ライフサイエンスコーパス: retinoblastoma tumor suppressor

1 e regulator, was initially identified as the retinoblastoma tumor suppressor.

2 pocket family of proteins that includes the retinoblastoma tumor suppressor.

3 ellular senescence through activation of the retinoblastoma tumor suppressor.

4 53 tumor suppressor, and the function of the retinoblastoma tumor suppressor.

5 (CDK2) and concomitant dephosphorylation of retinoblastoma tumor suppressor.

6 s deficient in MIF have significantly higher retinoblastoma tumor suppressor and lower E2F transcript

7 -phase entry through the inactivation of the retinoblastoma tumor suppressor and related pocket prote

8 e patterns--loss of H3K4 methylation--to the retinoblastoma tumor suppressor and the H3K4 demethylase

9 ssing repressor or activator subunits of the retinoblastoma tumor suppressor complex (RBC).

10 The product of the retinoblastoma tumor suppressor gene (Rb) can control ce

11 The retinoblastoma tumor suppressor gene (Rb) has many funct

12 The loss of the retinoblastoma tumor suppressor gene (RB) is common in m

13 ctivity of a crucial E2F target in vivo, the retinoblastoma tumor suppressor gene (Rb).

14 The retinoblastoma tumor suppressor gene (RB-1) is a key reg

15 The retinoblastoma tumor suppressor gene (RB1) and its relat

16 by truncating mutations or deletions in the Retinoblastoma tumor suppressor gene (RB1) are frequentl

17 radiation (IR) and germline mutations in the retinoblastoma tumor suppressor gene (RB1) are the stron

18 The Retinoblastoma tumor suppressor gene (RB1) plays a role

19 The retinoblastoma tumor suppressor gene (RB1; encoding RB)

20 The retinoblastoma tumor suppressor gene plays important rol

21 The retinoblastoma tumor suppressor gene product (pRb) is in

22 The retinoblastoma tumor suppressor gene product (Rb) binds

23 Functional inactivation of the retinoblastoma tumor suppressor gene product (RB) is a c

24 ed from normal mice or mice deficient in the retinoblastoma tumor suppressor gene product do not disp

25 dependent kinase activity phosphorylates Rb (retinoblastoma tumor suppressor gene product) family pro

26 lation of p27(kip1), hyperphosphorylation of retinoblastoma tumor suppressor gene product, and cellul

27 ro kinase assay using recombinant, truncated retinoblastoma tumor suppressor gene protein (Rb protein

28 Mutations of the retinoblastoma tumor suppressor gene RB are frequently o

29 Mutations in the retinoblastoma tumor suppressor gene Rb are involved in

30 The retinoblastoma tumor suppressor gene Rb is essential for

31 tremely sensitive to loss of function of the retinoblastoma tumor suppressor gene RB.

32 tic DNA templates and a PCR product from the retinoblastoma tumor suppressor gene.

33 DNA templates and on a PCR product from the retinoblastoma tumor suppressor gene.

34 d the inactivation of Rb, the product of the retinoblastoma tumor suppressor gene.

35 d in part by pRB, the protein product of the retinoblastoma tumor suppressor gene.

36 The product of the retinoblastoma tumor-suppressor gene (pRB), a nuclear ph

37 wnregulate the levels of hyperphosphorylated retinoblastoma tumor-suppressor gene (Rb) and cyclin D1,

38 The retinoblastoma tumor-suppressor gene (Rb1) is centrally

39 Although the retinoblastoma tumor-suppressor gene (RB1) is frequently

40 Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components

41 he function of short RNAs synergize with the retinoblastoma tumor suppressor homolog lin-35 in negati

42 The retinoblastoma tumor suppressor homolog MAT3 is a Volvox

43 16(INK4A) expression is not a consequence of retinoblastoma tumor suppressor inactivation but is trig

44 The retinoblastoma tumor suppressor is frequently inactivate

45 ggesting that in cervical cancer cells where retinoblastoma tumor suppressor is inactivated, CDK4/CDK

46 eins, which is essential for blockade of the retinoblastoma tumor suppressor, is also important for a

47 risk HPV E7 proteins to bind and degrade the retinoblastoma tumor suppressor or activate E2F target g

