ライフサイエンスコーパス: rhomboid

1 ic N-terminal domain (NRho) of P. aeruginosa Rhomboid.

2 roaden the spatially regulated expression of Rhomboid.

3 lo in Drosophila) and p120-catenin to induce rhomboid.

4 g transcription of the EGF maturation factor rhomboid.

5 of the observed optical transitions for the rhomboids.

6 odel for substrate binding and hydrolysis in rhomboids.

7 gle-square mixture is converted into [2 + 2] rhomboids.

8 vely on the emerging biological functions of rhomboids.

9 n the lipid bilayer are now answered for the rhomboids.

10 platinum-based supramolecular triangles and rhomboids.

11 ozoite organelle that contains P. falciparum rhomboid-1 (PfROM1), a protease that cleaves the transme

12 MA1 is susceptible to cleavage by Drosophila rhomboid-1, showing that it can be a substrate for intra

13 Recently, inactive Rhomboid 2 (iRhom2), which has seven transmembrane domai

14 tz group genes, Rhomboid-3/roughoid, but not Rhomboid-2 or -4, and the neuregulin-like ligand Vein al

15 vival: in addition to the spitz group genes, Rhomboid-3/roughoid, but not Rhomboid-2 or -4, and the n

16 otently stimulates proteolysis by endogenous rhomboid-4 in Drosophila cells, and, remarkably, when rh

17 4 in Drosophila cells, and, remarkably, when rhomboid-4 is purified and reconstituted in liposomes.

18 ecular architecture is observed in the small rhomboid 5 and this interaction gradually decreases upon

19 The rhomboid 5 homolog 2 (Rhbdf2) gene encodes an inactive r

20 resulting polygonal structures from a small rhomboid 5 through a large rhomboid 6 to a hexagon 7.

21 olecular metallacycles including two [2 + 2] rhomboids (5 and 6) and a [3 + 3] hexagon (7) is reporte

22 ures from a small rhomboid 5 through a large rhomboid 6 to a hexagon 7.

23 Interestingly, the fused rhomboid 7 shows a weaker fluorescence in dilute solutio

24 Rhomboid, a polytopic membrane serine protease, represen

25 riptional mechanisms regulating SOP-specific rhomboid activation.

26 ond selectivity by optimally positioning the Rhomboid active site relative to the membrane plane.

27 e now developed an in vitro assay to monitor rhomboid activity in the detergent solubilised state.

28 from a variety of diverse sources exhibited rhomboid activity.

29 visible light emission for a suite of simple rhomboids along with the predictive nature of the wavele

30 and its incorporation into a supramolecular rhomboid and rectangle via platinum-mediated self-assemb

31 of three new supramolecular complexes 6-8 (a rhomboid and two hexagons) via coordination-driven self-

32 in the construction of supramolecular D(2h) rhomboids and a D(6h) hexagon.

33 degrees di-Pt(II) acceptors forms molecular rhomboids and hexagons bearing cyclooctynes.

34 These findings and the significance of rhomboids and other intramembrane proteases are discusse

35 We identify a motif shared between rhomboids and the recently discovered derlins, which par

36 lar, the biochemical analysis of solubilized rhomboids and, most recently, a flurry of high-resolutio

37 presenilin, signal peptide peptidase and the rhomboids, and they have a wide range of cellular functi

38 types of post-mitotic epithelial cells, the Rhomboid- and the Broad-positive cells.

39 ane domain, a mechanism in stark contrast to rhomboid--another family of intramembrane-cleaving prote

40 e robustly active in pure form, proving that rhomboids are a new class of enzymes and do not require

41 The rhomboids are a well-conserved family of intramembrane s

42 Rhomboids are intramembrane proteases that use a catalyt

43 Rhomboids are intramembrane serine proteases conserved i

44 role in many important biological pathways, rhomboids are potential drug targets.

45 Rhomboids are ubiquitous integral membrane proteases tha

46 These effects are specific to rhomboid, because its paralogue roughoid is neither requ

47 RHBDL2, a human homolog of the rhomboids, belongs to a unique class of serine intramemb

48 Here we show that loss of rhomboid blocks the induction of Rh5 expression and mise

49 em for elucidating the reaction mechanism of rhomboid but also will facilitate the characterization o

50 tionship, the emission wavelength of a given rhomboid can be predetermined on the basis of the Hammet

51 s unexpectedly stable intermediate indicates rhomboid catalysis uses an unprecedented reaction coordi

52 We further show that Broad represses rhomboid cell autonomously.

53 pindle-like versus spread-out or epithelioid/rhomboid cell shapes.

