ライフサイエンスコーパス: salen

1 ld asymmetrically substituted 2-quinoxalinol salens.

2 Nonsymmetric substitution of salen (1(R(1),R(2))) and reduced salen (2(R(1),R(2))) Cu

3 involving an equilibrium between nickel(II) salen (15) and two reduced forms, one being the metal-ce

4 titution of salen (1(R(1),R(2))) and reduced salen (2(R(1),R(2))) Cu(II)-phenoxyl complexes with a co

5 ort on the use of a simple, bench-stable [Fe(salen)(2)]-mu-oxo precatalyst in the reduction of nitro

6 alkyne cyclotrimerization regime with an [Fe(salen)](2) -mu-oxo (1) catalyst to triphenylmethylphosph

7 f the bimetallic aluminum(salen) complex [Al(salen)](2)O and tetrabutylammonium bromide (or tributyla

8 which the apical Ni site of the Ni*Cs-BINOL-salen activates the enone and the naphthoxide base activ

9 Chiral (salen)Al complex 1a catalyzes the highly enantioselectiv

10 A salen-Al-catalyzed aldol reaction was employed to constr

11 ylaluminum bromide was used to prepare three Salen aluminum bromide compounds salen((t)Bu)AlBr (1) (s

12 Optimization of a (salen)aluminum complex revealed significant remote elect

13 in catalytic applications compared with the salen analogues.

14 ernary complexes of Co(III)(salen)+, Fe(III)(salen)+, and Mn(III)(salen)+ with several angiotensin pe

15 ves of salicylaldehyde with chiral diamines (salens) are privileged ligands in asymmetric organometal

16 n (EHC) reactions using catalytic nickel(II) salen as a mediator.

17 sion between helical diastereomers of nickel-salen-based foldamers can be observed on a NMR time scal

18 heir uranyl complexes combine a chiral (R,R) salen bridge and an inherent chiral tris-bridged quinoxa

19 '- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsi

20 Specifically, the dimeric yttrium salen catalyst accelerates the ring opening of aliphatic

21 ation of celestolide with a chiral manganese salen catalyst afforded the azide product in 70% ee, rep

22 e report a bifunctional complex in which the salen catalyst and an aminocyclopropenium cocatalyst are

23 n be catalyzed using a Cu(II) 2-quinoxalinol salen catalyst and with tert-butyl hydroperoxide (TBHP).

24 ation of celestolide with a chiral manganese salen catalyst followed by trapping with aniline afforde

25 ter treatment with the Jacobsen (S,S)-Co(III)salen catalyst for the hydrolytic kinetic resolution of

26 A chiral cobalt-salen catalyst generates a highly electrophilic carbocat

27 h CO2 using a bifunctional rac-/(S,S)-cobalt salen catalyst in high carbonate linkage selectivity (>9

28 The optimized bifunctional aluminum salen catalyst maintains excellent activity for the ring

29 ol cross-coupling reaction catalyzed by a Cr-salen catalyst was developed.

30 An enantiopure aluminum salen catalyst with binaphthyl backbone facilitates the

31 A crystal structure of a Co-salen catalyst with two equivalents of benzaldehyde prov

32 e reaction is first order in the Ni*Cs-BINOL-salen catalyst.

33 insights assisted the discovery of a new Ti(salen) catalyst, which substantially expanded the reacti

34 available manganese porphyrin and manganese salen catalysts and various fluoride ion reagents, inclu

35 uctures show that this new class of Ni-BINOL-salen catalysts contains an unoccupied apical site for p

36 the design and development of chiral Co(III)-salen catalysts for enantioselective Diels-Alder reactio

37 In addition, chromium salen catalysts have been discovered as uniquely effecti

38 expressed in the design and synthesis of new salen catalysts whose effectiveness has been compared wi

39 ane-1,2-diamine-a common component of chiral salen catalysts-is a surprisingly weak director of absol

40 pproach toward polymer-supported, metalated, salen catalysts.

41 toward highly active and selective supported salen catalysts.

42 s with excess propylene oxide using aluminum salen catalysts.

43 4-EB) and CO2 using bifunctional cobalt(III) salen catalysts.

