ライフサイエンスコーパス: ribosylate

1 ory of smoking was, in fact, mono- or di-ADP-ribosylated.

2 oli and promotes rDNA transcription when ADP-ribosylated.

3 e wild-type ART2a, ART2a(Y204R) was auto-ADP-ribosylated.

4 ins of 50 and 25 kDa were preferentially ADP-ribosylated.

5 ty returned as GRP78 became increasingly ADP-ribosylated.

6 n of signals through TCRs, which are not ADP-ribosylated.

7 ith Tankyrase 1 and is subsequently poly-ADP-ribosylated.

8 In response to DNA damage, ADP-ribosylated 53BP1 increased significantly, resulting in

9 is study, ExoS is shown to be capable of ADP-ribosylating 6 candidate arginine residues that are loca

10 The fact that ExoS could ADP-ribosylate a target protein at multiple sites, along wit

11 H. pylori strains release a factor that ADP-ribosylates a mammalian target protein.

12 Pertussis toxin ADP-ribosylates a specific Cys side chain in the alpha-subun

13 Although the ADP-ribosylating A subunit has been implicated in augmenting

14 (Clostridium difficile transferase) that ADP-ribosylates actin and induces microtubule-based cell pro

15 racellular virulence factor, spvB, which ADP-ribosylates actin, strongly inhibited VAP formation in H

16 rected mutagenesis demonstrates that the ADP-ribosylating activity of SpvB is essential for Salmonell

17 osely related to ExoT but has additional ADP-ribosylating activity, can substitute for ExoT as an ant

18 arp1 or Parp7, or upon inhibition of the ADP-ribosylating activity, ES cells exhibit a decrease in gr

19 no acids associated with NAD binding and ADP-ribosylating activity, similar to pertussis toxin (PTX)

20 combinant protein exhibits a strong auto-ADP-ribosylating activity.

21 diverse human serum proteins and possess NAD-ribosylating activity.

22 t the N-terminal region is essential for ADP-ribosylating activity.

23 core structure forms the active site of ADP-ribosylating (ADPRT) toxins, the limited-sequence homolo

24 cities of ART1-Pro257 and ART1-Leu257 to ADP-ribosylate agmatine or fibroblast growth factor-2 were s

25 Tiparp ADP-ribosylated AHR but not its dimerization partner, the AH

26 We found that PT efficiently ADP ribosylated AM G proteins both in vitro and after intran

27 CerADPr ADP-ribosylated an ~120 kDa protein in HeLa cell lysates and

28 a mitochondrial enzyme that uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH

29 ance was due to the inability of HA22 to ADP-ribosylate and inactivate EF2.

30 e resistant cell line, HA22 is unable to ADP ribosylate and inactivate elongation factor-2 (EF2), owi

31 inum toxin C3 exoenzyme has been used to ADP-ribosylate and inactivate rho.

32 th C3 exoenzyme to adenine diphosphate (ADP)-ribosylate and inactivate RhoA, and the function of inte

33 tryptophan mutant ART2b(R204W) was auto-ADP-ribosylated and exhibited enhanced NADase activity.

34 only ten amino acids, only ART2b is auto-ADP-ribosylated and only ART2a is glycosylated.

35 Our results support that ExoS ADP-ribosylates and affects the function of the cytosolic pr

36 Treatment with pertussis toxin, which ADP-ribosylates and inactivates G(i), blocked S1P-mediated i

37 Treatment with pertussis toxin, which ADP-ribosylates and inactivates G(i)-coupled receptors, bloc

38 C3 exoenzyme ADP-ribosylates and inactivates Rho with high specificity, w

39 The C3 exoenzyme, which ADP-ribosylates and inactivates Rho, fully inhibited both th

40 nsferase of Clostridium botulinum, which ADP-ribosylates and inactivates RhoA, to investigate the inv

41 Pertussis toxin, which ADP-ribosylates and inactivates susceptible G proteins, prom

42 lostridium botulinum, which specifically ADP-ribosylates and inactivates the small G protein Rho.

