ライフサイエンスコーパス: ryanodine receptor

1 consistent with no major modification of the ryanodine receptor.

2 CaMKIIdelta-dependent phosphorylation of the ryanodine receptor.

3 A1er in cells cotransfected with SERCA2a and ryanodine receptor.

4 arcoendoplasmic reticulum calcium ATPase and ryanodine receptor.

5 that these phenotypes are caused by a leaky ryanodine receptor.

6 proteins is to inhibit calcium release from ryanodine receptors.

7 g), an effect dependent on the activation of ryanodine receptors.

8 ic Ca(2+) release via activation of neuronal ryanodine receptors.

9 ge of the APP-ICD and involves activation of ryanodine receptors.

10 te-mediated ER-calcium efflux occurs through ryanodine receptors.

11 lization via inositol-1,4,5-triphosphate and ryanodine receptors.

12 state of calcium release channels, i.e. the ryanodine receptors.

13 drugs can be attributed to their actions at ryanodine receptors.

14 cortical neurons from wild-type (WT) and/or ryanodine receptor 1 ([Formula: see text]) mice between

15 Mutations in ryanodine receptor 1 (RyR1) are often associated with my

16 Mutations in the ryanodine receptor 1 (RYR1) gene are associated with sev

17 e tubule membrane and Ca(2+) release channel ryanodine receptor 1 (RyR1) in the sarcoplasmic reticulu

18 Recessive ryanodine receptor 1 (RYR1) mutations cause congenital m

19 nocked out for MTM1 show severe reduction of ryanodine receptor 1 mediated calcium release but, since

20 was to determine the influence of the R163C ryanodine receptor 1 mutation, a common MH mutation in h

21 by recessive RYR1 mutations is a decrease of ryanodine receptor 1 protein content in muscle.

22 a significant decrease in expression of the ryanodine receptor 1, a decrease in muscle-specific micr

23 lipid on the skeletal muscle calcium channel ryanodine receptor 1, a negative effect on the structure

24 sis and calcium release mediated through the ryanodine receptor 1, though they do affect myotube size

25 stic insight into the causes of this reduced ryanodine receptor 1.

26 the sarcoplasmic reticulum (SR) that include ryanodine receptor 2 (RyR2) clusters.

27 ng and upregulation of the ER Ca(2+) channel ryanodine receptor 2 (RyR2) have been implicated in cone

28 c reticulum can be normalized by the cardiac ryanodine receptor 2 (RyR2) inhibitor, dantrolene, witho

29 calmodulin-protein kinase (CaMKII) activity, ryanodine receptor 2 (RyR2) phosphorylation and sarcopla

30 either 1a or 1b shRNA, but native KCNE1 and ryanodine receptor 2 (RYR2) transcripts were unaffected.

31 Mutations in ryanodine receptor 2 (RyR2), a Ca(2+) release channel lo

32 regulates the cardiac Ca(2+) release channel/ryanodine receptor 2 (RyR2), and mutations in CaM cause

33 ew, we focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reti

34 diated amplitude and frequency modulation of ryanodine receptor 2 (RyR2)-mediated Ca2+ oscillations a

35 mic reticulum Ca(2+)-ATPase 2b (SERCA2b) and ryanodine receptor 2 (RyR2).

36 of cardiac calcium release channels [cardiac ryanodine receptor 2 (RyR2)] at doses threefold lower th

37 and spark activity, a cellular phenotype of ryanodine receptor 2 activation.

38 ytes isolated from mutant mice that have the ryanodine receptor 2 calcium and calmodulin-dependent pr

39 to evoke arrhythmogenic Ca disturbances via ryanodine receptor 2 dysregulation, which explains the a

40 protein kinase A-dependent phospholamban and ryanodine receptor 2 phosphorylation (-42+/-9% for P-pho

41 FRD-S2814A mice, in which the CaMKII site on ryanodine receptor 2 was ablated.

42 hosphorylation of CaMKII, phospholamban, and ryanodine receptor 2 was detected in the postarrest peri

43 ng this notion, we found expression of RYR2 (Ryanodine Receptor 2) and SERCA2 further increased by co

44 PKP2 reduces expression of Ryr2 (coding for Ryanodine Receptor 2), Ank2 (coding for Ankyrin-B), Cacn

45 nations in the inactivation of cardiac RyR2 (ryanodine receptor 2).

