ライフサイエンスコーパス: saccular

1 up for more than 5 years were most commonly saccular (189 of 274 cysts [69% axially]) and retrostern

2 Most RAAs were saccular (79%) and noncalcified (63%).

3 CT revealed 25 saccular (93%) and two fusiform (7%) aneurysms with a me

4 These results suggest that alteration in saccular afferent firing rates are sufficient to induce

5 tern of current spread involving only PC and saccular afferent neurons at this level of stimulation.

6 the vestibular nuclear complex suggest that saccular afferents contribute to the vestibulospinal sys

7 robiotin was injected iontophoretically into saccular afferents of toadfish (Opsanus tau) after intra

8 semicircular canal terminal fields, whereas saccular afferents projected to regions that received ve

9 Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, an

10 ions, physiology, and best directions of the saccular afferents.

11 cheal fluid from preterm infants can prevent saccular airway branching.

12 in the fetal lung mesenchyme causes arrested saccular airway branching.

13 s chronic lung disease results from arrested saccular airway development and is most common in infant

14 radic somatic mutations in 65 IA tissues (54 saccular and 11 fusiform aneurysms) and paired blood sam

15 senchymal Wnt expression patterns during the saccular and alveolar stages - wherein major expansion o

16 Expression of Spry-4 during the saccular and alveolar stages, from E18.5 to postnatal da

17 iary bundles, that are presumed to represent saccular and lagenar maculae.

18 Only saccular and PC afferent neurons exhibited increases in

19 soura), a Stellifer-group sciaenid, both the saccular and utricular otoliths are enlarged relative to

20 Although there is extensive overlap of saccular and utricular projections, saccular inputs to t

21 ns, NT3 expression is weak and restricted to saccular and utricular supporting cells.

22 e concomitant large iliac diameter (91%) and saccular aneurysm (82%).

23 edominantly for fusiform aneurysm (n = 144), saccular aneurysm (n = 94), acute (n = 64) or chronic (n

24 neutralizing anti-TGF-beta antibody promoted saccular aneurysm formation and aorta rupture in Sm22 Cr

25 lished the feasibility of an animal model of saccular aneurysm inflammation that can be seen with cli

26 Saccular aneurysm of left internal carotid artery was di

27 may be a cause of stroke; (2) it may mimic a saccular aneurysm on radiographic studies; and (3) it su

28 width >20 mm, thrombosed PAU, and associated saccular aneurysm were associated with larger changes in

29 Saccular aneurysms (especially those with lobulated cont

30 Saccular aneurysms did not demonstrate a significantly h

31 Platinum coils placed into experimental saccular aneurysms in New Zealand White rabbits failed t

32 of whether to treat incidental intracranial saccular aneurysms is complicated by limitations in curr

33 Besides fusiform and saccular aneurysms that can thrombose, SA/C vasculitis l

34 er (mean age, 62.5 years; 68% women) who had saccular aneurysms that were 3 mm or more in the largest

35 Elastase-induced saccular aneurysms were created at the root of the right

36 onal animal care and use committee approval, saccular aneurysms were created in 20 rabbits and treate

37 Saccular aneurysms were created in New Zealand White rab

38 Elastase-induced, saccular aneurysms were created in rabbits and embolized

39 Angiography showed 13 saccular aneurysms with lobulated contour in 10 (77%).

40 ted at branch points of major vessels, large saccular aneurysms with multiple efferent arteries, doli

41 troying the wall into the adventitia causing saccular aneurysms, which can thrombose or rupture.

42 MR imaging showed three saccular aneurysms.

43 ion loop in 4/6 fusiform aneurysms (and 0/38 saccular aneurysms; Fisher's exact test, p < 0.001).

44 tilated lungs appeared immature, retaining a saccular architectural pattern.

45 th airway morphometry, elastin staining, and saccular branching similar to those in control littermat

46 abetes for 5 years resulted, as expected, in saccular capillary aneurysms, pericyte ghosts, acellular

47 s phase and became brightly hyperfluorescent saccular caps.

