ライフサイエンスコーパス: ruffling

1 res (from purely saddled to saddled with 30% ruffling).

2 ace ORAI1 and increasing the plasma membrane ruffling.

3 evident in podosomes and regions of membrane ruffling.

4 esulting in a substantial increase in dorsal ruffling.

5 ed with enhanced cell spreading and membrane ruffling.

6 no additive effect on the amount of membrane ruffling.

7 cell survival, transformation, and membrane ruffling.

8 0alpha also restored PDGF-dependent membrane ruffling.

9 a functional link between SOCE and membrane ruffling.

10 wild-type cells retained normal PDGF-induced ruffling.

11 trafficking, glucose transport, and membrane ruffling.

12 a-/-) are defective in PDGF-induced membrane ruffling.

13 of endocytosis, actin dynamics, and membrane ruffling.

14 e D (PLD) homolog, which facilitate membrane ruffling.

15 e staining was observed in regions of active ruffling.

16 rum and PDGF, along with a reduction in cell ruffling.

17 amics, lamellipodia protrusion, and membrane ruffling.

18 ting that PIPKIalpha and PIP2 participate in ruffling.

19 causes transformation and leads to membrane ruffling.

20 omplexes to promote membrane protrusion over ruffling.

21 n PDGF-stimulated cells resulted in membrane ruffling.

22 stimulate actin reorganization and membrane ruffling.

23 nt negative fashion, preventing rounding and ruffling.

24 6-regulated membrane movement or Rac-induced ruffling.

25 ut, surprisingly, did not eliminate membrane ruffling.

26 to induce actin reorganization and membrane ruffling.

27 s but may be required downstream of membrane ruffling.

28 stems, also inhibited GH-stimulated membrane ruffling.

29 The small GTPase Rac mediates membrane ruffling.

30 actin cytoskeletal organization and membrane ruffling.

31 cytosol to the plasma membrane, and membrane ruffling.

32 o stimuli (e.g., serum) that induce membrane ruffling.

33 as endocytosis, exocytosis, and cell surface ruffling.

34 ith increases in cell spreading and membrane ruffling.

35 NQ2/3 channel currents, and loss of membrane ruffling.

36 g actin polymerization and reducing membrane ruffling.

37 me pocket residue in IsdI implicated in heme ruffling.

38 ctor (PDGF) and growth factor-induced dorsal ruffling.

39 ed, Abi1-KO cells exhibited decreased dorsal ruffling.

40 al organization, and reduced plasma membrane ruffling.

41 ts the formation of CrkII-dependent membrane ruffling.

42 nal morphogenesis and in PDGF-induced dorsal ruffling.

43 superoxide production and increased membrane ruffling.

44 ve GTP-bound Rac and EGF-stimulated membrane ruffling.

45 ate precisely localized cell protrusions and ruffling.

46 ciated with a combination of heme doming and ruffling.

47 order of magnitude smaller than the observed ruffling (1B(1u)) deformation.

48 Antigen-induced cell ruffling, a calcium-independent event, is blocked by inj

49 with a smaller amount of stress fiber and/or ruffling actin confined to the cell bottom in contact wi

50 -alpha causes pronounced defects in membrane ruffling, actin organization, and focal adhesion formati

51 le that maintains leading-edge structure and ruffling activity and that supports the chemoattractant

52 in1 and that contraction depends on cellular ruffling activity, rather than on the protrusion and ret

53 en, cAMP-elevating agents stimulate membrane ruffling, Akt phosphorylation, and p70 ribosomal S6 prot

54 ndent growth assays, cell cycle and membrane ruffling analyses showed that Akt exerts estrogen-like a

55 Eklf-deficient EryP exhibit membrane ruffling and a failure to acquire the typical discoidal

56 nnoma-derived Schwann cells exhibit membrane ruffling and aberrant cell spreading when plated onto la

57 e L. pneumophila, without affecting membrane ruffling and actin polymerization.

58 nd the actin cytoskeleton to induce membrane ruffling and bacterial internalization.

59 hese data show that SHEP1 regulates membrane ruffling and cell migration and that binding to Cas is p

60 s to induce JNK and PAK activation, membrane ruffling and cell migration, suggesting that it is defec

61 ction downstream of Arf6 to control membrane ruffling and cell migration, this pathway has not been d

62 bition of Hsp90 activity suppressed membrane ruffling and cell migration, while expression of an acet

63 cting with Crk inhibits Bmx-induced membrane ruffling and cell migration.

