ライフサイエンスコーパス: retrotransposon

1 wed L1 to become an autonomous, interspersed retrotransposon.

2 ngle guide RNA (sgRNA) against the human Alu retrotransposon.

3 s (TEs): the T1 DNA transposon and the TCN12 retrotransposon.

4 (KAP1/TRIM28) play a key role in regulating retrotransposons.

5 ed high rates of sequence diversification in retrotransposons.

6 ots") on foreign genomes such as viruses and retrotransposons.

7 stage embryos, including MERVL and ERVL-MaLR retrotransposons.

8 pe 1 (HIV-1) and the mobility of LTR/non-LTR retrotransposons.

9 ells but affecting a different repertoire of retrotransposons.

10 esis of MIWI2 piRNAs, and de-represses LINE1 retrotransposons.

11 eeds to evolve quickly to restrict telomeric retrotransposons.

12 the transcriptional repression of methylated retrotransposons.

13 of all cancers have somatic integrations of retrotransposons.

14 h are characteristics shared with endogenous retrotransposons.

15 urden of replicating pathogens and expressed retrotransposons.

16 ng viral envelope genes that are part of LTR retrotransposons.

17 tributable to changes in the amount of Gypsy retrotransposons.

18 ion and recombination directed by endogenous retrotransposons.

19 A retrotransposon, named Harlequin Orchid RetroTransposon 1 (HORT1), was identified and inserted i

20 Alu retrotransposons account for more than 10% of the human

21 ed from many of the 4000 copies of ERV-9 LTR retrotransposons acted by a similar cis mechanism to mod

22 es (Piwi) proteins are known for suppressing retrotransposon activation in the mammalian germline.

23 Retrotransposon activation is generally assumed to be a

24 e beginning of development and indicate that retrotransposon activation is integral to the developmen

25 regulation of mRNA export during stress via retrotransposon activation.

26 pport the current model that recent waves of retrotransposon activity drove the expansion of KRAB-ZFP

27 e is emerging evidence for the modulation of retrotransposon activity during the development of speci

28 However, the contribution of retrotransposon activity to ageing and age-associated di

29 ress granule assembly, cell differentiation, retrotransposon activity, symbiosis, apoptosis, and more

30 s that repress transcription of the targeted retrotransposon and adjacent genes.

31 ctor ERI-6/7, a homolog of MOV10 helicase, a retrotransposon and retrovirus restriction factor in hum

32 nts revealed widespread induction of Class I retrotransposons and activation of cytoplasmic DNA viral

33 We found that both LTR retrotransposons and endogenous viral elements are silen

34 the transcriptional activation of Ty3/Gypsy retrotransposons and host defense are controlled by mast

35 ion for achieving metal selectivity in human retrotransposons and metalloregulatory proteins.

36 AID / APOBEC hotspots have a large impact on retrotransposons and non-mammalian viruses while having

37 ecific classes of long terminal repeat (LTR) retrotransposons and organize into large loci (>50 kbp)

38 ppeared to target long terminal repeat (LTR) retrotransposons and other unrelated genes.

39 to investigate host mechanisms that inhibit retrotransposons and reinforce genomic integrity.

40 e assembled capsids is conserved between LTR retrotransposons and retroviruses.

41 homologous recombination (HR) factors and L1 retrotransposons and reveal a potential role for L1 in t

42 is composed of highly repetitive centromeric retrotransposons and satellite repeats that are highly v

43 LINE-1 retrotransposons and specific miRNAs, lncRNAs, and mRNAs

44 eq provides a comprehensive landscape of LTR retrotransposons and their control at transcriptional, p

45 re specifically bound to promoters of active retrotransposons and to imprinting control regions, the

46 and related Caenorhabditis spp. contain LTR retrotransposons and, as described here, numerous integr

47 eteriously mutating invading retroviruses or retrotransposons and, in the case of AID, changing antib

48 elements (MITEs), long terminal repeat (LTR) retrotransposons, and non-LTR retrotransposons, includin

49 et1 was strongly bound to the SET1 mRNA, Ty1 retrotransposons, and noncoding RNAs from the ribosomal

50 human immunodeficiency virus type 1 (HIV-1), retrotransposons, and other viruses such as hepatitis B

51 a unique target to specifically inhibit LTR-retrotransposons, and tRF-targeting is a potentially hig

