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1 biosynthesis from an intermediate (corrinoid salvaging).
2 ential but not sufficient to guarantee brain salvage.
3 the malate cycle, supports phosphoglycolate salvage.
4 herefore can synthesize tryptophan by indole salvage.
5 anagement to maximize the potential for limb salvage.
6 iated with increased extracellular adenosine salvage.
7 regulatory role in the modulation of NAD(+) salvage.
8 imary enucleation, suggesting safe trial eye salvage.
9 ibonucleosides needed for dNTP production by salvage.
10 n identified for C. parvum purine nucleotide salvage.
11 subretinal seeds regressed, with 100% globe salvage.
12 n in the infarct area and reduced myocardial salvage.
13 low histopathologic risk support safe trial salvage.
14 ven alongside reperfusion to increase tissue salvage.
15 tively delineate MaR and quantify myocardial salvage.
16 thway is the main route for phosphoglycolate salvage.
17 profile and may contribute to improved globe salvage.
18 h A3 and A2 and a 50% increase in myocardial salvage.
19 T-ALL relapses are particularly difficult to salvage.
20 combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicil
21 ural duration, blood product transfusion and salvages a small subset of patients who would not otherw
22 ls reveals substantial remaining de novo and salvage activities, and could not eliminate the disease
23 mmunohistochemistry, and deoxyribonucleoside salvage activity in brain-infiltrating leukocytes was an
25 kocyte infiltration, and deoxyribonucleoside salvage activity is present at similar levels in brain-i
27 d by an induction of extracellular adenosine salvage, AMPK activation, and the acquisition of metabol
28 adiotracer that measures deoxyribonucleoside salvage and accumulates preferentially in immune cells.
32 e findings uncover differences in nucleotide salvage and de novo biosynthesis using a histologically
33 the purine, pyrimidine de novo synthesis and salvage and interconversion routes, were significantly u
34 nts a plausible nonenzymatic pathway for the salvage and recovery of genetic information following st
36 metric, partially contaminated images can be salvaged and highly contaminated images can be excluded
37 1 and T2 could not differentiate between the salvaged and the infarcted myocardium, but ECV was signi
39 ltransferase (NAMPT), a key enzyme in NAD(+) salvage, and loss of NAMPT activity alters their inflamm
43 baseline at 3 months of follow-up and globe salvage at last available follow-up in eyes with filteri
44 independent pathway, widespread in bacteria, salvages at least two by-products of SAM-dependent enzym
47 vention had cell salvage deployed (50.8% had salvaged blood returned; mean 259.9 ml) versus 3.9% of 1
52 assumptions, each therapy was compared with salvage chemoimmunotherapy regimens and stem-cell transp
53 th quizartinib had a survival benefit versus salvage chemotherapy and had a manageable safety profile
54 -C) is an essential component of primary and salvage chemotherapy regimens for acute myeloid leukemia
60 loelectron-volt VM imaging may be useful for salvaging CT studies with suboptimal contrast material d
62 % of 1,498 assigned to intervention had cell salvage deployed (50.8% had salvaged blood returned; mea
65 by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with it
66 esent in another (p)ppGpp target, the purine salvage enzyme HPRT, suggesting evolutionary conservatio
67 phosphoribosyltransferase (XPRT) is a purine salvage enzyme that produces the nucleotide XMP from PRP
69 as-yet undiscovered purine transporters and salvage enzymes; however, genetic and pharmacological ex
70 tive chemoradiotherapy (DCR) with or without salvage esophagectomy (SALV) in the treatment of esophag
73 e., CblT) and a kinase (i.e., CblS) that can salvage exogenous alpha-ribazole (alpha-R) from the envi
78 ted with intravenous chemotherapy and IVM as salvage for vitreous seeding, and further to determine w
82 dality treatments initiated with IVC, 50% of salvaged Group D retinoblastoma eyes had <20/200 vision,
83 neage acute lymphoblastic leukemia (ALL) can salvage >80% of patients having relapsed/refractory dise
86 gest the more general term "phosphoglycolate salvage." Here, we study phosphoglycolate salvage in the
87 approximately 22 patients were candidates to salvage IAT during emergency relaparotomy because of pos
88 ft survival, and insulin-free survival after salvage IAT were not different from those documented aft
92 adiotracer that measures deoxyribonucleoside salvage in humans, were analyzed to evaluate whether (18
94 te salvage." Here, we study phosphoglycolate salvage in the model chemolithoautotroph Cupriavidus nec
96 hieved in 119 (99%) patients (both eyes were salvaged in 92 [76%] patients and at least 1 eye was sal
97 2.5+/-14.5 versus 24.0+/-18.5 g), myocardial salvage index (30.3+/-15.6% versus 31.5+/-23.6%), or mea
98 mained associated with both final myocardial salvage index (beta=-0.12; P=0.03) and MVO (beta=0.18; P
100 d early QW in the ECG had smaller myocardial salvage index and more extensive MVO than non-QW despite
102 postconditioning on infarct size, myocardial salvage index, and LV function compared with routine PCI
103 on (edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular o
104 myocardial infarction, with the final aim of salvaging jeopardized myocardium and preventing left ven
105 baseline induction of the reperfusion injury salvage kinase pathway but were less able to respond via
106 ylguanine ([18F]F-AraG), targeted toward two salvage kinase pathways preferentially accumulates in ac
111 ther patients are good candidates for LR and salvage liver transplantation should be encouraged in el
112 nce of eyelid or ocular surface tumor, globe salvage, locoregional and systemic metastasis, and death
115 ays, amputation-free survival (AFS) and Limb salvage (LS) were noticeably worse in P2 compared to P1
116 ate-specific antigen (PSA) persistence after salvage lymph node dissection (SLND) and pre-procedure a
117 atient cohort with PSA persistence following salvage lymph node dissection (SLND) and pre/post proced
118 choline, 101 (68)Ga-PSMA) originated from 73 salvage lymphadenectomies at biochemical recurrence and
120 T1, T2 and ECV in both the infarcted and the salvaged myocardium were significantly higher than in th
122 not differentiate between the infarcted and salvaged myocardium, whereas ECV could differentiate bet
123 the expression of genes encoding enzymes for salvage NAD synthesis from nicotinamide (NAM) and nicoti
125 oss cellular membranes and are essential for salvage nucleotide synthesis and purinergic signaling.
