ライフサイエンスコーパス: saccharide

1 ril interactions from the perspective of the saccharide.

2 form, and in complex with a tetra- or hepta-saccharide.

3 the difference of the dipole moment in each saccharide.

4 he lipid may not be covalently linked to the saccharide.

5 rene increase with the increase units of the saccharide.

6 ch showed that beta-Gal is the major binding saccharide.

7 g no functional group with which to bind the saccharide.

8 importance of the multivalent binding to PG saccharides.

9 eUmChlE was also active towards feruloylated saccharides.

10 p, deprotection affords water-soluble 2-thio saccharides.

11 ers to conjugates bearing a larger number of saccharides.

12 nation complexes, peptides, nucleobases, and saccharides.

13 enzyme, the glycan chains consist of 8 or 4 saccharides.

14 ows high selectivity for glucose, over other saccharides.

15 es, which could be inhibited by N-acetylated saccharides.

16 produce near-quantitative levels of soluble saccharides.

17 ancer cells manifested by truncated O-linked saccharides.

18 quence of variable recognition of peripheral saccharides.

19 be due to the molecular architectures of the saccharides.

20 removal of side-chain Kdo from the LPS core saccharides.

21 hat contain purified, or partially purified, saccharides.

22 red to have progressively truncated LPS core saccharides.

23 n shown to be effective for the synthesis of saccharides.

24 nd cAMP was triggered by the introduction of saccharides.

25 detection of characteristic oxonium ions of saccharides.

26 rin since they shared the same compositional saccharides.

27 determined to be fructose > glucose > other saccharides.

28 mimic Prochlorococcus proteins, lipids, and saccharides.

29 state was studied in absence and presence of saccharides.

30 hing, which is diminished in the presence of saccharides.

31 iological properties with respect to regular saccharides.

32 ed MOS indicated minimal amounts of branched saccharides.

33 f alpha-FucN3 linkages relevant to bacterial saccharides.

34 stress, with carbon accumulating as complex saccharides.

35 d to be glycosylated with a similar terminal saccharide, 4-(3-hydroxybutanamido)-4,6-dideoxy-2-O-meth

36 minimal functional units and that additional saccharides adjacent to these units can alter binding ou

37 LMW) organic compounds, including alkaloids, saccharides, amino acids, nucleosides, nucleic bases, an

38 ns in cellular components (lipids, proteins, saccharides, amino acids...) and cellular functions (cel

39 purine moiety as well as the polyoxygenated saccharide and a labile glycosidic bond in the nucleosid

40 eractions, and that the interactions between saccharide and fullerene increase with the increase unit

41 ing has been invoked recently in crystalline saccharide and protein systems.

42 of binding, a monovalent binding to shorter saccharides and a bivalent mode for higher glycans, invo

43 sidues at the reducing ends of the S. sonnei saccharides and aminooxy linkers bound to BSA or a recom

44 tegral membrane protein EIIC that transports saccharides and assists in their phosphorylation.

45 nd the understanding of interactions between saccharides and cations in presence of water molecules,

46 mall intestine accumulate mannose-containing saccharides and glycogen particles in their apical cytop

47 ropolymerized 3-aminophenylboronic acid with saccharides and hydroxy acids also confirm that the obse

48 nsidering sensors for polyols, particularly, saccharides and hydroxy acids.

49 rmed to determine the relative enrichment of saccharides and inorganic ions in nascent fine (PM2.5) a

50 Maximal enrichments of saccharides and ions coincided with the second of two ph

51 Interactions between saccharides and ions in aqueous solutions are of great i

52 329S, was found to bind the tetra- and hepta-saccharides and may represent a higher-affinity site emp

53 sity B-coefficients of transfer (DeltatB) of saccharides and other parameters such as isobaric expans

54 n regarding the hydration characteristics of saccharides and play a pivotal role in the study of tast

55 or reduce fermentable oligo-, di-, and mono-saccharides and polyols.

