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1  extend their axons ventrally, away from the roof plate.
2  regulation of the Lhx2 homeobox gene by the roof plate.
3 on of non-autonomous signals provided by the roof plate.
4 e in the control of neural patterning is the roof plate.
5 oderm and induce dorsal midline cells of the roof plate.
6 tle layers of the spinal cord but not in the roof plate.
7 spinal cord) as well as being present in the roof plate.
8 fective formation of either the floor or the roof plate.
9  by expression of exogenous ephrin-B3 at the roof plate.
10  followed by the emergence of the definitive roof plate.
11 ound-null mutants fail to generate hindbrain roof plate.
12 4 are required for development of the dorsal roof plate.
13 and the expanding squamous epithelium of the roof plate.
14 d at the dorsal neuroepithelium flanking the roof plate.
15 ns (Bmps), the major signals produced by the roof plate.
16  domain of the spinal cord that includes the roof plate.
17 loses, Lmx1a expression is restricted to the roof plate.
18 ns through inductive signals provided by the roof plate.
19 icle and include greatly thickened floor and roof plates.
20  sensory neurons and to the spinal floor and roof plates.
21 ion in the ciliated LR organizer (gastrocoel roof plate), a marked enrichment compared with 40 of 845
22                                              Roof plate ablation results in reduced cortical size and
23 late, BMP7, but not BMP6 or GDF7, mimics the roof plate activity in vitro.
24                    Lmx1a is expressed in the roof plate along the neuraxis during development of the
25 ogenetic proteins (BMPs) are produced by the roof plate and are responsible for inducing dorsal neura
26                                The hindbrain roof plate and choroid plexus are essential organizing c
27                    Our data suggest that the roof plate and choroid plexus may be formed of functiona
28 ricts the dorsal Wnt signaling center to the roof plate and consequently limits pallial identities.
29 d in the absence of retinoic acid signaling, roof plate and crest markers are co-expressed in single
30  the dI1 progenitor fate, distinguishing the roof plate and dI1 interneuron programs, two major devel
31 ys leading to the formation of neural crest, roof plate and dorsal interneuron cell types.
32  accompanied by a reduction in the domain of roof plate and dorsal patterning genes, both of which ar
33  defect is concomitant with expansion of the roof plate and is also evident in a mouse mutant for ano
34 scription factor family, is expressed in the roof plate and its progenitors at all axial levels of th
35   Early BMP-dependent dorsal cell fates, the roof plate and neural crest, form in the absence of Nogg
36 pregulation of BMP inhibitors in the nascent roof plate and prolongs the period of BMP responsiveness
37 ained by interactions between the non-neural roof plate and the neural rhombic lip.
38 us, Lmx1a is required for development of the roof plate and, in turn, for specification of dorsal cel
39 d within it (e.g., radial glia, Muller glia, roof plate, and floor plate cells) were not immunoreacti
40 correlated with development of the floor and roof plates, and is expressed in a rostral-caudal manner
41 e same embryonic primordium as the hindbrain roof plate; and that, unlike the floor plate, these dors
42  that secreted signals from the rhombomere 1 roof plate are both necessary and sufficient for specifi
43 we show that the organiser properties of the roof plate are determined by its boundaries with the adj
44         Numerous studies have identified the roof plate as an embryonic signaling center critical for
45         Numerous studies have identified the roof plate as an important signaling center controlling
46      These findings provide evidence for the roof plate as an organizing center of the developing cor
47   However, adult ETs lack characteristically roof plate-associated structures and express Shh through
48 e dorsal and ventral nerve roots, and in the roof plate at E13, when neurocan immunoreactivity is see
49               Of three Bmps expressed in the roof plate, BMP7, but not BMP6 or GDF7, mimics the roof
50 f atonal1 in the rhombic lip adjacent at the roof plate boundary is acutely dependent on both boundar
51                         Correspondingly, the roof plate boundary organiser also signals to the roof p
52                                    Thus, the roof plate boundary organiser signals bi-directionally t
53          Annexin IV is also expressed in the roof plate, but not until E10.5.
54 ricted stem zone that generates the squamous roof plate by direct transformation and asymmetrically f
55 5, its expression is lost in the spinal cord roof plate by E10.5.