44 ary degradation studies using enantiopure Co(salen) catalysts are also reported.

45 ded the development of a set of eight new Ti(salen) catalysts with modified diamine backbones.

46 We report herein the development of a cobalt(salen) catalytic system that enables carbofunctionalizat

47 g alkyn-1-yl radicals arising from nickel(I) salen catalyzed cleavage of the carbon-halogen bond of e

48 ble for elucidating the mechanism of Mn(III) salen catalyzed reactions and ultimately for designing o

49 Tricomponent cobalt(salen)-catalyzed carbofunctionalization of unsaturated s

50 rigin of asymmetric induction in the Mn(III)(salen)-catalyzed epoxidation by peracetic acid have been

51 In this study, we present a new Co(salen)-catalyzed hydrofluorination of simple alkenes uti

52 m merges acridine photocatalysis with cobalt(salen)-catalyzed regioselective 1,4-carbofunctionalizati

53 tudy the Mn salen complex during the Mn(III) salen-catalyzed epoxidation of cis-beta-methylstyrene.

54 dinuclear clusters formed during the Mn(III) salen-catalyzed epoxidation reaction.

55 pproach was utilized for developing a Co(II)[salen]-catalyzed aerobic oxidative cross-coupling of phe

56 A pair of diastereomeric salen cavitands and their uranyl complexes combine a chi

57 e report here that simple (salen)cobalt and (salen)chromium complexes catalyze the beta-glucuronidati

58 ne oxide (PO) using biaryl-linked bimetallic salen Co catalysts was investigated experimentally and t

59 R) of terminal epoxides catalyzed by chiral (salen)Co(III) complex 1 x OAc affords both recovered unr

60 ution of terminal bis-epoxides catalyzed by (salen)Co(III) complexes affords epoxy-diols and N-protec

61 that the stereochemistry of each of the two (salen)Co(III) complexes in the rate-determining transiti

62 e absolute stereochemistry of each of these (salen)Co(III) complexes is the same.

63 g of oxetanes with alcohols is catalyzed by (salen)Co(III) complexes.

64 (salen)Co(III)](+), is capable of oxidizing (salen)Co(III)(iPr) to the formally cobalt(IV) state.

65 carbon dioxide with indene oxide utilizing (salen)Co(III)-2,4-dinitrophenoxide in the presence of an

66 In the (salen)Co(III)-catalyzed hydrolytic kinetic resolution (H

67 The (salen)Co(III)-catalyzed hydrolytic kinetic resolution (H

68 Even another cobalt(III) complex, [(salen)Co(III)](+), is capable of oxidizing (salen)Co(III

69 Here, we characterize a metastable (salen)Co(isopropyl) cation, which is capable of forming

70 The commonly used (salen)Co-OAc and (salen)Co-Cl precatalysts undergo complete and irreversib

71 The commonly used (salen)Co-OAc and (salen)Co-Cl precatalysts undergo compl

72 antitative formation of weakly Lewis acidic (salen)Co-OH and severely diminished reaction rates in th

73 lled by partitioning between a nucleophilic (salen)Co-OH catalyst and a Lewis acidic (salen)Co-X cata

74 In contrast, (salen)Co-OTs maintains high reactivity over the entire c

75 to epoxide is reversible in the case of the (salen)Co-OTs.

76 ic (salen)Co-OH catalyst and a Lewis acidic (salen)Co-X catalyst.

77 ion of catalyst partitioning with different (salen)Co-X precatalysts and demonstrate that counterion

78 The polymers are prepared using the salen cobalt(III) complex catalyzed copolymerization of

79 We report here that simple (salen)cobalt and (salen)chromium complexes catalyze the

80 these targets with [(18)F]KF, labeling with (salen)CoF is possible in the last step and under excepti

81 transition metal fluoride catalyst, [(18)F](salen)CoF, and its use for late-stage enantioselective a

82 st catalyst system, which is prepared from a salen complex and an onium salt, this convenient route e

83 es in the modes of binding between the metal-salen complex and the peptide ligand.