56 This study aimed to assess the contents of saccharides and potential fructooligosaccharides (FOS) o

57 These findings indicate that saccharides and proteins with numerous and well-ordered

58 J-couplings within the N-acetyl fragment of saccharides and related structures to be used for more c

59 affected significantly the contents of these saccharides and sFOS.

60 ctures and physicochemical properties of the saccharides and their degradation species correlate well

61 information available in the NMR spectra of saccharides and to advance our understanding of the corr

62 apid and sensitive analysis of underivatized saccharides and was used for determination of sugars in

63 stances (EPS), and lipids using the protein, saccharide, and lipid signatures, respectively, together

64 drolyze lignocellulosic biomass into soluble saccharides, and the bacterium Escherichia coli, which m

65 Most other saccharides are bound approximately 100 times more weakl

66 Three of four saccharides are conserved in all serotypes.

67 uencing (SIMMS(2)) method in which intact HS saccharides are dissociated in an ion mobility mass spec

68 All saccharides are intimately bound through hydrogen bond,

69 manipulations at the C1 anomeric position of saccharides are one of the central goals of preparative

70 Saccharides are ubiquitous biomolecules, but little is k

71 is labeling pattern is expected for 4-carbon saccharides arising from the pentose phosphate pathway.

72 glycan structure, we show that the number of saccharides attached at residue serine 63 affects the ra

73 rnover linked to the stepwise elimination of saccharides attached to the termini of N-glycans.

74 sis of the crosslinked peptide stem from the saccharide backbone of the peptidoglycan on one side is

75 Saccharide-based systems with inherent pH- and temperatu

76 couplings matched the experimental values in saccharides bearing an ionizable substituent.

77 particularly useful for the sequencing of HS saccharides, because the lack of contaminating isomeric

78 Two of them bind to the saccharide binding site of the RBP and are able to fully

79 he near-infrared fluorescence in response to saccharide binding.

80 that a conjugate of nucleobase, peptide, and saccharide binds to peptides from molecular nanofibrils

81 urfaces is used to identify the formation of saccharide bonds and to challenge their stability agains

82 adjacent membranes via the formation of weak saccharide bonds.

83 ereas UVPD gives more detailed insight about saccharide branching and the positions of nonstoichiomet

84 This barrier is assembled from saccharide building blocks not found in mammals, includi

85 s on the concentration of negatively charged saccharides but is independent of oligosaccharide length

86 tocks that harbor easy-to-access fermentable saccharides by incorporating self-destructing lignin; an

87 llerene-bonded columns were used to separate saccharides by LC under aqueous conditions.

88 ates that present patches of electropositive saccharide C-H bonds engage more often in CH-pi interact

89 nstrate how these nanomolecules grafted with saccharides can exhibit dramatically improved binding af

90 On the other hand, diols and saccharides can form tetrahedral adducts with boronic ac

91 use of phenylboronic acid as a receptor for saccharide capture onto the substrate and the ability of

92 saccharides was explained from the study of saccharide/cation interactions.

93 In saccharide/cation/water systems, the decrease in hydrati

94 Contacts between aromatic surfaces and saccharide CH groups are common motifs in natural carboh

95 doglycan (PG), a complex polymer composed of saccharide chains cross-linked by short peptides, is a c

96 scattered evidence that other, more abundant saccharide chemistries exhibit similar behavior.

97 Here, we show that the saccharide component of LOS/LPS have direct, high-affini

98 of three allosteric ligands: muramic acid (a saccharide component of the peptidoglycan), the cell wal

99 ) but instead 4-linked glucose as their main saccharide component, with low levels of glucosamine and

100 Abundant saccharide components in milk, such as lactose and lacto

101 nd/or nitrogen sources could alter monomeric saccharide composition and concentrations of the free EP

102 mass spectrometry due to their complexity in saccharide composition, polydispersity, and sequence het

103 he most complex natural matrices in terms of saccharides composition, this innovative approach can be

104 nds corresponding to a total of 20 different saccharide compositions with sialylated bi-, tri-, and t

105 ach molecule were a good reflection of their saccharide compositions.

106 ce their contents of monosaccharides and non-saccharide compounds.

