ライフサイエンスコーパス: ribosome biogenesis

1 as well as c-Myc and its targets involved in ribosome biogenesis).

2 actions are critical for snoRNP assembly and ribosome biogenesis.

3 pregulation of hundreds of genes involved in ribosome biogenesis.

4 for protein and RNA interactions involved in ribosome biogenesis.

5 ultiple aspects of translational control and ribosome biogenesis.

6 tem in yeast to identify genes essential for ribosome biogenesis.

7 sitol 4-phosphate 5-kinase, and required for ribosome biogenesis.

8 s been associated with ssDNA interaction and ribosome biogenesis.

9 off or on RP mRNA translation and subsequent ribosome biogenesis.

10 nses to the inhibition of different steps in ribosome biogenesis.

11 g complexes highlighted proteins involved in ribosome biogenesis.

12 acking the Sch9p protein kinase regulator of ribosome biogenesis.

13 undance of Myc protein, a known regulator of ribosome biogenesis.

14 tion and repair, transcription, splicing and ribosome biogenesis.

15 mal protein haploinsufficiency or defects in ribosome biogenesis.

16 olymerase I (Pol I) is the first key step of ribosome biogenesis.

17 Here, we show that LepA functions in ribosome biogenesis.

18 in particle assembly, primarily dedicated to ribosome biogenesis.

19 uding genome integrity, gene expression, and ribosome biogenesis.

20 n block and down-regulates genes controlling ribosome biogenesis.

21 d TOP mRNA cap-binding protein that controls ribosome biogenesis.

22 riazinoindole-based inhibitors of eukaryotic ribosome biogenesis.

23 s of processing and maturation of mtRNAs and ribosome biogenesis.

24 the cells, asymmetric mRNA distribution and ribosome biogenesis.

25 structure that colocalizes genes involved in ribosome biogenesis.

26 ein complexes involved in RNA processing and ribosome biogenesis.

27 ts in telomere maintenance, and (3) abnormal ribosome biogenesis.

28 onserved non-protein-coding RNAs involved in ribosome biogenesis.

29 al GTPase of bacteria recently implicated in ribosome biogenesis.

30 erase I represents the rate-limiting step in ribosome biogenesis.

31 ion of genes encoding products that regulate ribosome biogenesis.

32 se eIF6 recruitment to the nucleolus and 60S ribosome biogenesis.

33 th ribosomal protein S6, a committed step in ribosome biogenesis.

34 acrofacial disorders caused by disruption of ribosome biogenesis.

35 or Ubp10's known roles in gene silencing and ribosome biogenesis.

36 ependent ribosomal protein genes involved in ribosome biogenesis.

37 nism by which LARP1 links mTOR signalling to ribosome biogenesis.

38 cohesin ring are associated with defects in ribosome biogenesis.

39 ol of ribosomal DNA (rDNA) transcription and ribosome biogenesis.

40 y of 5S rRNA is preserved due to its role in ribosome biogenesis.

41 ubunit and essential for rRNA processing and ribosome biogenesis.

42 n translation, no such probes exist to study ribosome biogenesis.

43 oncogenic stimuli and as a key regulator of ribosome biogenesis.

44 res due to an improved efficiency of plastid ribosome biogenesis.

45 ncers and functions as a global regulator of ribosome biogenesis.

46 A transcription, which is a critical step in ribosome biogenesis.

47 ate switch is generally linked to defects in ribosome biogenesis.

48 ed, consistent with a phenotype of perturbed ribosome biogenesis.

49 nscription of ribosomal DNA (rDNA) genes and ribosome biogenesis.

50 ulation of genes involved in translation and ribosome biogenesis.

51 owing this pattern primarily associated with ribosome biogenesis.

52 ogenesis and tp53 activation, which monitors ribosome biogenesis.

53 case mutant and identified genes involved in ribosome biogenesis.

54 localizes in the nucleolus and regulates 60S ribosome biogenesis.

55 nthetic interaction between U2AF1, NPM1, and ribosome biogenesis.

56 rythroid differentiation related to impaired ribosome biogenesis.

57 ancer cells involving rDNA transcription and ribosome biogenesis.

