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3 SI-2 meets all of the criteria of Lipinski's rule for a drug-like molecule and has a half-life of 1 h
4 learning rule, we present an online learning rule for a recurrent neural network that achieves near-m
5 a subset of bacterial OSTs follow their own rules for acceptor-site specificity, thereby expanding t
7 structure given the task of defining uniform rules for access to and distribution of health care, ben
8 h the circularly polarized optical selection rules for addressing individual valley excitons and trio
9 ign of ligands targeting RNA has established rules for affecting RNA targets and provided a potential
10 n inference to identify three key behavioral rules for aggregation: cluster-edge reversals, a density
11 a variety of locations follow a generalized rule: for all nerve pathway origins, the soma cluster ce
13 In this review, five of the effective design rules for approaching LBG semiconducting polymers with h
14 te the efficacy of this 'Eighty Five Percent Rule' for artificial neural networks used in AI and biol
16 ssifications and structural analyses provide rules for assigning current and future human RBD-targeti
18 4.1, Glt1, and Ca(2+) The data show that the rules for astrocyte engagement in a neuronal circuit are
19 a(2+)and glutamate indicators to explore the rules for astrocyte engagement in the corticostriatal ci
20 linear discriminant analysis, classification rules for authentic and paraffin adulterated beeswax sam
22 al principles for AI, and derived evaluation rules for autonomous AI, grounded in bioethical principl
23 in a generative model, we investigate growth rules for axonal branching patterns in cat area 17, orig
24 and February 2013 (when predefined stopping rules for benefit were met) and outcome evaluations cont
26 'runaway transcription' creates alternative rules for both global RNA surveillance and translational
27 SC-like structures provide insight into the rules for building and maintaining the SC by offering an
28 what these structures can tell us about the rules for building the SC and the roles of the SC in mei
29 sed on our experiences, we present 10 simple rules for busy faculty who want to create similar progra
30 Consequently, progress in developing design rules for cancer nanomedicines has been slow, hindering
32 ed to derive three additional classification rules for case subjects and one for control subjects.
33 t, and recently on bacteria, have identified rules for cell size regulation in single cells, but in t
34 ISECT) to identify the heterogeneous binding rules for cell-type-specific TF occupancy and analyze th
35 normal cell function and delineate possible rules for cellular geometry maintenance in populations o
39 during evolution, and Hebbian-like learning rules for clusters where neurons increase their synchron
42 y validate two previously derived prediction rules for community-onset (CO) and hospital-onset (HO) s
43 the first steps toward developing synthetic rules for complex two-dimensional covalent organic chemi
52 nd this large amount of new information, new rules for crystal growth need to be developed and tested
53 the inter-Landau-level transition selection rules for dark trions, manifested by a distinctively dif
56 temperature programs and instituted a set of rules for defining the separation of OC and EC to quanti
59 s improved understanding, we propose several rules for designing experiments for minimizing off-targe
60 ifying new Env-host cell receptor pairs, the rules for designing optimal Env libraries are still uncl
63 itivity analyses revealed that modifying the rule for determining vulnerability increased the vulnera
65 ent sorts of input, forms of processing, and rules for determining the output are appropriate under d
68 ITDP may provide a general synaptic learning rule for distinct forms of hippocampal-dependent memory
69 which RNAs conforming to the strict sequence rules for DNA.RNA triplex formation may participate in f
71 t algorithm that properly addresses all SBGN rules for drawing PD maps, including placement of substr
75 ings establish ganglionic eminence-dependent rules for early synaptic integration programs of distinc
76 ticular food web matrix properties as design rules for economically and biologically sustainable indu
78 vestigate single-guide RNA (sgRNA) targeting rules for effective transcriptional activation, to demon
80 ogether these properties define the temporal rules for efficient information transfer at DG-CA3 synap
81 dented opportunity to investigate the design rules for efficient nanoparticle occlusion within host i
86 und, we have identified new materials design rules for emerging sodium-ion systems that do not apply
87 ndent plasticity (STDP), a synaptic learning rule for encoding learning and memory, relies on relativ
89 electronic-based discussion, following clear rules for establishing consensus and agreement/disagreem
94 atibilities in a rare exception to Haldane's rule for female sterility in field cricket sister specie
96 , derived from the histograms, traffic-light rules for frequently observed, rare, and highly unlikely
97 for inhibitory neurons, suggesting different rules for functional excitatory-inhibitory interactions
98 Finally, we observe that there are general rules for functional molecular motors across the differe
101 In accordance with a prespecified stopping rule for futility of finding one drug to be superior or
102 ials (n = 36 per group), additional stopping rules for futility lead to the saving of resources of up
103 s a step toward establishing a set of design rules for future immunotherapies, materials that intrins
106 ment specific enhancements, such as negation rules for general practitioners' entries and a regular e
107 ic tissue-specific genes, uncover regulatory rules for generating diverse gene expression patterns, a
109 and propose a new probabilistic analysis of rules for glass forming ability using rough set theory.
