ライフサイエンスコーパス: retrograde transport

1 dosome-localized complex involved in protein retrograde transport.

2 hila motoneuron terminals by anterograde and retrograde transport.

3 early endosomes for clathrin removal during retrograde transport.

4 upregulation of the ARF6 GEF ARNO enhancing retrograde transport.

5 l of various endosomal activities, including retrograde transport.

6 LIP-170), and dynactin-1 (DCTN1) to initiate retrograde transport.

7 the trans-Golgi network and is essential for retrograde transport.

8 port whereas IFT-A and dynein participate to retrograde transport.

9 orting to signaling endosomes and supporting retrograde transport.

10 de from the cis-Golgi to the ER through COPI retrograde transport.

11 mage signals and virus particles compete for retrograde transport.

12 other by tethering to organelles rather than retrograde transport.

13 d rates of transport, stalling, or increased retrograde transport.

14 chondria, whereas full-length PINK1 promoted retrograde transport.

15 ynactin thereby inhibiting the initiation of retrograde transport.

16 -ends to receive kinesin-3-delivered EEs for retrograde transport.

17 (TA) proteins, including SNAREs required for retrograde transport.

18 nent of IFT complex A, which is required for retrograde transport.

19 hypothesized that complex A is required for retrograde transport.

20 ofiles seen in fast and slow anterograde and retrograde transport.

21 together with reductions in FluoroGold (FG) retrograde transport.

22 rly and sustained changes in anterograde and retrograde transport.

23 aps mediating cytoskeletal attachment during retrograde transport.

24 olved in Golgi to endoplasmic reticulum (ER) retrograde transport.

25 motility in axons, with a strong bias toward retrograde transport.

26 her back to the ER by KDEL receptor-mediated retrograde transport.

27 sferase, an established cargo of intra-Golgi retrograde transport.

28 a partner in Actr10-dependent mitochondrial retrograde transport.

29 out MTs to stabilize MTs and allow efficient retrograde transport.

30 PKC-dependent inhibition of dynein-dependent retrograde transport.

31 while they bud, thereby promoting efficient retrograde transport.

32 ion at presynaptic terminals by enhancing AV retrograde transport.

33 formation of Kupffer's vesicle and delays in retrograde transport.

34 ade pathway complex), a central component of retrograde transport.

35 bleaching DCVs entering a synaptic bouton by retrograde transport.

36 early step in Golgi-to-endoplasmic reticulum retrograde transport, affects amyloid precursor protein

37 sicular trafficking was evidenced by delayed retrograde transport after brefeldin A treatment and abn

38 autophagosomes undergo robust unidirectional retrograde transport along axons.

39 here diffusion is slow-is thought to utilize retrograde transport along the microtubule network by th

40 agosomes from the distal axon, for sustained retrograde transport along the midaxon, and for autophag

41 isiae golgin Coy1 contributes to intra-Golgi retrograde transport and binds to the conserved oligomer

42 ein gene, App, acts to markedly decrease NGF retrograde transport and cause degeneration of BFCNs.

43 the molecular processes that underlie their retrograde transport and cell transduction.

44 in-BicD2, the dynactin p150 subunit promotes retrograde transport and could serve as a target for reg

45 In axons, JNK and Rab5 were required for retrograde transport and death signaling mediated by axo

46 sicle circulation, which includes long-range retrograde transport and inefficient bidirectional captu

47 f axonal mRNAs is required for efficient PRV retrograde transport and infection of cell bodies.

48 tic insights into how Snapin-DIC coordinates retrograde transport and late endosomal-lysosomal traffi

49 the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal

50 f TMEM16K function led to impaired endosomal retrograde transport and neuromuscular function, one of

51 step in Golgi-to-endoplasmic reticulum (ER) retrograde transport and one of the very first trafficki

52 ing that Strip is a molecular linker between retrograde transport and Rab5 activation.

53 , which require retromer physiologically for retrograde transport and recycling, respectively.