126 cause local regrowth (with the potential for salvage) occurs in 25% of patients, and distant metastas
127 addressing the dependency on biosynthesis or salvage of fatty acids (FAs), purine nucleotides (AMP an
130 bacteria are capable of Q de novo synthesis, salvage of the prokaryotic Q precursors preQ(0) and preQ
132 ravel the interplay between biosynthesis and salvage of vitamins and cofactors in apicomplexans.
138 uctone dioxygenase (ARD) from the methionine salvage pathway (MSP) is a unique enzyme that exhibits d
141 e reductase (GMPR) is involved in the purine salvage pathway and is conserved throughout evolution.
142 bstrate enhancement of the purine nucleoside salvage pathway and might improve the liver pathology in
143 Our work highlights pabA and the pyrimidine salvage pathway as potential targets for novel therapeut
144 wide search allows us to identify the NAD(+) salvage pathway encoded by an operon of nadR-pnuC-nrtR (
145 h FK866, a selective inhibitor of the NAD(+) salvage pathway enzyme nicotinamide phosphoribosyltransf
146 sitive to selective inhibition of the NAD(+) salvage pathway enzyme nicotinamide phosphoribosyltransf
147 Two phosphoribosyltransferases in the purine salvage pathway exhibit exquisite substrate specificity
148 stablishes a bifunctional oxygen-independent salvage pathway for 5'-deoxyadenosine and 5'-methylthioa
149 smodium falciparum (Pf) relies solely on the salvage pathway for its purine nucleotide requirements,
153 external stimuli and expansion of nucleoside salvage pathway genes potentially for competition with M
155 sumption products (i.e., nicotinamide) via a salvage pathway in order to maintain NAD(+) homeostasis.
159 conditions, suggesting that the dual-purpose salvage pathway plays a central role in numerous environ
162 pyridoxal kinase (PDXK) acts in vitamin B(6) salvage pathway to produce pyridoxal 5'-phosphate (PLP),
163 thesis enzyme dihydrofolate reductase (DHFR, salvage pathway) mRNA levels showed a significant (P <0.
165 onent of the mitochondrial purine nucleotide salvage pathway, encoded by the nuclear gene encoding de
166 MPT), the rate-limiting enzyme of the NAD(+) salvage pathway, governs the proinflammatory SASP indepe
167 monstrates a so far unknown phosphoglycolate salvage pathway, highlighting important diversity in mic
168 tical enzyme in the mitochondrial pyrimidine salvage pathway, is essential for mitochondrial DNA (mtD
169 compensatory activation of the sphingolipid salvage pathway, resulting in significant accumulation o
170 ammalian cells is synthesized via the NAD(+) salvage pathway, where nicotinamide phosphoribosyltransf
171 MT tumors preferentially used the nucleotide salvage pathway, whereas papillary tumors preferred de n
172 (NAMPT), the rate-limiting enzyme in the NAD salvage pathway, which acts as negative regulator of the
179 hese results reveal new aspects of mammalian salvage pathways and serve as a new benchmark for design
180 g and a targetable molecule driving nutrient salvage pathways in PDAC and validates oncogene-driven s
181 e is known about the NAD(+) biosynthesis and salvage pathways in the opportunistic pathogen Streptoco
183 phorylase (UP) is a key enzyme of pyrimidine salvage pathways that enables the recycling of endogenou
186 ls demonstrate the efficacy of venetoclax to salvage patients with disease progression on BTKis, but
189 had nystagmus and 12 of 20 (60%) bilaterally salvaged patients had strabismus (n = 10 exotropia and n
193 gut flora such as Clostridioides difficile, salvages preQ(1) from q through an unprecedented reactio
196 h-Nyhan disease (LND), caused by a deficient salvage purine pathway, is characterized by severe neuro
197 , is accomplished by de novo synthesis or by salvaging pyrimdines from e.g. nucleic acid turnover.