43 We found that PARP-1 ADP-ribosylates and inhibits negative elongation factor (NEL

44 scriptional activation, where SIRT6 mono-ADP-ribosylates and recruits chromatin remodeling proteins t

45 Clostridium botulinum C3, an enzyme that ADP-ribosylates and specifically inactivates RhoA, inhibited

46 maged cells during inflammation, ARTC2.2 ADP-ribosylates and thereby gates the P2X7 ion channel.

47 lls) efficiently adenosine diphosphate (ADP)-ribosylates and thus inactivates the guanosine triphosph

48 oxin that kills CD22-expressing cells by ADP-ribosylating and inactivating elongation factor-2 (EF2).

49 ribution of the unique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respirat

50 y reported that an M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acqu

51 Recently, we identified an ADP-ribosylating and vacuolating toxin of M. pneumoniae, des

52 VahC was shown to ADP-ribosylate Arg-177 of actin, and the kinetic parameters

53 In this study, we show that Certhrax ADP-ribosylates Arg-433 of vinculin, a protein that coordina

54 hat the hydrophobic amino acid mimics an ADP-ribosylated arginine.

55 The P gamma domain containing ADP-ribosylated arginines was shown to be involved in its in

56 Based on the change in mobility of auto-ADP-ribosylated ART5 by SDS-polyacrylamide gel electrophores

57 Auto-ADP-ribosylated ART5 isolated after incubation with NAD was

58 small GTP-binding protein family Rho by ADP-ribosylating asparagine 41, which depolymerizes the acti

59 somerization include PARPs, enzymes known to ribosylate aspartate residues in the process of poly(ADP

60 ine, the +2 position, are preferentially ADP-ribosylated at the +2 residue.

61 It also ADP ribosylates at least 10 additional Arabidopsis NOI domai

62 s a crucial regulator for degradation of ADP-ribosylated Axin and, thus, of Wnt/beta-catenin signalin

63 We demonstrate that the pool of ADP-ribosylated Axin, which is degraded under basal conditio

64 the toxicity and cellular effects of the ADP-ribosylating bacterial toxin and reveal that mutants def

65 ture distinct from other well-recognized ADP-ribosylating bacterial toxins.

66 evated levels of adenosine diphosphate (ADP)-ribosylated BiP in the inactive pancreas of fasted mice

67 Interestingly, MPN372 ADP ribosylates both identical and distinct mammalian protei

68 sults from this study indicate that ExoS ADP-ribosylates both normal and mutant Ras proteins in vivo

69 T-cadherin could be ADP-ribosylated by a transferase that was also present in th

70 orylation but that arginine 33, which is ADP-ribosylated by an endogenous ADP-ribosyltransferase, is

71 However, rather than being ADP-ribosylated by an H. pylori toxin, the intrinsic poly(AD

72 Thus, arginines 14 and 24, which can be ADP ribosylated by ART1, are critical to the regulation of t

73 ar mass 80-110 kDa were more extensively ADP-ribosylated by ART1-Pro257 than ART1-Leu257, in accordan

74 P-ribosylation comigrated with a protein ADP-ribosylated by cholera toxin and was recognized and immu

75 40Q dinitrogenase reductase could not be ADP-ribosylated by DRAT, although it still formed a cross-li

76 unit of cGMP phosphodiesterase (PDE), is ADP-ribosylated by endogenous ADP-ribosyltransferase when P

77 rginine 33 and arginine 36 are similarly ADP-ribosylated by endogenous ADP-ribosyltransferase, but on

78 of the Ras GTPase subfamily that can be ADP ribosylated by ExoS and indicates that ExoS can inhibit

79 The 27-kDa protein ADP-ribosylated by ExoS was determined to be apolipoprotein

80 cterized the mammalian proteins that are ADP-ribosylated by ExoT, using two-dimensional SDS-PAGE and

81 Several mammalian cell proteins are ADP-ribosylated by MYPE9110, and the full-length recombinant

82 ranscription factor NFAT binds to and is ADP-ribosylated by PARP-1 in an activation-dependent manner.

83 , and the catalytic subunit of DNA-PK is ADP-ribosylated by PARP.

84 29 human epithelial cells, where Rac1 is ADP-ribosylated by TTS-ExoS, Rac1 was activated and relocali

85 The Rho ADP-ribosylating C3 exoenzyme (C3bot) is a bacterial protein

86 crophages, express ADPRT and are able to ADP-ribosylate cell surface proteins.