84 Using a Cu(II) 2-quinoxalinol salen complex as the catalyst and tert-butyl hydroperoxi

85 A chiral iron(III)-salen complex based on a cis-2,5-diaminobicyclo[2.2.2]oc

86 l butyrate, and CO(2), catalyzed by a cobalt salen complex bearing a quaternary ammonium salt, yields

87 , we have used dual-mode EPR to study the Mn salen complex during the Mn(III) salen-catalyzed epoxida

88 The aluminum salen complex exhibits exceptional selectivity for copol

89 The Fe(III)-salen complex has been applied successfully as a catalys

90 present the first instances wherein a nickel salen complex has been used in this manner.

91 Coordination of cis-stilbene sulfide to the salen complex in a ligand substitution reaction was esta

92 For a nickel salen complex made from a particularly bulky ligand, pre

93 a bifunctional aminocyclopropenium aluminum salen complex maintains excellent activity in the presen

94 evaluate the proposed mechanism of a yttrium-salen complex-catalyzed acylation of secondary alcohols

95 ety of epoxides catalyzed by a chromium(III) salen complex.

96 The combined use of the bimetallic aluminum(salen) complex [Al(salen)](2)O and tetrabutylammonium br

97 ed salen ligand and the corresponding Co(II)(salen) complex at low monomer concentrations results in

98 carboxylic acids catalyzed by Jacobsen's Co(salen) complex.

99 synthesis using the same bimetallic aluminum(salen) complex.

100 Oxidation of a series of Cr(V) nitride salen complexes (Cr(V)NSal(R)) with different para-pheno

101 fective, and readily synthesizable iron(III) salen complexes (Fe-1 and Fe-2) for facilitating the sel

102 ree, bench-stable, and cost-effective Mn(II)-salen complexes (Mn-ph, Mn-di-F, and Mn-di-Me) as precat

103 The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources,

104 Halide or alkoxide free yttrium-salen complexes are excellent catalysts for the ring ope

105 e synthesis of monofunctionalized Mn- and Co-salen complexes attached to a norbornene monomer via a s

106 A series of modified cobalt salen complexes has proven optimal for achieving good ef

107 ronic tuning at the phenyl diimine bridge of salen complexes in this reaction.

108 catalyzed by chromium, cobalt, and aluminum salen complexes is reported.

109 condary alcohols catalyzed by chiral Mn(III)-salen complexes using HOBr, Br(2)/H(2)O/KOAc or PhI(OAc)

110 Chiral polymeric Co(III) salen complexes with chiral ((R)/(S)-BINOL, diethyl tart

111 of a series of oxidized nitridomanganese(V) salen complexes with different para ring substituents (R

112 ble synthetic catalysts (chiral cobalt-based salen complexes) have been used for the efficient asymme

113 Here we show that chiral Al-salen complexes, which have well-defined photophysical p

114 ated with redox properties of the metal(III)(salen) complexes (Co > Fe > Mn), while differences in th

115 Ti(salen) complexes catalyze the asymmetric [3 + 2] cycload

116 ss-linked micelles (SCMs) containing Co(III)-salen cores were prepared from amphiphilic poly(2-oxazol

117 Whereas the mechanism for the (salen)Cr(III)-catalyzed ARO of epoxides displays a squar

118 Preliminary investigations of this (salen)Cr(III)-catalyzed system for the coupling of propy

119 The air-stable, chiral (salen)Cr(III)Cl complex (3), where H(2)salen = N,N'-bis(

120 ohexene oxide or propylene oxide) using the (salen)Cr(III)Cl complex as catalyst, where H(2)salen = N

121 on pathway involving anionic six-coordinate (salen)Cr(N3)X- derivatives.

122 he reactions between (TPP)AlCl/DMAP and (R,R-salen)CrCl and rac-PO/S-PO/R-PO and CO(2), has been inve

123 with carbonyl sulfide (COS) facilitated by (salen)CrCl/cocatalyst systems.

124 d poly(cyclohexylene)carbonate catalyzed by (salen)CrN3 (H2salen = N,N,'-bis(3,5-di-tert-butylsalicyl

125 using TBHP as oxidant with a 2-quinoxalinol salen Cu(II) complex as catalyst is reported.