64 attachment-induced JNK activation, membrane ruffling and cell motility in a Rac-dependent manner.

65 e-dependent actin reorganization in membrane ruffling and cell motility.

66 4-3-3zeta to increase AngII-induced membrane ruffling and cell motility.

67 of Rac1 activation, actin-dependent membrane ruffling and cell spreading are Rac1-dependent processes

68 Abnormal ruffling and cell spreading by cells with identified NF2

69 Rac1 activation and Rac1-dependent membrane ruffling and cell spreading were restored.

70 mLDL activates macrophages inducing membrane ruffling and cell spreading, activation of ERK1/2 and Ak

71 which Neisseria gonorrhoeae elicits membrane ruffling and cellular invasion of the cervical epithelia

72 PLD may be necessary to potentiate membrane ruffling and clustering of gonococci on the cervical cel

73 l structure of haem-bound IsdI in which haem ruffling and constrained binding of oxygen is consistent

74 These data are consistent with heme ruffling and coordination geometry serving to stabilize

75 h signaling when persistent induced membrane ruffling and decreased cell motility.

76 actin-binding domain cause aberrant membrane ruffling and defective actin stress fibre formation in c

77 eletal rearrangements manifested by membrane ruffling and disruption of intercellular junctions.

78 and produced smooth T cells void of membrane ruffling and filopodia.

79 nd assayed for GH- and PDGF-induced membrane ruffling and fluid phase pinocytosis.

80 tiple cellular responses, including membrane ruffling and focal complex formation.

81 3D) retained the ability to promote membrane ruffling and focus formation.

82 not Nckalpha blocks PDGF-stimulated membrane ruffling and formation of lamellipoda.

83 ot Nckalpha blocks Rac1-L62-induced membrane ruffling and formation of lamellipodia, suggesting that

84 ed shape changes in the cells, with membrane ruffling and formation/retraction of thin actin-like pro

85 Bmx with Cas results in an enhanced membrane ruffling and haptotactic cell migration.

86 ion of MAYP decreased CSF-1-induced membrane ruffling and increased filopodia formation, motility and

87 nts encompass increased Rac-induced membrane ruffling and lamellipodia, Cdc42-initiated filopodia, an

88 ystem (T3SS), leading to pronounced membrane ruffling and macropinocytic uptake of attached bacteria.

89 Rac activity and abolishing the constitutive ruffling and macropinocytosis that characterize macropha

90 uptake in a process associated with membrane ruffling and macropinocytosis.

91 prerequisite for the stimulation of membrane ruffling and macropinocytosis.

92 the force on the macrocycle that causes the ruffling and makes the redox potential more negative tha

93 activated Rac explains its positive role in ruffling and negative role in cell spreading and migrati

94 CV1 cells and blocked PDGF-induced membrane ruffling and nucleated actin assembly.

95 orphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increase

96 r these conditions causes extensive membrane ruffling and overrides the block in membrane fusion caus

97 Arf6 and its GEFs facilitated membrane ruffling and pathogen invasion via ARNO, and triggered a

98 a functional SH2 domain, inhibited membrane ruffling and pinocytosis induced by GH and PDGF.

99 erexpression of wild-type SH2-Bbeta enhanced ruffling and pinocytosis produced by submaximal GH but n

100 ac-dependent readouts: induction of membrane ruffling and pinocytosis, stimulation of cell motility,

101 negative regulator of CSF-1-induced membrane ruffling and positively regulates formation of filopodia

102 intracellular pathways that induce membrane ruffling and promote cell survival.

103 ing was characterized by (1) plasma membrane ruffling and protrusion into the wound, (2) lamellipodia

104 ANI-1 is essential for cortical ruffling and pseudocleavage, contractile events that occ

105 yphimurium into host cells requires membrane ruffling and rearrangement of the actin cytoskeleton.

106 le was able to rescue the defect in membrane ruffling and restore the localization of a fluorescent P

107 0-750 cm(-1) region known to be sensitive to ruffling and saddling deformations, as well as increased

108 in 1B S2D mutant have attenuated PMA-induced ruffling and slower cell speed.