56 ing cellular ablations in mice, we show that roof plate cell loss causes failed midline induction and
57 12) of chick neural tube development induces roof-plate cell fate, accompanied by an increase of prog
58 g molecule that is expressed by boundary and roof plate cells in the zebrafish hindbrain.
59 ere that expression of both Bmp7 and Gdf7 by roof plate cells is required for the fidelity of commiss
60                                              Roof plate cells provide a secondary source of TGFbeta-r
61 hat flank the neural plate and propagated by roof plate cells within the neural tube.
62 a BMP family member expressed selectively by roof plate cells, in the generation of neuronal cell typ
63 e is no annexin IV expression in presumptive roof plate cells.
64 direct their differentiation into functional roof plate cells.
65 itor cells lose their competence to generate roof-plate cells in response to Bmp signaling and instea
66  explants of dorsal neural tube or hindbrain roof plate chemorepelled cranial motor axons, while expl
67 These findings establish selective roles for roof plate-dependent Bmp signaling in dorsal telencephal
68 ity in midline gene regulation and to rescue roof plate-dependent midline patterning.
69 ing the molecular and cellular mechanisms of roof plate-dependent patterning of the dorsal CNS.
70  that a GDF7:BMP7 heterodimer functions as a roof plate-derived repellent that establishes the initia
71 n can be recapitulated in explants using two roof plate-derived signaling molecules, Bmp4 and Bmp2.
72 d, a growing number of studies indicate that roof plate-derived signals are also critical for the pat
73 mx1b function is required for both hindbrain roof plate development and 4th ventricle morphogenesis,
74         Lmx1b can, however, partially rescue roof plate development in dreher (Lmx1a-/-) mice, indica
75 ling perturbs the balance between vermis and roof plate development in rhombomere 1.
76 s to inhibit the BMP signaling that promotes roof plate development.
77 e chick, Lmx1b acts upstream of Lmx1a in the roof plate developmental program.
78     In the anterior CNS, however, a residual roof plate develops in the absence of Lmx1a.
79 re the major components of Lmx1a/b-dependent roof plate dorsal patterning activity.
80 d tissues, including neural tube, gastrocoel roof plate, epidermal multi-ciliated cells, otic vesicle
81                               Both hindbrain roof plate epithelium (hRPe) and hindbrain choroid plexu
82 sponsiveness which otherwise ceases close to roof plate establishment.
83                  Experimental restriction of roof plate expansion leads to extrusion of veil cell dau
84                We show that the boundary and roof plate expression of wnt1 each contribute to upregul
85  requirements for mediating r5/r6 and dorsal roof plate expression.
86 outset, patterned in this axis as there is a roof plate, floor plate, and differing numbers and types
87         Currently, the molecular pathways of roof plate formation and function are poorly understood.
88 ith the general hypothesis that a failure of roof plate formation and function results in deficits in
89 roles for Lmx1 genes in regulating hindbrain roof plate formation and growth and also revealed roles
90  the CNS and is necessary and sufficient for roof plate formation in the spinal cord.
91 4th ventricle morphogenesis, confirming that roof plate formation is a critical component of ventricl
92                    Instead, mouse caudal CNS roof plate formation relies entirely on Lmx1a.
93 t show a substantial deficiency in hindbrain roof plate formation, Lmx1a/Lmx1b compound-null mutants
94 es act in concert to direct normal hindbrain roof plate formation.
95                                     Once the roof plate forms, we show that Bmp and Wnt signaling are
96                                          The roof plate function of Lmx1b is not conserved across ver
97               Within cranial ventricles, the roof plate gives rise to choroid plexus, which regulates
98 fate is regulated by the space available for roof plate growth.
99 t-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are sev
100 cilia-driven leftward flow at the gastrocoel roof plate (GRP), and aberrant expression of both Coco a
101 of Drosophila Prickle, in Xenopus gastrocoel roof plate (GRP).
102                              The role of the roof plate has become evident through studies of mutatio
103 nd other BMP family members expressed by the roof plate have non-redundant functions in vivo.
104 embryonic NSC populations differentiate into roof plate identities when protected from endogenous Hed
105 , notochordal plate in rabbit and gastrocoel roof plate in frog appears to be a conserved mechanism t
106 highly related to Lmx1a, is expressed in the roof plate in the anterior CNS.
107 tor Lmx1b is sufficient to induce functional roof plate in the early chick developing spinal cord.
