cells affected by diabetic c

115 e diseases has emerged with the neurosensory retina as a unique window into deeper brain tissues.

116 q analysis on 16 time points from developing retina as well as four early stages of retinal organoid

117 with early or intermediate AMD have thinner retinas as compared to eyes from the Chr1-risk group wit

118 RGC loss was greater in peripheral retina at 2 weeks and widespread at longer durations.

119 s the potential of detecting diseases of the retina at earlier stages before irreversible structural

120 VI was lower in the inferior versus superior retina at matching eccentricities and a significant diff

121 obins that allow O(2) to be delivered to the retina at PO(2)s more than ten-fold that of arterial blo

122 CTA en face images were generated using the "retina," "avascular," "choriocapillaris," and "outer ret

123 Blood-retina barrier breakdown occurs in three patterns in cer

124 variety of noninvasive measurements in skin, retina, brain, and sublingual tissue, as well as plasma

125 r cells are tightly connected throughout the retina, but that spatial resolution is lost at the level

126 We have approached this problem in mouse retina by analysing the kinetic differences between rod

127 gic features (melanoma, 8720-8790) and site (retina, C69.2; choroid, C69.3; and ciliary body, C69.4)

128 ces in different layers and locations of the retina can explain the patterns of retinal hemorrhage (R

129 and neuroprotective role of VEGF, albeit in retina, cellular mechanisms underlying the VEGF neuropro

130 ma(-) memory T-helper 17 (Th17) cells in the retina, cervical lymph nodes, inguinal lymph nodes, and

131 To describe changes in the retina/choroid in patients with Serpiginous Choroiditis

132 tio of reduced/oxidized redox in db/db mouse retina compared with control retinas.

133 , to quantitate nuclear layers following the retina contour.

134 The retina decomposes visual stimuli into parallel channels

135 RBCs from retinas deficient in GABA release also demonstrate dyad

136 eceptor CREs from wild-type and mutant mouse retinas, defined by presence or absence, respectively, o

137 ysis of eight different mosaics in the mouse retina, demonstrating conspicuous variability in the deg

138 "developed" state at a rate similar to human retina development in vivo.

139 ells are produced and that the layers of the retina differentiate normally.

140 ve photoreceptor degeneration in the central retina, disease progression involves epigenetic changes

141 Moreover, Dcc-deficient retinas displayed a massive postnatal loss of retinal ga

142 lso altered vascular patterning in the mouse retina during development when delivered exogenously.

143 s simultaneously using a CRISPR/Cas9 in vivo retina electroporation strategy.

144 In the retina, Eml1 disruption caused abnormal positioning of p

145 Cone photoreceptors in the retina enable vision over a wide range of light intensit

146 ent to spontaneously polarise the developing retina, establishing the first organisational axis of th

147 Bax-KO retinas exhibited a threefold increase in dendritic cove

148 The retina exhibits direction-selective responses across gli

149 The retina experiences increased oxidative stress in diabete

150 Here we show that the larval zebrafish retina extracts a diversity of naturalistic motion cues,

151 The vertebrate retina first evolved some 500 million years ago in ances

152 in retinal pigmented epithelium/choroid and retina for more than six months.

153 ribution of all cone types across the entire retina for two commonly used mouse strains.

154 Stability of the inner retina found in these mutants 2 months after PR degenera

155 optimized for disease analysis, to study the retina from a 48-y-old woman suffering from MacTel.

156 sretinal signaling only occurs in the murine retina from Ca(v)2.3 competent mice, supporting the idea

157 s prior to light insult remarkably protected retina from deterioration and preserved its function.