54 imics the boundary; Notch levels are high in Rhomboid cells and low in Broad cells.

55 clones generate an ectopic boundary: ectopic Rhomboid cells arise in Notch(+) cells adjacent to the N

56 dation for understanding how a single row of Rhomboid cells arises adjacent to the Broad cells in the

57 HL(+) cells grew as clusters of cuboidal and rhomboid cells, whereas VHL-silenced cells took on an el

58 cently discovered, it is becoming clear that rhomboids control many important cellular functions.

59 and Pax2-independent mechanisms to stimulate rhomboid CRM activity to induce proper oenocyte numbers.

60 factors are differentially integrated on the rhomboid CRM by abdominal versus thoracic Hox proteins i

61 lts show that proper spatial activity of the rhomboid CRM is dependent upon direct integration of the

62 erein, a series of functionalized D2h [D2A2] rhomboids (D = 2,6-bis(4-ethynylpyridine)aniline-based l

63 in and intervein cell development, including rhomboid, decapentaplegic, thick veins, and blistered, s

64 termine that these "pseudoproteases" inhibit rhomboid-dependent signaling by the epidermal growth fac

65 d distorted surrounding lipids and propelled rhomboid diffusion.

66 trate processing in living cells scaled with rhomboid diffusivity.

67 es of CuI(L) network structures built on CuI rhomboid dimers.

68 can distinguish between active and inactive rhomboids due to covalent, reversible binding of the act

69 636-1646) report that the single proteolytic rhomboid (EhROM1) from Entamoeba histolytica cleaves cel

70 arge genome, E. histolytica encodes only one rhomboid (EhROM1) with residues necessary for protease a

71 In a screen to identify rhomboid-encoding genes from Proteus mirabilis, tatA was

72 Mutational analysis of a rhomboid enhancer reveals at least 5 distinct types of f

73 We identified a rhomboid enhancer that is active in these cells and show

74 CRISPR/Cas9 was used to delete defined rhomboid enhancers mediating expression at each site of

75 Prior work has uncovered a role for rhomboid enzymes in host cell invasion by malaria and re

76 vasion and suggest that a common function of rhomboid enzymes in widely divergent protozoan pathogens

77 Recently, we identified a CRM that activates rhomboid expression and thereby EGF secretion from a sub

78 Hairless levels are insufficient to activate rhomboid expression by itself, but does so in conjunctio

79 rhomboid expression in a subset of sensory cells stimula

80 mutants, which results from a disruption of rhomboid expression.

81 re integral membrane serine proteases of the Rhomboid family and we propose that several malaria adhe

82 Rhomboid family multipass transmembrane proteins regulat

83 Members of the widespread rhomboid family of intramembrane proteases cleave transm

84 cia stuartii AarA protein is a member of the rhomboid family of intramembrane serine proteases and is

85 cia stuartii AarA protein is a member of the rhomboid family of intramembrane serine proteases and re

86 interaction arrays, we identified Rbd2 as a rhomboid family protease required for SREBP proteolytic

87 coli GlpG, an intramembrane protease of the rhomboid family, has revealed an internal and hydrophili

88 2), a proteolytically inactive member of the rhomboid family, is required for TNF release in mice.

89 g like a sheddase, similar to members of the rhomboid family, which belong to the class of intramembr

90 served, catalytically inactive member of the Rhomboid family, which has recently been shown to regula

91 We show here that a novel gene, human rhomboid family-1 (RHBDF1), which was recently reported

92 ophobic mismatch with the irregularly shaped rhomboid fold distorted surrounding lipids and propelled

93 cells mitigate this constraint by using the rhomboid fold to overcome the "speed limit" of membrane

94 Rhomboids form a family of polytopic intramembrane serin

95 a-SiB(3), where silicon atoms also adopt the rhomboid framework.

96 We examined rhomboid function in Entamoeba histolytica, an extracell

97 rough consideration of all known examples of rhomboid function suggests that, despite biochemical sim

98 erves as a useful host system to investigate rhomboid function.