54 tic components by inhibiting dynein-mediated retrograde transport and setting the balance between ant

55 Given that dynactin initiates retrograde transport and that amino acid sequences impli

56 is a large multisubunit complex involved in retrograde transport and the positioning of various orga

57 ese data support a model where Asna1 ensures retrograde transport and, hence, ER and insulin homeosta

58 endosomes to support both endosome-to-Golgi (retrograde transport) and endosome-to-plasma membrane (r

59 ablishment of latency in peripheral ganglia (retrograde transport) and for viral spread in axons to e

60 vents involving their formation, processing, retrograde transport, and somal signaling in sympathetic

61 autophagosomes undergo UNC-16/JIP3-mediated retrograde transport, and that autophagosomes containing

62 Although effects on retrograde transport are predicted by the proposed funct

63 virus (AAV) undergoes microtubule-dependent retrograde transport as part of a program of vectorial t

64 brane-to-trans Golgi network and Golgi-to-ER retrograde transport as well as to ER stress in beta-cel

65 al. reveals a role for p150 in initiation of retrograde transport at synaptic terminals.

66 ed) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this funct

67 xcess distal DCVs undergo dynactin-dependent retrograde transport back through proximal boutons into

68 GARP with SNAREs are insufficient to promote retrograde transport, because deletion of the C-terminal

69 in protein Coy1 and document its function in retrograde transport between early Golgi compartments.

70 ed interaction partner p31, both involved in retrograde transport between endoplasmic reticulum and G

71 ed in SMA disease conditions, with decreased retrograde transport but no effect on anterograde transp

72 Increased retrograde transport by BICD2 mutants also was observed

73 mplexes and determine the specific cargo for retrograde transport by binding cargo receptors such as

74 fore, Rab7 plays an essential role in axonal retrograde transport by controlling a vesicular compartm

75 interestingly that kinesin-1 is critical for retrograde transport by dynein.

76 Defective retrograde transport by genetic ablation of snapin in mi

77 hat Abeta oligomers compromise BDNF-mediated retrograde transport by impairing endosomal vesicle velo

78 Regulation of normal retrograde transport by Kinesin-1 is independent of dyne

79 It plays a key role in initiating retrograde transport by recruiting and tethering endosom

80 Inhibition of retrograde transport by small molecule inhibitors reduce

81 In mice, the fusion protein underwent retrograde transport by spinal cord motor neurons follow

82 rdered pathway, leading to the initiation of retrograde transport by the motor dynein.

83 Retrograde transport carriers bud from the endosome coat

84 l sorting and fission machineries to produce retrograde transport carriers.

85 Early endosomes undergo retrograde transport (clustering) before their homotypic

86 early endosomes supports their maturation to retrograde transport-competent endosomes.

87 Here, we demonstrate that defective retrograde transport contributes to autophagic stress in

88 tlas of the brain, although its capacity for retrograde transport currently limits its use to unidire

89 Thm1-mutant cilia also show a retrograde transport defect for the Hedgehog transducer,

90 gos, and help to explain previously reported retrograde transport defects generated when kinesin-1 is

91 e abnormal axon morphology and mitochondrial retrograde transport defects observed in actr10 mutants

92 d that pk2 knockdown suppresses bbs7-related retrograde transport delay.

93 h, in turn, facilitates the microtubule- and retrograde transport-dependent mutant SOD1 aggregation.

94 ants of kinesin-2 (fla10) showed exclusively retrograde transport events, driven by 7 motors on avera

95 Many retrograde transport factors were required for efficient

96 t mitochondria that are stranded in axons by retrograde transport failure; a protective process aimed

97 etromer plays an important role in efficient retrograde transport for endosome-to-Golgi retrieval of

98 it is difficult to uncouple the functions of retrograde transport from anterograde, as null mutants i

99 gainst Shiga toxins by specifically blocking retrograde transport from early endosomes to the trans-G

100 In contrast, we provided evidence that retrograde transport from early endosomes to the trans-G

101 he retromer complex is well known to mediate retrograde transport from endosomes to the Golgi.

102 ese findings indicate that GARP orchestrates retrograde transport from endosomes to the TGN by promot

103 esicles might correspond to intermediates in retrograde transport from endosomes to the TGN.

104 retrograde protein (GARP) complex regulates retrograde transport from endosomes to the trans-Golgi n

105 ynein and its partner complex dynactin drive retrograde transport from the distal axon.