126 mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in

127 Chromium salen derivatives in the presence of anionic initiators

128 nganese(III) complexes of three fluorophilic salen derivatives were used to prepare ion-selective ele

129 iamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic

130 and cyclohexene oxide catalyzed by chromium salen derivatives.

131 pathway include (1) the formation of a Mn(V)-salen dibromide, (2) its subsequent reaction with the al

132 iation (SID) of ternary complexes of Co(III)(salen)+, Fe(III)(salen)+, and Mn(III)(salen)+ with sever

133 weak director of absolute helicity in nickel-salen foldamers.

134 ly, electron withdrawing substituents on the salen framework resulted in a more redox stable Co(III)

135 Here, we show that an iron-salen, i.e., mu-oxo N,N'- bis(salicylidene)ethylenediami

136 Fe(Salen) is an anti-cancer compound with magnetic property

137 ve, which is a good precursor for an unusual salen ligand and its Ni-complex.

138 to both the electron-donating ability of the salen ligand and the [cocatalyst], where N-heterocyclic

139 s of a monocyclooct-4-en-1-yl functionalized salen ligand and the corresponding Co(II)(salen) complex

140 ymerization, and the interaction between the salen ligand and the growing polymer chain is a fundamen

141 ohexane-(1R,2R)-diamine) with a non-innocent salen ligand has been investigated both in the solid sta

142 A series of manganese Hangman salen ligand platforms functionalized by tert-butyl grou

143 minum initiator stabilized by a C2-symmetric salen ligand which shows a hitherto unknown high activit

144 hromium(III) system was achieved utilizing a salen ligand with tert-butyl groups in the 3,5-positions

145 mediated by the stepped conformation of the salen ligand, and not the shape of the chiral diamine ba

146 of hydrogen from carbon to an oxygen of the salen ligand.

147 e most widely used Schiff base ligands, the "salen" ligand, has been extensively researched.

148 iminophosphorane derivative of the popular "salen" ligand, termed "phosphasalen".

149 Salen ligands are tunable for steric as well as electron

150 etic strategy for the construction of chiral salen ligands bearing two rigid xanthene spacers functio

151 1R,2R)-(-)-1,2-diaminocyclohexane to produce salen ligands featuring an expandable molecular cleft ca

152 e-pot synthesis of enantiopure unsymmetrical salen ligands is described, using a 1:1:1 molar ratio of

153 onbiological molecules based on salophen and salen ligands that fold into single-stranded helices in

154 at could arise from tetradentate ligation of salen ligands to rhenium, one major isomer is observed a

155 The triplesalen ligand system based on three salen-like coordination environments bridged by a common

156 MR studies performed on 6 indicated that the salen macrocycle had rearranged upon thiirane coordinati

157 The addition of the steric groups to the salen macrocycle leads to enhanced catalase activity by

158 nder aerobic and acidic conditions, these Co(salen) macrocycles exhibit extremely high reactivities a

159 Two free radical scavengers, the salen-manganese complex EUK-134, and the spin trap s-PBN

160 This supports the concept that salen-manganese complexes represent a class of SOD and,

161 This study describes two series of salen-manganese complexes, comparing catalytic ROS scave

162 In previous papers, two salen-manganese complexes, EUK-8 and EUK-134, had supero

163 UK-8 is a member of a new class of synthetic salen-manganese compounds with low toxicity that possess

164 cterized as a side product of the nickel(II) salen mediated electroreductive cyclization of 11.

165 Salen metal complexes incorporating two chiral BINOL moi

166 ghly enantioselective addition reactions by (salen)metal catalysts to an important new class.

167 centration, which stands in contrast to the (salen)metal-catalyzed opening of simple epoxides where s

168 primarily summarizes developments in chiral salen-metal catalysis over the last two decades with par

169 ge number of metals gives the derived chiral salen-metal complex very broad utility in asymmetric cat

170 Chiral salen-metal complexes are among the most versatile asymm

171 class of chiral 5,5'-di(2,4,6-trialkyl)aryl salen-metal complexes have been developed and shown to c

172 of H(2) in THF, the manganese nitride ((tBu)Salen)Mn=N underwent hydrogenation to liberate free ammo

173 f macrocyclic oligomeric structures with the salen moieties being attached in an unsymmetrical, flexi

