ライフサイエンスコーパス: salubrinal

1 plasmic reticulum (ER) stress, we identified salubrinal, a selective inhibitor of cellular complexes

2 A receptor blocker AP-5 or by treatment with salubrinal, a selective inhibitor of eukaryotic translat

3 Furthermore, treatment with salubrinal, a small chemical compound that specifically

4 Salubrinal also blocks eIF2alpha dephosphorylation media

5 Salubrinal also protected osteoblast development by upre

6 ype PC12 cells, activation of this module by salubrinal ameliorates the response to Abeta.

7 erference to knock down caspase-12 levels or salubrinal (an ER stress inhibitor) partially protected

8 y, we explored the underlying means by which salubrinal, an activator of eIF2alpha signaling, enhance

9 onnection with ME/CFS, and the potential for salubrinal, an agent known for its influence on cellular

10 ly, treatment of alphaS transgenic mice with Salubrinal, an anti-ER stress compound that delays the o

11 More important, treatment with Salubrinal, an anti-ERS compound, significantly attenuat

12 Sublethal dosage of salubrinal, an eIF2alpha phosphatase inhibitor, increase

13 In contrast, salubrinal, an inhibitor of eIF2alpha-P dephosphorylatio

14 Salubrinal, an inhibitor of eIF2alpha-P phosphatase PP1c

15 Furthermore, salubrinal, an inhibitor of ER stress-induced apoptosis,

16 neous or sequential combination therapy with salubrinal, an inhibitor of GADD34-PP1C phosphatase comp

17 mutation was more affected by treatment with salubrinal, an inhibitor of the ER-stress pathway.

18 induction of the PERK-eIF2alpha pathway with salubrinal attenuated the inflammatory response to both

19 More broadly, salubrinal demonstrates the feasibility of selective pha

20 or increasing eIF2alpha phosphorylation with salubrinal did not affect Nrf2 elevation by H(2)O(2).

21 tcome in the surgery-induced ONFH model, and salubrinal improves ONFH symptoms by enhancing angiogene

22 e our understanding of the potential role of salubrinal in improving the quality of life for individu

23 he specific eIF2alpha phosphatase inhibitor, salubrinal, induces resistance against oxidative glutama

24 Salubrinal is a synthetic chemical that inhibits de-phos

25 with an inhibitor of eIF2alpha phosphatase, salubrinal, led to improved photoreceptor survival.

26 nd reduction of adult hemoglobin as possible salubrinal mechanisms.

27 ion of translational arrest and ER stress by salubrinal or of MAPK signaling pathways attenuate cytok

28 es disposal of reactive oxygen species), and salubrinal (prevents endoplasmic reticulum stress) follo

29 wn inhibitor of eIF2alpha dephosphorylation, salubrinal, revealed that elevated eIF2alpha phosphoryla

30 se 1 a (PP1a)-specific phosphatase inhibitor Salubrinal (SAL) synergized with TG to induce EBV lytic

31 We then determined that salubrinal selectively increased the number of actively

32 t the ER stress was associated with ONFH and salubrinal significantly improved ONFH-induced symptoms

33 demise by co-treatment with calpastatin and salubrinal suggests co-activation of the calpain and ER-

34 osphorylation with systemically administered salubrinal throughout hypoxia/reoxygenation exposure pre

35 ion of apocynin, tert-butylhydroquinone, and salubrinal to prevent oxidative stress and endoplasmic r

36 rical development and mechanism of action of salubrinal, to mitigate endoplasmic reticulum (ER)/cellu

37 Intriguingly, salubrinal treatment of differentiating human CD34(+) ce

38 urgery-induced animal model was employed and salubrinal was administered to evaluate the role of ER s

39 avior tests in wild-type mice cotreated with salubrinal (which inhibits translation by inducing eIF2a

40 g eIF2alphaP signaling by the small molecule salubrinal, which inhibits dephosphorylation of eIF2alph