ライフサイエンスコーパス: retinol dehydrogenase

1 of dehydrogenases that can oxidize retinol (retinol dehydrogenases).

2 specificities of the photoreceptor all-trans-retinol dehydrogenase.

3 cycle and as a substrate carrier for 11-cis-retinol dehydrogenase.

4 11-cis-retinyl-ester synthase, and an 11-cis-retinol dehydrogenase.

5 nzymes, lecithin retinol acyltransferase and retinol dehydrogenases.

6 th human enzymes as physiologically relevant retinol dehydrogenases.

7 family and shares 65% sequence identity with retinol dehydrogenase 1 (RoDH1), which catalyzes the oxi

8 hort-chain dehydrogenase/reductase isozymes (retinol dehydrogenases 1-3 and CRAD1), closely related i

9 In embryos overexpressing aldh1a2 or retinol dehydrogenase 10 (rdh10) in the presence of thei

10 ed that oxidation of vitamin A to retinal by retinol dehydrogenase 10 (RDH10) is critical for embryon

11 nstrates that DHRS3 requires the presence of retinol dehydrogenase 10 (RDH10) to display its full cat

12 Human retinol dehydrogenase 10 (RDH10) was implicated in the o

13 Here, we sought to determine whether retinol dehydrogenase 10 (RDH10), upregulated in rod/con

14 of at least two subunits of NAD(+)-dependent retinol dehydrogenase 10 (RDH10), which catalyzes the ox

15 y, we discovered that mice with mutations in retinol dehydrogenase 10 (Rdh10), which perturbs Vitamin

16 B1 (Cyp26b1), which results in excess RA, or retinol dehydrogenase 10 (Rdh10), which results in RA de

17 study demonstrate that ectopic expression of retinol dehydrogenase 10 (RDH10, SDR16C4) in skin rafts

18 Here, we show that RGR opsin and retinol dehydrogenase-10 (Rdh10) convert all-trans-retin

19 , c.C199T:p.R67* and c.C322T:p.R108*, in the retinol dehydrogenase 11 (RDH11) gene, resulting in a no

20 lecithin:retinol acetyltransferase (Lrat) or retinol dehydrogenase 11 (Rdh11) mRNA or a decrease in a

21 genase/reductase 1, retinal reductase 1, and retinol dehydrogenase 11.

22 retinoid visual cycle is catalyzed by 11-cis-retinol dehydrogenases (11-cis-RDHs) that oxidize 11-cis

23 This reaction is catalyzed by 11-cis-retinol dehydrogenases (11-cis-RDHs), prior to the chrom

24 Retinol dehydrogenase 12 (RDH12) is a novel member of th

25 Retinol dehydrogenase 12 (RDH12) is an NADP(+)-dependent

26 Retinal levels of retinol dehydrogenase 12 (RDH12) were measured by immuno

27 lly related to DHRS9, i.e., human SDR9C8 (or retinol dehydrogenase 16), the rat SDR9C family member k

28 heca cells were aldehyde dehydrogenase 6 and retinol dehydrogenase 2, which play a role in all-trans-

29 NA library encodes a 317-amino acid protein, retinol dehydrogenase 4 (RoDH-4), which exhibits the str

30 retinol/sterol substrate specificity, namely retinol dehydrogenase 4 (RoDH4, SDR9C8), RoDH-like 3alph

31 pression of two retinoid biosynthesis genes: retinol dehydrogenase 5 (RDH5) and retinol dehydrogenase

32 Pathogenic variants in retinol dehydrogenase 5 (RDH5) attenuate supply of 11-ci

33 Retinol dehydrogenase 5 (RDH5) is responsible for a majo

34 PE65 operates in a multiprotein complex with retinol dehydrogenase 5 and retinal G protein-coupled re

35 Levels of retinol dehydrogenase 5, and dehydrogenase/reductase sho

36 ream, attributable to mass action by CRALBP, retinol dehydrogenase 5, and high affinity of opsin apop

37 se 16), the rat SDR9C family member known as retinol dehydrogenase 7, and the mouse ortholog of human

38 binding cassette subfamily A member 4 (-/-) /retinol dehydrogenase 8 (-/-) and wild-type BALB/c mice

39 P-binding cassette transporter 4 (Abca4) and retinol dehydrogenase 8 (Rdh8) activities.

40 eport that two chromophore binding proteins, retinol dehydrogenase 8 (RDH8) and photoreceptor-specifi

41 e roles of two chromophore-binding proteins, retinol dehydrogenase 8 (RDH8) and photoreceptor-specifi

42 P-binding cassette transporter 4 (ABCA4) and retinol dehydrogenase 8 (RDH8), proteins critical for al

43 ng cassette transporter 4 (Abca4) and enzyme retinol dehydrogenase 8 (Rdh8), proteins critical for al

44 TP-binding cassette transporter 4) and RDH8 (retinol dehydrogenase 8), manifested retinal abnormaliti

45 retinoic acid synthesis, whereas microsomal retinol dehydrogenase (a short-chain dehydrogenase/reduc

46 brane-associated retinaldehyde reductase and retinol dehydrogenase activities are decreased by approx