48 cyclin E promoter was repressed by wild-type Retinoblastoma tumor suppressor p105 protein (pRB) and b

49 action of E2F transcription factors and the retinoblastoma tumor suppressor/p107/p130 family of pock

50 The p16(INK4a)-cyclin D-retinoblastoma tumor suppressor pathway is disrupted in

51 whose inactivation suppresses defects in the retinoblastoma tumor suppressor pathway, and we successf

52 part independent of the inactivation of the retinoblastoma tumor suppressor pRb and is dependent on

53 The retinoblastoma tumor suppressor pRB is required for skel

54 Inactivation of the retinoblastoma tumor suppressor (pRB) alters the express

55 Inactivation of the retinoblastoma tumor suppressor (pRb) is a common oncoge

56 The retinoblastoma tumor suppressor (pRb) protein associates

57 cogenic activities is destabilization of the retinoblastoma tumor suppressor (pRB) through a ubiquiti

58 heterodimers from repression mediated by the retinoblastoma tumor suppressor (pRB) triggers cell cycl

59 E7 is its binding to and inactivation of the retinoblastoma tumor suppressor (pRb), but at least 18 o

60 to bind to and induce the degradation of the retinoblastoma tumor suppressor, pRb, and related "pocke

61 The retinoblastoma tumor suppressor, pRB, plays a central ro

62 ion with p53, and partially resistant to the retinoblastoma tumor suppressor, pRB.

63 Mutations in the gene encoding the retinoblastoma tumor suppressor predispose humans and mi

64 transcription factor E2F is a target of the retinoblastoma tumor suppressor protein (pRB) and may me

65 domain, which is required for binding of the retinoblastoma tumor suppressor protein (pRb) and pRb-li

66 of proliferation and differentiation by the retinoblastoma tumor suppressor protein (pRB) and relate

67 cells, CAK interacts with and phosphorylates retinoblastoma tumor suppressor protein (pRb) and retino

68 A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the tr

69 ibits cell proliferation, interacts with the retinoblastoma tumor suppressor protein (pRb) and the tr

70 rgo G1 arrest because of inactivation of the retinoblastoma tumor suppressor protein (pRb) by the pap

71 suppressor protein or by inactivation of the retinoblastoma tumor suppressor protein (pRb) by transdu

72 The retinoblastoma tumor suppressor protein (pRb) can associ

73 studies have shown that inactivation of the retinoblastoma tumor suppressor protein (pRb) can cause

74 The retinoblastoma tumor suppressor protein (pRB) can inhibi

75 Inactivation of the retinoblastoma tumor suppressor protein (pRB) contribute

76 The retinoblastoma tumor suppressor protein (pRb) controls c

77 Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family bot

78 The E7 protein of HPV-16 binds all retinoblastoma tumor suppressor protein (pRB) family mem

79 Inactivation of the retinoblastoma tumor suppressor protein (pRb) has been i

80 Retinoblastoma tumor suppressor protein (pRB) inhibition

81 The retinoblastoma tumor suppressor protein (pRB) is a trans

82 The retinoblastoma tumor suppressor protein (pRB) is a trans

83 cells, p53, p21, Bax, and hypophosphorylated retinoblastoma tumor suppressor protein (pRb) levels inc

84 The retinoblastoma tumor suppressor protein (pRB) negatively

85 During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites o

86 Downregulation of Cdc25A led to reduction in retinoblastoma tumor suppressor protein (pRb) phosphoryl

87 The mammalian retinoblastoma tumor suppressor protein (pRb) regulates

88 cooperate with removal of the E2F inhibitor retinoblastoma tumor suppressor protein (pRB) to drive c

89 Only the under-phosphorylated form of the retinoblastoma tumor suppressor protein (pRB) was detect

90 le arrest depends on an interaction with the retinoblastoma tumor suppressor protein (pRb), but diffe

91 factors is the key downstream target of the retinoblastoma tumor suppressor protein (pRB), which is

92 encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which nor

93 nuclear p21, and hypophosphorylation of the retinoblastoma tumor suppressor protein (pRb), with no e

94 The targets of E1A protein include the retinoblastoma tumor suppressor protein (pRb).

95 regulated most closely by phosphorylation of retinoblastoma tumor suppressor protein (pRb).