107 Saccharides comprise a significant fraction of organic m

108 firmed the bonding of the anomeric region of saccharide configuration of lactulose with WPH.

109 y x-ray and neutron reflectometry reveal the saccharide conformation and allow quantifying the area p

110 Stability of di- and tri-saccharide conjugates of anthocyanidins slightly, but si

111 of synthetic antifouling polymer composed of saccharide containing N-substituted polypeptide (glycope

112 pharmaceuticals, common monosaccharides, and saccharides containing free hydroxyl groups.

113 Results show that the saccharide coordination numbers, as well as the sacchari

114 acid on the terminal galactose of a neutral saccharide core (binding order GT1b = GD1a >> GM3; no bi

115 dentified potential subsites for binding the saccharide core of PG using computational docking experi

116 determined and discussed in terms of solute (saccharide)-cosolute (sodium gluconate) interactions.

117 This exoskeleton is composed of repeating saccharides covalently cross-linked by peptide stems.

118 DeltaH degrees (), and DeltaS degrees () for saccharide CTI.

119 ereas the stabilizing effect per mole of all saccharides decreased.

120 roles in the environment, identifying algal-saccharide-degrading coastal subclades, protein-degradin

121 ws that both species are dehydrated and that saccharide dehydration depends on the nature of the cati

122 e used a set of mutants that have successive saccharide deletions from the nLc4 alpha chain to charac

123 possible to create 1D-fibers with adjustable saccharide densities exhibiting tailored dynamic exchang

124 A number of saccharide-derived alcohols were subjected to the benzyl

125 ducing three membrane protein complexes from saccharide detergents and show how reducing their overal

126 However, many of the saccharide detergents widely employed in structural biol

127 Though these saccharides differ dramatically in structure, they share

128 In absence of saccharides, differences were observed in the extent of

129 nknown phase II metabolites, conjugates with saccharides, disaccharides, malonic acid, and sulfate, w

130 ed with the capability of adapting the inter-saccharide distances and orientations in the presence of

131 sition, without regard to the arrangement of saccharide domains typically found in vertebrate HS.

132 as focused on reactions of nucleophiles with saccharide donors equipped with a leaving group.

133 nsity are believed to interact strongly with saccharides due to CH-pai and/or OH-pai interactions.

134 ng drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocar

135 (iii) The saccharide effect depends on the global regulatory prote

136 (ii) The saccharide effect results in increased levels of TcuB ac

137 stereoselective synthesis of beta-(1-->2)-C-saccharides employing 3-deoxy- and 3-C-branched glycals

138 elective fucose cleavage from the H2-antigen saccharide enables efficient removal of H2 antigen from

139 ally glycosylated with O-GlcNAc by metabolic saccharide engineering using tetra-O-acetyl-2-N-azidoace

140 chain conformation in biologically important saccharides, especially those where this structural elem

141 gh this was improved through the addition of saccharide excipients without detriment to the biologica

142 Most saccharides, fatty acids, amino acids and many sterols s

143 ferent from that of phages binding cell wall saccharides, for which structural information is availab

144 In comparison to saccharide-free peptoids, the interfacial saccharide res

145 rides, the structural diversity displayed in saccharides from tissue or cell sources cannot be readil

146 emonstrated that a supramolecular complex of saccharide-fullerene was formed through CH-pai and/or OH

147 of multiple concentrations of each of seven saccharides (glucose, galactose, fructose, sucrose, treh

148 lutaric, azelaic, and palmitic acids), three saccharides (glucose, sucrose, and raffinose), and lipop

149 ing this method, bioactive molecules such as saccharides, glycoalkaloids, flavonoids, organic acids,

150 on of a group of small molecules, called non-saccharide glycosaminoglycan mimetics (NSGMs), as direct

151 Saccharides have a central role in the nutrition of all

152 ion behaviour and the basic taste quality of saccharides have been studied from measured apparent mol

153 re of lignin coexisting with poly- and oligo-saccharides, have very low but variable oxygen permeabil

154 Some of the saccharide headgroup types investigated are able to bind

155 In the first part, the saccharide hydration properties (xylose, glucose, sucros

156 charide coordination numbers, as well as the saccharides hydration enthalpy, increase with the saccha

157 the second part, the influence of cations on saccharides hydration properties, and inversely, is eval

158 arides hydration enthalpy, increase with the saccharide hydrophilic group number.

