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1 moieties at the 2' position suggest a clear role for 2'-OH in catalysis by providing an indispensabl
2 ion in cells expressing mSTING, suggesting a role for 2C in recruiting STING to RV-A replication orga
4 Together our findings demonstrate opposing roles for 5-HT2C receptors in the effects of SSRIs on mo
5 Recent studies have revealed an extensive role for a completely distinct layer of networked activi
7 ogether, this study unveils an unprecedented role for a transcription sigma factor in spatially coord
14 d in both patients, highlighting a potential role for activation of MAPK signaling in iMCD-TAFRO path
19 optotic degeneration of photoreceptors and a role for apoptosis in secondary degeneration of cones, h
25 phila melanogaster model to reveal a pivotal role for basement membrane composition in the formation
28 t the idea that ascribes to PFo an important role for behavioral flexibility.SIGNIFICANCE STATEMENT W
30 derived endocardial cells identified a novel role for BMP10 in the specification of this lineage from
31 ether, the data herein support a synergistic role for both Abeta and tau in driving neuronal dysfunct
32 to late-pachytene spermatocytes suggesting a role for both in meiotic and post-meiotic germ cell RNA
34 In addition, recent work has established a role for both the Kappa Opioid Receptor (KOR) and its en
40 ) diffusion theory to propose a novel active role for capillaries that explained the prodigious incre
41 arotenoid accumulation, but also suggested a role for carotenoid degradation in L. japonica's dynamic
43 re and telomere defects suggests a prominent role for CBX2 in heterochromatin homeostasis and the reg
44 tion was established, promoting a functional role for CCR3-dependent eosinophil influx in immune cont
52 ions, spindle-shaped cells, an insignificant role for classic oncogenes in tumor development, the rel
55 er perceptual uncertainty suggests a unified role for confidence in learning under different types of
59 ances in research have demonstrated critical roles for cytoplasmic sensors and inflammasomes during L
60 alterations in SCZ, these studies support a role for disruption of PI3K/GSK3 signaling as a risk fac
62 ive and incentive cues, support an important role for dopamine neurons in the attribution of incentiv
64 clinical manifestations of DS and suggest a role for DTBM in the investigation of other brain disord
65 e (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping
67 by chemosensory blends, suggesting different roles for EGCs than analogous interneurons in the MOB.SI
70 e yields, suggesting an important regulatory role for EMP3 in erythropoiesis and control of cell prod
74 mmunity and clinical diagnosis may suggest a role for epigenetics in T1D pathogenesis; however, funct
75 n together, these results support a critical role for ER Ca(2+) depletion-activated Ca(2+) current in
76 .Conclusions: These results support a causal role for ER stress and resulting epithelial dysfunction
77 udy their function as transcripts, revealing roles for eRNAs in enhancer-promoter looping, recruiting
78 from M. tuberculosis Our findings support a role for EspE and EspF in virulence that is independent
81 mputationally derived observations support a role for feedforward parietal-prefrontal information pro
82 light contemporary findings that implicate a role for flavivirus antibodies in mediating protection,
91 Both basic and clinical evidence reveal dual roles for GJs, in tumor suppression, generally referred
94 ects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediate
96 n Drosophila melanogaster, we identify a key role for gut-innervating neurons with sex- and reproduct
106 r normal behavior in this task, but a causal role for human OFC in outcome-guided behavior has not be
111 ctors of the NF-kappaB family play a crucial role for immune responses by activating the expression o
112 epidemiological evidence supports a critical role for inflammation and adaptive immunity in the onset
113 a German cohort, supporting the concept of a role for inflammation in PRKN/PINK1-linked Parkinson's d
115 in adaptive immunity, indicating a critical role for innate immunity in endometrial control of C. tr
117 Clostridioides difficile Here we describe a role for intestinal bile acids in directly binding and n
119 been recently shown that Wnt plays a priming role for ISC self-renewal by inducing RSPO receptor LGR5
120 recordings revealed a critical and selective role for K(v)1 channel inactivation in synaptic facilita
128 tion, additively with 1-NM-PP1, indicating a role for matrix metalloproteases in TrkA activation.