87 enine dinucleotide phosphate, and/or may ADP-ribosylate cell-surface receptors, resulting in activati

88 hway, impairing tagraxofusp's ability to ADP-ribosylate cellular targets.

89 to provide the first genome-wide view of ADP-ribosylated chromatin.

90 of Ibp was necessary for docking of the ADP-ribosylating component, iota a (Ia).

91 tion, and ExoT was subsequently shown to ADP-ribosylate Crk (CT10 regulator of kinase)-I and Crk-II.

92 ExoS did not ADP-ribosylate Crk-I.

93 -down and far Western assays showed that ADP-ribosylated Crk-I or Crk-I(R20K) failed to bind p130cas

94 Activated PARP-1 ADP-ribosylates DDX21, an RNA helicase that localizes to nuc

95 ADP-ribosylated defensin-1 had decreased antimicrobial and c

96 We identified ADP-ribosylated defensin-1 in bronchoalveolar lavage fluid f

97 Further, ADP-ribosylated defensin-1 inhibited cytotoxic and antimicro

98 s of aminoglycosides and their corresponding ribosylated derivatives synthesized by attaching a beta-

99 noglycoside scaffolds neamine and nebramine, ribosylated derivatives were both more potent antimicrob

100 ctase, in that both oxygen-denatured and ADP-ribosylated dinitrogenase reductase fail to form a cross

101 ngation factor 2 (eEF2) is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exoto

102 It is shown that ART-1 ADP-ribosylates distinct cell surface molecules, causing inh

103 al permeability were associated with the ADP-ribosylating domain of ExoS, as bacteria expressing plas

104 egulator of actin polymerization; and an ADP-ribosylating domain that affects the ERM proteins, which

105 Ras was found to be ADP-ribosylated during coculture with 388 but not with 388De

106 Purified PARP1 can ribosylate EBNA1 at multiple sites throughout its amino

107 s of eukaryotic ribosomes complexed with ADP-ribosylated eEF2 (ADPR-eEF2), before and after GTP hydro

108 ion and found that DTM has no ability to ADP-ribosylate EF-2 at 18 or 30 degrees C.

109 than by direct recognition of either ToxA or ribosylated EF2.

110 slational inhibitor Exotoxin A (ToxA), which ribosylates elongation factor 2 (EF2), upregulates a sig

111 hen translocates to the cytosol where it ADP-ribosylates elongation factor 2 and inhibits protein syn

112 ent that translocates to the cytosol and ADP-ribosylates elongation factor 2.

113 fects of ExoS on RalA, ExoS was found to ADP-ribosylate endogenous RalA and recombinant RalADeltaCAAX

114 chimeric toxin DC3B (10(-6) M, 48 h; ; ) ADP-ribosylated endogenous RhoA, including cytosolic RhoA co

115 The ADP-ribosylating enterotoxins, cholera toxin (CT) and the Es

116 The structure of a ribosylated enzyme intermediate reveals movements that o

117 eraldehyde-3-phosphate dehydrogenase and ADP-ribosylating enzyme activities that may relate to early

118 Production of the ADP-ribosylating enzyme exoenzyme S (ExoS) by Pseudomonas ae

119 r beta signaling mediated by the nuclear ADP-ribosylating enzyme poly-(ADP-ribose) polymerase 1 (PARP

120 Exoenzyme S (ExoS), an ADP-ribosylating enzyme produced by the opportunistic pathog

121 ine where they secrete cholera toxin, an ADP-ribosylating enzyme that is responsible for the volumino

122 we present evidence that spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and d

123 g EGFR inhibition, particularly the poly-ADP-ribosylating enzymes tankyrase 1 and 2 that positively r

124 9 stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2.

125 ADP-ribosylating enzymes, such as cholera and diphtheria tox

126 DP-ribosyl transferase (C3) toxin, a Rho-ADP-ribosylating exoenzyme, potently inhibited migration.

127 Auto-ADP-ribosylated ExoS analyzed from eukaryotic cells displaye

128 50-kDa protein was determined to be auto-ADP-ribosylated ExoS, whereas the 25-kDa protein appeared to

129 I secreted ExoS but more basic than auto-ADP-ribosylated ExoS.

130 J774A.1 macrophages, where Rac1 was not ADP-ribosylated, ExoS caused a decrease in the levels of act

131 CT, a member of the bacterial ADP-ribosylating exotoxin (bARE) family, is most potent as a

132 unization is not restricted to CT or the ADP-ribosylating exotoxins as adjuvants.