58 with ribosomal proteins are the linchpins of ribosome biogenesis.

59 s to 1000s of copies, to meet the demand for ribosome biogenesis.

60 emble hierarchically during a process termed ribosome biogenesis.

61 A that includes defects in DNA repair and in ribosome biogenesis.

62 Ribosome biogenesis, a complex multistep process, result

63 rowth potential is determined by the rate of ribosome biogenesis, a complex process that requires mas

64 TCR signaling was suboptimal, was linked to ribosome biogenesis, a rate-limiting factor in both cell

65 enewal to differentiation relies on enhanced ribosome biogenesis accompanied by increased protein syn

66 B cells, the expression of genes involved in ribosome biogenesis, aerobic respiration, and mammalian

67 enic signals from the BCR-ABL oncoprotein to ribosome biogenesis, affecting cellular growth.

68 ion of EIF2 signaling, steroid biosynthesis, ribosome biogenesis and activation of the cytochrome P45

69 n in several systems, we show that increased ribosome biogenesis and activity are a hallmark of prema

70 ribosome assembly complexes captured during ribosome biogenesis and assembly under different perturb

71 ontrol of the cluster of genes implicated in ribosome biogenesis and cell growth.

72 that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways prom

73 ANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, the

74 enes associated with lipoprotein metabolism, ribosome biogenesis and E2F and MYC transcriptional acti

75 CBFbeta further promoted ribosome biogenesis and enhanced gene translation in act

76 ucleoli, that plays a number of functions in ribosome biogenesis and export, cell cycle control, and

77 l protein (RP) genes that lead to defects in ribosome biogenesis and function and result in ribosomal

78 cation, transcription, nucleotide synthesis, ribosome biogenesis and function, as well as lipid metab

79 ibosomal protein gene expression and, hence, ribosome biogenesis and functions.

80 While ribosome biogenesis and global protein synthesis were un

81 Gadd34 expression that facilitated enhanced ribosome biogenesis and global protein synthesis.

82 anine, tyrosine and tryptophan biosynthesis, ribosome biogenesis and glycolysis/gluconeogenesis were

83 esis, whereas up-regulated pathways included ribosome biogenesis and methanogenesis.

84 arly dynamics of phosphorylation and delayed ribosome biogenesis and mitochondrial activation.

85 to various environmental cues by regulating ribosome biogenesis and mRNA translation at multiple lev

86 many aspects of protein synthesis, including ribosome biogenesis and mRNA translation.

87 ue studies to unravel the systems biology of ribosome biogenesis and open the way to new methods for

88 tion (LLPS) facilitates the initial steps of ribosome biogenesis and other functions.

89 n contrast, MYC induction leads to increased ribosome biogenesis and p53 protein stabilization.

90 polr1a loss of function led to perturbed ribosome biogenesis and p53-dependent cell death, result

91 al proteins, suggesting their direct role in ribosome biogenesis and plant development.

92 ecent data showed that AATF is essential for ribosome biogenesis and plays a role in rRNA maturation.

93 pports transcriptional programs that promote ribosome biogenesis and protein synthesis in cells stimu

94 ilization of RNA structure and regulation of ribosome biogenesis and protein synthesis.

95 s with de novo PLAG1 motifs were involved in ribosome biogenesis and protein synthesis.

96 ghly fragmented nucleoli and defects in both ribosome biogenesis and protein translation.

97 t loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective adv

98 identify the first target of an inhibitor of ribosome biogenesis and provide the mechanism of inhibit

99 disassembly of the 90S/SSU processome during ribosome biogenesis and repress nucleolar stress.

100 o untangle the complexities underlying human ribosome biogenesis and ribosomopathies.

101 osomal proteins, including those involved in ribosome biogenesis and rRNA processing.

102 g diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subuni

103 , recombination, transcription, translation, ribosome biogenesis and splicing which regulate plant gr

104 r pathways associated with mRNA translation, ribosome biogenesis and stress signaling.

105 widely available chemical probe of bacterial ribosome biogenesis and suggests a role for E. coli IF2

106 Nucleoli, the sites of ribosome biogenesis and the largest structures in human

107 We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a c

108 TOR1) signaling, we suspected a link between ribosome biogenesis and TOR1 signaling in NKKY101.

109 We report that glucose controls ribosome biogenesis and translation by modulating mRNA d

110 es involved in the regulation of cell cycle, ribosome biogenesis and translation in dKO mutants.