159 ccurately determined the profile of 20 minor saccharides in a set of 46 European acacia honeys using

160 s are commonly used as molecular sensors for saccharides in aqueous media.

161 the differential solubility of its component saccharides in aqueous-ethanol solutions.

162 ntial abundances of glycerophospholipids and saccharides in females and males.

163 d optimized to afford both anomers of common saccharides in high anomeric selectivities.

164 ETD effectively dissociates GAGs up to eight saccharides in length, but the low resolution of the ion

165 specific interaction between fullerenes and saccharides in liquid chromatography (LC).

166 otal role in the study of taste behaviour of saccharides in mixed aqueous solutions.

167 ent regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive

168 ng showed the presence of mannose-containing saccharides in the epithelium of proximal kidney tubules

169 c owing to the frequent occurrence of acidic saccharides in the glycan, rendering traditional proteom

170 binders (proteins, lipids, nucleic acids and saccharides) in the matrix.

171 etching vibration were determined in various saccharides including FOS (1-kestose, nystose and kestop

172 ereas the stabilizing effect per mole of all saccharides increased, and that the absolute stability o

173 creen-printed electrode through boronic acid-saccharide interactions, with the boronic acid units spe

174 Escherichia coli, which metabolizes soluble saccharides into desired products.

175 ted by ultrafiltration and freeze-dried with saccharides (inulin and sucrose).

176 number of isoforms, structural assignment of saccharides is challenging and often requires a use of d

177 In addition, a number of these saccharides (L-arabitol, D-fructose, sucrose, D-glucose,

178 Larger saccharides led to a decrease in Maillard induced aggreg

179 ural and semi-synthetic heparan sulfate (HS) saccharide libraries are a valuable resource for investi

180 In contrast, saccharide libraries can be generated by partial digesti

181 r generation of structurally diverse natural saccharide libraries from HS variants that is fast (appr

182 ia neutral loss fragments in addition to the saccharide linkage arrangement, whereas UVPD gives more

183 he complexity of heparin and heparan sulfate saccharides makes their purification, including many iso

184 harides by using chromatographic methods and saccharide mapping.

185 The manufacture of this type of bioactive, saccharide material-based NPs (defined as LCD NP) is str

186 e three-dimensional conformation of terminal saccharides may partly explain reduced enzymatic activit

187 ies involved in osmotic stress tolerance and saccharide metabolism that support phenomic studies.

188 ers and epimers, for the characterization of saccharide mixtures with a varying extent of sulfation a

189 romatographic fractionation of the resulting saccharide mixtures.

190 the distinct stimuli-sensitive properties of saccharide-modified polymers to mediate drug release und

191 ps to allow selective attachment of specific saccharide moieties by chemical glycosylation.

192 t heparin fragments containing two- or eight-saccharide monomers protect against amylin cytotoxicity

193 supramolecular entities displaying different saccharide motifs in a controlled manner is of critical

194 mutual influence of varying densities of the saccharide motifs in the binding properties toward diffe

195 ugar, strongly suggesting that "mismatching" saccharide motifs may modulate carbohydrate-lectin speci

196 ermined for use in conformational studies of saccharide N-acetyl side-chains in solution by NMR spect

197 aterials according to their proteinaceous or saccharide nature.

198 n of validated standards and unknown natural saccharides, notably including variants with 3O-sulfate

199 lysis of vinyl ether groups from unsaturated saccharides occurs independently of the alpha or beta co

200 HIL on APC to a heparin/heparan sulfate-like saccharide of syndecan-4 on activated T cells, we posite

201 agarose gels loaded with various non-gelling saccharides of increasing molecular weights.