158 f LncRNA MALAT1 has potential to protect the retina from oxidative damage and to prevent or slow down

159 We performed immunohistochemistry using retinas from Bardet-Biedl Syndrome (BBS) mouse models an

160 The electrode array-retina gap distance was found to effect performance in S

161 Electrode array-retina gap distances were measured at each of the array'

162 everal structures (i.e., optic disc, macula, retina, globe, lens, ciliary body) correlated with clini

163 PPV/SB for primary RRD in 2015 from 5 large retina groups were included in the database.

164 intraocular gas bubble and contact with the retina has been evaluated in different head positions in

165 Although the mammalian retina has no inherent regenerative capabilities, fish h

166 g visual pigment kinetics across the central retina, high fidelity IRD provides a unique insight into

167 The smartphone-based retina imaging systems can be used as an alternative to

168 In normal retina, IMPG1 and IMPG2 occupy distinct IPM compartments

169 light exposure eliminates PRs in the central retina in 1 week, but interneurons and their synapses ar

170 the posterior pole and around the peripheral retina in AHT.

171 sidering the demonstrated implication of the retina in Parkinson disease (PD) pathology and the impor

172 current study confirms the plasticity of the retina in response to the natural photic conditions.

173 generating spatiotemporal maps of the entire retina in the cpfl1 mouse model for primary cone degener

174 utein from zeaxanthin in images of the human retina in vivo or in donor eye tissues has been challeng

175 se, is associated with significantly thicker retinas in the perifovea.

176 ct non-BCs to the same extent in bipolarless retinas, indicating that AII ACs establish partner-type-

177 Two types of transition from normal retina into intercalary membrane (ICM) were noted: abrup

178 imarily affects the oxygenation of the inner retina involved in signal processing and transduction, a

179 ouse retina.SIGNIFICANCE STATEMENT The mouse retina is a leading model for analyzing the development,

180 gh the presence of cotton wool appearance in retina is a nonspecific sign it needs to be properly eva

181 types of neurons as the architecture of the retina is assembled, and the distinct mechanisms by whic

182 The retina is recognized as an approachable part of the brai

183 OCT offering 3-dimensional imaging of the retina is widely used to guide treatment.

184 ecorded as an ERG from the superfused murine retina isolated from wildtype and Ca(v)2.3-deficient mic

185 To develop an automated retina layer thickness measurement tool for the ImageJ p

186 Diseases and damage to the retina lead to losses in retinal neurons and eventual vi

187 d in pigmented glial cells of the Drosophila retina leads to age-related degeneration of both glia an

188 t antioxidant that has shown efficacy in the retina light damage mouse model and in humans for multip

189 f the cellular architecture of the mammalian retina, little is known about the organization and dynam

190 In the retina, LRR proteins have been implicated in the develop

191 in three regions of the human visual system (retina, macula, and retinal pigment epithelium/choroid)

192 ions of lutein and zeaxanthin in human donor retinas mapped with confocal resonance Raman microscopy.

193 -infrared light sensitivity in a blind human retina may supplement or restore visual function in pati

194 tinal ganglion cell (RGC) types in the mouse retina mediate pattern vision by responding to specific

195 The neural retina metabolizes glucose through aerobic glycolysis ge

196 e, we report that during colonization of the retina, microglia contacts the deep layer of high stiffn

197 IPANTS: Randomized clinical trial at 39 DRCR Retina Network sites in the US and Canada including 205

198 er expression in restricted subsets of inner retina neurons.

199 for segmented features such as neurosensory retina (NSR), drusen, intraretinal fluid (IRF), subretin

200 g dataset measurements of immunofluorescence retina nuclear layers disclosed no significant differenc

201 tivity and prevented oxidative stress in the retina of diabetic mice.

202 r of different photoreceptors present in the retina of G. australis and whether each cell type expres

203 This suggests, therefore, that the retina of G. australis possesses five spectrally and mor

204 ken together, these results suggest that the retina of H. portusjacksoni is well adapted for nocturna

205 e ECS volume fraction (alpha) in the ex vivo retina of male and female mice.

206 generation, has been linked to a loss in the retina of Muller glial cells and the amino acid serine,

207 me of their main postsynaptic neurons in the retina of PD.

208 f diabetes on Nrf2 activity is absent in the retina of REDD1-deficient mice compared with WT.