111 Bacterial ribosome biogenesis and translation occur in the same ce

112 ene (but not to genes that are not linked to ribosome biogenesis) and that the presence of Tor1p is a

113 f acute resistance exercise on mechanisms of ribosome biogenesis, and (2) the impact of mammalian tar

114 ions direct nucleolar disorganization, alter ribosome biogenesis, and activate the Rpl11-Mdm2-p53 nuc

115 membrane trafficking, telomere maintenance, ribosome biogenesis, and apoptosis.

116 veal a mechanistic connection between FGFR2, ribosome biogenesis, and cellular stress that links cell

117 Numerous factors direct eukaryotic ribosome biogenesis, and defects in a single ribosome as

118 such as mRNA translation, pre-mRNA splicing, ribosome biogenesis, and double-stranded RNA sensing.

119 ll cycle control, flagella and basal bodies, ribosome biogenesis, and energy metabolism, all had dist

120 oundation to map ribosome allostery, explore ribosome biogenesis, and engineer ribosomes for new func

121 ng transcription, translation, RNA splicing, ribosome biogenesis, and more recently, different classe

122 nal regulation, elongation, and termination, ribosome biogenesis, and mRNA decay.

123 e impact of mammalian target of rapamycin on ribosome biogenesis, and muscle protein synthesis (MPS)

124 n nucleotide metabolism, glucose metabolism, ribosome biogenesis, and phosphorylation-based signal tr

125 tifaceted role of DDX21 in multiple steps of ribosome biogenesis, and provide evidence implicating a

126 ation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuc

127 lation for RP-mRNAs, enhancing RP synthesis, ribosome biogenesis, and the overall protein synthesis i

128 In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane gro

129 the molecular mechanisms by which they drive ribosome biogenesis are poorly understood.

130 creases in muscle mass and strength point to ribosome biogenesis as a determinant of dose-dependent t

131 xpected functions, including DNA-related and ribosome biogenesis-associated activities.

132 ols RE-induced changes in protein synthesis, ribosome biogenesis, autophagy, and the expression of pe

133 The nucleolus serves as a principal site of ribosome biogenesis but is also implicated in various no

134 g mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP

135 es early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution

136 Furthermore, miR-542-3p suppressed ribosome biogenesis by downregulating a subset of riboso

137 lear condensate that plays a central role in ribosome biogenesis by facilitating the transcription an

138 ensitive mTOR could prevent the induction of ribosome biogenesis by RE, but it only partially inhibit

139 Here, we asked whether targeting of ribosome biogenesis can be used as the basis for selecti

140 vates a multifaceted growth program in which ribosome biogenesis, carbon metabolism, and amino acid a

141 gulates both QNPs and TAPs, and importantly, ribosome biogenesis, cell cycle and neuronal genes in th

142 several growth-promoting processes, such as ribosome biogenesis, cellular detachment and pyrimidine

143 ed to limit muscle protein synthesis, making ribosome biogenesis central to skeletal muscle hypertrop

144 Nucleophosmin 1 (NPM1) acts in ribosome biogenesis, centrosome duplication, maintenance

145 complex leading to induction of the impaired ribosome biogenesis checkpoint (IRBC) and p53 stabilizat

146 that make up the recently described impaired ribosome biogenesis checkpoint (IRBC) complex, RPL5, RPL

147 and translational programs, and the impaired ribosome biogenesis checkpoint (IRBC) provide a foundati

148 Oncogenic MYC induces the impaired ribosome biogenesis checkpoint, which could be potential

149 The structure reveals how large ribosome biogenesis complexes assist the 5' external tra

150 re on cells to select for suppressors of the ribosome biogenesis defect, allowing them to reestablish

151 riants in the same RP gene can drive similar ribosome biogenesis defects yet still have markedly diff

152 RNA helicases play various roles in ribosome biogenesis depending on the ribosome assembly p

153 re maintenance (dyskeratosis congenita), and ribosome biogenesis (Diamond-Blackfan anemia, Shwachman-

154 Ribosome biogenesis dictates the translational capacity

155 t appeared to change at the RNA level (e.g., ribosome biogenesis) did not do so at the protein level,

156 Ribosome biogenesis drives cell growth and proliferation

157 ed in all stages of protein biosynthesis and ribosome biogenesis during both stages of hibernation th

158 ated mRNA localization as a key regulator of ribosome biogenesis during cell migration and demonstrat

159 mor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest.