110 e aromaticity, combined with Huckel's 4n + 2 rule for ground-state aromaticity, to tailor new potenti
113 DNA </= 2 x 10(5) IU/mL, the APASL stopping rule for HBeAg-negative CHB patients with proper off-the
114 The sensitivities of three clinical decision rules for head injuries in children were high when used
119 urthermore, this approach may reveal general rules for how circuit structure and neural coding within
121 t guilds, suggesting that there may be basic rules for how sets of antagonists interact with resource
122 membrane proteins must be recovered, but the rules for how this multiple cargo selection is accomplis
123 Using these results, we postulated a folding rule for i-motif formation, analogous to (but different
124 guide future research by delineating several rules for identifying appropriate templates and molecula
126 dy was the first to establish classification rules for identifying CRS in school-aged children, using
128 igators to train and evaluate classification rules for identifying objects related to processes like
132 two dimensions, one can similarly define ice rules for in-plane Ising-like spins arranged on a kagome
134 the system automatically generates low-level rules for independent climbing robots that guarantee pro
136 ceptors to control the efficacy and temporal rules for information transfer at DG-CA3 connections.
142 the need for developing individual agronomic rules for iodine biofortification of carrot for: (a) con
150 provides a powerful heterosynaptic learning rule for long-term gating of information flow through th
152 labeling experiments as a central filtering rule for maximizing phosphopeptide identification and qu
156 ed that long-term persistence (>1 y) was the rule for most dsDNA viruses observed, suggesting that bo
163 e scientific community to develop consistent rules for nomenclature of uncultivated taxa in order to
167 nt dimensionality regimes informs new design rules for optical devices where complex microstructures
173 ial databases, we sought to develop stopping rules for patients destined to fail boceprevir-based com
177 can be prevented by precisely balancing STDP rules for potentiation and depression; however, experime
178 hat represents a novel methodology to define rules for predicting gene function by examining the emer
180 reaction led to the development of powerful rules for predicting the regioselectivity of borylation,
181 stic acceptance of it to evaluate prediction rules for primary prevention of cardiovascular disease.
183 results provide important and useful design rules for QD-based light harvesting applications using t
185 vations and physical model establish general rules for raft partitioning of TMDs and support the cent
188 subtle material issues of control and design rules for reconfigurable dipolar materials with building
189 marking reveals distinctive factor-specific rules for recruitment of these crucial transcription fac
192 ate how to implement a sequential monitoring rule for safety using a completed phase I trial that inc
193 The system generates candidate names using rules for scientific names and applies probabilistic mac
194 vailability of electronic media and parental rules for sedentary behaviours was self-reported by chil
197 s transplanted bacterial enzyme, and provide rules for selecting Cas9 target sites distinct from and
198 ve inhibitors targeting these sites, but the rules for selective targeting of site 3 are less clear.
