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1 g the actin-dependent dispersal of the Golgi ribbon.
2 ation of a supramolecular H-bonded polymeric ribbon.
3 zone, which is localized at the base of the ribbon.
4 of endocytic activity close to the synaptic ribbon.
5 organized into identical antiparallel dimer ribbons.
6 contact that bridges neighboring SERCA dimer ribbons.
7 with RIBEYE, the main component of synaptic ribbons.
8 rial-Ca(2+) (mito-Ca(2+)) uptake adjacent to ribbons.
9 phene onto template-stripped ultraflat metal ribbons.
10 le is known about the structural dynamics of ribbons.
11 ciated with the release site at the synaptic ribbons.
12 nsmission at active zone structures known as ribbons.
13 nd expand outward from the far ends of flare ribbons.
14 ding of the polaritons in arbitrarily narrow ribbons.
15 ade of two-dimensional topological insulator ribbons accounting for scattering with phonons and imper
16 s forming many-turn Mobius strips or twisted ribbons along closed loops around a central singularity.
17 the superstructure of plate-shaped synaptic ribbons, although with variable manifestation in the cel
18 gulating the balance between a compact Golgi ribbon and a dispersed Golgi, a pathway with relevance t
19 have focused on the globular isomers as the ribbon and bead isomers typically have lower potency at
20 ulations, we find two isomers, two-atom wide ribbon and single-atom chain, linked by a tension-driven
21 n of photoreceptor transduction proteins and ribbon and synaptic markers in fetal human and Macaca re
23 ol of vesicles (RRP) underneath the synaptic ribbons and a slowly releasable pool of vesicles (SRP) a
25 kinetics are shaped by vesicle delivery down ribbons and by properties of exocytotic Ca(2+) sensors.
26 retina perturbs the organization of synaptic ribbons and impairs the function of inhibitory synapses.
27 mpared with abneural-side short HCs with few ribbons and large efferent synapses.SIGNIFICANCE STATEME
28 ise exposure caused unpairing of presynaptic ribbons and presynaptic Ca(V)1.3, but not in Vglut3(KO)
29 terned scNSCs to differentiate within neural ribbons and project axons for integration with 3-D exter
33 c AMPA receptors juxtaposed with presynaptic ribbons and voltage-gated calcium channels (Ca(V)1.3).
34 thickness was computed on the whole cortical ribbon, and deep gray matter volumetry was performed aft
35 ct measurements of vesicle movement down the ribbon, and suggest that multiple factors contribute to
36 ynaptic vesicle recycling, abnormal synaptic ribbons, and higher resting calcium concentrations in ha
39 upts resting calcium levels, alters synaptic ribbon architecture, and perturbs transcription of hair
41 ease neurotransmitter continuously, synaptic ribbons are assumed to act as platforms for supplying ve
42 uter plexiform layer, synaptic proteins, and ribbons are first reliably recognized in cone pedicles.
43 e depression.SIGNIFICANCE STATEMENT Synaptic ribbons are macromolecular scaffolds that tether synapti
52 umerous synaptic vesicles, some of which are ribbon associated, that have difference susceptibilities
55 ilar to bipolar cells, fusion of the initial ribbon-associated synaptic vesicle cohort was not blocke
56 portant implication of these results is that ribbon-associated vesicles can form intervesicular SNARE
60 Moreover, the active layers for the helical ribbon-based photodetectors are solution-cast but have p
61 ially recovered by 2 weeks after exposure as ribbons became larger, whereas recovery was significantl
62 pillar sides of the IHC exhibited a loss of ribbons, but there was an increased volume of those that
63 Here, we show that dispersal of the Golgi ribbon by GCC88 is dependent on actin and the involvemen
65 interaction between Piccolino and the major ribbon component RIBEYE that supports plate-shaped synap
66 fically, discretizing desired shapes into 2D ribbon components allows for analytic solutions to the i
67 electron-dense presynaptic structures called ribbons, composed primarily of the structural protein Ri
69 e property, a fabric/matrix made using these ribbons could be highly beneficial for powering wearable
70 bular (Cys(I)-Cys(III) and Cys(II)-Cys(IV)), ribbon (Cys(I)-Cys(IV) and Cys(II)-Cys(III)), or bead (C
73 nd mole rats, inner hair cell (IHC) afferent ribbon density was reduced, whereas outer hair cell affe
74 rt linkers led to selective formation of the ribbon disulfide isomer without requiring orthogonal pro
75 erizing the initial as-adsorbed system with "ribbon" domain boundaries isolating rotationally offset
79 ologies, including randomly-oriented crystal ribbons, elongated needles with enhanced long-range orde
80 is approach to fabricate 9- and 13-atom wide ribbons, enabling short-channel transistors with 10(5) o
82 structured peptide to mature amyloid twisted-ribbon fibrils over a few hours when incubated on polyst