48 By screening a bullfrog saccular cDNA library, we identified abundant PMCA1b and

49 g the glossopharyngeal nerve that enters the saccular chamber and in having the glossopharyngeal fora

50 of cells along one side of a fused utriculo-saccular-cochlear organ.

51 hemical features and the localization of the saccular collagen (SC) protein in vivo using polyclonal

52 Conversely, the saccular cysts described by others arise predominantly b

53 tic arch, and a 72-year-old man with a 70 mm saccular degenerative atheromatous aortic arch aneurysm.

54 SWOPP was diagnosed when a saccular dilatation of the terminal portion of the dorsa

55 s, the cytoplasmic droplet contains numerous saccular elements as its key content.

56 1 dictates the formation and accumulation of saccular elements in the forming cytoplasmic droplet.

57 t understanding of the active role played by saccular epithelium in the local regulation of the [Na(+

58 Most of the hair cells in the saccular epithelium in vitro were electrically tuned to

59 pulmonary mesenchyme in actively shaping the saccular epithelium.

60 ts mesenchymal thinning and expansion of the saccular epithelium.

61 central (striolar)-zone afferents of the rat saccular epithelium.

62 Saccular fibers entered the medulla posterior to and at

63 RCH appeared as small heterogeneous saccular flow areas associated with focal capillary hypo

64 addition, Cdh23 is expressed in the urticulo-saccular foramen,the ductus reuniens, and Reissner's mem

65 ckened interstitial mesenchyme and defective saccular formation.

66 Saccular geometry did not increase diameter-normalized s

67 , intraluminal thrombus, calcifications, and saccular geometry on peak wall stress (PWS) in finite el

68 in the number of small, potentially immature saccular hair bundles in reproductive females.

69 han the specific loss of Cx30 that underlies saccular hair cell death in Cx30(-/-) mice.

70 The seasonal increase in saccular hair cell density and smaller hair bundles in r

71 ty are concurrent with seasonal increases in saccular hair cell receptors.

72 CN1 was immunolocalized to discrete sites on saccular hair cell stereocilia, consistent with gradated

73 -Mb goldfish bipolar neuron and the bullfrog saccular hair cell.

74 leads to significant reduction of numbers of saccular hair cells and neuromasts and to hearing loss.

75 of voltage-gated Ca(2+) channels in bullfrog saccular hair cells by means of perforated and cell-atta

76 These results show that some frog saccular hair cells can generate spontaneous rhythmic ac

77 There was no loss of ANF, SGN or saccular hair cells in the BHK-2, BEP and BEPHK-2 groups

78 revealed on-going apoptosis specifically in saccular hair cells of Cx30(-/-) mice.

79 d this hypothesis at the afferent synapse of saccular hair cells of the leopard frog, Rana pipiens.

80 We conclude that frog saccular hair cells possess an intrinsic synaptic freque

81 ngle voltage-gated Ca2+ channels in bullfrog saccular hair cells to assess the roles of the channels

82 We used electron tomography of frog saccular hair cells to reconstruct presynaptic ultrastru

83 confocal and electron microscopy of bullfrog saccular hair cells using an anti-myosin-Ibeta antibody

84 xpressed in the mammalian organ of Corti and saccular hair cells was found to interact with an intrac

85 lectrophysiological recordings from bullfrog saccular hair cells with such spontaneously oscillating

86 As in frog saccular hair cells, adaptation shifted the current-defl

87 In saccular hair cells, TRPN1 was located prominently in th

88 y full-length HCN isoform expressed in trout saccular hair cells, was found by yeast two-hybrid proto

89 Using an in situ binding assay on saccular hair cells, we demonstrated previously that Myo

90 Using grassfrog (Rana pipiens) saccular hair cells, we show that the reported discrepan

91 of hair bundles and apical surfaces of frog saccular hair cells.