199 iews, peer interviews, scores using an "and" rule for self- and peer reports, and separate tests for
201 extrinsic plasticity (DEP) as a new synaptic rule for self-learning systems and apply it to a number
204 formly distributed over its surface, and the rules for self-replication are encoded into the specific
205 any have viewed microbes as following strict rules for shifting their metabolic activities when preva
206 orrhage score is a valid clinical prediction rule for short-term mortality in intracerebral hemorrhag
207 Our observations allowed for deducing a rule for SLC6 family members: a hydrophobic residue (Tyr
208 alized to the compliance with another set of rules for social interactions, namely the fairness norm,
210 rm competition, (ii) use the same allocation rules for sperm and seminal fluid, and (iii) experience
211 structure-activity relationships and design rules for spherical nucleic acids (SNAs) functioning as
212 re to nicotine during adolescence alters the rules for spike timing-dependent plasticity in prefronta
213 dividual release sites also revealed general rules for spontaneous and evoked release, and indicate t
214 d Protection Agency (EPA) proposed a revised rule for "Standards of Performance for Greenhouse Gas Em
215 ve ability of the CHA(2)DS(2)VASc prediction rule for stroke and death in a nonanticoagulated populat
216 y new metabolites and development of general rules for structural determination of tagged metabolites
217 lometric method harnessing normative scaling rules for subcortical size and shape in humans, which we
227 urones in the inferior olive implement novel rules for synaptic integration and suggest new principle
228 are robustly expressed, suggesting different rules for synaptic plasticity across these regions.
229 c events in a wide temporal window, and that rules for synaptic plasticity in human neocortex are rev
233 emical and genetic analyses to delineate the rules for TAM receptor-ligand engagement and find that t
237 at allows the formulation of a new empirical rule for the direct assignment of the C2 stereochemistry
239 n described by the 70% proportional recovery rule for the Fugl-Meyer motor upper extremity (FM-UE) sc
241 which provides a hitherto unexpected design rule for the incorporation of nanoparticles within cryst
243 interactions between networks play a crucial rule for the outcome of evolutionary games taking place
244 iously explained by an economical clustering rule for the probability of functional connectivity betw
245 We unambiguously demonstrated the solvation rule for the solid-electrolyte interphase (SEI) enabler
249 This review seeks to set the basic ground rules for the analysis of different initiation pathways
251 icomponent droplets is still incomplete, and rules for the coexistence of condensed phases are lackin
254 AD co-oligomer and therefore to draw general rules for the design of PDI-based dyads and triads with
255 the mathematics of tessellations, we derive rules for the design of single CMPs that self-assemble i
256 ds have been condensed into a set of general rules for the design of thermostable CHA circuits with h
261 e segment, providing simple geometric design rules for the fabrication of complex 3D structures.
265 colleagues, has developed DSSs and decision rules for the management of diseases in a variety of cro
266 mmunity ecology, as a way of finding general rules for the mechanisms driving changes in community st
267 sualize the resulting networks, defining the rules for the molecular interactions typically requires
268 ved of these CTCF interactions have specific rules for the orientation of the paired CTCF sites, impl
272 of these experiments provide a set of ground rules for the successful engineering of hr-PKS and PKS-N
274 ent literature regarding clinical prediction rules for the use of cranial computed tomography (CT) in
275 rto overlooked dependence on (or 'propensity rule' for) the magnetic quantum number m of the molecule
278 lack of a clear physical picture and design rule for this device has led to numerous invalid fabrica
279 are few organizational principles or guiding rules for this highly hysteretic, dissipative material.
280 ditis elegans, uncovering a conserved set of rules for this protein modification and identifying subs
281 e an important exception to temperature-size rules for three reasons: (i) we use many more species th
282 d Drug Administration (FDA) issued the final rule for title 21 of Code of Federal Regulations part 21
284 cal structural descriptors to derive general rules for trapping molecules in high-energy conformation
285 progressed, and use of a CVR-based decision rule for treatment in which patients with CVR impairment
289 a range of force-fields), we derived robust rules for urea unfolding that are valid at the proteome
290 ant next step would be to develop prediction rules for use in clinical practice, so that older person
292 and Drug Administration recently issued new rules for using ceftiofur in food animals in part becaus
294 This is discussed in terms of the general rules for Voronoi patterns (Dirichlet tessellations) in
296 ediction error, with an approximate Bayesian rule, for which beliefs in latent states are proportiona
297 e resulting model combines a Rescorla-Wagner rule, for which updates to associations are proportional
300 lectric material, cannot be a general design rule for ZT enhancement and a detailed transport study i