160 While limiting ribosome biogenesis extends lifespan in several systems,

161 to identify apum23-4, a mutant allele of the ribosome biogenesis factor (RBF) gene ARABIDOPSIS PUMILI

162 The ribosome biogenesis factor Las1 is an essential endoribo

163 ly, in complex with the G-patch motif of the ribosome biogenesis factor NKRF.

164 Budding yeast Tsr1 is a ribosome biogenesis factor with sequence similarity to G

165 P2, the RNA helicase yRok1/hROK1(DDX52), the ribosome biogenesis factor yRrp7/hRRP7 and yUtp24/hUTP24

166 n yeast have established YVH1 as a novel 60S ribosome biogenesis factor.

167 While we know that >80 ribosome biogenesis factors are required throughout the

168 urthermore, AATF binds to mRNAs encoding for ribosome biogenesis factors as well as snoRNAs.

169 S rRNA and retarded recycling of late-acting ribosome biogenesis factors, revealing an unexpected con

170 hologous proteins with demonstrated roles as ribosome biogenesis factors; knockdown of GLTSCR2 impair

171 How cells ensure quality control in ribosome biogenesis for the fidelity of its complex func

172 an expansion factor (DEF), has a key role in ribosome biogenesis, functioning in pre-ribosomal RNA (p

173 ranslational proteins, especially those with ribosome biogenesis functions.

174 demonstrated reduced expression of multiple ribosome biogenesis genes and the key translation initia

175 n regulatory mechanism in a metazoan whereby ribosome biogenesis genes communicate with genes control

176 Transcriptional profiling revealed that ribosome biogenesis genes were significantly up-regulate

177 re 60S subunits and increased translation of ribosome biogenesis genes.

178 eQ (also called RsgA), RbfA, RimM and Era in ribosome biogenesis has been derived in part from the st

179 However, its specific function in ribosome biogenesis has not been described.

180 nd structural analysis, studies on mammalian ribosome biogenesis have lagged behind.

181 tion of select post-transcriptional steps of ribosome biogenesis holds potential for therapeutic targ

182 eolar Pol-II-dependent mechanism that drives ribosome biogenesis, identify disease-associated disrupt

183 presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-

184 ese findings have important implications for ribosome biogenesis in bacteria.

185 how these findings shape our current view of ribosome biogenesis in bacteria.

186 cipating in the regulation of cell cycle and ribosome biogenesis in cancer.

187 yc expression, allowing a tightly controlled ribosome biogenesis in cells.

188 we broaden our understanding of the role of ribosome biogenesis in diverse tissue types throughout e

189 During ribosome biogenesis in eukaryotes, nascent subunits are

190 nsequence of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts.

191 Our results reveal a novel role for PARN in ribosome biogenesis in human cells.

192 (Pol) I and II to control multiple steps of ribosome biogenesis in human cells.

193 is purification method for the dissection of ribosome biogenesis in human cells.

194 10 with testis-specific expression, disturbs ribosome biogenesis in late-prophase spermatocytes and p

195 During the early steps of ribosome biogenesis in mammals, the two ribosomal subuni

196 e chondrocyte homeostasis in osteoarthritis, ribosome biogenesis in osteoarthritis is unexplored.

197 nstream targets, which are known to regulate ribosome biogenesis in other cell types, were upregulate

198 We found that TOR regulates ribosome biogenesis in plants at multiple levels, but th

199 king TOR signaling to rDNA transcription and ribosome biogenesis in plants.

200 tional silencing of rDNA genes and decreased ribosome biogenesis in quiescent old HSCs.

201 Ribosome biogenesis in Saccharomyces cerevisiae involves

202 work is incorporated into a model of in vivo ribosome biogenesis in slow-growing E. coli.