133 Consistent with the latter finding, non-ADP-ribosylating exotoxins, including an oligonucleotide DNA

134 t of such toxins is the NAD(+)-dependent ADP-ribosylating exotoxins, which include pertussis, cholera

135 icles, was identified with antibodies to ADP-ribosylating factor and to epsilon-COP.

136 IT1 and GIT2) are scaffold proteins with ADP-ribosylating factor GTPase activity.

137 n intermediate in which the phosphate is ADP-ribosylated followed by a presumed transesterification t

138 ied by ARTs, the sites on these proteins ADP-ribosylated following DNA damage and the ARTs that catal

139 ue 141 (E141) of variant histone H2AX is ADP-ribosylated following oxidative DNA damage.

140 de resulted in the selective loss of the ADP-ribosylated form of GRP78 and increased sensitivity of e

141 mune cells independent of its ability to ADP-ribosylate G proteins.

142 se treatment with pertussis toxin, which ADP-ribosylates G proteins of the G(i/o) family, caused a si

143 ivity nor the related cholera toxin that ADP-ribosylates G(s) (but not G(i)) proteins blocked EAU ind

144 at PT can affect neutrophils directly by ADP ribosylating G(i) proteins associated with surface chemo

145 The cytosolic CTA1 then ADP ribosylates Gsalpha, resulting in adenylate cyclase acti

146 (SIR2) protein family employs NAD(+) to ADP-ribosylate histones, deacetylate histones, or both.

147 we find no evidence that these proteins ADP-ribosylate histones.

148 d found that the FACT complex recognized ADP-ribosylated histones and mediated the removal of histone

149 PARP-1 binds to nucleosomes and poly(ADP-ribosylates) histones and several chromatin-associated f

150 d nonenzymatically to ornithine and that ADP-ribosylated HNP-1 and ADP-ribosyl-HNP-(ornithine) were i

151 n the surface of airway epithelial cells ADP-ribosylated HNP-1 specifically on arginines 14 and 24, w

152 ADP-ribosylated HNP-1 was identified in bronchoalveolar lava

153 Di- and mono-ADP-ribosylated HNP-1 were isolated from bronchoalveolar lav

154 yl-HNP-ornithine as well as mono- and di-ADP-ribosylated HNP-1, consistent with in vivo conversion of

155 (both GTP- and GDP-bound forms) was not ADP-ribosylated; however, agmatine, which cannot interact wi

156 ubtyping showed that ExoS preferentially ADP-ribosylated human IgG3 and that ADP-ribosylation occurre

157 ntified the previously unknown structures of ribosylated imidazoleacetic acids in rat, bovine, and hu

158 combinant Gialpha1-subunits were rapidly ADP-ribosylated in the absence of betagamma-subunits, with a

159 , which cannot interact with Talpha, was ADP-ribosylated in the presence of Talpha, suggesting that a

160 Analysis of ADP-ribosylated in vitro transcribed/translated Ras mutants

161 nd Smad5, interact with PARP1 and can be ADP-ribosylated in vitro, whereas PARG causes deribosylation

162 sin homologs ezrin and radixin were also ADP-ribosylated, indicating the ERMs collectively represent

163 hway in the cytosol and then proceeds to ADP ribosylate its target G(s)alpha, triggering the downstre

164 (ADP-ribose) polymerase 1 (PARP1), which ADP ribosylates KDM4D after damage.

165 Tankyrases interact with and ribosylate LKB1, promoting its K63-linked ubiquitination

166 irulence factor of Bordetella pertussis, ADP ribosylates mammalian G(i) proteins and plays an importa

167 damage response, many noncanonical mono(ADP-ribosylating) (MARylating) PARPs are associated with cel

168 rements were made of their capacities to ADP-ribosylate membrane-associated proteins on the surface o

169 ivered exoenzyme S (ExoS) preferentially ADP-ribosylated membrane-associated His(6)HRas, relative to

170 negligible, and so was the formation of the ribosylated metabolites by human purine nucleoside phosp

171 vitro led to an early increase of poly(ADP) ribosylated modified protein levels.