109 d PAO effectively inhibit antigen-stimulated ruffling and spreading in these cells, and they inhibit

110 Rac1 and RhoA regulate membrane ruffling and stress fiber formation.

111 en-like activity on cell growth and membrane ruffling and that a selective ErbB2 inhibitor, but not a

112 may be a key protein that modulates membrane ruffling and that this may involve changes in caldesmon

113 the membrane, which in turn causes membrane ruffling and the formation of cellular protrusions.

114 experiments show that activation of membrane ruffling and transcriptional activation of c-jun, SRF, o

115 ranscription factor c-Jun and cause membrane ruffling and transformation, indicating that switching i

116 with GGTIs led to the inhibition of membrane-ruffling and transforming activities of both activated a

117 cells with 2-10 muM P27 caused cell membrane ruffling and uptake of virus and polymerized forms of th

118 a recruited and activated Arf1 to facilitate ruffling and uptake.

119 filamentous actin filament into the membrane rufflings and uropods of human neutrophils.

120 4 induced Rac morphology, cell spreading and ruffling (and the formation of neurites).

121 rane trafficking, which is necessary for Rac ruffling, and another involved in protrusion formation.

122 ble to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth fac

123 stimulated lamellipodial extension, membrane ruffling, and chemotaxis of immortalized NLT GnRH neuron

124 embrane bound vacuoles formed by projection, ruffling, and contraction of plasma membranes.

125 tivity, disassembly of F-actin, cessation of ruffling, and decay of chemoattractant signals.

126 ranslocation, growth factor-induced membrane ruffling, and DNA synthesis, indicating that PtdIns 3,4,

127 zed with respect to catalytic activity, heme ruffling, and electrochemical properties.

128 embrane and stimulates GTP loading, membrane ruffling, and filopodia formation.

129 red for growth hormone (GH)-induced membrane ruffling, and increases mitogenesis stimulated by platel

130 tion with cortical actin filaments, membrane ruffling, and lamellipodia formation, compared with wild

131 t for cell polarity, lamellipodial assembly, ruffling, and macropinocytosis.

132 ial actin, along with defects in protrusion, ruffling, and macropinocytosis.

133 owth factor-mediated proliferation, membrane ruffling, and migration.

134 ted G-actin accumulation and plasma membrane ruffling, and Myo1c knockdown confirmed its contribution

135 hepatocyte autophagosomes, nuclear membrane ruffling, and porphyrin-containing vacuoles with endopla

136 , including surveillance movements, membrane ruffling, and process extension or retraction.

137 signaling induces motility, peripheral actin ruffling, and RhoA activation in MDA-MB-231 human breast

138 that CapG is required for receptor-mediated ruffling, and that it is a major functional component of

139 MLCK at the cell periphery controls membrane ruffling, and that the spatial regulation of MLC phospho

140 rvation of ORAI1-CTTN co-localization during ruffling, and the inhibition of membrane ruffling by the

141 led to become polarized, to undergo membrane ruffling, and to migrate in response to chemokine stimul

142 in localized actin polymerization, membrane ruffling, and, ultimately, pathogen entry.

143 ided that actin-myosin assembly and membrane ruffling are regulated by distinct signaling pathways in

144 proliferation, cell morphology, and membrane ruffling are suppressed by the TRQQKRP motif deletion.

145 a regulator of the cytoskeleton at membrane ruffling areas.

146 phagocytosis process was required to inhibit ruffling as BMM from Fc gamma (-/-) mice that bound C. n

147 roblasts PAK1 localizes to areas of membrane ruffling, as well as to amiloride-sensitive pinocytic ve

148 sphorylation and blocked peripheral membrane ruffling, as well as turnover of focal adhesions and cel

149 of RalA or Sec5 results in reduced membrane ruffling at sites of attachment and impairs bacterial en

150 lipodium, a response accompanied by membrane ruffling at the cell margin.

151 ts demonstrated that SOCE regulates membrane ruffling at the leading edge of cells.

152 on of the PI(4,5)P(2) biosensor and membrane ruffling at the opposite side of the cells.

153 ack to the plasma membrane (PM) and also for ruffling at the PM induced by Rac.

154 We have developed a ruffling-based translocation reporter system that uses t

155 d Ras(V12) mutant induces prominent membrane ruffling, branching morphogenesis on three-dimensional c

156 telet-derived growth factor-induced membrane ruffling but not Bradykinin-induced filopodia formation.

157 439 and Tyr-494 inhibits GH-induced membrane ruffling but still activates JAK2.