52 posons transfer horizontally more often than retrotransposons, and unveil phylogenetic relatedness an

53 hymena Long interspersed element (LINE)-like retrotransposon are very frequently found physically adj

54 Retrotransposons are "copy-and-paste" insertional mutage

55 LINE-1 (L1) retrotransposons are a noted source of genetic diversity

56 Retrotransposons are a pervasive class of mobile element

57 In Arabidopsis, LTR retrotransposons are activated by mutations in the chrom

58 This way, retrotransposons are divided into young, potentially mob

59 LTR retrotransposons are mobile elements that are able, like

60 retroviruses and long terminal repeat (LTR) retrotransposons are mobile genetic elements that are cl

61 cted discovery that specific low-copy number retrotransposons are mobile in the pollen of some maize

62 Retrotransposons are populated in vertebrate genomes, an

63 LTR retrotransposons are repetitive DNA elements comprising

64 on during mitosis, demonstrating that active retrotransposons are required for stable genetic inherit

65 In Schizosaccharomyces pombe the Tf2 LTR retrotransposons are transcriptionally silenced and are

66 ical bird lineages exclusively share a novel retrotransposon, AviRTE, resulting from horizontal trans

67 RVs), also called long terminal repeat (LTR) retrotransposons, begins with transcription by RNA polym

68 responding to integrated viral genes and LTR retrotransposons, but not to DNA transposons, are depend

69 uses evolved from long terminal repeat (LTR) retrotransposons by acquisition of envelope functions, a

70 e myeloid leukemia cells to evade sensing of retrotransposons by innate immune receptors.

71 Thus, IFI16 restricts retroviruses and retrotransposons by interfering with Sp1-dependent gene

72 a dramatic induction of a class of noncoding retrotransposons called B2 SINEs in multiple cell types.

73 ings inform how genes that are evolving from retrotransposons can build upon existing regulatory netw

74 Insertions of Alu retrotransposons can disrupt splice sites or bind splici

75 trast, the absence of structural data on LTR retrotransposon capsids hinders our understanding of the

76 ings provide a structural basis for studying retrotransposon capsids, including those domesticated in

77 Here, we applied mouse retrotransposon capture sequencing (mRC-seq) and whole-g

78 mammalian endogenous retrovirus-related ERVL retrotransposon class on gene expression in the germline

79 Retroviruses and retrotransposons commonly appropriate major components o

80 Retrotransposons compose a staggering 40% of the mammali

81 Long interspersed element-1s (L1) are mobile retrotransposons comprising 17% of the human genome.

82 r species group, we generated de novo jockey retrotransposon consensus sequences and used phylogeneti

83 y population of chromosomally integrated LTR retrotransposons consisting of pairwise recombination pr

84 niature (TRIMs) are small non-autonomous LTR retrotransposons consisting of two terminal direct repea

85 Retrotransposons containing long terminal repeats (LTRs)

86 tial, strictly conserved function: telomeric retrotransposon containment, not end-protection, require

87 Here, we review the many ways human retrotransposons contribute to genome function, their dy

88 ycomb protein EZH2 and RNA made from B2 SINE retrotransposons controls stress-responsive genes in mou

89 e positions and the degradation level of LTR retrotransposons copies.

90 retrotransposons than DNA transposons and as retrotransposon copy number in both rice and maize genom

91 probably due to a songbird-specific burst of retrotransposon CR1-E1 elements at its boundary, instead

92 confirmed this species-specific collapse of retrotransposon-dependent telomere elongation.

93 The retrotransposon-derived enzyme TGIRT exhibits more slipp

94 The retrotransposon-derived paternally expressed gene 10 (PE

95 Retrotransposon-derived RNAs are also known to give rise

96 L1 retrotransposon-derived sequences comprise approximately

97 We demonstrate that retrotransposon-derived transcripts act as decoys for mi

98 y LINE1 (long interspersed nuclear element1) retrotransposon-derived].

99 Surprisingly, the mutagenic LTR retrotransposons differed in the active lines, suggestin

100 Telomeric retrotransposon diversification and disappearance sugges

101 A cassette from Drosophila retrotransposon Dme1_chrX_2630566, a candidate for utili

102 In comparison with retrotransposons, DNA transposons make up a smaller prop

103 retrotransposition rate for the three active retrotransposon elements: L1, Alu, and SVA.