209 er cell-specific ribosomes isolated from the retina of RiboTag mice.

210 ~85,000 cells from the fovea and peripheral retina of seven adult human donors.

211 r the development of oxidative stress in the retina of streptozotocin-induced diabetic mice.

212 However, the spherical shape and the retina of the biological eye pose an enormous fabricatio

213 and rh1) were uniformly expressed across the retina of the common sole but, in the Senegalese sole, s

214 The adult retina of zebrafish self-repairs after damage by activat

215 In the retina of zebrafish, Muller glia have the ability to rep

216 array recordings during light stimulation in retinas of adult guinea pigs of either sex.

217 The retinas of nonmammalian vertebrates have cone photorecep

218 -scale multi-electrode array recordings from retinas of treatment-naive patients who underwent enucle

219 n stimulate pSmad3 expression in the injured retina, only Tgfb3 inhibits injury-dependent MG prolifer

220 In mature retinas, only one of four bipolar cell types rewires hom

221 hours from 3 academic nonhospital-associated retina-only private practice institutions over a 2-year

222 temporally incident light rays to the nasal retina pass anterior to the IOL and some are refracted p

223 m the interphase centrosomes of immortalized retina pigment epithelial (RPE1) cells.

224 ients with diabetes from a tertiary academic retina practice and obtained 3-mm x 3-mm macular OCTA sc

225 were gathered on all patients from multiple retina practices in the United States with RRD in 2015 a

226 were similar throughout all 3 layers of the retina (preretinal, intraretinal, and subretinal layers)

227 e expression of antiapoptotic markers in the retina, preventing the degeneration in vivo.

228 cant decrease in rhodopsin levels in Prcd-KO retina prior to photoreceptor degeneration.

229 ents in the cone photoreceptors of the mouse retina provides an excellent model to address this quest

230 ers (24.0%) and shorter follow-up times to a retina rather than a nonretina clinic for 52 of 151 pati

231 with the risk of cataract, and the volume of retina receiving 52 Gy was associated with the risk of r

232 s diagnosed with nePVAC were identified at 4 retina referral centers worldwide.

233 2 (1 with SRF, 1 with CNVM) had distinctive retina-related VF defects at presentation.

234 which parallel OFF channels generated in the retina remain segregated across three stages of visual p

235 These data support the idea that the retina reproduces brain neurodegeneration and is highly

236 Importantly, bead occlusion and ONC retinas resulted in differential subtype-specific loss o

237 in transcripts expressed in the N. oerstedii retina reveals the potential for previously undocumented

238 Using rat retina RNA-seq data from ischemic and normal conditions,

239 In mammalian retinas, rod and cone photoreceptors form selective syna

240 l understanding of vertebrate vision and the retina's computational purpose, it is therefore importan

241 urces remain attractive given their cost and retina safety.

242 Thus, the retina-SC-LP-V1 pathway forms a differential circuit wit

243 he optic disc, whereas others perforated the retina, separating photoreceptors from the retinal pigme

244 types and nearly 140 cell types in the mouse retina.SIGNIFICANCE STATEMENT The mouse retina is a lead

245 e may contribute to visual processing in the retina.SIGNIFICANCE STATEMENT The volume fraction of the

246 receive a monofocal IOL and be referred to a retina specialist for evaluation and management.

247 American Society of Retina Specialists members prescribed opioids at a rate

248 Most retina specialists rely on OCT to guide treatment decisi

249 ations for the prescription of opioids among retina specialists.

250 raded in a masked fashion independently by 2 retina specialists.

251 months of age, suggesting intervention with retina-specific CLN2 gene therapy should occur ideally b

252 We also unmasked a retina-specific gene expression signature that might con

253 Peripherin 2 (PRPH2) is a retina-specific tetraspanin protein essential for the fo

254 to be about the same in wild type and mutant retinas, suggesting that the mutant protein is expressed

255 ), consisting of the brain, spinal cord, and retina, superintends to the acquisition, integration and

256 lantation (OR, 0.39; 95% CI, 0.31-0.49), and retina surgery (OR, 0.46; 95% CI, 0.41-0.51).

