ライフサイエンスコーパス: sarcoplasmic reticulum

1 lease probably due to Ca(2+) overload in the sarcoplasmic reticulum.

2 sensitive release channels on the peripheral sarcoplasmic reticulum.

3 erize structural changes in mitochondria and sarcoplasmic reticulum.

4 A/DDD and controls in calcium content of the sarcoplasmic reticulum.

5 current mediated by Ca(2+) released from the sarcoplasmic reticulum.

6 iculum Ca2+ ATPase (SERCA2a), located in the sarcoplasmic reticulum.

7 ith type 1 ryanodine receptors (RyR1) in the sarcoplasmic reticulum.

8 rticularly spontaneous Ca2+ release from the sarcoplasmic reticulum.

9 alignment with the terminal cisternae of the sarcoplasmic reticulum.

10 r Thr-17 relieves this inhibition in cardiac sarcoplasmic reticulum.

11 mall space between sarcolemma and junctional sarcoplasmic reticulum.

12 ious rates in the release of Ca(2+) from the sarcoplasmic reticulum.

13 he active transport of calcium back into the sarcoplasmic reticulum.

14 duit for passive proton transport across the sarcoplasmic reticulum.

15 vitro, along with Ca(2+) uptake in isolated sarcoplasmic reticulum.

16 tracellular fluxes in both the cytoplasm and sarcoplasmic reticulum.

17 ing calcium ions from the cytoplasm into the sarcoplasmic reticulum.

18 are caused by cyclic Ca(2+) release from the sarcoplasmic reticulum, although Ca(2+) influx via plasm

19 er beating rate, disorganised sarcomeres and sarcoplasmic reticulum and a blunted response to isopren

20 se in the amount of Ca(2+) stored within the sarcoplasmic reticulum and activated Ca(2+)/calmodulin-d

21 ebral arterial smooth muscle which comprised sarcoplasmic reticulum and caveolae.

22 hondria but exhibited only a small effect on sarcoplasmic reticulum and cytosolic Ca(2+) levels under

23 uscles of SHR showed reduced activity of the sarcoplasmic reticulum and decreased sarcolemmal calcium

24 tudies uncovered progressive dilation of the sarcoplasmic reticulum and ectopic and misaligned transv

25 the dyad, linking the transverse tubule and sarcoplasmic reticulum and ensuring close proximity of C

26 the Ca needed for contraction comes from the sarcoplasmic reticulum and is released by the process of

27 hat can prolong the AP duration and load the sarcoplasmic reticulum and likely contributes to the alt

28 e underwent extensive remodeling of both the sarcoplasmic reticulum and mitochondria, including alter

29 ultrastructural abnormalities of junctional sarcoplasmic reticulum and transverse tubules, and (4) a

30 bules), the intracellular calcium store (the sarcoplasmic reticulum), and the co-localisation of thes

31 r in the regulation of calcium uptake in the sarcoplasmic reticulum, and by probing its dynamical act

32 ban is a small phosphoprotein in the cardiac sarcoplasmic reticulum, and it is the major regulator of

33 channels (ryanodine receptors, RyR2) in the sarcoplasmic reticulum, and the frequency of Ca(2+) spar

34 consisting of ryanodine receptors (RyRs) at sarcoplasmic reticulum apposing CaV1.2 channels at t-tub

35 leading to inhibition of Ca-uptake into the sarcoplasmic reticulum, are linked to inherited DCM.

36 similar to those present in the lumen of the sarcoplasmic reticulum at rest, whereas Ca(2+) concentra

37 cell shortening, Ca transient amplitude and sarcoplasmic reticulum Ca content compared with sham car

38 cell shortening, Ca transient amplitude, and sarcoplasmic reticulum Ca content in colon ascendens ste

39 ak from the sarcoplasmic reticulum, reducing sarcoplasmic reticulum Ca content, Ca transient amplitud

40 t the T tubules and regulates arrhythmogenic sarcoplasmic reticulum Ca leak.

41 waves is a highly nonlinear function of the sarcoplasmic reticulum Ca load.

42 mined the subcellular mechanisms involved in sarcoplasmic reticulum Ca loss that mediate altered Ca h

43 sim) in adult cardiac myocytes during cyclic sarcoplasmic reticulum Ca release, by simultaneous live

44 icantly reduced the frequency of spontaneous sarcoplasmic reticulum Ca release, while QX-flecainide a

45 mic reticular calcium ATPase 2 abundance and sarcoplasmic reticulum Ca uptake are depressed in both s

46 hate receptors (IP3 R) and upon depletion of sarcoplasmic reticulum Ca(2+) .

47 Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca(2+) ATPase (SERCA) in muscle.

