ライフサイエンスコーパス: rosacea

1 ia (163 trials [79%] on acne and 43 [21%] on rosacea).

2 tract infection, chest pain, back pain, and rosacea).

3 including atopic dermatitis, psoriasis, and rosacea.

4 ilation and the inflammation associated with rosacea.

5 ow-up, we identified 5,462 incident cases of rosacea.

6 ent thinking about the parent disorder, acne rosacea.

7 antimicrobial peptide LL-37 is a hallmark of rosacea.

8 tory skin diseases, including dermatitis and rosacea.

9 known about use of PROMs in RCTs on acne and rosacea.

10 nder TRPV4 a translational-medical target in rosacea.

11 ciation between smoking and risk of incident rosacea.

12 e development of new treatments for acne and rosacea.

13 lammation in murine models of dermatitis and rosacea.

14 pro-inflammatory and vasodilative signals in rosacea.

15 ol for assessing gland involvement in ocular rosacea.

16 owest proportion of erythematotelangiectatic rosacea.

17 and impaired muscle contraction function in rosacea.

18 en different measures of smoking and risk of rosacea.

19 comes assessed during intervention trials of rosacea.

20 wenty-four patients had associated cutaneous rosacea.

21 nd 7.62 (95% CI, 6.78-8.57) in patients with rosacea.

22 lation and 4.99 (4.32-5.76) in patients with rosacea.

23 = 1.14-1.37), respectively, in patients with rosacea.

24 42.2 [16.5] years) were registered as having rosacea.

25 individuals, including 82,439 patients with rosacea.

26 to enhanced sensitivity to UVB radiation in rosacea.

27 influence of environmental factors affecting rosacea.

28 etinoin, are associated with improvements in rosacea.

29 and expectations of individuals affected by rosacea.

30 uture studies to better understand and treat rosacea.

31 eutrophils reach a maximum in papulopustular rosacea.

32 n underestimated hallmark in all subtypes of rosacea.

33 therapy, and topical cyclosporine for ocular rosacea.

34 owed by a crescendo pattern toward phymatous rosacea.

35 urveyed regarding risk factors implicated in rosacea.

36 entarium for recalcitrant cases of childhood rosacea.

37 es such as psoriasis, atopic dermatitis, and rosacea.

38 as a critical element in the pathogenesis of rosacea.

39 cal protease involved in the pathogenesis of rosacea.

40 icacy and fewest adverse events for treating rosacea?

41 vs. 0.43 without disease; P < 0.001), facial rosacea (0.47 vs. 0.43; P = 0.002), rheumatoid arthritis

42 1.88, 1.96)], psoriasis [2.62 (2.54, 2.69)], rosacea [2.84 (2.78, 2.90)], hidradenitis suppurativa [1

43 timates being psoriasis [3.52 (3.42, 3.61)], rosacea [2.85 (2.79, 2.92)], and alopecia areata [2.81 (

44 , contact lens wear in the setting of ocular rosacea (3 eyes), benzalkonium chloride toxicity (2 eyes

45 7] years) and 184 of the 68372 patients with rosacea (67.3% women; mean [SD] age, 42.2 [16.5] years).

46 Rosacea, a common facial skin disorder, has a poorly und

47 have been implicated in the pathogenesis of rosacea, a disorder treated by the use of low-dose doxyc

48 e by 2 of the authors, using the search term rosacea, according to the Preferred Reporting items for

49 ection of the cathelicidin peptides found in rosacea, addition of SCTE, and increasing protease activ

50 ease in patients classified as having ocular rosacea (adjusted IRR, 2.03 [95% CI, 1.67-2.48]), and te

51 ed at significantly higher concentrations in rosacea-affected than in normal tear fluids.

52 trend = 0.003) and with a decreased risk of rosacea among current smokers (P for trend < 0.0001).

53 king was associated with an elevated risk of rosacea among past smokers (P for trend = 0.003) and wit

54 Humans with rhinophymatous acne rosacea, an inflammatory condition associated with Demod

55 Thirty eyes from 30 patients with ocular rosacea and 34 eyes from 34 controls were analyzed.

56 is, France) included 42 children with ocular rosacea and 44 healthy volunteers (median ages of 10 and

57 eligible for analysis; of these, 68 372 had rosacea and 5 416 538 constituted the reference populati

58 ons, we investigated the association between rosacea and dementia, including AD in Danish registers.

