ライフサイエンスコーパス: rolling velocity

1 ce in rolling velocity, scales linearly with rolling velocity.

2 from 21 +/- 8 to 30 +/- 2%) and no change in rolling velocity.

3 mall fraction of rolling cells and increased rolling velocity.

4 -, P-, and E-selectin and slightly increased rolling velocity.

5 ary to see the shear threshold effect in the rolling velocity.

6 oll much more stably, with small variance in rolling velocity.

7 ctin-coated substrate with large variance in rolling velocity.

8 ence with associated decreases in neutrophil rolling velocity.

9 ptor-ligand pair does not uniquely determine rolling velocity.

10 ges in neutrophil aggregation, adhesion, and rolling velocity.

11 es the bond lifetime, and decreases the cell rolling velocity.

12 ear stresses, and significantly slowed their rolling velocities.

13 did not further reduce P-selectin-dependent rolling velocities.

14 ncreasing pause times and decreasing average rolling velocities.

15 resistant and exhibited less fluctuation in rolling velocities.

16 significantly higher (approximately doubled) rolling velocities.

17 dramatically reduced with markedly increased rolling velocities (81 +/- 4 microm/s vs 44 +/- 3 microm

18 The similar properties include rolling velocity, a threshold shear stress above 0.4 dyn

19 shortened tether lifetimes, which increased rolling velocities and decreased rolling regularity.

20 s into longer-lived tethers, which decreased rolling velocities and increased the regularity of rolli

21 y the effects of force versus shear rate for rolling velocities and mean stop times.

22 olling steps that translated into lower mean rolling velocities and variances in velocity.

23 ity, and number of receptors per particle on rolling velocity and compare them with experimental resu

24 density varied inversely with instantaneous rolling velocity and directly with instantaneous deforma

25 adhesion under flow conditions, with reduced rolling velocity and increased rolling flux and cellular

26 CD44 controlled rolling velocity and mediated E-selectin-dependent redis

27 The instantaneous rolling velocity and other unknowns of the model are cal

28 ster muscle venules show increased leukocyte rolling velocity and reduced leukocyte recruitment effic

29 racellular activation loop reduces leukocyte rolling velocity and stimulates adhesion.

30 The IC-mediated slow leukocyte rolling velocity and subsequent adhesion and emigration

31 Neutrophil rolling velocity and the number of neutrophils adherent

32 cell-surface contact area and influenced the rolling velocity, and modulated the dependence of rollin

33 iated interactions in shear flow: tethering, rolling velocity, and strength of rolling adhesions.

34 Rolling velocities are fast, between 25 and 225 microm/s

35 The rolling velocity as a function of shear rate showed a mi

36 ce resulted in a dose-dependent reduction in rolling velocity associated with increased numbers of ad

37 rolling lymphocytes, a reduction in overall rolling velocity associated with more frequent pausing o

38 Successive leukocytes had similar rolling velocities at the same axial positions along eac

39 se in accumulation and threefold decrease in rolling velocity at elevated shear.

40 both LFA-1 and Mac-1 were absent or blocked, rolling velocity became dependent on shear rate and appr

41 However, KD-IX-73-4 decreased mean rolling velocity by 29% from 23 to 16 micrometer/seconds

42 luidity and reduced capture, ethanol reduced rolling velocity by 37% and rolling flux by 55% on P-sel

43 n receptor density, we predict that particle rolling velocity calculated in simulations is more sensi

44 gnificantly reduced, with markedly increased rolling velocity compared with control mice.

45 il infiltration was partially due to altered rolling velocity correlated with weaker binding of L-sel

46 ntact time, tethering frequencies increased, rolling velocities decreased, and median arrest duration

47 phil effector functions and causes increased rolling velocity, decreased adhesion, impaired crawling,

48 cifically, Myo1e deficiency caused increased rolling velocity, decreased firm adhesion, aberrant craw

49 leukocytes affect cell rolling, and that the rolling velocity decreases inversely with the separation

50 e thin membrane tethers that might stabilize rolling velocities despite marked alterations in wall sh

51 A decrease in the rolling velocity, drag, and torque with the formation of

52 ure due to PSGL-1 redistribution, 2) reduced rolling velocity due to increased membrane tether growth

53 Specifically, leukocyte rolling velocities during inflammation are significantly

54 istance to detachment in shear and decreased rolling velocity equivalent to an 8-fold increase in lig

55 ng of tether architecture may further reduce rolling velocities, facilitating integrin-dependent dece

56 The rolling velocities for wt-wt interactions first decrease

57 of the model to reproduce in vivo neutrophil rolling velocities from the literature.