96 e of underphosphorylated, growth-suppressive retinoblastoma tumor suppressor protein (pRb).

97 of growth-regulatory proteins, including the retinoblastoma tumor suppressor protein (pRb).

98 These include the retinoblastoma tumor suppressor protein (Rb) and histone

99 phate site to promote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other s

100 at least 3 h prior to phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and the res

101 tumor-derived virus mutations do not affect retinoblastoma tumor suppressor protein (Rb) binding by

102 ment of E2F1 and concomitant dissociation of retinoblastoma tumor suppressor protein (Rb) from surviv

103 Disruption of murine retinoblastoma tumor suppressor protein (Rb) in mature p

104 The retinoblastoma tumor suppressor protein (RB) is a negati

105 The retinoblastoma tumor suppressor protein (RB) is a potent

106 Expression of the retinoblastoma tumor suppressor protein (Rb) is required

107 The retinoblastoma tumor suppressor protein (RB) is targeted

108 xhibit overexpression of hyperphosphorylated retinoblastoma tumor suppressor protein (Rb) or a marked

109 The retinoblastoma tumor suppressor protein (Rb) pathway is

110 ibition of cyclin D3 and Cdk4 expression and retinoblastoma tumor suppressor protein (Rb) phosphoryla

111 The retinoblastoma tumor suppressor protein (RB) plays a cri

112 The retinoblastoma tumor suppressor protein (Rb) plays a vit

113 The retinoblastoma tumor suppressor protein (RB) plays an im

114 The retinoblastoma tumor suppressor protein (RB) plays impor

115 radigm for G1/S control, Cdks inactivate the retinoblastoma tumor suppressor protein (Rb) through pho

116 fferentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typically a

117 Hepatitis C virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central

118 The retinoblastoma tumor suppressor protein (RB), a critical

119 he pathway that controls the activity of the retinoblastoma tumor suppressor protein (Rb), which in t

120 t inducible in tumor cells defective for the retinoblastoma tumor suppressor protein (Rb).

121 ent kinase activity, and underphosphorylated retinoblastoma tumor suppressor protein (RB).

122 h encodes proteins capable of binding to the retinoblastoma tumor suppressor protein (Rb).

123 ells, a key regulator of this process is the retinoblastoma tumor suppressor protein (RB).

124 the hypophosphorylated (active) form of the retinoblastoma tumor suppressor protein (Rb).

125 7 is associated with its ability to bind the retinoblastoma tumor suppressor protein (Rb).

126 e to bind to and inhibit the function of the retinoblastoma tumor suppressor protein (RB).

127 on-gamma, in solid tumor cells, requires the retinoblastoma tumor suppressor protein (Rb).

128 Interestingly, cells lacking the retinoblastoma tumor suppressor protein also display arr

129 e genes encoding TS and RR was enriched with retinoblastoma tumor suppressor protein and histone H3 t

130 The retinoblastoma tumor suppressor protein and its family m

131 cell cycle regulatory proteins including the retinoblastoma tumor suppressor protein and the coactiva

132 that was associated with phosphorylation of retinoblastoma tumor suppressor protein and the up-regul

133 Western blot analysis of the retinoblastoma tumor suppressor protein antigen from ker

134 of HPV-16 E7 involved in degradation of the retinoblastoma tumor suppressor protein as well as regio

135 phorylated growth inhibitory 105 kDa form of retinoblastoma tumor suppressor protein coimmunoprecipit

136 rmally RA-induced hypophosphorylation of the retinoblastoma tumor suppressor protein consistent with

137 not only by E2Fs but also by members of the retinoblastoma tumor suppressor protein family and by RN

138 Mutations which impaired binding of the retinoblastoma tumor suppressor protein family members p

139 The retinoblastoma tumor suppressor protein has been shown t

140 The retinoblastoma tumor suppressor protein has been shown t

141 Both protein kinase C and the retinoblastoma tumor suppressor protein have been linked

142 n which we expressed a fragment of the human retinoblastoma tumor suppressor protein in fission yeast

143 iolet radiation-induced dephosphorylation of retinoblastoma tumor suppressor protein in human skin an

144 hosphorylation of this fragment of the human retinoblastoma tumor suppressor protein is dependent on

145 independent of its ability to inactivate the retinoblastoma tumor suppressor protein pRB and the rela