59 luid was collected from patients with ocular rosacea and normal control subjects.

60 olved non-genital-tract pathologies, such as rosacea and psoriasis.

61 nd as an immunomodulator in diseases such as rosacea and psoriasis.

62 ings suggest that MRGPRX2/B2 participates in rosacea and that beta-arrestin 2 contributes to its path

63 We identified correlations between rosacea and UV radiation exposure, alcohol, smoking, ski

64 nformation on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005.

65 in the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients wit

66 pport the concept of a genetic component for rosacea, and provide candidate targets for future studie

67 th regards to etiology and therapy of ocular rosacea, and will also examine current thinking about th

68 uture studies should use the phenotype-based rosacea approach.

69 ssed forms of cathelicidin peptides found in rosacea are different from those present in normal indiv

70 signaling may represent a novel therapy for rosacea as clinical agents become available.

71 er smoking, we observed an increased risk of rosacea associated with past smoking (multivariable-adju

72 ndividuals and patients with dry eye who had rosacea-associated meibomian gland disease (MGD) or Sjog

73 and likely contribute to the pathogenesis of rosacea, atopic dermatitis, allergic contact dermatitis,

74 in all except 1 patient who had significant rosacea blepharokeratoconjunctivitis, whose BCVA remaine

75 ea patients have signs or symptoms of ocular rosacea, but few cases were confirmed by an ophthalmolog

76 ) has been implicated in the pathogenesis of rosacea, but the receptor involved and the mechanism of

77 ited to patients with a primary diagnosis of rosacea by a hospital dermatologist (n = 5964), the adju

78 ggest an explanation for the pathogenesis of rosacea by demonstrating that an exacerbated innate immu

79 discovery group of 22,952 individuals (2,618 rosacea cases and 20,334 controls) was analyzed, leading

80 in a new group of 29,481 individuals (3,205 rosacea cases and 26,262 controls).

81 tion of the immune system in all subtypes of rosacea, characterizing erythematotelangiectatic rosacea

82 (BP), and chronic atopic and chronic ocular rosacea cicatrizing conjunctivitis; and normal human ser

83 A systematic literature review of rosacea clinical trials was conducted.

84 identified a final core set of 8 domains for rosacea clinical trials: ocular signs and symptoms; skin

85 as 1.71 (95%, CI 1.52-1.92) in patients with rosacea compared with the reference population.

86 Rosacea constitutes an independent risk factor for Parki

87 cifically upregulated in fibroblasts, blocks rosacea development in mice.

88 entifies fibroblasts as a key determinant in rosacea development.

89 found that skin biopsies from patients with rosacea display higher frequencies of MCs expressing MRG

90 cea, characterizing erythematotelangiectatic rosacea (ETR) already as a disease with significant infl

91 with the erythematotelangiectatic subtype of rosacea (ETR).

92 Here we show that individuals with rosacea express abnormally high levels of cathelicidin i

93 observed that the epidermis of patients with rosacea expressed higher amounts of Toll-like receptor 2

94 he perifollicular inflammatory infiltrate of rosacea for both proteins.

95 AWE group and phlyctenular keratitis/ocular rosacea group, respectively.

96 ormal control subjects, patients with ocular rosacea had a greater delay of tear fluorescein clearanc

97 We observed that dermal endothelial cells in rosacea had an increased expression of VCAM1 and hypothe

98 ecent articles on the pathogenesis of ocular rosacea have focused on the role of bacterial lipases, a

99 Therapies currently in vogue for ocular rosacea have not been rigorously studied with regards to

100 Acne and rosacea have substantial implications for quality of lif

101 rimary initial diagnosis of acne vulgaris or rosacea in 2010.

102 outcome was the proportion of patients with rosacea in each of the 4 major subtype groups defined by

103 Recent articles on the prevalence of ocular rosacea in patients with acne rosacea suggested that bet

104 proteins, were significantly associated with rosacea in the discovery group and confirmed in the repl

105 ted using the search terms acne vulgaris and rosacea in the following databases: MEDLINE through PubM

106 cians from 17 countries and 25 patients with rosacea in the US) on 9-point Likert scale.