84 GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for ce
86 Wildtype BCs make both ribbon-containing and ribbon-free synapses with these GCs even at maturity.
88 (group 1, n = 25), 1-week ostium packing by ribbon gauze (group 2, n = 29) or non-medicated absorbab
89 d as well as increase the serum stability of ribbon GeXIVA while preserving activity at the alpha9alp
95 Dtr protein TraK, a predicted member of the Ribbon-Helix-Helix (RHH) family of DNA-binding proteins,
96 identify CdbA, a DNA-binding protein of the ribbon-helix-helix family that binds c-di-GMP in Myxococ
97 sembled into micrometer length scale twisted ribbon hierarchical superstructures during storage of co
98 width for detection results from the helical ribbons' high absorption coefficient, good electron mobi
100 ce microscopy to image synaptic vesicles and ribbons in retinal bipolar cells of goldfish (Carassius
101 s time-lapse imaging of fluorescently-tagged ribbons in retinal cone bipolar cells (BCs) and postsyna
103 s showed disruption of synapses and synaptic ribbons in the outer plexiform layer of Sfxn3 (-/-) mice
105 napses with age, the volume of the remaining ribbons increased and the size and kinetics of Ca(2+) -d
106 cteristic plate-shaped structure of synaptic ribbons, indicating a role of Piccolino in synaptic ribb
107 - 2 PF per cell tip) and fail to form a flat-ribbon, indicative of a role of BB0270 in the control of
110 timulus intervals, vesicle movement down the ribbon is fast enough to replenish released vesicles, bu
112 A recent report showed that the bead and ribbon isomers of GeXIVA are more potent than the globul
113 lucidated and revealed a transformation of a ribbon-like 1D building unit into 2D layers and finally
114 resence of [PSI(+) ] or [PIN(+) ], Swi1 ring/ribbon-like aggregates predominantly colocalize with the
118 Its crystal structure consists of planar ribbon-like molecular arrays packed into offset layers t
119 ies ranged from large crescent-like to small ribbon-like shapes, also had the slender cross-sectional
120 ns of porcine myocardium were laser-cut into ribbon-like shapes, decellularized, and mounted in speci
124 show that Swi1 aggregates are initially ring/ribbon-like then become dot-like in mature [SWI(+) ] cel
126 eterotopia posterior to the caudate nuclei, "ribbon-like" heterotopia in the posterior frontal region
131 that ribbon enlargement results in increased ribbon-localized calcium signals, yet reduces afferent s
132 ch indicated that rod photoreceptor synaptic ribbons lose their structural integrity in a knockdown o
140 e residues at the tip of the C-terminal zinc ribbon of TFS4; the inhibition likely involves an allost
141 o link infinite building blocks, such as the ribbons of COF-76, into higher dimensionality COFs, pave
144 units of the crystals are antiparallel dimer ribbons of SERCA, known for decades as an assembly of ca
146 ther assembly into membranes and intertwined ribbons on substrates in aqueous solution, depending on
148 for CaV1.4 function, but is not required for ribbon organization, synaptogenesis, or synaptic transmi
152 f outer segment-like structures and synaptic ribbons, photoreceptor neurotransmitter expression, and
153 ficient detection via photons emitted in the ribbon plane, which enables the measurement of key prope
156 maturation is characterized by the fusion of ribbon precursors with membrane-anchored ribbons that al
158 across arrays of separated or interconnected ribbons provide scalable routes to 3D surfaces with a br
160 nt; where vesicles higher up on the synaptic ribbon replenish the rapidly releasing vesicle pool; and
161 Surprisingly, the guiding of these modes in ribbons-representing typical linear waveguide structures
162 dings revealed that hair cells with enlarged ribbons resulted in reduced spontaneous spike rates.