108         Furthermore, we demonstrate that the roof plate-inducing activity of Lmx1b can be suppressed
109 tify Lmx1b as a key regulator of spinal cord roof plate induction and function.
110  co-factors that also regulate the extent of roof plate induction.
111                                          The roof plate is a critical dorsal signaling center that oc
112                                          The roof plate is a signalling centre positioned at the dors
113                                          The roof plate is a transient signaling center on the dorsal
114                                          The roof plate is a well known signaling center in CNS devel
115                                          The roof plate is an organizing center in the dorsal CNS tha
116 e cellular and molecular architecture of the roof plate is compromised.
117                These results reveal that the roof plate is essential for specifying multiple classes
118          We previously demonstrated that the roof plate is missing in the dreher mouse.
119               Surprisingly, we show that the roof plate is not absolutely required for initial specif
120 e squamous epithelium of the rhombencephalic roof plate is pioneered by distinct mesenchymal cells at
121                                          The roof plate is the source of a diffusible repellent that
122 plate boundary organiser also signals to the roof plate itself to specify the expression of early cho
123                            Embryos without a roof plate lack all the interneuron subtypes that are no
124 ng center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning.
125 plate, where it is required to segregate the roof plate lineage from neuronal rhombic lip derivatives
126 of the fourth ventricle within the domain of roof plate marker, Lmx1a.
127               In Zic morphants expression of roof plate markers, including lmx1b.1 and lmx1b.2, is di
128  GDF7, which is exclusively expressed in the roof plate, marks neural crest cells with a 10-fold high
129 iferation, decreased cell death and impaired roof plate morphogenesis.
130              Thus, Pax3 is restricted to the roof plate of prosomere 2, pretectum, optic tectum, rhom
131  prominent expression in the floor plate and roof plate of the developing neural tube and its rhombom
132  be expressed specifically in the developing roof plate of the fourth ventricle within the domain of
133  neuroepithelium immediately adjacent to the roof plate of the fourth ventricle, and it gives rise to
134 all natriuretic peptides, was present in the roof plate of the hindbrain and spinal cord and in bilat
135 , we show that distinct regions of hindbrain roof plate originate from discrete subdomains of rhomben
136 athways that regulate Pax3 expression in the roof plate probably represent early upstream signals in
137   During caudal neural tube development, the roof plate produces proteins of the Bmp and Wnt families
138 ates because Lmx1b is not expressed in mouse roof plate progenitors.
139 ons from dorsal sources that may include the roof plate region itself.
140        Thus, in addition to the isthmus, the roof plate represents an important signaling center cont
141 ow that GDF7 is an inductive signal from the roof plate required for the specification of neuronal id
142                                          The roof plate resident BMPs have sequential functions in th
143 e signaling centers of the midbrain, the FP, roof plate (RP) and the midbrain-hindbrain boundary (MHB
144                             We show that the roof plate (RP) expresses a diffusible activity that rep
145 ommissural spinal axons extend away from the roof plate (RP) in response to a chemorepellent mediated
146 t in the dorsal midline in the region of the roof plate (RP).
147  we devised a genetic strategy to ablate the roof plate selectively in mouse embryos.
148 lants, exogenous Bmp4 is sufficient to mimic roof plate selectivity in midline gene regulation and to
149 e and Lhx2 expression defects that implicate roof plate signals in the bimodal regulation of Lhx2 in
150 ters depend on Zic1 and Zic4 function and on roof plate signals, and provide evidence that these boun
151                             Although several roof plate-specific genes are normally expressed in the
152                         With the addition of roof plate-specific spondin 1, a wingless-int agonist, R
153 rophil infiltration, up-regulating Ki67, and Roof plate-specific spondin 3.
154                                          The roof plate-specific spondin-leucine-rich repeat-containi
155 on and emigration are extended well into the roof plate stage.
156 bits the onset of retinoic acid synthesis in roof plate suggesting a mutual repressive interaction be
157 sults in shorter monocilia in the gastrocoel roof plate that control left-right patterning and in sho
158 se dreher (dr) results from a failure of the roof plate to develop.
159 cent to the neural tube is propagated by the roof plate to dorsalize the neural tube.
160 the contribution of signals derived from the roof plate to the specification of neuronal cell types i
161 ressive interaction between neural crest and roof plate traits.
162 loping cerebellum, Lmx1a is expressed in the roof plate, where it is required to segregate the roof p

 
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