47 Several enzymes exhibit retinol dehydrogenase activities in vitro; however, thei

48 These results indicate that the retinol dehydrogenase activities of murine SDR16C5 and S

49 onsistent with a nearly 80% reduction in the retinol dehydrogenase activities of skin membrane fracti

50 All-trans retinol dehydrogenase activity assays were performed usi

51 The NADPH-dependent all-trans-retinol dehydrogenase activity in isolated RPE microsoma

52 survival but are responsible for most of the retinol dehydrogenase activity in skin, essential for th

53 horylated and reduced forms of NAD-dependent retinol dehydrogenase activity may function in the nucle

54 In turn, the retinol dehydrogenase activity of RDH10 is reciprocally

55 In rMC-1 cells, all-trans retinol dehydrogenase activity was detected in the micro

56 In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-h

57 g the control of RA production by APC is via retinol dehydrogenase activity.

58 de the first genetic evidence of a candidate retinol dehydrogenase affecting either vitamin A-related

59 involves two sequential steps, catalyzed by retinol dehydrogenases and retinal dehydrogenases, respe

60 Therefore, multiple retinol dehydrogenases are involved in regeneration of 1

61 s generated in the RPE, because no all-trans retinol dehydrogenase (atRDH) has been identified in the

62 tion of a putative RDH, referred to as RDHB (retinol dehydrogenase B), which functions in the visual

63 Retinol dehydrogenases catalyze the rate-limiting step i

64 DH) has been shown to function in vitro as a retinol dehydrogenase catalyzing the synthesis of retino

65 We identified Rdh5 as a retina-specific retinol dehydrogenase controlled by APC.

66 Recently, we identified a cis-retinol dehydrogenase (cRDH) that oxidizes 9-cis-retinol

67 ied by mass spectrometric analysis as 11-cis-retinol dehydrogenase (cRDH), and enzymatic assays have

68 dh10 and an increase in the estrogen-induced retinol dehydrogenase Dhrs9.

69 of cellular retinol-binding protein (Crbp), retinol dehydrogenase (Dhrs9/eRoldh), retinal dehydrogen

70 l-trans-retinol dehydrogenase (photoreceptor retinol dehydrogenase) displays identical stereospecific

71 molecularly cloned; here we focus on 11-cis retinol dehydrogenase (encoded by the gene RDH5; chromos

72 that requires the action of a zinc-dependent retinol dehydrogenase enzyme.

73 nto its active form, retinoic acid, requires retinol dehydrogenase enzymes.

74 g evidence that Xenopus rdhe2 functions as a retinol dehydrogenase essential for frog embryonic devel

75 A novel all-trans-retinol dehydrogenase exists in the RPE and performs a c

76 ent-binding proteins and showed that it is a retinol dehydrogenase expressed in non-ocular tissues su

77 RDH11 and RDH12 are closely related retinol dehydrogenases expressed in the retina.

78 rate retinal generated in situ by microsomal retinol dehydrogenases, from the physiologically most ab

79 s shown with CRISPR/Cas9 knockout lines, the retinol dehydrogenase gene Rdh10 and a functional RARE i

80 Recombinant mutant 11-cis retinol dehydrogenases had reduced activity compared wit

81 strate in the absence of apo-CRBP microsomal retinol dehydrogenases have the higher specific activity

82 of apo-CRBP, a potent inhibitor of cytosolic retinol dehydrogenases (IC50 = approximately 1 microM),

83 Here we describe a third retinol dehydrogenase in the RPE, RDH10, which can produ

84 o function as a substrate carrier for 11-cis-retinol dehydrogenase in the synthesis of 11-cis-retinal

85 generation of rhodopsin by inhibiting 11-cis-retinol dehydrogenase in the visual cycle.

86 plished by a family of enzymes termed 11-cis-retinol dehydrogenases, including RDH5 and RDH11.

87 his result is unusual, because photoreceptor retinol dehydrogenase is a member of a short chain alcoh

88 ely catalyzed by abundantly expressed 11-cis-retinol dehydrogenase, is pro-S-specific to both 11-cis-

89 hares close amino acid similarity with mouse retinol dehydrogenase isozyme types 1 and 2 and CRAD1 (8

90 res closest amino acid similarity with mouse retinol dehydrogenase isozymes types 1 and 2 (86 and 91%

91 Unlike recombinant retinol dehydrogenase isozymes, recombinant CRAD was inh

92 ntensely in kidney and liver, in contrast to retinol dehydrogenase isozymes, which show strong mRNA e

93 uced neuritogenesis was partly attenuated in retinol dehydrogenase knockout (Rdh12(-/-)) mice and by

94 is genes: retinol dehydrogenase 5 (RDH5) and retinol dehydrogenase L (RDHL) in colon adenomas and car

95 result of the transcriptional repression of retinol dehydrogenase l1 via a complex that includes Lef

96 ll-trans-retinol via reversible oxidation by retinol dehydrogenases, members of the short-chain dehyd

97 which is the product of action by the enzyme retinol dehydrogenase on all-trans retinal, was not toxi

98 for chromophore regeneration and requires a retinol dehydrogenase, PDH, in retinal pigment cells.