165 ifies the physical mechanisms underlying the ribbon's nonlinear response to an apparently simple defo
170 structures such as open caps, cylindrical or ribbon-shaped shells may emerge, preventing the successf
171 nd organic photovoltaics fabricated with the ribbons show efficiencies of approximately 8% without op
172 ng triggered vesicle movement and release at ribbon sites in retinal bipolar cells, and find that, al
173 These observations suggest that varying ribbon size alone can influence sensory encoding, and gi
175 MENT Numerous studies support that hair-cell ribbon size corresponds with functional sensitivity diff
178 Together, our work indicates that hair-cell ribbon size influences the spontaneous spiking and the p
181 ion of NAD(+) or NADH increases or decreases ribbon size respectively, possibly acting through the NA
185 Here, we show that Piccolino, the synaptic ribbon specific splice variant of Piccolo, interacts wit
186 ubunit (GABAA Ralpha1 ), and that a synaptic ribbon-specific protein (RIBEYE) is found adjacent to so
189 ils possess a common double stranded twisted ribbon structure which can result in a mesoscopic right-
190 igand results in a neutral double zigzag 2,4-ribbon structure which exhibits SCM behavior with a high
192 indicating that few vesicles outside of the ribbon-style active zones were initially fusion competen
193 the retinal bipolar cell are situated at the ribbon-style active zones, where they functionally inter
197 n-redox cathodes by forming materials with a ribbon superstructure in the transition metal layers tha
198 s non-uniform over the sunspot: as the flare ribbon sweeps across, its different portions accelerate
199 nting magnetic flux through the feet and the ribbon-swept area reveals that the rope's core is more t
200 contribute to synaptic depression at the IHC ribbon synapse and spike rate adaptation in the auditory
202 pre- and postsynaptic mechanisms at the IHC ribbon synapse contribute to synaptic depression at the
204 cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a
206 fates [short hair cells (HCs) are missing], ribbon synapse numbers, outward ionic currents, and effe
208 for a priming mechanism at the photoreceptor ribbon synapse that is independent of the formation of a
209 ddressing the significance of Piccolino, the ribbon synapse-specific splice variant of Piccolo, for s
214 fundamental difference between photoreceptor ribbon synapses and conventional chemical synapses in sy
215 fundamental difference between photoreceptor ribbon synapses and conventional chemical synapses with
216 active zones.SIGNIFICANCE STATEMENT Retinal ribbon synapses are a specialized type of chemical synap
217 r, the transfer characteristics at hair cell ribbon synapses are still poorly understood at different
218 ntials, the so called "receptor potentials." Ribbon synapses between IHCs and auditory nerve neurons
220 mobility and turnover of Ribeye at hair cell ribbon synapses by monitoring fluorescence recovery afte
221 ctural analyses to probe the architecture of ribbon synapses by perturbing the function of RIM-bindin
222 ls into sequences of numbers up to about 11, ribbon synapses can increase the dynamic range, temporal
223 hysiological and morphological properties of ribbon synapses change with age remains largely unknown.