106 M4 cells are readily labeled by retrograde transport from the dorsal lateral geniculate

107 le subunits of the retromer, which initiates retrograde transport from the endosome to the trans-Golg

108 with PACS-1, a cytosolic protein, to mediate retrograde transport from the endosomes to the TGN.

109 Also retrograde transport from the endosomes to the trans-Gol

110 nriched in the endoplasmic reticulum (ER) by retrograde transport from the Golgi that is mediated by

111 ell, mediate the early secretory pathway and retrograde transport from the Golgi to the endoplasmic r

112 oat protein I (COPI)-coated vesicles mediate retrograde transport from the Golgi to the endoplasmic r

113 tivin, the transcription factor, dSmad2, and retrograde transport from the growth cone to the R7 nucl

114 Trafficking of Anc.a did not require retrograde transport from the late endosome to the Golgi

115 Neurobiotin retrograde transport from the spinal cord combined with

116 art et al. with general staining methods and retrograde transport from the spinal cord.

117 tidylinositol-3,5-bisphosphate synthesis and retrograde transport from the vacuole.

118 h are required for sensory transduction, and retrograde transport genes, which are required to differ

119 endosomes are in fact amphisomes that during retrograde transport have local signaling capacity in th

120 tment and excluded from axons by predominant retrograde transport However, on overexpression rab11 wa

121 RV share a conserved mechanism for postentry retrograde transport in axons and provides the foundatio

122 Cytoplasmic dynein mediates retrograde transport in axons, but it is unknown how its

123 of intermediate chains for their subsequent retrograde transport in axons.

124 rt, whereas WT La shows both anterograde and retrograde transport in axons.

125 o, a new capsid variant capable of efficient retrograde transport in brain, was generated in mice usi

126 mpaired organelle transport and particularly retrograde transport in hippocampal neurons.

127 for trans-Golgi network (TGN) functions and retrograde transport in HSV entry.

128 r symptoms, demonstrating the involvement of retrograde transport in inducing alphaS CNS inclusion pa

129 Of note, pharmacological inhibition of retrograde transport in isolated islets and insulinoma c

130 y active type I BMP receptors or by reducing retrograde transport in motor neurons also restored syna

131 Intriguingly, enhancement of retrograde transport in mutant hAPP neurons facilitates

132 serves as a dynein-independent mechanism for retrograde transport in plants.

133 o quantum dots, we selectively analyzed TrkB retrograde transport in response to BDNF stimulation at

134 ation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that a

135 ed DYNC2H1, a cytoplasmic dynein involved in retrograde transport in the cilium.

136 Finally, retrograde transport in the nerve terminal is regulated

137 and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of

138 Thus imaging selective retrograde transport inhibition led to the discovery of

139 an altered secretome and sensitivity to the retrograde transport inhibitor brefeldin A (BFA) in cell

140 ssential role for +TIPs in the regulation of retrograde transport initiation in the neuron.

141 rade transport is driven by kinesin, whereas retrograde transport is ensured by a specific dynein.

142 Retrograde transport is required to maintain homeostasis

143 Disruption of retrograde transport leads to a variety of neurodegenera

144 Mouse models with defects in the retrograde transport machinery, including the Loa mouse

145 Our results suggest that Golgi to ER retrograde transport may be important under conditions o

146 An impairment of axonal retrograde transport may therefore represent one of the

147 neuronal survival/death decisions through a retrograde transport mechanism.

148 first clear evidence of linkage between the retrograde transport mediated by the retromer complex an

149 obe for the quantitative in situ tracking of retrograde transport neurons with single-particle resolu

150 tor, GTP-bound Rab46 evokes dynein-dependent retrograde transport of a subset of WPBs along microtubu

151 Together, these studies demonstrate strong retrograde transport of AAV2.retro in NHP brain, highlig

152 The retrograde transport of associated focal adhesion protei

153 rrant activation of kinesin to ensure robust retrograde transport of autophagosomes along the axon.

154 iated with reduced anterograde and increased retrograde transport of axonal mitochondria.