158 t the DN construct had no effect on membrane ruffling, but dramatically inhibited stress fiber and fo

159 In contrast, membrane ruffling, but not cell contraction, requires Rac GTPase

160 6%, GLUT4 translocation by 35%, and membrane ruffling by 50%, all of which are phosphatidylinositol 3

161 Dominant-negative Akt inhibited membrane ruffling by 54%; however, R25C-Akt did not have any effe

162 tors stimulate actin remodeling and membrane ruffling by integration of signaling pathways that regul

163 control membrane protrusion, retraction and ruffling by local illumination in both COS7 cells and in

164 )-induced chemotaxis was to promote membrane ruffling by regulating phosphatidylinositol 3,4,5-trisph

165 STIM1 and ORAI1 in the promotion of membrane ruffling by showing that phospho-STIM1 localizes at the

166 ing ruffling, and the inhibition of membrane ruffling by the Ca(2+)-channel inhibitor SKF96365, furth

167 distinct linear or circular/dorsal membrane ruffling, c-Abl-null cells demonstrated dramatically red

168 y, (3) for sterically encumbered porphyrins, ruffling can actually result in hypsochromic shifts in v

169 iverse cellular functions including membrane ruffling, cell cycle progression, and transformation.

170 in Rac1 signalling, trigger optimal membrane ruffling, cell migration and invasion.

171 eading, lamellipodia formation, and membrane ruffling, cell morphologies generated by active Rac1.

172 also induces actin reorganization, membrane ruffling, cell spreading, polarization, and migration.

173 In ruffling cells, alpha 5-GFP and alpha-actinin--GFP local

174 ggested to contain a large component of heme ruffling, consistent with the imidazole-bound ferrous he

175 ious assignments of gammaa as having a large ruffling content.

176 out-of-plane deformations, mainly along the ruffling coordinate.

177 , local PI(3,4,5)P(3) synthesis and membrane ruffling could be induced, with corresponding loss of ru

178 the electron transfer rates and suggest that ruffling could play an important role in redox control.

179 This ruffling defect was quantified using a newly developed m

180 of p85alpha or p85beta rescues the membrane ruffling defect.

181 eme plane, show strong correlations with the ruffling deformation and the average twist angle of the

182 n the F7A mutant, which has nearly twice the ruffling deformation as the WT.

183 e (EPR) g-tensor at several points along the ruffling deformation coordinate.

184 Consequently, the heme ruffling deformation decreases the electronic coupling o

185 The ruffling deformation of its heme cofactor has been sugge

186 could be induced, with corresponding loss of ruffling distally to the illuminated region.

187 atives of NP4 with different degrees of heme ruffling distortion are also investigated.

188 The heme is markedly nonplanar, displaying a ruffling distortion postulated to contribute to stabiliz

189 epends quadratically on the magnitude of the ruffling distortion.

190 gest a role of N-WASP in regulating membrane ruffling downstream of phosphatidylinositol 4,5-bisphosp

191 e inhibitory effect on growth factor-induced ruffling dynamics.

192 reading and is also shown to localize to the ruffling edge of spreading cells, indicating a function

193 This was associated with decreased membrane ruffling, failure to establish cell polarity, and loss o

194 n actin-dependent processes such as membrane ruffling, filopodial protrusion, and cell motility.

195 Consistent with membrane ruffling, gonococci were found residing within macropino

196 the electronic structure and its response to ruffling has been established.

197 tin cytoskeleton reorganization and membrane ruffling in 3T3-L1 fibroblasts and Rat1 cells that stabl

198 hat FKN or CSF-1 stimulated strong transient ruffling in both LR5 cells and BMM.

199 A major relaxation of heme ruffling in cytochrome c, upon binding to the mitochondr

200 additional effects of ASAP1 on PDGF-induced ruffling in fibroblasts suggest that multiple Arf GAPs f

201 he distribution of caveoli and reduce dorsal ruffling in human skin fibroblasts.

202 inositol-3 kinase is required for tumor edge ruffling in N and S cells, with stimulation of focal adh

203 lculations presented here show that the heme ruffling in NP2 is a consequence of the interaction with

204 he CSF1R/IRDelta960 rapidly induced membrane ruffling in Rat1 fibroblasts.