104 rsed Elements (LINEs), also known as non-LTR retrotransposons, encode a multifunctional protein that

105 and should be widely applicable to other LTR retrotransposons, endogenous retroviruses (ERVs), and ex

106 Here we report that certain classes of retrotransposons ensure transgenerational inheritance by

107 through exaptation of a retroduplicated LINE retrotransposon (EPCOT3) into an enhancer.

108 rt interspersed nuclear elements (SINEs) are retrotransposons evolutionarily derived from endogenous

109 TypeTE can be readily adapted to other retrotransposon families and brings a valuable toolbox a

110 rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million year

111 genomic approach to address whether specific retrotransposon families play a direct role in chromatin

112 dy, and long-term amplification of a few LTR retrotransposon families.

113 Both types are found within a single retrotransposon family and it is assumed that the old me

114 ied transposition bursts of a heat-activated retrotransposon family in Arabidopsis We recorded a high

115 A new retrotransposon family was also a source of many recent

116 y reactivated the expression of the targeted retrotransposon family without loss of DNA methylation.

117 tly transposes in P. patens, being the first retrotransposon from a vascular plant reported to transp

118 has been used to mine potentially active L1 retrotransposons from the reference genome sequences of

119 e, we uncover an unusual family of giant LTR retrotransposons from the Solanum clade, named MESSI, wi

120 Arc originates in evolution from a Ty3-Gypsy retrotransposon GAG domain.

121 ity, originated through the domestication of retrotransposon Gag genes and mediates intercellular mes

122 We showed here that CCDC8, derived from a retrotransposon Gag protein in placental mammals, exclus

123 mbination of gene-disruption platforms (Tnt1 retrotransposons, hairpin RNA-interference constructs, a

124 42% of the human genome, and mobilisation of retrotransposons has resulted in rearrangements, duplica

125 , we observe that VNTRs not originating from retrotransposons have a propensity to cluster near genes

126 'Copy-and-paste' long-terminal-repeat (LTR) retrotransposons have been particularly successful durin

127 f human LINE-1 (long interspersed element-1) retrotransposons highlighting their interaction with DNA

128 r a role for the primate-specific endogenous retrotransposon human endogenous retrovirus subfamily H

129 Unlike the mutagenic LTR retrotransposons identified previously, dRemp is present

130 he ms2 mutant has acquired a terminal-repeat retrotransposon in miniature (TRIM) element in its promo

131 resent the only currently active, autonomous retrotransposon in the human genome, and they make major

132 LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of i

133 all, our results provide direct evidence for retrotransposons in actively shaping cell type- and spec

134 f young long interspersed element 1 (LINE-1) retrotransposons in cancer, often distinct to the adjace

135 A particle (IAP) long terminal repeat (LTR) retrotransposons in cultivated cells.

136 demonstrated that p53 genes act to restrict retrotransposons in germline tissues of flies and fish b

137 refully annotated, full-length Sirevirus LTR retrotransposons in maize, we show that their silencing

138 Terminal repeat retrotransposons in miniature (TRIMs) are a unique group

139 Terminal repeat retrotransposons in miniature (TRIMs) are small non-auto

140 Their impact on retrotransposons in non-coding regions shed light on imp

141 and genomic studies of long terminal repeat retrotransposons in other genomes.

142 ions, we also found patterns of unrestrained retrotransposons in p53-driven mouse and human cancers.

143 Given the established role of L1 retrotransposons in shaping mammalian genomes, it become

144 The activation of retrotransposons in the ADAR- and ERI-6/7/MOV10-defectiv

145 were primarily associated with the LTR/Gypsy retrotransposons in the heterochromatin flanking the cen

146 he CRISPR/Cas9 system at centromere-specific retrotransposons in the human fungal pathogen Cryptococc

147 on Helitrons, Pack-MULEs, and Sirevirus LTR retrotransposons in the maize genome.

148 ciated with large deletions or insertions of retrotransposons in the Noemi gene.

149 ng model for studying the propagation of LTR retrotransposons in these genomes.

150 e conserved presence of the targeted RMER19B retrotransposons in these species.