257 he study of the photo response of artificial retina systems.

258 the gas bubble and the inferior and anterior retina than prone positioning even when the gas fill is

259 ipolar cells (BCs), secondary neurons of the retina that form synapses with rod photoreceptors.

260 terial and venous blood flow patterns in the retina that may facilitate research into disease pathoph

261 eas derived from previous work in the bovine retina that R-type Ca(2+) channels are involved in shapi

262 report on an identified synapse in the mouse retina, the cone photoreceptor type 4 bipolar cell (BC4)

263 In the vertebrate retina, the location of a neuron's receptive field in vi

264 Interestingly, in the retina, the Musashi proteins MSI1 and MSI2 are different

265 grade axonal transport from the brain to the retina through the optic nerve.

266 ad their processes across the surface of the retina to achieve a degree of dendritic coverage that is

267 We here use the zebrafish retina to address this gap, exploiting its suitability f

268 "avascular," "choriocapillaris," and "outer retina to choriocapillaris (ORCC)" slabs automatically p

269 tional and optogenetic analyses of the mouse retina to discover that surround inhibition of the AII d

270 pendent processes in both the RPE and neural retina to ensure adequate 11-cis-retinal production unde

271 ield flicker stimulus was presented onto the retina to induce a vascular response to neural activity.

272 from destruction of the peripheral avascular retina to inhibit angiogenic stimuli to anti-VEGF agents

273 uch candidates, we used the laminated murine retina to screen 92 lacZ reporter lines available throug

274 ibutes to the alignment of networks spanning retina to thalamus to cortex.

275 ry of the mouse, describing projections from retina to thalamus, between thalamus and cortex, and wit

276 as a crucial communication channel from the retina to the brain.

277 photoreceptors at the rim of the hemispheric retina, topological defects, called "Y-Junctions", form

278 At night retinas undergo a mitochondrial biogenesis event, corres

279 ble without any labeling in the living mouse retina using near-infrared light alone.

280 T angiography (OCTA), capable of visualizing retina vasculature.

281 ascular cells in the brain, autophagy in the retina, viral gene delivery, and chemical diffusion thro

282 d atrophic holes within peripheral avascular retina, visible vitreous condensation ridge-like interfa

283 A connectome from central macaque retina was generated by serial blockface scanning electr

284 ceptor density in 2-month old pomgnt1 mutant retina was similar to the wild-type animals but was sign

285 requency-modulated electrical stimulation of retina was tested.

286 The near-maximum dose to the retina was the only variable with clear impact on the ri

287 In the mouse retina, we find that LRRTM4 is enriched at GABAergic syn

288 Using human retinal organoids and mouse retina, we observed that a similar actin dynamics-driven

289 ng serial electron microscopy in the macaque retina, we reconstructed the neurons and synapses of the

290 In young retinas, we find that three bipolar cell types precisely

291 er to maintain hemodynamic regulation in the retina when exposed to visual stimulation, in our case f

292 re are 30-50 types of ganglion cell in mouse retina, whereas only a few years ago it was still writte

293 ntage of a compact circuit in the vertebrate retina, whereby the AII amacrine cell (AII AC) provides

294 have a specific spatial distribution in the retina, which is potentially associated with changes in

295 izontal cells (HCs) are neurons of the outer retina, which provide inhibitory feedback onto photorece

296 d by depletion of photoreceptor cells in the retina, which ultimately leads to blindness.

297 ral occlusion produced severe damage to both retinas, while unilateral occlusion produced damage main

298 l role in vision by focusing light on to the retina with loss of lens transparency leading to impairm

299 we made use of the genetically tractable fly retina, with a focus on the mechanisms that coordinate m

300 ly altered by the loss of TRPM1 in the adult retina, with significantly less dendritic and axon termi