172 Type III delivered ExoS ADP-ribosylated moesin and ezrin (and/or radixin) in culture

173 The ADP-ribosylated moiety of ubiquitin is a substrate for the n

174 ADP-ribosylated molecules were identified as LFA-1, CD8, CD2

175 ysis also revealed that levels of a poly(ADP-ribosylated) Mr 100,000 protein, tentatively identified

176 seudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylates multiple eukaryotic targets to promote cytop

177 ndicated that ribose selectively formed mono-ribosylated N(6) adenine, but in the presence of (Ade)2C

178 plexes and their hydrolysis products of mono-ribosylated N(6) and N(9) adenine adducts and di-ribosyl

179 sylated N(6) and N(9) adenine adducts and di-ribosylated N(6,9) adenine.

180 adione via the oxidation of N-alkylated or N-ribosylated nicotinamides.

181 niae, enable transformants to reversibly ADP-ribosylate nitrogenase Fe protein in response to the pre

182 ith earlier observations that ExoS could ADP-ribosylate numerous target proteins, were properties tha

183 ties were tested for their ability to be ADP-ribosylated or to form a complex with dinitrogenase redu

184 ons, these observations suggest that the ADP-ribosylated P gamma cannot interact with GTP/T alpha.

185 (s) to release the radioactivity of [32P]ADP-ribosylated P gamma in concentration- and time-dependent

186 P)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimula

187 Although the well-known poly(ADP-ribosylating) (PARylating) PARPs primarily function in t

188 osylation acceptor sites but also boosts ADP-ribosylated peptide identifications.

189 lation reaction intermediate to yield an ADP-ribosylated peptide.

190 d enrichment of sub-femtomole amounts of ADP-ribosylated peptides from cell lysates.

191 generate large amounts of site-specific, ADP-ribosylated peptides would provide a useful tool for dec

192 a highly diverged PARP homologue TRPT1, ADP-ribosylate phosphorylated ends of RNA.

193 to most biglutamate ADPRTs, was able to ADP-ribosylate poly-l-arginine.

194 We have recently reported that certain ribosylated polyhalogenated benzimidazoles are potent an

195 These potentially ADP-ribosylated precursors were then selected and analyzed v

196 vity of the combined vector requires the ADP-ribosylating property of CTA1.

197 hemical analysis showed that the 150-kDa ADP-ribosylated protein was immunoglobulin of the immunoglob

198 by generating protein-free PAR from poly-ADP ribosylated protein, makes PAR translocation possible.

199 and intrinsic pathways as well as poly(ADP)-ribosylating protein (PARP) activity in myocardial and p

200 Tankyrase (TNKS) is a poly-ADP-ribosylating protein (PARP) whose activity suppresses ce

201 ing 1 to 10 weeks after injection of the ADP-ribosylating protein diphtheria toxin (DTX) into one-hal

202 ublicly available database encapsulating ADP-ribosylated proteins identified from the past 40 years,

203 have led to the discovery of hundreds of ADP-ribosylated proteins in both cultured cells and mouse ti

204 We found increased amounts of poly(ADP) ribosylated proteins in diabetic kidneys of Lepr(db/db)

205 statistically significant enrichment of ADP-ribosylated proteins in non-membranous RNA granules.

206 expression, resulting in increased poly-ADP-ribosylated proteins in the nucleus.

207 tilized a variety of methods to identify ADP-ribosylated proteins, recent proteomics studies bring th

208 tion, respectively) from mono- and poly(ADP)-ribosylated proteins, respectively.

209 To facilitate global enrichment of ADP-ribosylated proteins, we developed a dual metabolic labe

210 e have created ADPriboDB - a database of ADP-ribosylated proteins.

211 and has the potential to illuminate the ADP-ribosylated proteome and the molecular mechanisms used b

212 e human aspartic acid- and glutamic acid-ADP-ribosylated proteome.