46 urement of CaM-Ca(2+) (Ca)-binding affinity, ryanodine receptor 2-CaM binding, Ca handling, L-type Ca

47 % for P-phospholamban-S16 and -22+/-7% for P-ryanodine receptor 2-S2808; P<0.05).

48 us WT-CaM), but did not alter CaM binding to ryanodine receptor 2.

49 ent phosphorylation of phospholamban and the ryanodine receptor 2.

50 /endoplasmic reticulum Ca(2+)-ATPase], RyR2 [ryanodine receptor 2], and PLB [phospholamban]) was foun

51 of SN were investigated in CPVT mice (RyR2 [ryanodine receptor 2]-R2474S) using adeno-associated vir

52 ed "leaky" gain-of-function mutations in the ryanodine receptor-2 (RyR2) gene in both SUDEP and sudde

53 hat phosphorylate the Ca(2+)-release channel-ryanodine receptor-2, PKA, and calmodulin-dependent prot

54 ivity increased in cardiomyocytes, and (iii) ryanodine receptor-2-mediated calcium oscillations incre

55 TRAIL-DR-mediated ryanodine receptor activation and endocytosis is depende

56 aMKIIdelta binding and CaMKIIdelta-dependent ryanodine receptor activation in adult cardiac myocytes.

57 hanism of neferine-induced autophagy through ryanodine receptor activation in resistant cancers.

58 from the cortical endoplasmic reticulum via ryanodine receptor activation.

59 olved in maintaining ER Ca(2+) by inhibiting ryanodine receptor activity and playing a role in termin

60 ce or absence of SR K(+) -channels influence ryanodine receptor activity.

61 exor digitorum brevis (FDB) fibers, either a ryanodine receptor agonist (4-chloro-meta-cresol) or dep

62 n of skeletal muscle proteins, including the ryanodine receptor and calcium (Ca(2+)) release channel

63 ucifera, induces autophagy by activating the ryanodine receptor and calcium release.

64 functional interaction (cross talk) between ryanodine receptor and IP(3)R channels on the Ca(2+) tra

65 ion of key Ca2+ handling proteins, including ryanodine receptor and phospholamban.

66 ound for a direct gating interaction between ryanodine receptor and SR K(+) -channels in Tric-a KO SR

67 not subject to retrograde coupling with the ryanodine receptor and that the retrograde coupling mech

68 y response, due to biphasic behaviour of the ryanodine receptor and the combined effect of the rapid

69 lcium mobilization through the activation of ryanodine receptor and Ulk-1-PERK and AMPK-mTOR signalin

70 (2+) channels and endoplasmic reticulum (ER) ryanodine receptors and another between ryanodine recept

71 unolabeling demonstrated close apposition of ryanodine receptors and BK channels.

72 ated in the sarcoplasmic reticulum membrane (ryanodine receptors and inositol 1,4,5-trisphosphate rec

73 (ER) ryanodine receptors and another between ryanodine receptors and large-conductance, voltage- and

74 We identify ryanodine receptors and plasma membrane L-type calcium c

75 horylation of L-type Ca(2+) channels (LCCs), ryanodine receptors and sodium (Na(+)) channels.

76 ositol 1,4,5-trisphosphate receptor channel, ryanodine receptor, and Ca(2+)-binding proteins inside o

77 ed by dysfunction of sarco/ER Ca(2+) ATPase, ryanodine receptor, and inositol 1,4,5-trisphosphate rec

78 mic reticulum into the mitochondrion through ryanodine receptors, and the resultant mitochondrial cal

79 of IP3 IP3 potentiation was also blocked by ryanodine receptor antagonist.

80 s are obtained if CaMKII effects on LCCs and ryanodine receptors are considered separately.