151 that APOBEC3G can powerfully restrict active retrotransposons in vivo and demonstrates how transgenic

152 The lifecycle of retroviruses and retrotransposons includes a reverse transcription step,

153 l repeat (LTR) retrotransposons, and non-LTR retrotransposons, including long interspersed nuclear el

154 SINE-VNTR-Alu (SVA) retrotransposons, including their internal tandem repeat

155 horizontal transfer of host genes as well as retrotransposons, indicating gene flow to S. asiatica fr

156 nt involvement of TREX1 in preventing the L1 retrotransposon-induced DNA damage response.

157 d identify functional alleles that include a retrotransposon insertion and start codon mutation.

158 ed by a single mutation: SINE-VNTR-Alu (SVA) retrotransposon insertion in TAF1.

159 a, this gene was rendered nonfunctional by a retrotransposon insertion in the domesticated loss-of-sh

160 Phenotyping of retrotransposon insertion mutants revealed that NiCK4 pr

161 oung (~530,000 years) cis-acting 2.25-kb LTR retrotransposon insertion reducing expression of the NDP

162 y, we find that a long terminal repeat (LTR) retrotransposon insertion upstream of MdMYB1, a core tra

163 lotypes extending to entire chromosome arms, retrotransposon insertions and structural variants (SVs)

164 alized browser to visualize the evidence for retrotransposon insertions for both targeted and whole-g

165 e screenings for phylogenetically diagnostic retrotransposon insertions involving the representatives

166 nce long interspersed element-1 (LINE-1, L1) retrotransposon insertions selectively in the human geno

167 d data sets, a large proportion of which are retrotransposon insertions.

168 or visualizing the experimental evidence for retrotransposon insertions.

169 and large-scale complex SVs and nonreference retrotransposon insertions.

170 The Saccharomyces cerevisiae Ty3 retrotransposon inserts proximal to the transcription st

171 by 'plain' telomeres; insertion of the MAGGY retrotransposons into MoTeR arrays; MoTeR-independent ex

172 Long interspersed element 1 (LINE-1) retrotransposon is expressed in many carcinomas, includi

173 The LAVA retrotransposon is thought to have played a role in the

174 Inactivation of retrotransposons is accompanied by the emergence of cent

175 We propose that the activation of retrotransposons is an important component of sterile in

176 Silencing of LTR retrotransposons is dependent on downstream RNAi factors

177 Uncontrolled propagation of retrotransposons is potentially detrimental to host geno

178 By high-throughput sequencing of retrotransposon junctions, we established that retrotran

179 egion that evolved from tandem insertions of retrotransposons L1P1 and L1PA1 upstream (-60 kb) of OPR

180 igger the majority of known mobilizing plant retrotransposons, leading to the idea that most are acti

181 Some active retrotransposons, like Hopscotch, Magellan, and Bs2, a B

182 luster of miRNAs encoded by a non-translated retrotransposon-like one antisense (Rtl1as) transcript t

183 the Rtl1 sense transcript, that encodes the retrotransposon-like one protein (RTL1), which is also r

184 rrogate the striking correlation of FOA with retrotransposon LINE-1 (L1) expression in mice to unders

185 The retrotransposon LINE-1 (long interspersed element 1, L1)

186 to spermiogenic arrest and piRNA-independent retrotransposon LINE1 de-repression in round spermatids.

187 s, losses, and replacements account for this retrotransposon lineage diversity.

188 apid diversification of telomere-specialized retrotransposon lineages and, possibly, the breakdown of

189 t a novel microRNA (miR), miR-128, represses retrotransposon long interspaced element 1 (L1) by a dua

190 Analyzing the long terminal repeat-retrotransposon (LTR-RT) type of TE, we estimated their

191 Long terminal repeat retrotransposons (LTR-RTs) are prevalent in plant genome

192 his has been associated with the presence of retrotransposons (Magnaporthe oryzae Telomeric Retrotran

193 r, these telomere-specialized, jockey family retrotransposons may actually evolve to "selfishly" over

194 Our work provides initial evidence that some retrotransposons may evolve developmentally associated e

195 e duplication and dispersed duplications via retrotransposons may have played pivotal roles in the ex

196 methylation reprogramming genes and in LINE1 retrotransposons may play important roles in downstream

197 umbers of NLRs were greatly increased by LTR-retrotransposon-mediated retroduplication.

198 The amplification of athila LTR-retrotransposons, members of the gypsy superfamily, led

199 ge of the different mechanisms through which retrotransposons might influence the development of and

200 ish models, we found that diverse classes of retrotransposons migrate to the germ plasm, a specialize

201 lly interfere with reverse transcription and retrotransposon mobility.