202 power to detect an improvement from 90% with salvage radiotherapy (control) to 95% at 10 years with a
203 th adjuvant radiotherapy compared with early salvage radiotherapy (HR 0.95, 95% CI 0.75-1.21; p=0.70)
204 olume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy a
207 atients were randomly assigned, 699 (50%) to salvage radiotherapy and 697 (50%) to adjuvant radiother
209 diotherapy versus an observation policy with salvage radiotherapy for prostate-specific antigen (PSA)
210 t radiotherapy or an observation policy with salvage radiotherapy for PSA biochemical progression (PS
212 diotherapy group versus 92% for those in the salvage radiotherapy group (HR 0.88, 95% CI 0.58-1.33; p
213 radiotherapy group and 88% for those in the salvage radiotherapy group (HR 1.10, 95% CI 0.81-1.49; p
215 apy within 6 months; 228 (33%) of 699 in the salvage radiotherapy group reported radiotherapy within
216 ted PSMA-positive lesions outside a standard salvage radiotherapy volume in 39.4% of all patients.
219 choice of postprostatectomy adjuvant versus salvage radiotherapy, and to address emerging questions
220 immediate adjuvant radiotherapy versus early salvage radiotherapy, following radical prostatectomy in
221 t radiotherapy and 1078 to a policy of early salvage radiotherapy, of whom 421 (39.1%) had commenced
224 r survival analysis estimated a better globe salvage rate in the MPT group (66%) compared with the MA
225 38% to 5% (P < 0.0001), and the overall eye salvage rate increased from 4% to 61% (98% for group A,
227 The relatively low relapse rate and high salvage rates at relapse reduce the potential benefit of
229 provides a possible explanation for why the salvage reactions in purine metabolism exhibit lower act
230 Nivo was an active and well-tolerated first salvage regimen, potentially providing patients with R/R
231 to best incorporate immunotherapeutics into salvage regimens and investigate long-term survival and
233 adenine supplementation favors the pyridine salvage route resulting in an ATP-dependent increase of
235 ted in sex despite functional losses and can salvage satisfaction, thereby giving insight into attain
238 or unacceptable toxicity in 30 patients (27 salvage surgeries for recurrent cases and 3 cases of pri
239 with highest rate occurring in those having salvage surgery for anal cancer.Multivariable analysis s
241 , the risk for local recurrence and need for salvage surgery is similar, irrespective of the CRT regi
244 apse of disease may be eligible for curative salvage surgery, but the benefit of this surgery has not
245 clinical benefit was substantiated following salvage surgery, two of the three patients treated with
246 by transferring the endogenous molecules to salvage the injured neighboring cells by regulating apop
248 istance, not only to the azoles but also the salvage therapeutics amphotericin B and terbinafine with
254 into the paracolic gutters and pelvis or for salvage therapy after endoscopic or surgical debridement
255 ging from 0.2 to 2.0 ng/mL without any prior salvage therapy and with a Karnofsky performance status
256 nhibitors (NRTIs) can be safely omitted from salvage therapy as long as the regimen has a cumulative
258 zobactam-ceftazidime-avibactam may represent salvage therapy for individuals with CF and highly drug-
262 ponsive to conventional rituximab-containing salvage therapy from 12 oncology-haematology centres in
263 EN/AZA therapy represents a novel and active salvage therapy in patients who had relapsed post-allogr
264 red in combination were evaluated as initial salvage therapy in patients with relapsed or refractory
266 axel did not result in improved survival for salvage therapy of patients with advanced-stage lung ade
267 been in heterogeneous patient groups needing salvage therapy or presenting at varied time points.
271 leic acids in the AH from Rb eyes undergoing salvage therapy with intravitreous injection of melphala
273 -cell non-Hodgkin lymphoma chemosensitive to salvage therapy with: (1) positron emission tomography-p
274 assive bleeding with poor visualization, for salvage therapy, and for diffuse bleeding from malignanc
275 igh frequency of relapse, poorer response to salvage therapy, and shorter overall survival than those
276 radiation therapy (SIRT) has been tested as salvage therapy, but no data exist about its use as firs
277 R, 43 IR MRD-positive) plus 23 rescued after salvage therapy, for a total of 188 candidates; 150 (44%
278 le investigating the off-label use of BDQ as salvage therapy, seven of 13 patients with Mycobacterium
282 merase and aldolase sequentially function to salvage these two wasteful and inhibitory compounds into
285 living promotes spine formation but fails to salvage training-related spines in mice lacking BDNF-dep
287 ause inhibition of IGF1R offered efficacious salvage treatment of PI3K-delta inhibitor-resistant tumo
289 emia who were due to receive first or second salvage treatment were randomly assigned (1:1) via an in
290 ase recurrence are candidates for aggressive salvage treatment with high-dose chemotherapy and autolo
292 a on long-term outcomes are available, early salvage treatment would seem the preferable treatment po
295 ratoprosthesis type II is a viable option to salvage vision in patients with poor prognosis for other
298 , the contributions of pABA synthesis versus salvage were re-evaluated in a rodent malaria model with