99 insights provide new approaches for studying rhomboid functions by investigating upstream inputs that

100 roscopy revealed that the membrane restrains rhomboid gate and substrate conformation to limit proteo

101 Midline primordium expression of the rhomboid gene is dependent on cell signaling by the Notc

102 The rhomboid gene was discovered in Drosophila, where it enc

103 ubiquitous in the phylum and is encoded by a rhomboid gene.

104 e describe the structure of Escherichia coli rhomboid GlpG covalently bound to a mechanism-based isoc

105 umarin-based inhibitor with Escherichia coli rhomboid GlpG uncovers an unusual mode of binding at the

106 For the bacterial rhomboid GlpG, it has been proposed that one of the tran

107 ified within Apicomplexa, and one Toxoplasma rhomboid has been localized to the posterior end of the

108 The name rhomboid has since been widely used to describe a large

109 In contrast, the function of prokaryotic rhomboids has remained enigmatic.

110 T. gondii rhomboids have clear homologues in other apicomplexans i

111 ing cellular membrane trafficking machinery, rhomboids have evolved novel strategies to regulate prot

112 ily of intramembrane serine proteases called rhomboids have now been identified within Apicomplexa, a

113 One of the two rhomboid homologs of Haloferax volcanii (RhoII) is fused

114 t allows expression and isolation of YqgP, a rhomboid homologue from Bacillus subtilis, as a soluble

115 Induction of rhomboid in the dying enterocyte triggers activation of

116 tionary ancient organism and the presence of rhomboids in all domains of life, it is likely that this

117 These "extra" interactions foster potent rhomboid inhibition in living cells, thereby opening ave

118 ing avenues for rational design of selective rhomboid inhibitors.

119 Here we demonstrate that rhomboids instead primarily recognize a specific sequenc

120 Cipolat et al. and Frezza et al. show that a rhomboid intramembrane protease PARL and a dynamin-relat

121 We visualized single molecules of multiple rhomboid intramembrane proteases and unrelated proteins

122 Rhomboid intramembrane proteases are the enzymes that re

123 and characterized the five nonmitochondrial rhomboid intramembrane proteases encoded in the recently

124 Rhomboid intramembrane proteases occur throughout the ki

125 Rhomboid intramembrane proteolysis is thus a slow, kinet

126 c membrane proteins, including the canonical rhomboid intramembrane serine proteases and also others

127 a conserved subfamily of proteins related to rhomboid intramembrane serine proteases that lack key ca

128 y and is built of 15 edge- and vertex-shared rhomboids involving two mu3-N and six mu4-N bridging ato

129 homolog 2 (Rhbdf2) gene encodes an inactive rhomboid (iRhom) protease, iRhom2, one of a family of en

130 ), with the seven membrane-spanning inactive Rhomboids (iRhom) 1 and 2 implicated as candidate regula

131 s the breadth of the source for Spitz, since Rhomboid is necessary for the production of active Spitz

132 We show that rhomboid is required cell-autonomously within the R8 pho

133 Although the function of most rhomboids is not yet known, they have already been impli

134 Floor cells lack Broad, express the rhomboid-lacZ marker, and form the floor by directed cel

135 ction of Rh5 expression and misexpression of rhomboid leads to the inappropriate induction of Rh5.

136 from that of Oma1 and presenilin-associated rhomboid-like (PARL), two known Opa1 regulators.

137 ein 2 (RHBDL2), one of 3 catalytic mammalian rhomboid-like (RHBDL) proteases, but that it is not clea

138 member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2).

139 results in proteolysis at an intramembrane, rhomboid-like cleavage site, and PfAMA1 is susceptible t

140 Hrd1 and the rhomboid-like Der1 protein form two "half-channels" with

141 We identified a predicted rhomboid-like protease 10 (RBL10), located in plastids o

142 esence at the malaria merozoite surface of a rhomboid-like protease.

143 uminal half of its transmembrane domain by a rhomboid-like protease.

144 mitochondrial protease presenilin-associated rhomboid-like protein (PARL) and that loss of PARL resul

145 rane rhomboid protease presenilin-associated rhomboid-like protein (PARL) mediates cleavage of PINK1

146 Here, we show that CLEC14A is cleaved by rhomboid-like protein 2 (RHBDL2), one of 3 catalytic mam

147 For example, RHBDL4 (rhomboid-like protein 4) is an endoplasmic reticulum (ER

148 an NADPH oxidase) and TraesCS4D02G350300 (a rhomboid-like protein belonging to family S54), with SNP

149 The novel rhomboid-like protein RHBDD2 is distantly related to rho

150 pend on the seven-membrane-spanning inactive rhomboid-like proteins 1 and 2 (iRhom1/2 or Rhbdf1/2).