213 We showed that tankyrases interact with and ribosylate PTEN, which promotes the recognition of PTEN

214 ible for this inhibition is one in which ADP-ribosylated Rap binds inefficiently to C3G, relative to

215 In this study, we report that ExoS ADP ribosylates Rap1b at Arg41 and that ADP ribosylation of

216 of Ras, which suggested that ExoS could ADP-ribosylate Ras at more than one arginine residue.

217 onal electrophoresis found the former to ADP-ribosylate Ras at two sites, while the latter modified R

218 cells but limited the ability of ExoS to ADP-ribosylate Ras GTPases.

219 to HeLa cells, or the ability of ExoS to ADP-ribosylate Ras GTPases.

220 tants were examined for their ability to ADP-ribosylate Ras in vitro or in vivo.

221 r eukaryotic cells and has been shown to ADP-ribosylate Ras in vivo and uncouple a Ras-mediated signa

222 keleton (a Rho GAP activity), it did not ADP-ribosylate Ras.

223 Initial experiments showed that ADP-ribosylated Ras (ADP-r-Ras) and unmodified Ras (Ras) int

224 Previous studies showed that ExoS ADP ribosylated Ras at Arg41 which interfered with the abili

225 seudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylated Ras at multiple sites.

226 try of V8 protease generated peptides of ADP-ribosylated Ras identified the sites of ADP-ribosylation

227 e ADP-ribosylation of Ras by ExoS, where ADP-ribosylated Ras loses the ability to bind guanine nucleo

228 gel electrophoresis analysis showed that ADP-ribosylated Ras possessed a slower mobility than non-ADP

229 Under saturating conditions, ExoS ADP-ribosylated Ras to a stoichiometry of 2 mol of ADP-ribos

230 seudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylated Ras to a stoichiometry of approximately 2 mo

231 Ras possessed a slower mobility than non-ADP-ribosylated Ras.

232 ExoS ADP-ribosylates Ras and prevents it from interacting with an

233 seudomonas aeruginosa exoenzyme S double ADP-ribosylates Ras at Arg(41) and Arg(128).

234 ExoT ADP-ribosylated recombinant Crk-I at a rate similar to the A

235 ExoS ADP-ribosylated recombinant moesin at a linear velocity that

236 etreatment of myocytes with C3 exoenzyme ADP-ribosylated Rho and inhibited the characteristic alpha1-

237 ith exoenzyme C3 for 48 hours completely ADP-ribosylated Rho in vivo.

238 e for C3 transferase, which specifically ADP-ribosylates Rho GTPases.

239 C3 transferase ribosylates Rho in its effector domain thereby abolishin

240 e from Clostridium botulinum selectively ADP-ribosylates Rho in its effector-binding domain and there

241 Clostridium botulinum which selectively ADP-ribosylates Rho within its effector domain and thereby a

242 inant negative form of RhoA, or in vitro ADP-ribosylated RhoA impaired the ability of cells to migrat

243 ns to be defined, ExoS has been shown to ADP-ribosylate several eukaryotic proteins in vitro, includi

244 One of these effectors, ExoS, ADP-ribosylates several host cell proteins, including Ras an

245 LTA also ADP-ribosylates simple guanidino compounds (e.g., arginine)

246 acellular membranes and targeted ExoS to ADP-ribosylate small molecular weight membrane proteins as o

247 unknown, but may involve its ability to ADP-ribosylate-specific G-proteins.

248 All the Salmonella SeoC/SboC homologues ADP-ribosylate Src E310 in vitro Ectopic expression of SeoC/

249 Brefeldin-A ADP-ribosylated substrate (BARS) and dynamin function in mem

250 We now show that Brefeldin-A ADP-Ribosylated Substrate (BARS) plays a critical role in th

251 generated by ALDH7A1 targets Brefeldin-A ADP-Ribosylated Substrate (BARS) to inhibit COPI vesicle fis

252 nding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lip

253 e C-terminal binding protein/brefeldin A-ADP ribosylated substrate protein ANGUSTIFOLIA1, and our res

254 carboxy-terminal binding protein/brefeldin A-ribosylated substrate), a transcription co-repressor tha

255 rom the macrodomain family can hydrolyze ADP-ribosylated substrates and therefore reverse this post-t

256 an reverse ADP-ribosylation by acting on ADP-ribosylated substrates through the hydrolytic activity o

257 deletion peptide of ExoS (DeltaN222) to ADP-ribosylate target proteins in the absence of FAS.