81 Ca release channels such as IP3 receptors or ryanodine receptors arranged in clusters (release units)

82 AIPR-1 is physically associated with the ryanodine receptor at synapses.

83 ersecretion are reversed by mutations in the ryanodine receptor but not in the voltage-gated calcium

84 perthermia-triggering agent halothane or the ryanodine receptor Ca channels agonist 4-chloro-m-cresol

85 with and disrupt the function of the cardiac ryanodine receptor Ca(2+) release channel (RyR2) in the

86 nnel dihydropyridine receptor (DHPR) and the ryanodine receptor Ca(2+) release channel.

87 ), leading to diminished BKCa activation via ryanodine receptor Ca(2+) release channels (RyRs), causi

88 in 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca(2+) release, reverses aging-induce

89 Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel (RyR1) display

90 as the genetic cause of CPVT: RYR2 (encoding ryanodine receptor calcium release channel), CASQ2 (enco

91 The ryanodine receptor channel cluster structure inside dyad

92 pendent phosphorylation of the cardiac RyR2 (ryanodine-receptor channel type-2), and RyR2 single-chan

93 When co-incorporated into bilayers, ryanodine receptor channels did not directly affect the

94 lasmic reticulum (SR) Ca(2+) release through ryanodine receptor channels gated by conformational coup

95 aves originating from random fluctuations of Ryanodine receptor channels, and which occur after much

96 on of individual L-type calcium channels and ryanodine receptor channels, spatially detailed concentr

97 e to the activation of reticulum endoplasmic ryanodine receptor channels.

98 for the myospryn complex in the assembly of ryanodine receptor clusters in striated muscle.

99 t-system structure, density, and distance of ryanodine receptor clusters to the sarcolemma, including

100 exit from the ER further depends on IP3 and Ryanodine receptor-controlled Ca(2+) release as well as

101 uction of priming by an EsRalpha agonist was ryanodine receptor-dependent and prevented by the IP3 an

102 t, which in turn lowers [Ca(2+)](ER) through ryanodine receptor-dependent Ca(2+)-induced Ca(2+) relea

103 in chronification in the rat, is mediated by ryanodine receptor-dependent calcium release.

104 lar Zn(2+) induces a significant increase in ryanodine receptor-dependent cytosolic Ca(2+) transients

105 sult also leads to Kv2.1 redistribution in a ryanodine receptor-dependent fashion.

106 odine, and the ERalpha agonist, PPT, induced ryanodine receptor-dependent priming.

107 ate a profound regulatory role of ERalpha in ryanodine receptor-dependent transition to chronic pain.

108 Ryanodine itself modulates ryanodine-receptor-dependent Ca(2+) release in many orga

109 yperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemma

110 ely 'packed' with L-type Ca(2+) channels and ryanodine receptors during development, and 'unpacked' d

111 (2+) channels trigger release of Ca(2+) from ryanodine receptors for cellular contraction, whereas si

112 doplasmic reticulum Ca(2+) ATPase levels and ryanodine receptor function modulation, leading to norma

113 e addressed whether Zn(2+) modulates cardiac ryanodine receptor gating and Ca(2+) dynamics in isolate

114 Mutations in the skeletal muscle ryanodine receptor gene (RYR1) can cause susceptibility

115 severe muscle weakness, and mutations in the ryanodine receptor gene (RYR1) represent the most freque

116 RATIONALE: Mutations in the cardiac Ryanodine Receptor gene (RYR2) cause dominant catecholam

117 ssociation of the Calstabin protein from the ryanodine receptor has been shown to result in reduced m

118 ripartite motif family-like PRY SPla and the RYanodine Receptor immune recognition domain.

119 ould result in 50% reduced expression of the ryanodine receptor in skeletal muscle, but its observed

120 Local activation of ryanodine receptors in terminals with a spatially confin

121 ignificantly potentiated calcium release via ryanodine receptors induced by caffeine.

122 engers downstream of PKCepsilon, such as the ryanodine receptor, induces priming in both sexes.

123 content, both of which were prevented by the ryanodine receptor inhibitor tetracaine.

124 The ryanodine receptor ion channel RyR1 is present in skelet

125 odulate intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal

126 l triphosphate (IP(3)), IP(3) receptors, and Ryanodine receptors is required only for the maintenance

127 cal Ca(2+) imaging in myocytes and HEK-RyR2 (ryanodine receptor isoform 2-expressing human embryonic

128 alter binding affinity and selectivity among ryanodine receptor isoforms.