151 Rhomboid-like proteins are evolutionarily conserved, ubi

152 rticle, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclatu

153 iRhoms are inactive rhomboid-like pseudoproteases that lack essential cataly

154 Rhoms, catalytically inactive members of the rhomboid-like superfamily, have been shown to control th

155 drial proteases Parl (presenilin-associated, rhomboid-like) and HtrA2 (high-temperature-regulated A2,

156 ane revealed that all extracellular loops of rhomboid make stabilizing interactions with substrate, b

157 This suggests that rhomboid may function in R8 cells to activate Epidermal

158 egulate diverse cellular processes; however, rhomboid-mediated CME regulation has not been described.

159 ight on the plasticity of the active site of rhomboid membrane protease.

160 entral midline thalamic nuclei (reuniens and rhomboid) might play a substantial role in various cogni

161 leaves the transmembrane segment of the TatA rhomboid model substrate.

162 ent to rescue the loss of Rh5 induction in a rhomboid mutant.

163 nd the ventral midline thalamic reuniens and rhomboid nuclei (Re/Rh) have long been considered a pote

164 h of these structures makes the reuniens and rhomboid nuclei (ReRh) of the thalamus a major functiona

165 al parabrachial nucleus, periventricular and rhomboid nuclei of the thalamus, and paraventricular and

166 nt projections of RE as well as those of the rhomboid nucleus (RH) located dorsal to RE.

167 APP processing provides insight into APP and rhomboid physiology and qualifies for further investigat

168 pithelial stress, Yki activity, and Upd3 and Rhomboid production in enterocytes, catalyzing feedforwa

169 Removal of this extension by the rhomboid protease AarA is required to activate P. stuart

170 s work reveals a novel biological role for a rhomboid protease and highlights new avenues for definin

171 A consensus rhomboid protease cleavage site is present in ANAC017 ju

172 Rhomboid protease conducts proteolysis inside the hydrop

173 ases from alpha/beta hydrolase, patatin, and rhomboid protease families.

174 brane protein that belongs to the widespread rhomboid protease family.

175 embrane domain) of GlpG, a membrane-embedded rhomboid protease from Escherichia coli.

176 ly silence two E. invadens genes: a putative rhomboid protease gene and a SHAQKY family Myb gene.

177 the folding pathways of the Escherichia coli rhomboid protease GlpG and the human beta(2)-adrenergic

178 The recently solved crystal structures of rhomboid protease GlpG have provided useful insights int

179 Here we describe the crystal structure of rhomboid protease GlpG in complex with a phosphonofluori

180 allographic analysis of the Escherichia coli rhomboid protease GlpG in complex with inhibitors has pr

181 changes in accessibility and dynamics of the rhomboid protease GlpG, captured within three different

182 ied mucus-specific fitness genes encodes the rhomboid protease GlpG.

183 A dimeric form of the rhomboid protease has been shown to be important for act

184 olved ten structures of the Escherichia coli rhomboid protease in a bicelle membrane undergoing time-

185 tease, crystals of GlpG, an Escherichia coli rhomboid protease in a lipid environment, were obtained

186 oupled receptors, suggesting a role for this rhomboid protease in pathological conditions, including

187 Furthermore, addition of the rhomboid protease inhibitor N-p-Tosyl-l-Phe chloromethyl

188 s revealed in the gene encoding the inactive rhomboid protease iRhom2, which was not complemented by

189 The native environment of rhomboid protease is a lipid bilayer, yet all the struct

190 The polar active site of rhomboid protease is embedded in the membrane and normal

191 The mitochondrial intramembrane rhomboid protease PARL has been implicated in diverse fu

192 embrane and intramembrane proteolysis by the rhomboid protease Pcp1p.