155 eady-state BACE1 levels as well as increased retrograde transport of BACE1 in the endocytic pathway,

156 irs BACE1 endocytosis and produces a delayed retrograde transport of BACE1 to the trans-Golgi network

157 and 16, which are two major effectors in the retrograde transport of both exogenous and endogenous ca

158 intracellular journey of AAV by showing that retrograde transport of capsids to the trans-Golgi netwo

159 that disease triggered in muscle can impair retrograde transport of cargo in motoneuron axons, possi

160 Subcellular retrograde transport of cargo receptors from endosomes t

161 1 (dynein) is the motor responsible for most retrograde transport of cargoes along microtubules in eu

162 eurons in cats and on 80 neurons labelled by retrograde transport of cholera toxin b subunit injected

163 perturbation of retromer, which controls the retrograde transport of CI-M6PR via sorting nexins, incl

164 he cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the TGN

165 vertible fluorescent protein further reveals retrograde transport of CREB2 from distal neurites to th

166 We find that stimulus-induced retrograde transport of different cargos requires the lo

167 P complex is a tethering complex involved in retrograde transport of endosomes to the trans-Golgi app

168 acting as a retrieval signal, which mediates retrograde transport of escaped endoplasmic reticulum (E

169 ptic transmission to lumbar motoneurons, (2) retrograde transport of fluororuby anatomical tracer fro

170 n of constitutively active RAB-6.2 drove the retrograde transport of GLR-1 from dendrites back to cel

171 A2) in Golgi enzyme recycling, and show that retrograde transport of Golgi membrane underlies Golgi d

172 the ER occurs only from cis cisternae, that retrograde transport of Golgi resident proteins by COPIb

173 The retrograde transport of gp120 and apoptosis were mediate

174 The microtubule-dependent retrograde transport of injury signals from the lesion s

175 locally at the injury site to facilitate the retrograde transport of injury signals that are required

176 e mechanisms contributing to this process is retrograde transport of injury signals.

177 Unlike Glut4, retrograde transport of IRAP does not require sortilin,

178 arily due to maintenance of the constitutive retrograde transport of its components to the ER.

179 of the L-selectin tail blocks AP-1-dependent retrograde transport of L-selectin.

180 n acts as a dynein adaptor that mediates the retrograde transport of late endosomes (LEs) and interac

181 ase mice demonstrates impaired dynein-driven retrograde transport of late endosomes (LEs).

182 immature lysosomes, clustering and impaired retrograde transport of late endosomes along processes,

183 arance of the FRET signal is consistent with retrograde transport of lysosomal cargo back to late end

184 , concomitant with a block in Rab6-dependent retrograde transport of mannose 6-phosphate receptors to

185 t that regulates the retrieval, sorting, and retrograde transport of membrane receptors.

186 -negative bacteria and is thought to mediate retrograde transport of misplaced phospholipids from the

187 We show that retrograde transport of mitochondria from axon terminals

188 We found significantly slower retrograde transport of mitochondria in Ser135Phe, Pro39

189 pports a previously proposed role of AP-1 in retrograde transport of MPRs from late endosomes to the

190 t, delayed cytoplasmic release from NPCs and retrograde transport of mRNPs was observed.

191 Retrograde transport of multiple Golgi proteins to the E

192 TRIM46-labeled microtubules drive retrograde transport of Neurofascin-186 to the proximal

193 hat the dynein adaptor RILP is essential for retrograde transport of neuronal autophagosomes, and sur

194 toplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling

195 Retrograde transport of other important cargoes, such as

196 he site of nerve injury but is necessary for retrograde transport of p-STAT3 to the cell body.

197 ed intraflagellar Ca(2+) elevations initiate retrograde transport of paused IFT particles to modulate

198 ) has been implicated in the anterograde and retrograde transport of proteins and lipids between the

199 for synapse-to-nucleus signaling by means of retrograde transport of proteins from distal processes.

200 urons in cats by combining the transneuronal retrograde transport of rabies virus from the diaphragm

201 nsporter is a recycling system mediating the retrograde transport of released trehalose.