202 In humans, retrotransposon mobilization is mediated primarily by pr

203 factors for the bursts are unclear, although retrotransposon mobilization may contribute.

204 V, crippling the enzyme's ability to inhibit retrotransposon mobilization.

205 s operate at multiple levels to restrict Tf2 retrotransposon mobilization.

206 trotransposons (Magnaporthe oryzae Telomeric Retrotransposons-MoTeRs) inserted in the telomeres.

207 proliferation by blocking translation of the retrotransposon mRNA using amyloid-like assemblies of th

208 (SIV), murine leukemia virus (MLV), and the retrotransposon MusD.

209 While retrotransposons must be activated in developing germ ce

210 A retrotransposon, named Harlequin Orchid RetroTransposon

211 The Ty1 retrotransposon of Saccharomyces cerevisiae belongs to t

212 earlier study with the long-terminal-repeat retrotransposon of Saccharomyces cerevisiae, Ty1, which

213 throblasts, lncRNAs transcribed from the LTR retrotransposons of ERV-9 human endogenous retrovirus ac

214 Our results indicate that LINE-1 retrotransposons often become deregulated during progres

215 Retrotransposons often carry long terminal repeats (LTRs

216 f low-copy number long terminal repeat (LTR) retrotransposons or deletions, the same two classes of m

217 In the mouse, long terminal repeat (LTR)-retrotransposons, or endogenous retroviruses (ERV), acco

218 LINE-1 retrotransposon overexpression is a hallmark of human ca

219 how that post-translational regulation of L1 retrotransposons plays a key role in maintaining trans-g

220 The significant accordance of retrotransposon presence/absence patterns and flanking n

221 ty genome sequence of ~542 Mb and found that retrotransposon proliferation contributed to the relativ

222 Retrotransposon proliferation poses a threat to germline

223 s revealed that HOAP[yak] triggers telomeric retrotransposon proliferation, resulting in aberrantly l

224 e transcriptional program with innovation at retrotransposon promoters, and establish a basis for ani

225 ted removal of O-GlcNAc was directed against retrotransposon promoters.

226 A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and are ess

227 satellite repeat (Ss1) and several Ty3/gypsy retrotransposon-related repeats (Ss166, Ss51, and Ss68).

228 In contrast, the Ty3/gypsy retrotransposon-related repeats are either clustered spa

229 RNAs and their derivatives in retroviral and retrotransposon replication and shed light on the roles

230 ments may also be involved in retrovirus and retrotransposon replication.

231 LINE-1 (L1) retrotransposons represent approximately one sixth of th

232 Together, endogenous retroviruses and LTR retrotransposons represent major components of animal, p

233 peat content, high long-interspersed element retrotransposon representation, large body size, and lon

234 PP2A complex, demonstrating a role of URI in retrotransposon repression, a key function previously de

235 an RNA intermediate in a process mediated by retrotransposons (retroposition).

236 riants, plastomes and k-mers associated with retrotransposons reveals two independent origins for B.

237 motype) are contained within large (>250 kb) retrotransposon-rich regions that are highly nonhomologo

238 Retrotransposons (RTs) can rapidly increase in copy numb

239 KRAB-ZFPs recognize specific retrotransposon sequences and recruit KAP1, inducing the

240 Endogenous retrotransposon sequences constitute approximately 42% o

241 oligomerization without significant loss of retrotransposon silencing activity, indicating that, in

242 Here, we show that UHRF1 is responsible for retrotransposon silencing and cooperates with repressive

243 Pnldc1 mutant mice exhibit disrupted LINE1 retrotransposon silencing and defect in spermiogenesis.

244 Collectively, UHRF1 regulates retrotransposon silencing in male germ cells and provide

245 sive epigenetic pathways crosstalk to ensure retrotransposon silencing in the male germline.

246 RNA (piRNA) are essential for the control of retrotransposon silencing in the mammalian germline.

247 l regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromos

248 d KRAB binding and establishes their role in retrotransposon silencing.

249 racting RNA (piRNA) pathway is essential for retrotransposon silencing.