193 report that the mitochondrial inner membrane rhomboid protease presenilin-associated rhomboid-like pr

194 ned action of the Dsc E3 ligase complex, the rhomboid protease Rbd2, and the essential ATPases associ

195 89Leu] in RHBDF2, which encodes the inactive rhomboid protease RHBDF2 (also known as iRhom2), as the

196 Here we show that the inactive rhomboid protease RHBDF2 (iRHOM2) regulates thickening o

197 se FRET to analyze the dimerization of human rhomboid protease RHBDL2 in giant plasma membrane vesicl

198 h to investigate the substrate repertoire of rhomboid protease RHBDL2 in human cells.

199 Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes

200 y of APP through the mammalian intramembrane rhomboid protease RHBDL4.

201 e L1 loop and active-site region of the GlpG rhomboid protease suggest an important structural, rathe

202 ctions in other contexts, and characterize a rhomboid protease that harbours calcium-binding EF-hands

203 We show that EBA-175 is cleaved by PfROM4, a rhomboid protease that localizes to the merozoite plasma

204 Rhomboid protease was first discovered in Drosophila.

205 ystallographic analyses of GlpG, a bacterial rhomboid protease, and its complex with isocoumarin have

206 the effect of detergents on the structure of rhomboid protease, crystals of GlpG, an Escherichia coli

207 al. describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD

208 ses such as chymotrypsin, the active site of rhomboid protease, which contains a Ser-His catalytic dy

209 d for substrate access to the active site of rhomboid protease.

210 le model for explaining substrate binding to rhomboid protease.

211 to the regulation and function of this human rhomboid protease.

212 alidated natural substrate for a prokaryotic rhomboid protease.

213 te before they are shed by the activity of a rhomboid protease.

214 tants of bacteriorhodopsin and 25 mutants of rhomboid protease.

215 the Spitz ligand, which is processed by the Rhomboid protease.

216 idespread function, even in pathogens, since rhomboid proteases are also conserved in unrelated proto

217 Rhomboid proteases are evolutionary conserved intramembr

218 Rhomboid proteases are increasingly being explored as po

219 Rhomboid proteases are intramembrane proteases that play

220 Rhomboid proteases are membrane-embedded enzymes conserv

221 Most rhomboid proteases cleave membrane protein substrates ne

222 lution crystal structures have revealed that rhomboid proteases contain a catalytic serine recessed i

223 Remarkably, rhomboid proteases displayed no physiological affinity f

224 Collectively these results implicate rhomboid proteases for the first time in immune evasion

225 Here, we show that the Shigella sonnei rhomboid proteases GlpG and the newly identified Rhom7 a

226 Rhomboid proteases have many important biological functi

227 the first insight on the biological role of rhomboid proteases in Archaea, suggesting a link between

228 Rhomboid proteases occur in all domains of life; however

229 Rhomboid proteases represent a different evolutionary pa

230 Rhomboid proteases reside within cellular membranes, but

231 Structures of the prokaryotic homologue of rhomboid proteases reveal a core of six transmembrane he

232 fficiency with substrate mutants and diverse rhomboid proteases were reflected in k(cat) values alone

233 We probed rhomboid proteases with reversible, mechanism-based inhi

234 ates, which are cleaved by several unrelated rhomboid proteases, can be used both in detergent micell

235 Rhomboid proteases, like site-2 protease (S2P) and gamma

236 otif that is specifically recognized by many rhomboid proteases.

237 tors and developed activity-based probes for rhomboid proteases.

238 underlying cleavage site specificity for the rhomboid proteases.

239 nts to identify the gating mechanism used by rhomboid proteases.

240 of activity and development of inhibitors of rhomboid proteases.

241 ct), Apicomplexan DNA-binding protein (Ap2), Rhomboid protein 1 (Rom 1), and nucleoside diphosphate k

242 Inactive rhomboid protein 2 (iRhom2) is required for the maturati

243 Here, we report that inactive rhomboid protein 2 (iRhom2), recently identified as esse

244 Regulating cell signaling is at the heart of rhomboid protein function in many, but not all, of these

245 promises to reveal the evolutionary path of rhomboid protein function, which could provide insights

246 effort to further investigate the role of a rhomboid protein in cell physiology, a glpG mutant of E.