129 in LV myocytes, without affecting intrinsic ryanodine receptor leak or phosphorylation.

130 eration of the Ca transient due to increased ryanodine receptor leakiness and/or sarco/endoplasmic re

131 R function was impaired either by making the ryanodine receptor leaky (with caffeine or ryanodine) or

132 a high-affinity ligand for and modulator of ryanodine receptors-ligand-gated ion channels that are c

133 We show that TRAIL stimulation activates ryanodine receptor-mediated calcium release from endopla

134 action between endoplasmic reticulum IP3 and ryanodine receptor-mediated calcium signaling is present

135 ults suggest that improving the stability of ryanodine receptors might be useful to treat atrial fibr

136 ng voltage-gated Na and Ca channels, cardiac ryanodine receptors, Na/Ca-exchanger, and SR Ca-ATPase a

137 tes Ca(2+) spark parameters, a reflection of ryanodine receptor open probability, consistent with the

138 the protein expression of SERCA2a, PLN, and ryanodine receptor or in the PLN phosphorylation status.

139 pon inhibition of Ca(2+) release through the ryanodine receptors or inositol 1,4,5-trisphosphate rece

140 phosphate receptors but not by inhibition of ryanodine receptors or removal of extracellular Ca(2+).

141 roduction, posttranslational modification of ryanodine receptor, oxidative stress, proteolysis, and c

142 l formulas of the Ising model for respective ryanodine receptor parameters and SR Ca load that descri

143 protein modifications, which cause increased ryanodine receptor phosphorylation and downregulation of

144 /calmodulin-dependent protein kinase II and ryanodine receptor phosphorylation, were reduced by lept

145 We found that knockin alanine replacement of ryanodine receptor PKA (S2808) or CaMKII (S2814) target

146 In animals, cADPR targets the ryanodine receptor present in the sarcoplasmic/endoplasm

147 eased class II HDAC expression and decreased ryanodine receptor protein and miRNAs expression were al

148 onship between L-type Ca channels (LCCs) and ryanodine receptors results in markedly increased Ca con

149 The amino acid mutations in ryanodine receptor (RyR) and elevated activity of detoxi

150 Intracellular Ca(2+) release through ryanodine receptor (RyR) and inositol trisphosphate rece

151 , because dantrolene does not inhibit single ryanodine receptor (RyR) Ca(2+) release channels in lipi

152 2+) -induced Ca(2+) release (CICR) from j-SR ryanodine receptor (RyR) Ca(2+) release channels.

153 Here, we report ryanodine receptor (RyR) channel activity and Ca(2+) rel

154 The ryanodine receptor (RyR) channel pore is formed by four

155 inositol triphosphate receptor (InsP3 R) and ryanodine receptor (RyR) channels blocked ICC Ca(2+) tra

156 eletal muscle, and is localized closely with ryanodine receptor (RyR) channels in the SR terminal cis

157 ic reticulum, mediated by both the IP3R1 and ryanodine receptor (RyR) channels, requires physiologica

158 rcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels.

159 oscopy revealed subcellular heterogeneity of ryanodine receptor (RyR) density and the transverse tubu

160 ling of PM L-type Ca(2+) channels (LTCCs) to ryanodine receptor (RyR) ER Ca(2+) release channels.

161 1,4,5-trisphosphate receptor (IP3R) but not ryanodine receptor (RyR) expression was high in enamel c

162 Dantrolene is a ryanodine receptor (RyR) inhibitor, which is used to rel

163 We investigated effects of the ryanodine receptor (RyR) modulator caffeine on Na(+) cur

164 Ryanodine receptor (RYR) mutations confer stress-trigger

165 normal to long-lasting sparks can occur when ryanodine receptor (RyR) open probability is either incr

166 Moreover, a specific role for either ryanodine receptor (RyR) or inositol 1,4,5-triphosphate

167 ect and analyze the structural dynamics of a ryanodine receptor (RyR) peptide bound to calmodulin (Ca