146 targets of the HPV-16 E7 oncoprotein are the retinoblastoma tumor suppressor protein pRB and the rela

147 teady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decrease

148 E2F and retinoblastoma tumor suppressor protein pRB are importan

149 The retinoblastoma tumor suppressor protein pRb is a key reg

150 The retinoblastoma tumor suppressor protein pRB is conventio

151 The retinoblastoma tumor suppressor protein pRb restricts ce

152 osphorylated, growth suppressive form of the retinoblastoma tumor suppressor protein pRB was detected

153 ated family member, is in a complex with the retinoblastoma tumor suppressor protein Rb and activates

154 ntral ATPase domain, a domain that binds the retinoblastoma tumor suppressor protein Rb, and a C-term

155 cells, presumably because of mutation at the retinoblastoma tumor suppressor protein that allows func

156 M okadaic acid, resulted in an inhibition of retinoblastoma tumor suppressor protein translocation to

157 ted and ultraviolet-irradiated keratinocytes retinoblastoma tumor suppressor protein was localized to

158 tein, and accumulation of hypophosphorylated retinoblastoma tumor suppressor protein(105) was inhibit

159 tion of growth inhibitory hypophosphorylated retinoblastoma tumor suppressor protein(105).

160 functional role for the cyclin D1/Cdk4/pRb (retinoblastoma tumor suppressor protein) pathway in dela

161 ts activation of p57Kip2 expression, and the retinoblastoma tumor suppressor protein, a known Id2 inh

162 pression of cyclin E, phosphorylation of the retinoblastoma tumor suppressor protein, and a doubling

163 ion-induced depletion in hyperphosphorylated retinoblastoma tumor suppressor protein, and accumulatio

164 in a rapid depletion in hyperphosphorylated retinoblastoma tumor suppressor protein, and the accumul

165 mmortalizing activity, LMP1 does not bind to retinoblastoma tumor suppressor protein, but instead blo

166 of transcription and differentiation by the retinoblastoma tumor suppressor protein, contains a JmjC

167 Interestingly, unlike retinoblastoma tumor suppressor protein, MDMX, and p14(A

168 es 103 to 107), necessary for binding to the retinoblastoma tumor suppressor protein, pRB, and the re

169 E2F1 that facilitates complex formation with retinoblastoma tumor suppressor protein, pRB, and we fou

170 In vitro phosphorylation of the retinoblastoma tumor suppressor protein, pRB, by cyclin

171 best known for its ability to inactivate the retinoblastoma tumor suppressor protein, pRb, many other

172 The retinoblastoma tumor suppressor protein, RB, contains at

173 at examining the precise function(s) of the retinoblastoma tumor suppressor protein, RB, have been h

174 1/cip1) and promote dephosphorylation of the retinoblastoma tumor suppressor protein, Rb, in MCF-7 br

175 The retinoblastoma tumor suppressor protein, Rb, interacts d

176 The retinoblastoma tumor suppressor protein, RB, is a negati

177 The antiproliferative action of the retinoblastoma tumor suppressor protein, RB, is disrupte

178 cogene that functions by inactivation of the retinoblastoma tumor suppressor protein, RB.

179 inetics, and relative phosphorylation of the retinoblastoma tumor suppressor protein, using primary t

180 d overriding the checkpoint functions of the retinoblastoma tumor suppressor protein.

181 and depletion of hyperphosphorylation of the retinoblastoma tumor suppressor protein.

182 sphorylated and hyperphosphorylated forms of retinoblastoma tumor suppressor protein.

183 accompanied by unchecked inactivation of the retinoblastoma tumor suppressor protein.

184 k4/6 activity and active, hypophosphorylated retinoblastoma tumor suppressor protein.

185 generation of a complex also containing the retinoblastoma tumor suppressor protein.

186 ed because its gene products can bind to the retinoblastoma tumor suppressor protein.

187 ependent of the ability of E7 to inhibit the retinoblastoma tumor suppressor protein.

188 lix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein.

189 ays and inhibition of phosphorylation of the retinoblastoma tumor suppressor protein.