203 We provide a simplified model of ribosome biogenesis in slow-growing Escherichia coli.

204 Here, we show that arrest of ribosome biogenesis in the budding yeast Saccharomyces c

205 iSAT allows for manipulation and analysis of ribosome biogenesis in the context of an in vitro transc

206 exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and

207 d with promoter regions of genes involved in ribosome biogenesis, in addition to its roles at telomer

208 ar protein that regulates rRNA synthesis and ribosome biogenesis, interacts with CSA and CSB.

209 Eukaryotic ribosome biogenesis involves approximately 200 assembly

210 Early eukaryotic ribosome biogenesis involves large multi-protein complex

211 Ribosome biogenesis is a canonical hallmark of cell grow

212 Ribosome biogenesis is a complex and energy-demanding pr

213 ore the enormous complexity of 60S synthesis.Ribosome biogenesis is a dynamic process that involves t

214 Ribosome biogenesis is a fundamental process required fo

215 Ribosome biogenesis is a highly complex process in eukar

216 Ribosome biogenesis is a key process for maintaining pro

217 We find that ribosome biogenesis is a parallel process, that blocks o

218 As ribosome biogenesis is a well-known downstream phenomeno

219 EMT-associated ribosome biogenesis is also coincident with increased nu

220 ing p53 stability as a function of increased ribosome biogenesis is controversial.

221 Ribosome biogenesis is crucial for cellular metabolism a

222 In the yeast Saccharomyces cerevisiae, ribosome biogenesis is highly regulated at the transcrip

223 Eukaryotic ribosome biogenesis is initiated with the transcription

224 Ribosome biogenesis is orchestrated by the action of sev

225 The ancestral role of MYC as a regulator of ribosome biogenesis is reflected in reduced protein tran

226 Ribosome biogenesis is the primary determinant of transl

227 stasis, how its activity is coordinated with ribosome biogenesis is unknown.

228 sential in all cells, natural disruptions to ribosome biogenesis lead to heterogeneous phenotypes.

229 e other, it has been proposed that increased ribosome biogenesis leads the consumption of RPL5/RPL11

230 constitutes a mechanism by which cells adapt ribosome biogenesis level to the availability of growth

231 ) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR

232 regulation of the translation initiation and ribosome biogenesis machinery.

233 olus, an organelle whose primary function in ribosome biogenesis makes it key for cell growth and siz

234 hat somatic mutations in factors involved in ribosome biogenesis may also be drivers in sporadic canc

235 re-balance of the proteome via modulation of ribosome biogenesis may be a general adaptive response t

236 Deficiencies in ribosome biogenesis may result in varied faults in trans

237 During eukaryotic ribosome biogenesis, members of the conserved atypical s

238 found that proteins involved in translation, ribosome biogenesis, nuclear transport, and amino acid m

239 ginal discs drives a significant increase in ribosome biogenesis, nucleolar expansion and cell growth

240 Ribosome biogenesis occurs successively in the nucleolus

241 re, overexpression of individual REST target ribosome biogenesis or cell cycle genes is sufficient to

242 dimers also form after inhibition of either ribosome biogenesis or protein synthesis.

243 Dysregulation of ribosome biogenesis or translation can promote cancer, b

244 Several of these (ribosome biogenesis, oxidative phosphorylation) were ide

245 ha signaling up-regulates mTOR signaling and ribosome biogenesis pathways and perturbs the expression

246 ct of Pf1 in multiple regulatory arms of the ribosome biogenesis pathways.

247 uced activation of muscle protein synthesis, ribosome biogenesis, PGC-1alpha expression and hypertrop

248 Ribosome biogenesis plays key roles in cell growth by pr

249 ons that are introduced during the multistep ribosome biogenesis process are essential for protein sy

250 These findings implicate the EMT-associated ribosome biogenesis program with cellular plasticity, de

251 regulates many cellular processes, including ribosome biogenesis, proliferation, and genomic integrit

252 tions in health and disease, focusing on the ribosome biogenesis protein Utp5/WDR43.