168 from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca

169 on both refilling and the sensitivity of the ryanodine receptor (RyR) release channels that produce s

170 al studies reveal that the central domain of ryanodine receptor (RyR) serves as a transducer that con

171 the formation of disulfide bonds between two ryanodine receptor (RyR) subunits, referred to as inters

172 itol-1,4,5-triphosphate receptor (IP3R), and Ryanodine receptor (RyR), plays a major role in agonist-

173 in dendritic spines has been associated with ryanodine receptor (RyR), such that spines lacking SP re

174 Fourthly, a mutation in the Drosophila ryanodine receptor (RyR), which inhibits activity-induce

175 s is challenged, such as with suppression of ryanodine receptor (RyR)-evoked calcium signaling.

176 ular determinant of axonal growth, through a ryanodine receptor (RyR)-mediated Ca(2+) release mechani

177 om elevated L-type Ca2+ channel activity and ryanodine receptor (RyR)-mediated Ca2+ release, but unde

178 The latter is activated by ryanodine receptor (RyR)-mediated calcium (Ca(2+) ) rele

179 Alteration of ryanodine receptor (RyR)-mediated calcium (Ca(2+)) signa

180 arises from mutations on the skeletal muscle ryanodine receptor (RyR).

181 s regulation of the calcium release channel, ryanodine receptor (RyR).

182 ty at the thyroid hormone receptor (THR) and ryanodine receptor (RyR).

183 ntracellular calcium oscillation mediated by ryanodine receptor (RyR).

184 transient receptor potential A1 (TRPA1) and ryanodine receptor (RyR).

185 load: two stationary states, one with closed ryanodine receptors (RyR) and most calcium in the cell s

186 although evidence suggests they may regulate ryanodine receptors (RyR) via multiple mechanisms.

187 the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of th

188 motifs (EF1 and EF2) in the skeletal muscle ryanodine receptor (RyR1) functions as a Ca(2+) sensor t

189 lasmic reticulum (SR) Ca(2+) release channel/ryanodine receptor (RyR1) in the diaphragm.

190 een CaV1.1 in the plasma membrane and type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum

191 The type-1 ryanodine receptor (RyR1) is an intracellular calcium (C

192 The type 1 ryanodine receptor (RyR1) mediates Ca(2+) release from t

193 al muscle Ca(2+) release channel, the type 1 ryanodine receptor (RYR1), cause malignant hyperthermia

194 tage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1).

195 gated Ca(2+) channel (CaV1.1) and the type 1 ryanodine receptor (RyR1).

196 ate the intracellular calcium channel type 1 ryanodine receptor (RyR1).

197 Inhibitors of ryanodine receptors (RyR1) and L-type Ca(2+) channels pr

198 ions at which the DHPRs interact with type 1 ryanodine receptors (RyR1) in the sarcoplasmic reticulum

199 We also show that drugs that target ryanodine receptors (RyR1: dantrolene, tetracaine, S107)

200 smic reticulum (SR) calcium release channel (ryanodine receptor, RyR1 isoform) via a mechanism depend

201 Type 1 ryanodine receptors (RyR1s) release Ca(2+) from the sarc

202 ) constitutive pseudo-phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D(+/+) mice) ex

203 ial for normal SR-Ca(2+) cycling, the type-2 ryanodine receptor (RyR2) and phospholamban (PLN), enhan

204 and FKBP12.6, and phosphorylation on type II ryanodine receptor (RyR2) arrangement and function were

205 Activation of the cardiac ryanodine receptor (RyR2) by elevating cytosolic Ca(2+)

206 Cardiac ryanodine receptor (Ryr2) Ca(2+) release channels and ce

207 quire spontaneous Ca(2+) release via cardiac ryanodine receptor (RyR2) channels affected by gain-of-f

208 colocalization of JPH2 clusters with type 2 ryanodine receptor (RyR2) clusters near the cell surface

209 purifies with myospryn and the major cardiac ryanodine receptor (RyR2) from heart.