190 nd maturation by TGFbeta is dependent on the retinoblastoma tumor suppressor protein/E2 promoter bind

191 The retinoblastoma tumor-suppressor protein (pRb) is a criti

192 The retinoblastoma tumor-suppressor protein (pRb) is known t

193 The retinoblastoma tumor-suppressor protein (RB) is an impor

194 The retinoblastoma tumor-suppressor protein (Rb) plays a cri

195 The retinoblastoma tumor-suppressor protein, pRb, is a membe

196 receptor that is negatively regulated by the retinoblastoma tumor-suppressor protein.

197 F-1/DP1 transcription factor complex and the retinoblastoma tumor-suppressor protein.

198 g their cellular targets are the p53 and the retinoblastoma tumor suppressor proteins.

199 The retinoblastoma tumor suppressor RB and its related prote

200 The retinoblastoma tumor suppressor RB controls the prolifer

201 In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivat

202 The retinoblastoma tumor suppressor RB is the downstream med

203 The retinoblastoma tumor suppressor RB is well known for its

204 In this regard, we have found that both the retinoblastoma tumor suppressor (Rb) and a novel nuclear

205 The retinoblastoma tumor suppressor (RB) and mismatch repair

206 gh some E2F functions are independent of the Retinoblastoma tumor suppressor (Rb) and related family

207 E-cadherin and the retinoblastoma tumor suppressor (Rb) are traditionally a

208 The retinoblastoma tumor suppressor (Rb) controls the prolif

209 y methylation were correlated with increased Retinoblastoma tumor suppressor (RB) expression, suggest

210 with earlier work, HPV16 E7 can bind to the retinoblastoma tumor suppressor (RB) family member p130

211 The retinoblastoma tumor suppressor (RB) is a central cell c

212 The retinoblastoma tumor suppressor (RB) is a critical regul

213 The retinoblastoma tumor suppressor (Rb) is a multifunctiona

214 The retinoblastoma tumor suppressor (RB) is crucial for the

215 The retinoblastoma tumor suppressor (RB) is functionally ina

216 The retinoblastoma tumor suppressor (RB) is functionally ina

217 The retinoblastoma tumor suppressor (RB) is functionally ina

218 that only combined deletion of p27(Kip1) and retinoblastoma tumor suppressor (Rb) is sufficient to re

219 The integrity of the retinoblastoma tumor suppressor (RB) pathway is critical

220 ) type 16 E7 oncoprotein must inactivate the retinoblastoma tumor suppressor (Rb) pathway to bypass G

221 The role of the retinoblastoma tumor suppressor (RB) pathway, which is l

222 we demonstrate that Plk1 is a target of the retinoblastoma tumor suppressor (RB) pathway.

223 n is common in DCIS, as is disruption of the retinoblastoma tumor suppressor (RB) pathway.

224 oncogenic pathway and/or inactivation of the retinoblastoma tumor suppressor (RB) pathway.

225 The retinoblastoma tumor suppressor (RB) plays an important

226 eraction between CHT7 and the C. reinhardtii retinoblastoma tumor suppressor (RB) protein homolog MAT

227 The retinoblastoma tumor suppressor (RB) protein is function

228 Retinoblastoma tumor suppressor (Rb) protein stimulates

229 and has been implicated in the action of the retinoblastoma tumor suppressor (RB).

230 eminin is regulated transcriptionally by the retinoblastoma tumor suppressor (RB)/E2F pathway.

231 The retinoblastoma tumor suppressor, RB, assembles multiprot

232 The retinoblastoma tumor suppressor, RB, is a key regulator

233 The retinoblastoma tumor suppressor, RB, is a negative regul

234 The retinoblastoma tumor suppressor, RB, is thought to inhib

235 1 is required for the destabilization of the retinoblastoma tumor suppressor RB1 in HPV16 E7-expressi

236 sing an HPV16 E7 variant that can inactivate retinoblastoma tumor suppressor (RB1) but cannot degrade

237 the cell cycle defects caused by loss of the retinoblastoma tumor suppressor-related protein encoded

238 cus 3-4 (mat3-4), which contains a defective retinoblastoma tumor suppressor-related protein of Chlam

239 UL97 phosphorylated and inactivated the retinoblastoma tumor suppressor, stimulated cell cycle p

240 and cyclin A-dependent phosphorylation of a retinoblastoma tumor suppressor substrate.