253 mTORC1 mediates ribosome biogenesis, protein translation, and autophagy,

254 nucleolar localization, rDNA transcription, ribosome biogenesis, protein translation, and cell growt

255 n influx of acetyl-CoA, or downregulation of ribosome biogenesis proteins that belong to WD40 protein

256 ion of P. gracilior leaves were annotated as ribosome biogenesis proteins YTM and microtubule-assembl

257 id assays, MAS2 interacted with splicing and ribosome biogenesis proteins, and fluorescence in situ h

258 developmental defects caused by mutations in ribosome biogenesis proteins-can exhibit tissue-specific

259 ological blockade of TAK1 signaling hampered ribosome biogenesis (RBG) by reducing expression of RBG

260 of NPM1 in nucleolar chromatin dynamics and ribosome biogenesis remains unclear.

261 Thus, while ribosome biogenesis represents a potential site for the

262 and ribosome biogenesis, which suggests that ribosome biogenesis represents a promising therapeutic t

263 Eukaryotic ribosome biogenesis requires nuclear import and hierarch

264 Ribosome biogenesis requires stoichiometric amounts of r

265 Eukaryotic ribosome biogenesis requires the action of approximately

266 Eukaryotic ribosome biogenesis requires the nuclear import of appro

267 te that in human cells, as in budding yeast, ribosome biogenesis requires the presence of the modific

268 myces cerevisiae and show that challenges to ribosome biogenesis result in acute loss of proteostasis

269 Ribosome biogenesis (RiBi) is an extremely energy intens

270 Ribosome biogenesis (RiBi) is one of the most complex an

271 c, small cell phenotype and markedly reduced ribosome biogenesis (Ribi).

272 It has been shown that defect in ribosome biogenesis (ribosomal stress) induces apoptosis

273 s have significant functions associated with ribosome biogenesis, rRNA processing, ribosome binding,

274 Surprisingly, we find that restricting ribosome biogenesis stimulated human cytomegalovirus (HC

275 ress from chemotherapy or radiation therapy, ribosome biogenesis stress, and possibly inflammation ma

276 Rather, oxaliplatin kills cells by inducing ribosome biogenesis stress.

277 egulation of mitochondrial transcription and ribosome biogenesis that likely contribute to cell cycle

278 ependent, cNHEJ-independent functions during ribosome biogenesis that require the kinase activity of

279 d HDM2 also participate in the regulation of ribosome biogenesis, the involvement of CARF in this pro

280 ZNF658 thus links zinc homeostasis with ribosome biogenesis, the most active transcriptional, an

281 that the FA protein FANCI also functions in ribosome biogenesis, the process of making ribosomes tha

282 Yeast and human ribosome biogenesis thus have both conserved and distinc

283 n ITS1 of pre-rRNAs at early stages of human ribosome biogenesis; thus, it is likely that RRP1 integr

284 er, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poorly unders

285 in the pathways that link the cell cycle and ribosome biogenesis to membrane growth.

286 pathway, leading from rDNA transcription and ribosome biogenesis to mRNA synthesis, processing, and t

287 tion regulation, mRNA processing and export, ribosome biogenesis, translation initiation, and protein

288 ional phospho-protein with critical roles in ribosome biogenesis, tumor suppression, and nucleolar st

289 In eukaryotic ribosome biogenesis, U3 snoRNA base pairs with the pre-r

290 ies have uncovered distinct abnormalities in ribosome biogenesis underlying each of these 3 disorders

291 highlight key molecular processes, including ribosome biogenesis, underlying brain aging.

292 antagonism between PKA and Hog1 controlling ribosome biogenesis via mRNA stability in response to gl

293 Ribosome biogenesis was reduced in dKO and increased in

294 Ribosome biogenesis was upregulated in skin shortly afte

295 somal methyltransferase (rMtase) involved in ribosome biogenesis, was exploited as a model system to

296 nvolved in central and energy metabolism and ribosome biogenesis were dysregulated more in physiologi

297 related to immune response, cell cycle, and ribosome biogenesis were found.

298 tial cellular processes, such as splicing or ribosome biogenesis, where they remodel large RNA-protei

299 in synthesis, intracellular localization and ribosome biogenesis, which suggests that ribosome biogen

300 Ribosome biogenesis, which takes place mainly in the nuc