250 Likewise, vertebrate retrotransposons similarly migrated to the germ plasm in

251 e consists of repetitive elements, including retrotransposons, some of which are transcribed after fe

252 he DUX4 and DUX homeodomains correlates with retrotransposon specificity.

253 e annotation for various DNA transposons and retrotransposons, such as miniature inverted-repeat tran

254 ellular pathogens and genes coexpressed with retrotransposons suggests that there is a common respons

255 evolutionary scenarios received considerable retrotransposon support, leaving us with a network of af

256 ndem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8.

257 the widespread occurrence and importance of retrotransposons, systematic studies to reveal the exten

258 By screening of a retrotransposon-tagged mutant population of the model le

259 plicing and are evolutionary predecessors of retrotransposon, telomerase, and retroviral RTs as well

260 ethods annotating long terminal repeat (LTR) retrotransposons, terminal inverted repeat (TIR) transpo

261 TE-lincRNAs were more often derived from retrotransposons than DNA transposons and as retrotransp

262 ent-1 (LINE-1, or L1) is the only autonomous retrotransposon that is active in human cells.

263 In fact, we have identified a retrotransposon that is highly transcribed in roots and

264 produced by transposition of a defective LTR retrotransposon that we have termed dRemp (defective ret

265 LINE-1 elements are retrotransposons that are capable of copying their seque

266 a unique group of small long terminal repeat retrotransposons that are difficult to identify.

267 elements, or SINEs, are an abundant class of retrotransposons that are transcribed by RNA polymerase

268 Alu elements are retrotransposons that frequently form new exons during p

269 ong interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagat

270 a melanogaster instead relies on specialized retrotransposons that insert exclusively at telomeres.

271 rapid amplification of long terminal repeat retrotransposons that occurred 38 million years ago in c

272 tion: silencing of the specialized telomeric retrotransposons that, instead of telomerase, maintain c

273 causes DNA hypomethylation, upregulation of retrotransposons, the activation of a DNA damage respons

274 Together, these data support the retrotransposon theory of aging, which hypothesizes that

275 we show that the tobacco (Nicotiana tabacum) retrotransposon Tnt1 efficiently transposes in P. patens

276 lants carrying a tobacco (Nicotiana tabacum) retrotransposon Tnt1 insertion in MtTPS10 lacked the emi

277 xplored the possibility of using the tobacco retrotransposon Tnt1 to create a transposon-based insert

278 epresents a fitness strategy adopted by some retrotransposons to ensure transgenerational propagation

279 its the repressive TRIM28 complex to RMER19B retrotransposons to evoke regional heterochromatin forma

280 Mobilization of retrotransposons to new genomic locations is a significa

281 SINE is a class of retrotransposon transcribed by RNA polymerase III (Pol I

282 not only controls the accumulation of Gypsy retrotransposon transcripts but also regulates the splic

283 In order to succeed, retrotransposon transcripts must identify the subset of

284 hat the primordial germline is a hideout for retrotransposon transcripts, providing early access to f

285 Unlike other long terminal repeat retrotransposons, TRIMs are enriched in or near genes; t

286 Here we synthetically optimize the retrotransposon Ty1 to enable in vivo generation of muta

287 hology and structure of the archetypal Gypsy retrotransposon Ty3.

288 exameric lengths found in the unique XDP SVA retrotransposon using luciferase reporter constructs.

289 fusion points between the mRNAs and the LTR retrotransposons, we identified shared short similar seq

290 which endogenous Long Interspersed Element-1 retrotransposons were a major source.

291 ociated with centromere, 45S rDNA, knob, and retrotransposons were found among groups, revealing glob

292 read increases in chromatin accessibility at retrotransposons when HDACs are inhibited, and this is m

293 tivate expression of repetitive genes called retrotransposons, which are normally silenced due to the

294 c low-copy number long-terminal repeat (LTR) retrotransposons, which differ among lines.

295 The majority of these elements derive from retrotransposons, which expand throughout the genome thr

296 primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilize in pluripotent cells ea

297 ense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1 This unique ins

298 f ASAR6 map to the antisense strand of an L1 retrotransposon within ASAR6 RNA, deletion or inversion

299 in the preferential integration of Ty1/copia retrotransposons within environmentally responsive genes

300 vealed a comprehensive catalog of active LTR retrotransposons without the need for mapping transposit

301 This deletion leads to derepression of the retrotransposon ZAM in the somatic follicular cells and