174 iral (salen)Cr(III)Cl complex (3), where H(2)salen = N,N'-bis(3,5-di-tert-butyl-salicylidene)-1,2-cyc

175 len)Cr(III)Cl complex as catalyst, where H(2)salen = N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cycl

176 o the characterization of the Mn(III) salen (salen = N,N'-ethylene bis(salicylideneaminato)) complex

177 compound [Ru(salen)(NO)(H(2)O)](SbF(6)) (1) (salen = N,N'-ethylene-bis-salicylidene aminate) reacts c

178 inum bromide compounds salen((t)Bu)AlBr (1) (salen = N,N'-ethylenebis(3,5-di-tert-butylsalicylideneim

179 Manganese(V) salen nitrido complexes (salen = N,N'-ethylenebis(salicylideneaminato)) appended

180 Cation-binding salen nickel catalysts were developed for the enantiosel

181 Manganese(V) salen nitrido complexes (salen = N,N'-ethylenebis(salicy

182 The series, which includes the manganese(V) salen nitrido without an appended crown, spans 4 units o

183 reaction was established by isolation of [Ru(salen)(NO)(cis-stilbene sulfide)](SbF(6)) (6).

184 The compound [Ru(salen)(NO)(H(2)O)](SbF(6)) (1) (salen = N,N'-ethylene-bi

185 ic insight into the function of binary metal salen/nucleophilic cocatalyst systems at low concentrati

186 The method uses Mn(salen)OTs as an F-transfer catalyst and enables the faci

187 tron transfer during dissociation of Co(III)(salen)-peptide complexes is mainly determined by differe

188 on behavior was obtained for various Co(III)(salen)-peptide systems of different angiotensin analogue

189 ed by the cyclohexanediamine backbone of the salen platform is revealed by the epoxidation of 1,2-dih

190 ochemistry of the cyclohexyl backbone of the salen platform is revealed in the epoxidation of 1,2-dih

191 While nickel(II) salen proved effective, the analogous cobalt complex as

192 oxide, with this activity most influenced by salen ring alkoxy substitution and aromatic bridge modif

193 cellent enantioselectivities using a chiral (Salen)Ru(II) cyclopropanation catalyst in the key asymme

194 nique to the characterization of the Mn(III) salen (salen = N,N'-ethylene bis(salicylideneaminato)) c

195 ites, and the high local concentration of Co(salen) species resulting from the macrocyclic framework.

196 Here, we characterize relevant salen-supported cobalt complexes and their reactions wit

197 roperties which are not always observed with salen systems as a result of their pi-conjugation.

198 has been increased interest in pi-conjugated salen systems, known as "salphen" ligands, as a result o

199 six-coordinate cationic aluminum compounds [salen((t)Bu)Al(Ph(3)PO)(2)]Br (4), [salpen((t)Bu)Al(Ph(3

200 epare three Salen aluminum bromide compounds salen((t)Bu)AlBr (1) (salen = N,N'-ethylenebis(3,5-di-te

201 The alkane elimination reaction between Salen((t)Bu)H(2) ligands and diethylaluminum bromide was

202 The Salen(tBu) ligand and its derivatives were used to prepa

203 tive oxazaborolidine reduction and a chiral (salen)Ti(IV) catalyzed asymmetric synthesis of silyl cya

204 roups that can enhance enantioselectivity of salen titanium complexes when they are used in asymmetri

205 with laccases and other catalysts like a Co(salen) type catalyst and PdCl(2) clearly demonstrate tha

206 tization (HPD) reaction promoted by a chiral salen-type bis(lambda(5)-iodane) reagent, followed by an

207 when bis(3-pyridyl)-functionalized free-base salen-type ligand was employed in the reaction.

208 Zn(II)-metalation of the salen-type ligands in the molecular loops converts the l

209 with bis(4-pyridyl)-functionalized free-base salen-type ligands.

210 (2) and bis(4-pyridyl)-functionalized Zn(II)-salen-type ligands.

211 se in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging.

212 o(III)(salen)+, Fe(III)(salen)+, and Mn(III)(salen)+ with several angiotensin peptide analogues was s