129 c syndrome, the discovery of novel signaling roles for metabolites, and the increasing links between
130 er, these findings demonstrate an unexpected role for metabotropic NMDARs and postsynaptic Panx1 in s
132 combination, these findings establish a key role for microbiome-dependent circadian GLP-1 secretion
133 rains of naive littermates, suggesting a new role for microglia as homeostatic regulators of perineur
134 r work reveals a neuronal activity-regulated role for microglia in modifying developmental myelin tar
135 erous structural and genome-wide analyses of roles for minimal G4s in transcriptional regulation have
136 lution live-cell microscopy, we identified a role for mitochondria-lysosome contacts in regulating mi
138 ll priming, there is emerging evidence for a role for monocyte-derived APC (MoAPC) in tissue-resident
142 Collectively, our study reveals a novel role for mTORC2-Akt(S473)-FoxO1-T-bet axis in suppressin
144 kine activation, we can delineate biological roles for myeloid cells in different cytokine environmen
145 These findings suggest a previously unknown role for myocardial trabeculae in the function of the ad
148 relevant for beta cell signaling and plays a role for negative effects of statins on glycemic control
151 in cancer, and found an unexpected essential role for NMT1 at promoting lysosomal metabolic functions
152 OMT gene expression supported physiological roles for NnOMT1 and NnOMT5 in BIA metabolism, occurring
160 our findings elucidate a novel and specific role for P2X5 as a critical mediator of protective immun
161 ighs the evidence that supports a pathogenic role for PAD enzymes in RA as both promoters and targets
167 phenotypes; and they support a contributory role for PCM1 in some individuals diagnosed with schizop
170 th mounting evidence supporting an important role for peripheral dysfunction, particularly within ske
173 r, these data provide additional support for roles for PME-1 and LCMT-1 in regulating sensitivity to
176 ctively, these findings establish a critical role for Prdm12 in the anorexigenic neuron identity and
177 these results causally establish dissociable roles for prefrontal theta oscillations and parietal alp
178 sembly, and biological function, and provide roles for previously identified UAF domains that include
179 ves post-replicative gap repair and define a role for PrimPol in HR-mediated DNA damage tolerance.
181 SCRT-III-like filaments, suggesting a direct role for pUL51 in promoting membrane scission during vir
182 ns: Here, we demonstrate a unique protective role for pulmonary endothelial HIF-2alpha and how decrea
184 Recent evidence suggests a co-operative role for RAC1 activity in BRAF(V600E)-driven melanoma pr
187 our work supports a previously unappreciated role for retrograde mitochondrial transport in the maint
189 cular at glutamatergic synapses, a potential role for Rh50 proteins at synapses has not yet been inve
190 Taken together, our data indicate functional roles for RhoA and Rho-kinase in mediating depression-li
191 , here we show a kinase activity-independent role for RIPK1 in these processes using a model of TLR p
193 ly affected by RPLP1/2 knockdown, implying a role for RPLP1/2 in multi-pass transmembrane protein bio
194 ese data reveal a novel unexplored oncogenic role for RUNX genes in kidney cancer and indicate that t
196 ers to polymers, we demonstrate a surprising role for shuttling of F-actin across cells for lamellipo
197 n together, these results suggest a critical role for skeletal muscle lamin A/C to prevent cellular s
200 citatory cells, indicating a dominant causal role for SOM(+) cells in the integration of information
201 rtebrates singled out an expected functional role for some genes, while others displayed an unforesee
203 These data provide the first evidence for a role for spectraplakins in single-cell lumen formation a
204 ere, we discovered an unanticipated and sole role for spermine in facilitating mucilage production by
206 s tumor-promoting function by highlighting a role for ST6Gal-I in EMT, which may be mediated, at leas
208 d B16 tumor cells, suggesting that the major role for STING activation was to produce type I IFN.