92 K(+) (K(Ca)) currents of frog (Rana pipiens) saccular hair cells.

93 f the ribbon-class afferent synapses in frog saccular hair cells.

94 some in the Cx30(-/-) background rescued the saccular hair cells.

95 Cx30 were not essential for the survival of saccular hair cells.

96 of adults aged 40-84 years having intradural saccular IAs >= 2 mm.

97 g pathway-related genes in both fusiform and saccular IAs and opens a new avenue of research for deve

98 B signaling, were found in both fusiform and saccular IAs at a high prevalence (43% of all IA cases e

99 ed 263 patients with unruptured intracranial saccular ICA aneurysms treated with FDs from 2013 to 202

100 multimodal input early in development and on saccular input alone during the transition to amphibious

101 erlap of saccular and utricular projections, saccular inputs to the lateral portions of the vestibula

102 n contrast to the ubiquitous distribution of saccular inputs, those from the lagena are segregated to

103 minant polycystic kidney disease (ADPKD) and saccular intracranial aneurysms (ICA), the risk of MRA-d

104 Saccular intracranial aneurysms are balloon-like dilatio

105 Fluorescein angiography showed saccular lesions that filled slowly during the venous ph

106 phosphate-buffered saline or LPS during the saccular lung developmental phase.

107 romoted maturation with the development of a saccular lung.

108 ges, maintenance of otolith tethering to the saccular macula is dependent on tectorin alpha (tecta) f

109 amp recordings while the apical surface of a saccular macula was bathed with solutions containing var

110 the future superior crista, lateral crista, saccular macula, and posterior crista, as confirmed by i

111 canal ampullae, with weaker staining in the saccular macula.

112 the peristriolar zones of the utricular and saccular maculae.

113 striola is absent in both the utricular and saccular maculae.

114 s of homology to the zebrafish utricular and saccular maculae.

115 ulted in ablation of all hair cells from the saccular maculae.

116 ing the Gorab gene in mice resulted in fatal saccular maturation defects characterized by a thickened

117 cochlear sense organs, Reissner's membrane, saccular membrane, and the dark cells adjacent to canal

118 cell number (hyperplasia) in Reissner's and saccular membranes, present in both early and advanced E

119 ew, cerebral aneurysms can be classified as 'saccular' - most commonly occurring, and 'other types',

120 The central projections of the utricular and saccular nerve in macaques were examined using transgang

121 The principal brainstem areas of saccular nerve termination were lateral, particularly th

122 lar apparatus, including degeneration of the saccular neuroepithelium and occasional malformation of

123 l complications rates; at least 10 patients; saccular, nondissecting UAs; original study published in

124 ne of the two distinct layers of the sunfish saccular OM.

125 lysate and in homogenates of microdissected saccular OMs.

126 Intracranial saccular or berry aneurysms are common, occurring in abo

127 Only saccular or broad-based aneurysms 2 mm or larger in grea

128 143 patients, 178 aneurysms) with unruptured saccular or fusiform aneurysms or recurrent aneurysms af

129 dextran amine was injected directly into the saccular or utricular neuroepithelium of fascicularis (M

130 e utricular otolith gradually fuses with the saccular otolith.

131 ously, we identified a cDNA from the sunfish saccular otolithic organ that encoded a new member of th

132 nd the utricles, deeply grooved sulci on the saccular otoliths, two-planar saccular sensory epithelia

133 Late administration of heparin, after the saccular phase did not impact lung function or growth.

134 in neonatal mice, which are born during the saccular phase of lung development.

135 nctions for Six1-Eya1-SHH pathway during the saccular phase of lung morphogenesis, providing a concep

136 opment as well as alveolarization during the saccular phase of lung morphogenesis.

137 Mutant lung histology at the saccular phase shows mesenchymal and saccular wall thick

138 and alveolar phenotype of mutant mice at the saccular phase.

139 the histologic alterations described in the saccular phenotype of Eya1(-/-) or Six1(-/-) lungs.