205 ekin leads to loss of Rho-dependent membrane ruffling in response to epidermal growth factor, an incr

206 null cells demonstrated dramatically reduced ruffling in response to PDGF, which was rescued by physi

207 sing the Coronin 1B S2A mutant show enhanced ruffling in response to phorbol 12-myristate 13-acetate

208 The degree of ruffling in the heme cofactor of Hydrogenobacter thermop

209 As the degree of ruffling increases, the heme methyl (1)H resonances move

210 onstitutively active RacV12 induces membrane ruffling, increases PI4KIIbeta translocation to the plas

211 whereas the knockdown of PTP-PEST increased ruffling independent of oxidase activation.

212 s of SH2-Bbeta are shown to inhibit membrane ruffling induced by constitutively active Rac.

213 n receptor (HIRc-B), SHIP inhibited membrane ruffling induced by insulin and IGF-I by 76 +/- 3% (P <

214 there was no significant change in membrane ruffling induced by PMA in the cells expressing rPLD1-V5

215 of actin stress fibers and inhibits membrane ruffling induced by Rac.

216 SP deficient cells, CP depletion resulted in ruffling instead of filopodia.

217 Gonococcal induced ruffling is a novel finding and may be unique to the cer

218 Since cell ruffling is a prelude to chemotaxis, this observation li

219 ements on cytochrome c demonstrate that heme ruffling is correlated exponentially with the electron t

220 The degree of heme ruffling is coupled to the nature of the ligand and the

221 the modestly nonplanar porphyrins, porphyrin ruffling is found to cause a decrease in binding affinit

222 lls inhibited alpha6beta4-dependent membrane ruffling, lamellae formation, and migration.

223 bly nucleated by the Arp2/3 complex, forming ruffling lamellipodia.

224 on that showed CADTK at the leading edge and ruffling lamellipodial structures in freshly isolated, a

225 he Rho-family GTPases that promotes membrane ruffling, leading edge extension, and cell spreading.

226 e host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium.

227 l polarity, lamellipodial assembly, membrane ruffling, macropinocytosis, and collective cell migratio

228 Thus, ruffling may stabilize the Fe(III)-NO state, which is re

229 iety, possibly through protein-assisted heme ruffling, may lead to a nitrosyl-heme complex that is un

230 also play critical roles in the formation of ruffling membrane, microtubules provide an important tra

231 I isoform that concentrates on endosomal and ruffling membranes and is thought to play roles in membr

232 complex is translocated from the cytosol to ruffling membranes upon cell activation by serum.

233 67phox or Noxa1) colocalize with Rac1 within ruffling membranes, independently of their ability to bi

234 ediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis.

235 y by inducing membrane protrusions including ruffling movements.

236 ivity of this variant to the diminished heme ruffling observed for heme bound to this enzyme and conc

237 Heme ruffling occurs in both structures, apparently due to cl

238 Furthermore, Myo1c-induced membrane ruffling of 3T3-L1 adipocytes is also compromised follow

239 flattening, reduction of actin mesh density, ruffling of cortical actin, and mobilization of SGs.

240 ) stimulation, regulates PDGF-induced dorsal ruffling of fibroblasts and axonal morphogenesis, and co

241 In the first, MAC induced ruffling of HEp-2 cell membrane and formation of surface

242 ization of the cell's actin cytoskeleton and ruffling of its membrane.

243 these studies indicate that (1) substantial ruffling of porphyrins has a negligible effect upon thei

244 About half of the modulation is due to ruffling of the bacteriochlorin chromophore.

245 adhesion stability that appears in increased ruffling of the cell edge, reduced adhesion size, transi

246 r carbachol caused stretching and peripheral ruffling of the cytoplasmic aprons, and formation of new

247 mutant, ARF6(Q67L), led to a loss of AJs and ruffling of the lateral plasma membrane via mechanisms t

248 These amides are chiral due to the inherent ruffling of the macrocyclic plane.

249 ced exocytosis of melanosomes accompanied by ruffling of the melanocyte membrane.

250 Invasion was accompanied by extensive ruffling of the membranes of the HEp-2 cells.

251 10.5 have a neural-tube closure defect with ruffling of the neural fold ridges, a yolk sac erythropo

252 lipid droplets, and the rapid and transient ruffling of the nuclear periphery.

253 t of extraembryonic malformations, including ruffling of the yolk sac membrane, defective extraembryo

254 lin led to actin polymerization and membrane ruffling on cells, with the specific co-localization of

255 The effects of ruffling on the axial ligation properties of a series of

256 e assembly, and extensive protrusive lateral ruffling on TSP-1 or on syndecan-1 antibody.