58 to 71 +/- 24% (p < 0.05) and decreased mean rolling velocity from 63 +/- 29 to 32 +/- 2 micrometer/s

59 ent with tumor necrosis factor-alpha lowered rolling velocity further and induced CXC chemokine ligan

60 Interestingly, rolling velocity histograms of cell lines expressing equ

61 le-mutant controls, showed tenfold-increased rolling velocities in a TNF-alpha-induced model of infla

62 Rolling velocities in core 2(-/-) mice treated with an E

63 Leukocyte rolling velocities in cremaster muscle venules were incr

64 The average rolling velocities in venules were elevated in LFA-1(-/-

65 ophil adhesion and aggregation and increased rolling velocity in cells stimulated with both septic se

66 Rolling flux and average leukocyte rolling velocity in ICAM-1-deficient mice was not differ

67 n and binding frequencies, and a decrease in rolling velocity in the presence of erythrocytes.

68 ficiency or inhibition increased microsphere rolling velocity in TNFalpha-stimulated venules.

69 We found that the average rolling velocity in venules was not different in ICAM-1(

70 L-selectin shedding in regulating leukocyte rolling velocity in vivo.

71 tin mAb, increased rolling flux fraction and rolling velocity in wild-type mice.

72 Rolling velocities increased after monoclonal antibody b

73 When wall shear stress was increased, rolling velocity increased rapidly for antibodies but no

74 When both LFA-1 and ICAM-1 were blocked, rolling velocity increased, and adhesion efficiency and

75 scosity cells are characterized by high mean rolling velocities, increased temporal fluctuations in t

76 Rolling velocity increases with wall shear stress and de

77 r revealed that IVIG significantly increased rolling velocities, indicating that it alters adhesion p

78 Also, the calculated rolling velocity is more sensitive to the number of rece

79 In contrast, leukocyte rolling velocity is significantly decreased and leukocyt

80 ggest that neglecting cell deformability and rolling velocity may significantly overpredict the flow

81 We measured rolling velocities, mean stop times, and mean go times a

82 A minimum in rolling velocity occurs at an intermediate value of the

83 cell-rolling flux of neutrophils and slower rolling velocities of L-selectin-coated microspheres, re

84 tationally) and the observed decrease in the rolling velocities of model cells.

85 d cell rolling, as observed by the decreased rolling velocities of the MCF-7 cells upon treatment wit

86 nt and simulation by calculating the average rolling velocity of a population whose receptors follow

87 Also, the rolling velocity of A4-infected erythrocytes on ICAM-1(K

88 The rolling velocity of CD45E613R mutant neutrophils was dec

89 The rolling velocity of cells expressing truncated GP Ibalph

90 In addition, the rolling velocity of eosinophils was significantly higher

91 eu214 to Val229 was to slightly increase the rolling velocity of GP Ibalpha-expressing Chinese hamste

92 We also show that the rolling velocity of I-domain-coated particles depends on

93 y MEM-83, or its Fab fragment, decreased the rolling velocity of I-GPI cells on ICAM-1-containing mem

94 mpared to that on ICAM-1, in contrast to the rolling velocity of ItG-infected erythrocytes, which is

95 ing in vitro and significantly decreased the rolling velocity of leukocytes in untreated wild-type C5

96 ing substrates by ~85%, and increased median rolling velocity of remaining cells by 80-150%.

97 increasing microsphere diameter; and 3) the rolling velocity of the 19.ek.Fc microspheres increased

98 educed neutrophil tethering to and increased rolling velocities on cytokine-activated microvessels in

99 Consistent with previous studies, leukocyte rolling velocities on P-selectin were observed to be far

100 rophil attachment to and 17-fold increase in rolling velocities on p110gamma-/- microvessels in vivo

101 Similarly, rolling velocities on purified selectins and their ligan

102 mechanisms have been proposed for regulating rolling velocities on selectins.