107 fluid obtained from 13 patients with ocular rosacea (including 1 patient with recurrent epithelial e

108 The activated form of NFKB is enriched in rosacea, indicating a role for this pathway in the patho

109 ng these antibiotics exclusively for acne or rosacea (indications that could be risk factors for brea

110 fective anti-inflammatory strategy to reduce rosacea inflammation by restricting pathogenic T-cell in

111 Rosacea is a chronic inflammatory disease of facial skin

112 Rosacea is a chronic inflammatory skin disease whose pat

113 Rosacea is a chronic inflammatory skin disorder, whose u

114 Rosacea is a chronic skin disease characterized by photo

115 Ocular rosacea is a common and potentially blinding eye disorde

116 Rosacea is a common chronic inflammatory skin disease of

117 Rosacea is a common chronic inflammatory skin disorder w

118 Rosacea is a common skin disease that manifests unique i

119 Rosacea is a common, chronic skin disease that is curren

120 Acne rosacea is an inflammatory skin disease that affects 3%

121 Ocular rosacea is associated with marked meibomian gland dropou

122 The papulopustular rosacea is featured by expansion of pro-inflammatory fib

123 reporting of outcomes in clinical trials of rosacea is impeding and likely preventing accurate data

124 tors influence rosacea, the genetic basis of rosacea is not established.

125 The relationship between smoking and rosacea is poorly understood.

126 Rosacea is significantly associated with dementia, parti

127 The pathogenesis of rosacea is unclear, but increased matrix metalloproteina

128 A-DRA and BTNL2 expression in papulopustular rosacea lesions from six individuals, including one with

129 ier function damage is found to be unique to rosacea lesions.

130 /HNihrJaeBsmJ (KitW-sh) mice did not develop rosacea-like features.

131 d the molecular mechanisms of LL-37-mediated rosacea-like inflammation in an in vitro model of normal

132 We found that LL-37-induced rosacea-like inflammation was significantly reduced in m

133 f inflammatory mediators, and development of rosacea-like inflammation.

134 Blocking IFNgamma signaling alleviates rosacea-like phenotypes and skin barrier damage in mice.

135 in immunocompetent children with rosacea or rosacea-like refractory eruptions.

136 Elevated gelatinase B activity in ocular rosacea may be involved in the pathogenesis of the irrit

137 cognitive dysfunction in older patients with rosacea may be relevant.

138 ocus on neurologic symptoms in patients with rosacea may be warranted.

139 antly more important in children with ocular rosacea (mean meiboscore 2.1 +/- 1.36) than in healthy v

140 antly more important in children with ocular rosacea (mean meiboscore 2.1 1.36) than in healthy volun

141 Prices of acne and rosacea medications increased a mean of 195%, and prices

142 lytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates

143 1), peripheral ulcerative keratitis (n = 1), rosacea (n = 1), and stitch abscess (n = 1).

144 riant of NFKB (pNFKB) in eyelid specimens of rosacea (n = 12) and normal, healthy tissue (n = 12).

145 rried out for pNFKB and NFKB in specimens of rosacea (n = 15) and normal controls (n = 14).

146 leotide polymorphisms (SNPs) associated with rosacea, one of which replicated in a new group of 29,48

147 s with a hospital dermatologist diagnosis of rosacea only, the adjusted HRs of dementia and AD were 1

148 considered in immunocompetent children with rosacea or rosacea-like refractory eruptions.

149 However, its significance in rosacea pathogenesis is not fully understood.

150 tide that has been shown to be an enabler of rosacea pathogenesis.

151 single-cell atlas of facial skin from female rosacea patients and healthy individuals.

152 cea suggested that between 6 and 18% of acne rosacea patients have signs or symptoms of ocular rosace

153 he mean ratios of pNFKB:NFKB for control and rosacea patients measured 0.58 (standard deviation = 0.8

154 n of pro-MMP-9 (92 kDa) in the tear fluid of rosacea patients than controls.

155 nts and 39.3 (standard deviation = 16.9) for rosacea patients, and the difference between the 2 group

156 e immunohistochemistry on facial biopsies of rosacea patients, classified according to their clinical

157 (MC) numbers are increased in the dermis of rosacea patients.