140 both Six1 and Eya1 genes results in a severe saccular phenotype, including defects of mesenchymal cel

141 atic increase in the magnitude of the evoked saccular potentials and a corresponding decrease in the

142 Saccular projections remain stable across larval develop

143 d sulci on the saccular otoliths, two-planar saccular sensory epithelia, and a unique orientation pat

144 lasm of supporting cells at the edges of the saccular sensory epithelium, indicating that these cells

145 of sensory hair cell ciliary bundles on the saccular sensory epithelium.

146 We monitored the synaptic output of saccular sensory receptors (hair cells) by measuring the

147 Nine of 35 lesions had a saccular shape, while the remaining cases had a filiform

148 m of this was to analyze differences between saccular-shaped abdominal aortic aneurysms (SaAAAs) and

149 odynamics in microchannels designed to mimic saccular-shaped microaneurysms (microaneurysm-on-a-chip,

150 at a brief period of inflammation during the saccular stage (P3-P5) but not alveolar stage (P10-P12)

151 (<12 h old) exposed to hyperoxia during the saccular stage followed by air recovery until adulthood,

152 curred at birth and decreased throughout the saccular stage in mice.

153 al NF-kappaB activation selectively impaired saccular stage lung development, with a phenotype compri

154 Fibulin-5 expression by saccular stage lung fibroblasts was consistently inhibit

155 -5 rescued extracellular elastin assembly by saccular stage lung fibroblasts.

156 Elastin organization was disrupted in saccular stage lungs of preterm infants exposed to syste

157 inhibited maturation of the lung during the saccular stage of development.

158 s of AMF differentiation appeared around the saccular stage of lung development (E18.5).

159 Preterm infants born in the saccular stage of lung development are at risk for devel

160 iation as well as alveolarization during the saccular stage of lung development are still unknown.

161 eterm birth that affects infants born in the saccular stage of lung development at <32 weeks of gesta

162 t were major bioprocesses induced during the saccular stage of lung development at E16.5-E17.5.

163 ngs exhibited lung morphology typical of the saccular stage of lung development, including dilated ai

164 d for transition from the canalicular to the saccular stage of lung development.

165 e pups at embryonic day 18, during the early saccular stage of pulmonary development.

166 ular stage but not during the canalicular or saccular stage surprisingly delayed distal differentiati

167 tical window for elastin assembly during the saccular stage that is disrupted by inflammatory signali

168 nontransgenic littermates was typical of the saccular stage.

169 clusions: Increased mesenchymal Wnt5A during saccular-stage hyperoxia injury contributes to the impai

170 ive inflammasome activity displayed abnormal saccular-stage lung morphogenesis and died soon after bi

171 egulated elastin and fibulin-5 expression by saccular-stage mouse lung fibroblasts.

172 of maximal fetal growth, and canalicular and saccular stages of fetal lung development).

173 The more rostral saccular striola is a curving band with hair cell orient

174 cretory protein (CC10+) airway-like and SPC+ saccular structures within 6 days.

175 stress and their lungs failed to form normal saccular structures.

176 Small saccular terminals contacted a few dendrites in the tang

177 In contrast, small saccular terminals contacted many dendrites and a few ne

178 natal hyperoxia acutely initially diminished saccular TGF-beta signaling coincident with alveolar sim

179 we explore lineage relationships during the saccular to alveolar stage transition.

180 rtic aneurysms (n=10 total, 5 fusiform and 5 saccular) underwent 3-dimensional reconstruction with cu

181 Most auditory saccular units in reproductive, summer females showed ro

182 ans, including alveolar hypoplasia, variable saccular wall fibrosis, and minimal airway disease.

183 than 1,000 g: alveolar hypoplasia, variable saccular wall fibrosis, and minimal, if any, airway dise

184 at the saccular phase shows mesenchymal and saccular wall thickening, and abnormal proliferation of

185 geneity of pulse wave propagation within the saccular wall, which is lower in unstable aneurysms than

186 geneity of pulse wave propagation within the saccular wall.