202 We demonstrate that retrograde transport of retromer is impaired, leading to

203 que retinal ganglion cells were labeled with retrograde transport of rhodamine dextran injected into

204 sed signaling regulates the dynein-dependent retrograde transport of Shiga toxin to the Golgi apparat

205 enerative diseases, highlighting the role of retrograde transport of signaling endosomes for axonal m

206 nuclear transport adaptors in mediating the retrograde transport of signals from synapse to nucleus

207 receptor 1 to ciliary membranes and affects retrograde transport of Smoothened inside cilia.

208 This implies that retrograde transport of target-derived molecules is nece

209 and verification of projections by means of retrograde transport of the beta subunit of cholera toxi

210 I components, general protein secretion, and retrograde transport of the KDEL-containing protein BIP,

211 the first insight into the requirements for retrograde transport of the MLV preintegration complex.

212 Depletion of GARP subunits also blocks the retrograde transport of the TGN protein, TGN46, and the

213 However, 5C12 blocked the retrograde transport of the toxin into the Golgi and the

214 bly upon Shiga toxin binding facilitates the retrograde transport of the toxin through the secretory

215 alized chambers, we demonstrated that axonal retrograde transport of these vectors was rapid and effi

216 Retrograde transport of this organelle has been implicat

217 that the double lysine is important for the retrograde transport of tpn from late secretory compartm

218 cone turning and that local translation and retrograde transport of transcription factors mediate ne

219 Neurons exploit local mRNA translation and retrograde transport of transcription factors to regulat

220 The retromer complex mediates retrograde transport of transmembrane cargo from endosom

221 The retrograde transport of Trk-containing endosomes from th

222 on via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support neuron

223 We show that the retrograde transport of TrkB vesicles within striatal de

224 elope glycoprotein (RV-G) enabled the axonal retrograde transport of two distinct subtypes of lentivi

225 act double lysine retrieval signal regulates retrograde transport of unstable MHC I molecules from th

226 , including effecting nuclear migration, and retrograde transport of various cargos.

227 Ypt6 is critical for the retrograde transport of vesicles from endosomes to the t

228 ate cell-specific infection and monosynaptic retrograde transport of virus, which strongly labels eve

229 lation must exist for proper anterograde and retrograde transport of vital proteins, little is known

230 glutamatergic inputs to the VTA by combining retrograde transport of wheat germ agglutinin-bound gold

231 from aggregated proteins by dynein-dependent retrograde transport on microtubules to the microtubule

232 cell body, the precise impact of disrupting retrograde transport on the organelles and the axon was

233 enes encoding MAGEL2 partners, either in the retrograde transport or in the ubiquitination-deubiquiti

234 Inhibition of local translation and retrograde transport or knockdown of axonal Atf4 mRNA ab

235 all available tools suffer from inefficient retrograde transport or limited clinical potential.

236 ules from axon tips to neuronal cell bodies (retrograde transport) or from cell bodies to axon tips (

237 somes and autophagosomes is coupled to their retrograde transport, our results suggest that extracell

238 protein and sorts incoming virions into the retrograde transport pathway for trafficking to the nucl

239 Our data demonstrate that TeNT H(C) uses a retrograde transport pathway shared with p75(NTR), TrkB,

240 tion efficiency and relies on a nonclassical retrograde transport pathway that is independent of the

241 GLR-1 in Caenorhabditis elegans utilizes the retrograde transport pathway to regulate AMPAR synaptic

242 or Rab11 GTPases, which are involved in the retrograde transport pathway, resulted in only a slight

243 aptic strength by recycling AMPARs along the retrograde transport pathway.

244 irus Vaccinia virus (VACV) exploits cellular retrograde transport pathways to facilitate the wrapping

245 N) from the endosomal system through several retrograde transport pathways to maintain the compositio

246 Cellular retrograde transport pathways traffic cargo from endosom

247 To determine if cellular retrograde transport pathways were required for this wra

248 This work links cellular retrograde transport pathways with morphogenesis of poxv

249 Here, we demonstrate that Snapin-mediated retrograde transport plays a critical role in removing B

250 Retrograde transport, powered by dynein motors, supplies

251 es the foundation for further studies of the retrograde transport process.

252 relate to its proposed role in dynein-based retrograde transport processes.