258 ostasis and Wnt signaling, by covalently ADP-ribosylating target proteins and consequently regulating

259 Recombinant PARP was able to ADP-ribosylate TEF-1 in vitro.

260 ton dynamics, and the ability of ExoS to ADP-ribosylate the ERM proteins links ADP-ribosylation with

261 ExoS ADP-ribosylated the double mutant, RasR41K,R128K, to a stoic

262 Dtx3L/Parp9 ADP-ribosylates the carboxyl group of Ub Gly76.

263 Within the cell, ExoS ADP-ribosylates the cell signaling protein Ras and causes in

264 HopU1 ADP-ribosylates the conserved arginine 49 of GRP7, and this

265 Pertussis toxin, which ADP-ribosylates the Gi proteins known to couple to the C5a r

266 to the 5'-UTR of L1 loci, where it mono-ADP ribosylates the nuclear corepressor protein, KAP1, and f

267 ses the ER membrane, enters the cytosol, ADP-ribosylates the stimulatory alpha subunit of the heterot

268 After the PB2 and PA proteins are poly(ADP-ribosylated), they are associated with the region of ZAP

269 propose renaming the toxin ParT for Prs ADP-ribosylating toxin and ParS for the cognate antitoxin.

270 ortality, additionally produce the actin-ADP-ribosylating toxin C. difficile transferase (CDT).

271 rbidity and mortality, produce the actin-ADP ribosylating toxin Clostridium difficile transferase (CD

272 that SpvB functions as an intracellular ADP-ribosylating toxin critical for the pathogenesis of Salm

273 ifficile transferase) is a binary, actin ADP-ribosylating toxin frequently associated with hypervirul

274 Domain II resembles the ADP-ribosylating toxin from Bacillus cereus, but the active

275 rd C. difficile toxin, is a binary actin-ADP-ribosylating toxin that causes depolymerization of actin

276 This proposed bipartite ADP-ribosylating toxin turn-turn (ARTT) motif places the VIP

277 AB genes have the potential to encode an ADP-ribosylating toxin with similarity to pertussis toxin.

278 onsistent with the action of a bacterial ADP-ribosylating toxin.

279 he ytxAB locus, which encodes a putative ADP-ribosylating toxin.

280 is organism, termed SpyA, for S. pyogenesADP-ribosylating toxin.

281 ADP-ribosylating toxins comprise a large family, including t

282 AD-binding beta-sandwich fold with other ADP-ribosylating toxins despite little sequence conservation

283 neral recognition motif region for other ADP-ribosylating toxins that have a similar beta-structure f

284 in this study may also apply to several ADP-ribosylating toxins that move from the endosomes to the

285 Unlike the ADP-ribosylating toxins that possess the active site loop ne

286 oxin belonging to a larger family of A/B ADP-ribosylating toxins.

287 resistant to several different bacterial ADP-ribosylating toxins.

288 active site loop observed in many other ADP-ribosylating toxins.

289 Human tankyrase 1 is reported to ADP-ribosylate TRF1 and to down-regulate the telomeric repea

290 Tankyrase 1 ADP-ribosylates TRF1 in vitro, and its overexpression induce

291 Tankyrase 1 ADP-ribosylates TRF1, inhibiting its binding to telomeric DN

292 ExoT ADP-ribosylated two cytosolic proteins in cell lysates upon

293 e have observed that ExoS preferentially ADP-ribosylated two extracellular serum proteins with molecu

294 ate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.

295 activates ubiquitin by the formation of ADP-ribosylated ubiquitin.

296 ion that approximately 50% of P gamma is ADP-ribosylated under these conditions, these observations s

297 ecent studies observed that ExoS is auto-ADP-ribosylated upon delivery into eukaryotic cells.

298 a 2000-fold reduction in the capacity to ADP-ribosylate, were transiently expressed in eukaryotic cel

299 /BARS is an NAD-binding protein that becomes ribosylated when cells are exposed to BFA.

300 rboxy-terminal catalytic fragment became ADP-ribosylated with [32P]-3'-dNAD+ as a substrate.