158 Papulopustular rosacea (PPR) is a chronic inflammatory skin disease wit

159 under evaluation for treating papulopustular rosacea (PPR).

160 (110) included; PROM use was more common in rosacea RCTs (67% [n = 29]) compared with acne RCTs (50%

161 cluded in approximately one-half of acne and rosacea RCTs performed over the study period.

162 ogy, etiology, and optimal therapy of ocular rosacea remain to be determined, and will require a more

163 quency of these subtypes among patients with rosacea remains unknown.

164 This core domain set for rosacea research is now available; its adoption by resea

165 Faculty dermatologists determined a rosacea score for each twin participant according to the

166 2.46 and 42 fraternal twin pairs with a mean rosacea score of 0.75.

167 re were 233 identical twin pairs with a mean rosacea score of 2.46 and 42 fraternal twin pairs with a

168 nmelanoma skin cancer, dermatophytosis, acne rosacea, seborrheic keratosis, or warts; 74.1% of the su

169 n can be severe and are correlated to ocular rosacea severity.

170 h twin participant according to the National Rosacea Society (NRS) grading system.

171 subtype groups defined by the 2002 National Rosacea Society classification system.

172 a were confirmed on erythematotelangiectatic rosacea subjects who showed a decrease in matrix metallo

173 The NRS score and rosacea subtype were assessed using the NRS grading syst

174 and meta-analysis, differences were found in rosacea subtypes by patient sex and by continent of orig

175 Four distinct rosacea subtypes have traditionally been recognized, but

176 quency of patients affected by each of the 4 rosacea subtypes.

177 numbers or frequency of patients affected by rosacea subtypes.

178 ence of ocular rosacea in patients with acne rosacea suggested that between 6 and 18% of acne rosacea

179 m of gelatinase B was observed in 46% of the rosacea tear samples and none of the controls.

180 activity is greater in patients with ocular rosacea than in normal eyes.

181 Although environmental factors influence rosacea, the genetic basis of rosacea is not established

182 y improve the usefulness of future trials of rosacea therapies by enabling meta-analyses and other co

183 To our knowledge, this is the first study on rosacea to formally define genetic and environmental con

184 rm when BPO drug products, used for acne and rosacea treatment, are incubated at body temperature and

185 lation of activated MCs may be a therapy for rosacea treatment.

186 o presented with severe ocular and cutaneous rosacea unresponsive to oral doxycycline, oral isotretin

187 fficacy and safety of therapies for acne and rosacea vs any comparator were eligible for inclusion.

188 te ratio (95% CI) of glioma in patients with rosacea was 1.36 (1.18-1.58) in our primary analysis.

189 was 7.4% (95% CI, 6.1%-8.9%), and of ocular rosacea was 11.1% (95% CI, 6.7%-16.3%).

190 .7% (95% CI, 51.4%-62.0%), of papulopustular rosacea was 43.2% (95% CI, 38.8%-47.6%), of phymatous ro

191 ooled proportion of erythematotelangiectatic rosacea was 56.7% (95% CI, 51.4%-62.0%), of papulopustul

192 as 43.2% (95% CI, 38.8%-47.6%), of phymatous rosacea was 7.4% (95% CI, 6.1%-8.9%), and of ocular rosa

193 Rosacea was associated with a significantly increased ri

194 The risk of rosacea was significantly increased within 3-9 years sin

195 l of 39 studies examining 9190 patients with rosacea were included.

196 Comparatively few papers on ocular rosacea were published in the past year.

197 patients with phlyctenular keratitis/ocular rosacea were recruited.

198 Erythematotelangiectatic and papulopustular rosacea were the most prevalent subtypes, but data shoul

199 cells are increased in all three subtypes of rosacea, whereas neutrophils reach a maximum in papulopu

200 lly among men and women except for phymatous rosacea, which was more prevalent in men.

201 ly in the tear fluid of patients with ocular rosacea who had corneal epithelial disease.

202 h as acne, atopic dermatitis, psoriasis, and rosacea with an imbalance of the microflora even in the

203 ition of metronidazole (a drug used to treat rosacea) within the skin and proximal to its site of pha