253 Here, we reveal that dynein-Snapin-mediated retrograde transport regulates BACE1 trafficking in axon

254 However, the mechanisms initiating this retrograde transport remain poorly understood.

255 inesin and dynein motors for anterograde and retrograde transport, respectively.

256 monas dynein mutant cells, which show slower retrograde transport speed.

257 Finally, small molecule inhibitors of retrograde transport strongly suppressed VACV multi-step

258 fined partly because the constituents of the retrograde transport system and their interactions have

259 Thus, vaccinia virus makes novel use of the retrograde transport system for formation of the viral w

260 RNAi) mutant, an IFT-A protein essential for retrograde transport, the IFT dynein components are foun

261 ein in the Wobbler mouse strain is active in retrograde transport, thus explaining the viability of t

262 kely promotes coat protein complexI-mediated retrograde transport, thus maintaining the steady-state

263 he processes of autophagosome biogenesis and retrograde transport to control autophagic turnover.

264 (KSHV/HHV8), exploit microtubule (MT)-based retrograde transport to deliver their genomes to the nuc

265 orm and subverted subsequent Gb(3)-dependent retrograde transport to Golgi/ER to render cytotoxicity

266 omes cocontribute to these processes through retrograde transport to poles by dynein.

267 in the nerve terminals, which then underwent retrograde transport to the cell soma, where they fused

268 hromophore were made in MGBv, and, following retrograde transport to the cortical cell bodies, apopto

269 otriaosyl ceramide (Gb(3)), mediates VT1/VT2 retrograde transport to the endoplasmic reticulum (ER) f

270 Ricin undergoes retrograde transport to the endoplasmic reticulum (ER),

271 ing the coatomer protein I complex-dependent retrograde transport to the endoplasmic reticulum (ER).

272 receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).

273 es yeast and fungal cells by endocytosis and retrograde transport to the endoplasmic reticulum (ER).

274 ta strongly suggest that syntaxin 5-mediated retrograde transport to the Golgi apparatus is a broadly

275 STB normally requires MTs and dynein for its retrograde transport to the juxtanuclear Golgi complex a

276 capsid to the cytosol resulted in efficient retrograde transport to the neuronal cell body.

277 ding of virion capsids onto microtubules for retrograde transport to the nucleus.

278 t oxidative stress without a requirement for retrograde transport to the soma.

279 signal locally at presynaptic boutons during retrograde transport to the soma.

280 oxin into this transcytotic pathway bypasses retrograde transport to the TGN.

281 r multiple protein-sorting events, including retrograde transport to the trans-Golgi network (TGN) an

282 of endosomal trafficking pathways including retrograde transport to the trans-Golgi network (TGN), i

283 lycolipid receptor, enter cells, and undergo retrograde transport to ultimately reach the cytosol, wh

284 eripheral nervous system neurons and undergo retrograde transport toward the distant cell bodies.

285 e cleared from the bud via actin cable-based retrograde transport toward the mother and that Bni1p fo

286 tated GARP complex, suggesting that impaired retrograde transport uncouples nascent IMVs from the IEV

287 ing and fusion of recycling endosome-derived retrograde transport vesicles to the TGN.

288 GN, but appears to regulate the targeting of retrograde transport vesicles to the TGN.

289 plex into the rat hindpaw and its subsequent retrograde transport via sciatic nerve to DRG.

290 iary tips, suggesting that IFT turnaround or retrograde transport was affected.

291 Retrograde transport was effectively shut down in this m

292 Retrograde transport was evaluated from hypothalamic and

293 ondria, anterograde transport was slower yet retrograde transport was increased.

294 of the SNX5 phox domain (SNX5-PX) influence retrograde transport, we have determined the SNX5-PX str

295 phenotype can be reversed by Snapin-enhanced retrograde transport, which facilitates BACE1 traffickin

296 Lis1 overexpression stimulated retrograde transport, while a Lis1 dynein-binding mutant

297 pletion, phosphodeficient JIP1-S421A rescues retrograde transport, while phosphomimetic JIP1-S421D ab

298 on, we adopted moss kinesin-14 for efficient retrograde transport with minimal adverse effects on end

299 wing release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalol

300 ction in the number of IEVs, thereby linking retrograde transport with the wrapping of IMVs.