247 We report that yeast lacking the rhomboid protein Rbd2 exhibit accelerated endocytic-site

248 s work reveals that the previously unstudied rhomboid protein Rbd2 functions in vivo at the nexus of

249 RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2.

250 hat rbf is required for normal expression of Rhomboid proteins and activation of MAP kinase in the mo

251 and stem cell differentiation in eukaryotes; rhomboid proteins are also now starting to be linked to

252 rarely conserved outside the animal kingdom, rhomboid proteins are conserved in all kingdoms of life,

253 Rhomboid proteins directly recognized their substrates i

254 Rhomboid proteins from diverse organisms including two m

255 crystal structures have provided proof that rhomboid proteins function as novel intramembrane protea

256 cal similarity in mechanism and specificity, rhomboid proteins function in diverse processes includin

257 olysis with a pure recombinant substrate and rhomboid proteins in both detergent micelles and artific

258 Notably, only rhomboid proteins were able to diffuse above the Saffman

259 -like protein RHBDD2 is distantly related to rhomboid proteins, a group of highly specialized membran

260 c consequences, revealing that the levels of rhomboid proteolysis in parasites are not delicately bal

261 ducible reconstitution system to interrogate rhomboid proteolysis quantitatively within the membrane

262 nsin system, juxtaglomerular cells contained rhomboid protogranules with paracrystalline contents, di

263 Dsc2 is a rhomboid pseudoprotease family member homologous to mamm

264 at association of UBXD8 with the ER-resident rhomboid pseudoprotease UBAC2 specifically restricts tra

265 t transient inactivation of the reuniens and rhomboid (Re/Rh) nuclei of the ventral midline thalamus

266 Knowledge of how rhomboids recognize their substrates would illuminate th

267 anscriptional control of the serine protease rhomboid regulates EGF signaling to specify distinct cel

268 Rhomboid regulation is not orchestrated by either dimeri

269 rates means that the biological role of most rhomboids remains obscure.

270 Rhomboids represent an evolutionarily ancient protease f

271 ay, is required for Broad expression and for rhomboid repression.

272 C) and the hippocampus make the reuniens and rhomboid (ReRh) thalamic nuclei a putatively major funct

273 The reuniens (Re) and rhomboid (Rh) nuclei of the ventral midline thalamus are

274 dose-dependent manner, and that blockade of rhomboid (rho) expression in the nervous system decrease

275 pendent manner through the activation of the rhomboid (rho) protease.

276 ss that could be partially rescued by mutant rhomboid (rho), a known component of epidermal growth fa

277 Our results demonstrate that rhomboid (Rho)- and Star-mediated activation of EGFR and

278 f the epidermal growth factor (EGF) protease Rhomboid (Rho).

279 the EGF receptor ligand protease, encoded by rhomboid (rho).

280 ly through backbone interactions, explaining rhomboid's broad sequence selectivity.

281 The D(2h) rhomboid self-assembled from 2,6-bis(4-pyridylethynyl)an

282 mTORC1 is an obligate dimer with an overall rhomboid shape and a central cavity.

283 TORC2 displays a rhomboid shape with pseudo-2-fold symmetry and a promine

284 lar architecture of the heterohexamer as two rhomboid-shaped ring structures of Pnkp1-Rnl-Hen1 hetero

285 a foundation for a structural explanation of rhomboid specificity and mechanism, and for inhibitor de

286 l, these probes represent valuable tools for rhomboid study, and the structural insights may facilita

287 atalytic efficiency and selectivity toward a rhomboid substrate can be dramatically improved by targe

288 e a mass spectrometry-based assay to measure rhomboid substrate cleavage and inhibition.

289 Previous work has suggested that rhomboid substrates are specified by helical instability

290 iRhoms prevent the cleavage of potential rhomboid substrates by promoting their destabilization b

291 e metastable transmembrane domains (TMDs) of rhomboid substrates protected when they are incorporated

292 Based on the ability of rhomboid superfamily members to bind transmembrane prote

293 merozoite plasma membrane, but not by other rhomboids tested.

294 Four T. gondii rhomboids (TgROMs) were active proteases with similar su

295 Rhomboids, the most widespread and largest superfamily o

296 the mechanism of refolding for two distinct rhomboids to gain insight into their secondary structure

297 This indicates that the rhomboid transmembrane core is intrinsically monomeric.

298 lue similar to those determined recently for rhomboid-type I-CLiPs.

299 and seagrass-dwelling fish (pinfish, Lagodon rhomboides) using polarization-imaging and modeling pola

300 lippinarum, Venerupis corrugata, Polititapes rhomboides, Venus verrucosa, Dosinia exoleta, Glycymeris

301 Rhomboids were only discovered to be novel proteases in