224 the fewer, but larger, individual remaining ribbon synapses colocalized with the post-synaptic affer
225 the age-related morphological changes at IHC ribbon synapses contribute to the different progression
226 tinal bipolar cells, and find that, although ribbon synapses deliver and prime vesicles faster than m
228 analysis of three different types of retinal ribbon synapses in Piccolo/Piccolino-deficient male and
229 physical and morphological properties of IHC ribbon synapses in the ageing cochlea (9-12 kHz region)
230 ells and directly from rod bipolar cells via ribbon synapses in the innermost ON layer of the inner p
231 BBS mutant animals have significantly fewer ribbon synapses in the outer plexiform layer and increas
232 er release at auditory inner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergic ves
233 e finding that synaptic transmission at cone ribbon synapses is regulated by Gbetagamma/SNAP-25 inter
234 which stimulus-evoked exocytosis in retinal ribbon synapses is SNARE-dependent; where vesicles highe
236 we show here that the sensory photoreceptor ribbon synapses most likely lack RIM1 and predominantly
238 s (GPCRs) influence synaptic transmission at ribbon synapses of cones and other retinal neurons, it i
239 amate in live zebrafish, we demonstrate that ribbon synapses of retinal bipolar cells encode contrast
240 nd sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (
241 vate neural-side tall HCs, resulting in more ribbon synapses per HC compared with abneural-side short
243 mainly expressed in photoreceptors that use ribbon synapses to communicate with the inner retina.
247 otransduction complex to loss of specialized ribbon synapses, and may even result in hair cell death.
248 mouse stains is correlated with the loss of ribbon synapses, being most severe for the strains C57BL
249 or noise-induced threshold shift and loss of ribbon synapses, but both copies are required for normal
250 iated with the loss of inner hair cell (IHC) ribbon synapses, lower hearing sensitivity and decreased
251 essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiol
252 -type Ca(2+) channels to the active zones of ribbon synapses, thereby synchronizing vesicle exocytosi
253 rted previously that, at mouse photoreceptor ribbon synapses, vesicle priming is Munc13 independent.
254 se, Complexin3 (Cplx3), a SNARE regulator at ribbon synapses, was downregulated fivefold in the mutan
255 or synaptic vesicle priming at photoreceptor ribbon synapses, which represents a fundamental differen
256 This ability is largely conferred by their ribbon synapses, which tether a large number of vesicles
268 xtensive in vitro characterization of neural ribbon technology, and constitutes a plausible method fo
269 iometrically by imine linkages to produce 1D ribbons, termed COF-76, bearing free amines, which are t
270 ich are displaced farther from cone synaptic ribbons than CalipHluorin, reported a smaller pH change.
273 otodetectors based on four different helical ribbons that differ in the wavelength of their response.
274 5 no seizure, 14 early, 8 late) and cortical ribbon thinning (analysable sample: 46 patients; 29 no s
275 These models suggest that the salt-induced ribbon to cochleate transition should be common to all c
277 rod and cone photoreceptors utilize synaptic ribbons to sustain continuous exocytosis while making ra
278 se findings, made at two quite different non-ribbon type synapses, suggest that cleft alkalinization
279 , we explored the nanodomain organization of ribbon-type active zones by addressing the significance
280 interactions regulate synaptic function at a ribbon-type synapse, contributing to an emerging picture
281 BP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (R
282 study aims to understand how frog hair cell ribbon-type synapses preserve both sensitivity and tempo
287 n contrast, exchange of Ribeye between other ribbons via the cell's cytoplasm takes several hours.
289 nvestigate vesicle replenishment at synaptic ribbons, we used total internal reflection fluorescence
290 mation of many-turn Mobius strips or twisted ribbons when the topological charge of one of the compon
291 ribbon synapses is the plate-shaped synaptic ribbon, which extends from the release site into the ter
293 are stitched together as a perinuclear Golgi ribbon, which is required for the establishment of cell
294 a unique presynaptic structure, the synaptic ribbon, which organizes both synaptic vesicles and calci
295 s robust assembly of one-dimensional twisted ribbons, which behave as effective supramolecular polyme
296 structures with characteristic sizes (e.g., ribbon width) ranging from ~200 um to ~2 cm and with geo
297 that Ribeye can exchange between halves of a ribbon within 1 minute in a manner that is consistent wi
298 receptor architecture segregate the cortical ribbon within the IPS, and receptor fingerprints provide
300 ord involved the participant tying a knot in ribbons worn under the clothing each time they had an ep