48 ease models have shown that dysregulation of sarcoplasmic reticulum Ca(2+) ATPase (SERCA) pump is one

49 fects and that murine PDE3A1 associates with sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2), phospho

50 e-type versus Fork-type; P<0.01), because of sarcoplasmic reticulum Ca(2+) ATPase pump potentiation c

51 Calsequestrin1 (CSQ1), a sarcoplasmic reticulum Ca(2+) buffering protein, inhibit

52 dling proteins, intracellular [Ca(2+)]i, and sarcoplasmic reticulum Ca(2+) content and increases in p

53 crease in amplitude of Ca(2+) transients and sarcoplasmic reticulum Ca(2+) content in LQT2 myocytes.

54 n of transient outward potassium current and sarcoplasmic reticulum Ca(2+) content via rescue of cont

55 2+) transient amplitude, 50% decay rate, and sarcoplasmic reticulum Ca(2+) content were not different

56 , reduced Ca(2+) spark dimensions, increased sarcoplasmic reticulum Ca(2+) content, and augmented the

57 reased [Ca(2+)] transient amplitude, reduced sarcoplasmic reticulum Ca(2+) content, and short action

58 activation caused a compensatory increase in sarcoplasmic reticulum Ca(2+) content, Ca(2+) transient

59 arcoplasmic reticulum Ca(2+) leak, augmented sarcoplasmic reticulum Ca(2+) content, increased the mag

60 2+) current but had no significant impact on sarcoplasmic reticulum Ca(2+) content.

61 , sarcoplasmic reticulum Ca(2+) release, and sarcoplasmic reticulum Ca(2+) handling proteins in post-

62 vation of neuronal nitric oxide synthase and sarcoplasmic reticulum Ca(2+) handling proteins, and ide

63 osphorylated neuronal nitric oxide synthase, sarcoplasmic reticulum Ca(2+) handling proteins, intrace

64 iculum Ca(2+) release, and the expression of sarcoplasmic reticulum Ca(2+) handling proteins.

65 d enhanced ryanodine receptor (RyR)-mediated sarcoplasmic reticulum Ca(2+) leak in LQT2 cells.

66 )]Bulk=100 nmol/L) is dictated mainly by the sarcoplasmic reticulum Ca(2+) leak rather than sarcolemm

67 SN also reduced sarcoplasmic reticulum Ca(2+) leak, augmented sarcoplasm

68 loss without marked changes in cytosolic and sarcoplasmic reticulum Ca(2+) levels, likely owing to al

69 Ca(2+)-dependent mechanism without altering sarcoplasmic reticulum Ca(2+) load and by increasing uns

70 Ca(2+) concentration transients and a lesser sarcoplasmic reticulum Ca(2+) load due to a down-regulat

71 use STIM1 binding to phospholamban increases sarcoplasmic reticulum Ca(2+) load independent of store-

72 Sarcoplasmic reticulum Ca(2+) load was not changed with

73 f mutant ryanodine receptor type 2 channels, sarcoplasmic reticulum Ca(2+) load, measured by caffeine

74 There are reduced Ca(2+) transient and sarcoplasmic reticulum Ca(2+) load, together with decrea

75 lic cytosolic Ca(2+), RyR2 inactivation, and sarcoplasmic reticulum Ca(2+) release (ie, Ca(2+) altern

76 otoxin (but not ranolazine), suggesting that sarcoplasmic reticulum Ca(2+) release and Na(+) current

77 Simulations suggest that potentiated sarcoplasmic reticulum Ca(2+) release and Na(+)/Ca(2+) e

78 In the heart, sarcoplasmic reticulum Ca(2+) release and signaling are

79 hese models: one relies mainly on fractional sarcoplasmic reticulum Ca(2+) release and uptake, and th

80 Furthermore, ryanodine receptor 1 (the sarcoplasmic reticulum Ca(2+) release channel required f

81 ure for synchronization and stabilization of sarcoplasmic reticulum Ca(2+) release in healthy cardiom

82 enge slowed late repolarization, potentiated sarcoplasmic reticulum Ca(2+) release, and initiated EAD

83 orylation of neuronal nitric oxide synthase, sarcoplasmic reticulum Ca(2+) release, and sarcoplasmic

84 pterin, the dimers of nitric oxide synthase, sarcoplasmic reticulum Ca(2+) release, and the expressio

85 The resultant RyR2 inactivation diminishes sarcoplasmic reticulum Ca(2+) release, which, in turn, r

86 l, flecainide did not inhibit RyR2-dependent sarcoplasmic reticulum Ca(2+) release.

87 omal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca(2+) sensor.