209 mental questions about the recently proposed role for STK19 in melanoma progression via a function as
212 ruptions in chromatin structure and reveal a role for Suv39h2 in depositing sufficient H3K9me3 to pro
214 lating evidence has established an important role for symbiotic microorganisms in vector-virus intera
216 Previous studies have suggested an important role for T-cell-mediated immunopathology in LF pathogene
219 ow temperatures, and we highlight a specific role for TBCB/Alf1 in microtubule maintenance at low tem
222 eficient (Tbet KO) mice, we showed a partial role for Th1 subset CD4(+) T cells in vaccine protection
223 ontent of response feedback plays a critical role for the acquisition and long-term retention of VPL
224 lymphocytes isolated from patients support a role for the adaptive immune system in the pathogenesis
226 s challenge dual-stream accounts that deny a role for the arcuate fasciculus in semantic processing,
228 dynamics, and here, we report an unexpected role for the atypical actin motor Myo6 in creating prima
235 EEC deficiency to identify an unappreciated role for the EEC hormone peptide YY in regulating ion-co
236 In this study, we uncover a conditional role for the endodermal and pulmonary specifying TF GATA
237 in vivo experiments in zebrafish revealed a role for the ETS factor FEV in endothelial identity down
239 ar RNA metabolism and establish a biological role for the first 5' to 3' RNA exonuclease identified i
241 but recent evidence indicates an additional role for the genetic diversity among MTBC clinical strai
242 tive effects can be reinforcing, revealing a role for the hepatic vagus nerve in transforming sugar s
243 ith patient prognosis, implying an important role for the HIF/NICI/SLC2A3 axis in this malignancy.
245 oaches and live-cell imaging to reveal a key role for the histone chaperone complex FACT (SPT16 and S
246 sms leading to this failure and report a key role for the HIV-1 protein NEF in preventing B-cell matu
249 nesis in nematodes and provide evidence of a role for the Integrator complex as a terminator of promo
250 ust SAC signal, and it reveals a scaffolding role for the key mitotic kinase, Cyclin B1:CDK1, which u
253 domonas Lap system model, our data support a role for the predicted c-di-GMP-binding protein LapD in
256 alpha5beta1 integrin and supports a critical role for the RAP1/RAC1 signaling axis in HNSCC cell migr
258 of FA-independent ICL repair and establish a role for the RecQ4 helicases in the repair of these detr
259 Together, these data demonstrate a critical role for the Reissner fiber for the maintenance of a str
260 data indicate a previously underappreciated role for the relatively unexplored neuropeptide Pth2 in
261 ting burst occurrence, and a multifunctional role for the rosette structure in activity-prolongation
264 s toward hypoxia have identified a prominent role for the transcription factor hypoxia-inducible fact
267 ditional genetic studies indicated important roles for the exocyst regulators Rab8 and Rab11 in bacte
269 ndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the
271 r are discussed in line with the contrasting roles for these metabolites within the CAM mesophyll and
274 multiple mechanisms, further establishing a role for this coronary artery disease-associated gene in
275 and thus, to our knowledge, identify a novel role for this cytokine as a central regulator of immunit
278 tes the ERK and JNK cascades and highlight a role for this kinase in maintaining survival of KRAS-mut
279 taxanes plus an anthracycline, suggesting a role for this kinase in modulating taxane sensitivity.
280 egulates accumulation of R-loops, implying a role for this modification in safeguarding genomic stabi
281 C9 and TOGARAM1 patient cell lines suggest a role for this new JBTS-associated protein module in cili
283 biofilm formation, thus providing a defined role for this USP in mycobacterial physiology and stress
285 ssing TLR3 in infected B6 mice, suggesting a role for TLR sensing in the innate immune response.
290 ut fruit development, as well as revealing a role for transitory starch accumulation in ensuring opti
291 These findings indicate a novel mechanistic role for TSLP and CD11c-expressing IMs in the developmen
295 pproaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SC