202 The design and synthesis of amide-linked saccharide oligomers and polymers, which are predisposed

203 no acids of viral glycoproteins and sulfated saccharides on the GAG chain.

204 ther by modifying the pendant groups such as saccharides or by functionalizing the N- or C-terminal m

205 Poly-amido-saccharides (PAS) are carbohydrate-based, enantiopure sy

206 Enantiopure poly-amido-saccharides (PASs) with a defined molecular weight and n

207 Herein, right-handed helical poly amido-saccharides (PASs) with beta-N-(1-->2)-d-amide linkages

208 amide linkage to give enantiopure poly-amido-saccharides (PASs).

209 ns to evaluate the effects of peptide versus saccharide pathway structure on coupling magnitude.

210 A new class of functional saccharide-peptide copolymer-based hydrogels was synthes

211 These data suggest our saccharide-peptide hydrogels as promising synthetic extr

212 n isolated from cloudwaters, to biotransform saccharides present in the atmosphere was evaluated usin

213 acrocycle and especially the topology of the saccharide presentation in space influence the biologica

214 is Communication we describe a two-component saccharide probe with logic capability.

215 Analysis of the generated saccharide products revealed a novel HS design, involvin

216 The neutral saccharide profile of the wheat bran was dominated by ar

217 A detailed analysis of the saccharide profile of these Chinese honeys suggests prod

218 e from a commercial precursor using a single saccharide protecting group.

219 lead to antibody responses to the inner core saccharides provides an impetus to further explore this

220 es that do not process 6''-carboxyl-modified saccharides, recent structural studies reveal that this

221 Saccharide recognition using the nIR photoluminescence o

222 binding ligands to pendant diols useful for saccharide recognition.

223 tent regardless of the peptide length or the saccharide removed.

224 pecific sulfatases selective for the type of saccharide residue and the attachment position of the su

225 namics revealed a tight complex in which all saccharide residues are restrained without undergoing su

226 barrier' effect associated with the hydrated saccharide residues as well as steric hindrance from the

227 eak noncovalent interactions influence which saccharide residues bind to proteins, and how they are p

228 interactions between the high charge-density saccharide residues flanking the "canonical" antithrombi

229 for HS20 binding were between six and eight saccharide residues in length.

230 ealed that an oligosaccharide longer than 19 saccharide residues is necessary to display anti-IIa act

231 to saccharide-free peptoids, the interfacial saccharide residues of glycopeptoids formed a higher num

232 n of IdoA and sulphations in the surrounding saccharide residues.

233 queous interface enriched in highly hydrated saccharide residues.

234 ied N-sulfo-oligosaccharides having up to 21 saccharide residues.

235 estigated why low levels of glucose or other saccharides restored growth of an apbC strain on Tcb.

236 e enabled exact mass measurements of heparin saccharides roughly up to degree-of-polymerization 20, l

237 Using a well-known boronic acid-based saccharide sensor (3), this work reveals a new mechanism

238 Saccharide sensors represent a broad research area in th

239 fficult challenge of heparin/heparan sulfate saccharide separation and will enhance structure-activit

240 ecrease in hydration enthalpy of cations and saccharides shows that both species are dehydrated and t

241 and other alcohol) groups characteristic of saccharides, similar to biogenic carbohydrates found in

242 and analysis of heterogeneous mixtures of HS saccharide species.

243 against known values for 36 fully defined HS saccharide structures (from di- to decasaccharides) perm

244 arensis requires a detailed knowledge of the saccharide structures that can be recognized by protecti

245 sible catalytic mode strictly depends on the saccharide substrate structures.