210 minal region (residues 1-543) of the cardiac ryanodine receptor (RyR2) harbors a large number of muta

211 and proximity ligation assay identified the ryanodine receptor (RyR2) in the SR as prominent target

212 The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on t

213 ngle-channel level, oxidation of the cardiac ryanodine receptor (RyR2) is known to activate and inhib

214 intracellular Ca(2+) release via the type 2 ryanodine receptor (RyR2) that promotes AF.

215 o reduce the open probability of the cardiac ryanodine receptor (RyR2) while having no effect on the

216 um handling in myocytes, such as the cardiac ryanodine receptor (RyR2), critically regulate cardiac c

217 ced NS/FSGS mouse model, the podocyte type 2 ryanodine receptor (RyR2)/calcium release channel on the

218 f the combined actions of direct blockade of ryanodine receptors (RyR2) and Na(+) channel inhibition.

219 ysosomes formed stable complexes with type 2 ryanodine receptors (RyR2) on the sarcoplasmic reticulum

220 +) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial me

221 2+ binding to ligand-gated channels known as ryanodine receptors (RyR2).

222 The cardiac Ca(2+) release channel (ryanodine receptor, RyR2) plays an essential role in exc

223 els like the cardiac Ca(2+) release channel (ryanodine receptor, RyR2), and it appears that attenuate

224 CaM also modulates NaV1.5 and the ryanodine receptor, RyR2.

225 pression levels of calcium release channels (ryanodine receptors, RyR2) in the sarcoplasmic reticulum

226 Ca2+ release channels on cardiac SR: type 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-tr

227 diastolic calcium (Ca) release due to leaky ryanodine receptors (RyR2s) has been recently associated

228 In cardiac myocytes, clusters of type-2 ryanodine receptors (RyR2s) release Ca(2+) from the sarc

229 The cytosolic Ca(2+) sensitivity of the ryanodine receptor (RyRs) Ca(2+) release channel is low

230 odelling, including increased sensitivity of ryanodine receptors (RyRs) and decreased inward rectifyi

231 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosph

232 Ca(2+) release mechanisms involve both ryanodine receptors (RyRs) and inositol triphosphate rec

233 ease from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) and, while they often remaine

234 Ryanodine receptors (Ryrs) are a family of calcium relea

235 However, when a fraction of ryanodine receptors (RyRs) are blocked by tetracaine or

236 The ryanodine receptors (RyRs) are high-conductance intracel

237 t, which is initiated at dyads consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum app

238 Ryanodine receptors (RyRs) form calcium release channels

239 Historically, ryanodine receptors (RyRs) have presented unique challen

240 y describe the nanoscale, 3D organization of ryanodine receptors (RyRs) in cardiomyocytes.

241 Metaplastic activation of ryanodine receptors (RyRs) in these neurons reestablishe

242 Ryanodine receptors (RyRs) mediate calcium (Ca)-induced

243 Ryanodine receptors (RyRs) mediate the rapid release of

244 lar changes include increased sensitivity of ryanodine receptors (RyRs) to Ca(2+) release and down-re

245 Ryanodine receptors (RyRs) were observed to be laid down

246 Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a family of intracellular ca

247 Pharmacological regulation of ryanodine receptors (RyRs), L-type voltage-dependent Ca(

248 conformation-sensitive activators of insect ryanodine receptors (RyRs).

249 ted localised Ca(2+) events originating from ryanodine receptors (RyRs).

250 traction is dependent on Ca(2+) release from ryanodine receptors (RyRs).

251 and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).

252 Ca(2+) regulates ryanodine receptor's (RyR) activity through an activatin

253 Ejection fraction in patients with pre-LVAD ryanodine receptor-sarcolemma distances >1 microm did no

254 sity was reduced in HF, leading to increased ryanodine receptor-sarcolemma distances (0.96+/-0.05 ver

255 Low ryanodine receptor-sarcolemma distances at the time of L

256 1 channel modulation in this process is also ryanodine receptor-sensitive.

257 RAD, a concave surface of the Ash2L SPIa and ryanodine receptor (SPRY) domain binds to a cluster of a

258 ase measured by Ca sparks and promoted RyR2 (ryanodine receptor) structural organization.