103 Importantly, shear-dependent platelet rolling velocities on these VWF ligands in a flow chambe

104 ith N-glycan truncation also increasing cell rolling velocity on L-selectin.

105 ng velocity, and modulated the dependence of rolling velocity on microvillus stiffness.

106 ligand P-selectin glycoprotein ligand-1, but rolling velocity on P-selectin glycoprotein ligand-1 is

107 We calculate the dependence of rolling velocity on shear rate, intrinsic forward and re

108 er assay revealed a significant reduction in rolling velocity on the cells' contact with PAF.

109 address the effect of cell deformability and rolling velocity on the flow resistance due to, and the

110 nhibited binding to P-selectin and increased rolling velocities over P- and L-selectin relative to co

111 Increased leukocyte rolling velocities presumably translated into decreased

112 3.79 +/- 3.32 s) caused an acute jump in the rolling velocity, proving multiple bonding in the cell s

113 The variability of rolling velocity, quantified by the variance in rolling

114 duced PCa cell rolling numbers and increased rolling velocities resulting in a significant decreased

115 Rolling velocity results from a balance of the convectiv

116 BOP was independently associated with rolling velocity, rolling flux, and cellular adhesion.

117 ling velocity, quantified by the variance in rolling velocity, scales linearly with rolling velocity.

118 ells rolled, adhered, and transmigrated at a rolling velocity slightly higher (11 microm/s) than that

119 flow, (including rate of initial attachment, rolling velocities, stable adhesion, and transmigration)

120 kocyte rolling and recruitment and increased rolling velocity, suggesting a predominant role for ppGa

121 s were more uniform and shear resistant, and rolling velocities tended to plateau as wall shear stres

122 gradual beta2 integrin-dependent decrease in rolling velocity that correlates with an increase in int

123 and P-selectins, and are proportional to the rolling velocities through these selectins.

124 locking alpha4 integrin with a mAb increased rolling velocity to 24 microm/s.

125 ng dependence of the contact radius and cell rolling velocity under different conditions of shear str

126 l infiltration resulted in part from reduced rolling velocity under flow both in vivo and in vitro, w

127 -55 mAb, resulting in a dramatic decrease of rolling velocity under flow.

128 mic acid-based inhibitors reduced neutrophil rolling velocity under hydrodynamic flow, resulting in i

129 d a defect in B-cell tethering and increased rolling velocity (V(roll)) in C2GlcNAcT-I(-/-) mice that

130 Rolling velocities vary with time and depend on E-select

131 lling frequency, whereas E-selectin dictates rolling velocity (Vroll).

132 Leukocyte rolling velocity (Vwbc) and the number of adherent cells

133 ha treatment 2.5-3 h before the experiment), rolling velocity was 4 micrometer/seconds and did not ch

134 Neutrophil rolling velocity was calculated as the time required for

135 First, the rolling velocity was found to increase during rolling du

136 r (10 +/- 3 vs 30 +/- 6%, p < 0.05) and mean rolling velocity was higher (67 +/- 46 vs 52 +/- 36 micr

137 eukocyte rolling time was decreased, whereas rolling velocity was increased significantly in EC-TXNIP

138 ner was decreased while E-selectin-dependent rolling velocity was increased.

139 s, the fraction of cells that rolled and the rolling velocity was inversely proportional to the amoun

140 the mesenteric venules showed that leukocyte rolling velocity was markedly decreased and numbers of a

141 The median leukocyte rolling velocity was reduced in L-/- mice and increased

142 On IL-1-stimulated endothelium, rolling velocity was unchanged by ethanol treatment, but

143 olution, and the average and variance of the rolling velocity, we find that P-selectin ligands displa

144 Leukocyte rolling velocities were significantly reduced after TNF-

145 Leukocyte rolling flux and rolling velocity were assessed by intravital microscopy

146 ls rolling on E- or P-selectin reduced their rolling velocity when intercellular adhesion molecule (I

147 -we recorded significantly reduced leukocyte rolling velocity, which suggests PSGL-1 up-regulation; h

148 ith the main observation being a decrease in rolling velocity with increasing concentration of rollin

149 selectin shedding causes an increase in cell rolling velocity with rolling duration, suggesting a gra