246 Our data demonstrate that the saccharide substrates display distinct conformations whe

247 ST for distinguishing the fine structures of saccharide substrates.

248 ronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mamm

249 Our work shows that saccharides systematically decrease the agarose gel thin

250 h distributions were obtained from the (poly)saccharide taylorgrams, including non-UV absorbing polym

251 HS is composed of sulfated saccharides that are biosynthesized through a complex pa

252 actose, but also on a number of mono- and di-saccharides that involve the glucose-PTS or glucokinase

253 egulated by the sulphation pattern of nearby saccharides that is genetically controlled by the hepara

254 n (GAG) family are highly polyanionic linear saccharides that play important roles in a variety of ph

255 immune system, metabolic pathways involving saccharides that provide cells with energy, and energy a

256 ype capsules differed in the identity of one saccharide, the pendant phosphopolyalcohol, and the O-ac

257 emical or in vitro enzymatic synthesis of HS saccharides, the structural diversity displayed in sacch

258 ic compressibilities at infinite dilution of saccharides, their derivatives and sugar alcohols in (0.

259 are critical for the development of related saccharide therapeutics, and the data here establish tha

260 In the presence of saccharides, these cross-links were found to consist of

261 The stereoselective synthesis of saccharide thioglycosides containing 1,2-cis-2-amino gly

262 hesis of highly yielding and alpha-selective saccharide thioglycosides containing 1,2-cis-2-amino gly

263 -cis-2-amino glycosidic linkages because the saccharide thioglycosides obtained can serve as donors f

264 ree of polymerisation and molar mass of milk saccharides throughout the hydrolysis are discussed.

265 nding protein, predicted to be implicated in saccharide transport.

266 visualization of glycoconjugates in alkynyl-saccharide-treated cells at extremely low concentration

267 se, etc.), the recognition of other types of saccharide under natural (aqueous) conditions is less we

268 The N-glycan's first saccharide unit accounts for the entire acceleration of

269 al and biological properties imparted by the saccharide units and are unique from synthetic polymers.

270 ly, only heparin molecules longer than eight saccharide units enhanced hIL-12 activity.

271 ed to achieve stepwise removal of individual saccharide units from the nonreducing termini of the mul

272 Norovirus interactions with other saccharide units of the HBGAs were variable and involved

273 The approach added saccharide units to insulin to create insulin analogs wi

274 ong the ganglioside retention, the number of saccharide units, and their sequence.

275 ngths in these HS block co-polymers were ~40 saccharide units.

276 s FGF1 binds with a minimal footprint of 4.2 saccharide units.

277 to 3000 daltons, corresponding from 5 to 10 saccharide units.

278 the stabilization is derived from the next 2 saccharide units.

279 over a glycosidic bond between two different saccharide units.

280 Whereas several saccharide uptake systems are shared between the differe

281 for their bioorthogonal ligation to a model saccharide using a Huisgen alkyne-azide cycloaddition, t

282 olyte, where baseline separation of the five saccharides was achieved in 3.5 min.

283 The dehydration sequence of saccharides was explained from the study of saccharide/c

284 The chromatographic separation of all saccharides was performed on a BEH amide column using an

285 ar interactions between the antibody and the saccharide, we determined the X-ray crystal structure of

286 lcohols, polyols, ethyl esters, mono- and di-saccharides were associated with the classification of s

287 Relative to sodium, individual saccharides were enriched 14-1314-fold in fine SSA, 3-13

288 d that the signal-to-noise ratios for target saccharides were notably improved after chemical derivat

289 l "fingerprint" identities of UV transparent saccharides were revealed by photofragmentation of their

290 ses, containing mainly hemicellulose-derived saccharides, were refined by physicochemical methods to

291 in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved interaction

292 d derivative binds even at neutral pH to the saccharides which could expand the application towards b

293 sensor arrays for rapid screening of target saccharides will be available.

294 s are observed for oxides in the presence of saccharides with closely related compositions and struct

295 ith mono- and oligosaccharides, deoxysugars, saccharides with free hydroxyl groups, pyranose, and fur

296 SAX provides an orthogonal method to isolate saccharides with higher purity.

297 structures, progressively exposing different saccharides with increased protein age.

298 consist of tetra-, penta-, hexa-, and hepta-saccharides with molecular weights of 689, 851, 1013 and

299 series of oxo-phenylacetyl (OPAc)-protected saccharides, with divergent base sensitivity profiles ag

300 can arrays are limited resources and present saccharides without the context of other glycans and gly