259 Ryanodine receptor subtype 1 (RyR1) supports relaxation

260 ing protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular compl

261 dent, reciprocal interaction between IP3 and ryanodine receptors that contributes to sex differences

262 Ca) signaling between L-type Ca channels and Ryanodine receptors that occurs mainly at the cell bound

263 ion channels, including the closely related ryanodine receptor, the cytosolic carboxy termini are un

264 channels in close proximity to intracellular ryanodine receptors, the t-tubules enable synchronous Ca

265 ts in sustained Ca(2+) release via IP(3) and ryanodine receptors to activate calcineurin.

266 istent with the contribution of Ca(2+)-gated ryanodine receptors to EC coupling.

267 eable channel TRPML1 closely associates with ryanodine receptors to induce Ca(2+) sparks in native ar

268 ating stochastic openings of Ca channels and ryanodine receptors to investigate the effects of Ca-vol

269 o-electron microscopy (cryo-EM) snapshots of ryanodine receptor type 1 (RyR1), a calcium-activated ca

270 we examined the effects of BPA and TBBPA on ryanodine receptor type 1 (RyR1), dihydropyridine recept

271 c reticulum (SR) Ca(2+) release channel, the ryanodine receptor type 1 (RyR1).

272 Ca(2+) leak via ryanodine receptor type 2 (RyR2) can cause potentially f

273 with different forms of AF, have implicated ryanodine receptor type 2 (RyR2) dysfunction and enhance

274 rate is thought to be due to an increase in ryanodine receptor type 2 (RyR2) open probability by dir

275 oproterenol stimulation and nearly abolished ryanodine receptor type 2 (RyR2)-dependent sarcoplasmic

276 analysis of immunoprecipitated JMC proteins ryanodine receptor type 2 and junctophilin-2 (JPH2) foll

277 analysis of immunoprecipitated JMC proteins ryanodine receptor type 2 and junctophilin-2 (JPH2) foll

278 n severe Ca(2+) leakage through destabilized ryanodine receptor type 2 Ca(2+) release channels.

279 As a result of increased activity of mutant ryanodine receptor type 2 channels, sarcoplasmic reticul

280 neous Ca(2+) release events from hyperactive ryanodine receptor type 2 channels.

281 The PKA activation destabilized ryanodine receptor type 2 channels.

282 Deficiency of the protein induces ryanodine receptor type 2 dysfunction by a mechanism tha

283 Increased PKA signaling in turn promotes ryanodine receptor type 2 hyperphosphorylation, which co

284 9) expressing miRYR2-U10 in correcting RyR2 (Ryanodine Receptor type 2 protein) function after in viv

285 levels of Ca(2+)-cycling proteins including ryanodine receptor type 2.

286 Ryanodine receptor type I (RYR1)-related myopathies (RYR

287 Ryanodine receptor type I-related myopathies (RYR1-RMs)

288 sion was increased, and PKA sites Ser2808 in ryanodine receptor type-2, Ser16 in phospholamban, and S

289 ulin (CaM) for binding to intact, functional ryanodine receptors type I (RyR1) and II (RyR2) from ske

290 a prevention of the hyperphosphorylation of ryanodine receptors under isoproterenol administration i

291 current modulation by interactions with the ryanodine receptor using a chimeric CaV1.1e construct in

292 CaMKII target sites on phospholamban and the ryanodine receptor using genetically modified mice.

293 at a genetic reduction of the functioning of ryanodine receptors using synaptopodin-knock-out mice am

294 The cardiac ryanodine receptor was not altered in transcript, protei

295 Ryanodine receptor was protein kinase A-hyperphosphoryla

296 -type VGCCs, but not GluA2-lacking AMPARs or ryanodine receptors, was required to restore robust LTP.

297 initially involves SR release of Ca via the ryanodine receptor, which is regulated by its interactin

298 for the presence of a large pool of orphaned ryanodine receptors, which can fire and sustain Ca waves

299 cytes was related to hyperphosphorylation of ryanodine receptors, which was blunted in Nod1(-/-)-PMI

300 in kinase II, through phosphorylation of the ryanodine receptor would lead to Ca leak from the sarcop