99 A recently identified all-trans-retinol dehydrogenase (photoreceptor retinol dehydrogena

100 mal retinol dehydrogenases, versus cytosolic retinol dehydrogenases, provide the quantitatively major

101 Photoreceptor-specific retinol dehydrogenase (prRDH) catalyzes reduction of all

102 Photoreceptor retinol dehydrogenase (prRDH) is a membrane-associated c

103 ietary supplementation of retinaldehyde, and retinol dehydrogenase (RDH) activity assays, we demonstr

104 ociated with significant decrease in hepatic retinol dehydrogenase (RDH) activity, the rate-limiting

105 The protein has retinol dehydrogenase (RDH) activity, with enzymatic act

106 -induced internalization of rhodopsin, and a retinol dehydrogenase (RDH) that catalyzes the first ste

107 Retinol dehydrogenase (RDH), the enzyme that catalyzes t

108 RA including decreased protein expression of retinol dehydrogenase (RDH)-10 and increased protein exp

109 ated with Stargardt macular degeneration and retinol dehydrogenases (RDH) in the clearance of all-tra

110 RDH12 has been suggested to be one of the retinol dehydrogenases (RDH) involved in the vitamin A r

111 t neurons, biosynthesize atRA using multiple retinol dehydrogenases (Rdh) of the short chain dehydrog

112 esis at the rate-limiting step, catalyzed by retinol dehydrogenases (RDH).

113 erns in adult tissues and embryos of a mouse retinol dehydrogenase, RDH1.

114 The retinol dehydrogenase Rdh10 catalyzes the rate-limiting

115 ism, which is catalyzed in large part by the retinol dehydrogenase RDH10, is critical for the spatiot

116 The microsomal retinol dehydrogenase (RDH11) and cytosolic soluble alde

117 three enzymes from a novel subfamily of four retinol dehydrogenases (RDH11-14) that display dual-subs

118 Herein, we report that the novel retinol dehydrogenase, rdh1l, is required for proper gut

119 the gut by regulating the expression of the retinol dehydrogenase, rdh1l.

120 henotype associated with mutations in 11-cis-retinol dehydrogenase (RDH5) causing fundus albipunctatu

121 etinol and as a substrate carrier for 11-cis-retinol dehydrogenase (RDH5).

122 release, all-trans-retinal is reduced by the retinol dehydrogenase RDH8 to all-trans-retinol in an NA

123 amily, frog sdr16c5, acts as a highly active retinol dehydrogenase (rdhe2) that promotes retinoic aci

124 hat human colon adenomas and carcinomas lack retinol dehydrogenases (RDHs) and that APC regulates the

125 biosynthesis of retinoic acid from retinal, retinol dehydrogenases (RDHs), access retinol bound to c

126 aldehyde by alcohol dehydrogenases (ADHs) or retinol dehydrogenases (RDHs); and oxidation of retinald

127 ns isolated from Rbp1(-/-) mice have altered retinol dehydrogenase/reductase (Rdh) enzyme activity th

128 en shown that mutations in RDH12, encoding a retinol dehydrogenase, result in severe and early-onset

129 the strongest similarity with rat all-trans-retinol dehydrogenases RoDH-1, RoDH-2, and RoDH-3, and m

130 Previously, two genes encoding retinol dehydrogenases (RoDH), which recognize holo-cell

131 properties; yet ethanol inhibited cytosolic retinol dehydrogenase(s) (IC50 = 20 microM) while stimul

132 Cytosolic retinol dehydrogenase(s) and the isozymes of alcohol deh

133 e present evidence that two murine epidermal retinol dehydrogenases, short-chain dehydrogenase/reduct

134 e short-chain dehydrogenase/reductase (SDR), retinol dehydrogenase-similar (RDH-S), with intense mRNA

135 ytes, we have identified two novel zebrafish retinol dehydrogenases, termed zRDHA and zRDHB, that sho

136 lls contain a membrane-bound NADPH-dependent retinol dehydrogenase that reacts efficiently with all-t

137 iously unrecognized physiologically relevant retinol dehydrogenases that contribute to retinoic acid

138 e therefore determined the topology of mouse retinol dehydrogenase type 1 (Rdh1) and cis-retinoid and

139 Mouse rdh1 encodes retinol dehydrogenase type 1 (RDH1), a short-chain dehyd

140 rt-chain dehydrogenase/reductase) rat RoDH1 (retinol dehydrogenase type 1) in the endoplasmic reticul

141 This study shows that microsomal retinol dehydrogenases, versus cytosolic retinol dehydro

142 Compensatory expression of other retinol dehydrogenases was observed in both Rdh5(-/-) an

143 sual cycle component, RDH11, encoding 11-cis-retinol dehydrogenase, was observed in PYGM-null RPE.

144 At least two discrete forms of cytosolic retinol dehydrogenase were observed: NAD- and NADP-depen

145 viously unknown stereospecific enzyme, 9-cis-retinol dehydrogenase, which probably plays a role in 9-

146 tBP1 suppresses the expression of intestinal retinol dehydrogenases, which are required for retinoic