257 wever, EWI-2 markedly impaired spreading and ruffling on VCAM-1.

258 h DFT retain the characteristic saddling and ruffling only if the protein matrix is taken into accoun

259 lthough Trk and EGFR each stimulate membrane ruffling, only Trk undergoes both selective and specific

260 We demonstrate correlations between the heme ruffling OOP deformation and the (13)C and (1)H nuclear

261 LPS did not induce membrane ruffling or macropinocytosis in enterocytes, excluding t

262 om Rac1 in its ability to stimulate membrane ruffling or to interact with SmgGDS and IQGAP1-calmoduli

263 2152) is required for Pak1-mediated membrane ruffling, our results suggest a novel role for RSK in th

264 ncreasing cytosolic Ca(2+) enhances membrane ruffling, PI3K activity, and F-actin accumulation.

265 sma membrane and its mobilization to dynamic ruffling protrusions at the cell front.

266 he elastic moduli of the C domain and T zone ruffling region ranged between 3-7 and 7-23 kPa, respect

267 rophage colony stimulating factor-stimulated ruffling; reintroduction of CapG protein by microinjecti

268 lating factor resulted in a reduction in the ruffling response of CapG(-/-) cells compared to the res

269 ion by sucrose treatment did not inhibit the ruffling response.

270 l locomotion, spreading, actin assembly, and ruffling responses.

271 nts also indicate significant differences in ruffling-sensitive modes, particularly the low-frequency

272 Cell ruffling, spreading, and cell adhesion were dependent on

273 mulated by bradykinin and in dorsal membrane ruffling stimulated by PDGF, whereas the Cdc42GAP(-/-) c

274 a dominant negative mutant, blocked membrane ruffling, suggesting that PIPKIalpha and PIP2 participat

275 hat heme binds to this enzyme with less heme ruffling than observed for wild-type IsdI.

276 1 cells but does inhibit the active membrane ruffling that is necessary for cell polarization.

277 Membrane ruffling then becomes polarized, leading to an elongated

278 Active TRAF4 initiated robust membrane ruffling through Rac1, PAK1, and the oxidase, whereas th

279 tion from stress fiber formation to membrane ruffling to confer an invasive phenotype.

280 irulence effectors elicit host cell membrane ruffling to facilitate pathogen invasion.

281 Salmonella species trigger host membrane ruffling to force their internalization into non-phagocy

282 tin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cells, where

283 established its ability to promote membrane ruffling, transformation, and activation of c-jun transc

284 r roles in actin rearrangements and membrane ruffling, translocated effectors also affect host cell p

285 onal phagocytosis, coiling phagocytosis, and ruffling/triggered macropinocytosis.

286 and anti-PSR antibodies stimulated membrane ruffling, vesicle formation, and "bystander" uptake of c

287 inhibition of FKN- or CSF-1-stimulated cell ruffling was a direct consequence of the phagocytosis pr

288 The PDGF- and Rac1-stimulated ruffling was inhibited by expression of kinase-dead PIPK

289 This stimulated cell ruffling was inhibited by phagocytosis in an intracellul

290 The inhibition of ruffling was not simply a result of reduced membrane ava

291 d cytoskeletal rearrangement, i.e., membrane ruffling, was significantly inhibited (78 +/- 10, 64 +/-

292 telet-derived growth factor-induced membrane ruffling, we investigated whether NIH 3T3 cells stably e

293 nduce formation of lamellipodia and membrane ruffling, when transiently expressed in fibroblasts, ind

294 rapidly translocated to regions of membrane ruffling, where it colocalizes with polymerized actin.

295 e Mtss1-GFP promoted the PDGF-induced dorsal ruffling, whereas overexpression of a mutant deficient i

296 inding p47phox domain decreased VEGF-induced ruffling, whereas the active mutant p4-(S303D, S304D,S32

297 phenotypes did not correlate with peripheral ruffling, which was unaffected, Abi1-KO cells exhibited

298 induced lamellipodia formation and membrane ruffling, which was unrelated to the substrate domain ph

299 doses caused process retraction and membrane ruffling, which were blocked by joint application of P2Y

300 ymerization-dependent spreading and membrane ruffling while Rac1-independent BCR capping remains inta