88 (fl/fl) mice post HF revealed both increased sarcoplasmic reticulum Ca(2+) spark frequency and disrup

89 crease Ca(2+) influx to enhance refilling of sarcoplasmic reticulum Ca(2+) stores, slow muscle fatigu

90 Ca(2+) load due to a down-regulation of the sarcoplasmic reticulum Ca(2+)-adenosine triphosphatase p

91 h there is some evidence that suppression of sarcoplasmic reticulum Ca(2+)-ATP-ase (SERCA2) contribut

92 The calcium pump sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) counter-tra

93 The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) transports

94 namics (MD) simulations of the calcium pump (sarcoplasmic reticulum Ca(2+)-ATPase (SERCA)) in complex

95 Down-regulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) in the

96 merization of phospholamban, which activates sarcoplasmic reticulum Ca(2+)-ATPase and increases cytos

97 The sarcoplasmic reticulum Ca(2+)-ATPase SERCA promotes musc

98 ATP has dual roles in the reaction cycle of sarcoplasmic reticulum Ca(2+)-ATPase.

99 Enhanced sarcoplasmic reticulum Ca(2+)-leak via ryanodine recepto

100 Ca(2+)-spark frequency and total sarcoplasmic reticulum Ca(2+)-leak were increased in atr

101 embrane proteins, such as bacteriorhodopsin, sarcoplasmic reticulum Ca(2+)ATPase (SERCA1a), and its a

102 s improved function was coupled to increased sarcoplasmic reticulum Ca(2+)ATPase activity in the R92W

103 Sarcoplasmic reticulum Ca(2+)ATPase activity was measure

104 hosphorylation states on the activity of the sarcoplasmic reticulum Ca-ATPase (SERCA).

105 Patients with mutations in RyR2 or in the sarcoplasmic reticulum Ca-binding protein calsequestrin

106 sine formation in lymphocytes as an index of sarcoplasmic reticulum Ca-release-induced adenosine 5'-t

107 ally, EHD3-deficient myocytes show increased sarcoplasmic reticulum [Ca], increased spark frequency,

108 ed force production, fatigue resistance, and sarcoplasmic reticulum-Ca(2+) uptake, which were associa

109 However, mRNA and protein levels of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) regulatory pr

110 een linked to Ca2+ cycling proteins, such as sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), located in

111 nction of calcium transport ATPase increases sarcoplasmic reticulum Ca2+ concentration, thereby enhan

112 D amplitude and timing include cytosolic and sarcoplasmic reticulum Ca2+ concentrations, inwardly rec

113 sed, activation of X-ROS signaling increases sarcoplasmic reticulum Ca2+ leak and contributes to glob

114 Increased diastolic sarcoplasmic reticulum Ca2+ leak and related delayed aft

115 ady-state pacing, likely because of enhanced sarcoplasmic reticulum Ca2+ leak.

116 d stretching does not significantly increase sarcoplasmic reticulum Ca2+ leak; and 4) when the chemic

117 Ca2+ -transient amplitude and sarcoplasmic reticulum Ca2+ load (caffeine-induced Ca2+

118 studies point to a combination of increased sarcoplasmic reticulum Ca2+ load related to phospholamba

119 role in the normal sympathetic regulation of sarcoplasmic reticulum Ca2+ release or cardiac contracti

120 state contractions and increased spontaneous sarcoplasmic reticulum Ca2+ sparks mediated by enhanced

121 atrial alternans mainly due to the increased sarcoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ reuptake

122 In adult skeletal muscle, depletion of sarcoplasmic reticulum calcium activates STIM1/Orai1-dep

123 eased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a criti

124 eticulum stress, as well as an activation of sarcoplasmic reticulum calcium ATPase isoform 2 and citr

125 e activity in Runx1-deficient mice increased sarcoplasmic reticulum calcium content and sarcoplasmic

126 ibitor, consistent with a role for decreased sarcoplasmic reticulum calcium flux in Tbx5-dependent AF

127 This work defines a link between Tbx5 dose, sarcoplasmic reticulum calcium flux, and AF propensity.

128 forms raise the interesting possibility that sarcoplasmic reticulum calcium handling and cardiac cont

129 onged calcium-transient duration and reduced sarcoplasmic reticulum calcium loading and release, cons

130 phorylation of Ser(16) acutely stimulate the sarcoplasmic reticulum calcium pump (SERCA) by relieving

131 The sarcoplasmic reticulum calcium pump (SERCA) is regulated

132 nance of myofilament calcium sensitivity and sarcoplasmic reticulum calcium pumping.

133 o-cell differences through intracellular and sarcoplasmic reticulum calcium regulation.

134 Calcium transient amplitude and fractional sarcoplasmic reticulum calcium release were larger and a

135 Flecainide acetate directly suppresses sarcoplasmic reticulum calcium release-the cellular mech

136 are strongly correlated with fluctuations in sarcoplasmic reticulum calcium, because of strong releas

137 as associated with altered protein levels of sarcoplasmic reticulum calcium-regulatory proteins parti

138 the elevated diastolic Ca(2+) leak from the sarcoplasmic reticulum can be normalized by the cardiac

139 effect on the mechanisms responsible for the sarcoplasmic reticulum charge-compensating counter curre

140 We found that CFTR localizes to the sarcoplasmic reticulum compartment of airway smooth musc

141 ases that are present despite a reduction of sarcoplasmic reticulum content.

142 -signaling nanodomains between lysosomes and sarcoplasmic reticulum dependent on NAADP and TPC2 compr

143 liable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventric

144 dyads (triads that have lost one junctional sarcoplasmic reticulum element); both results suggest a

145 Experiments using sarcoplasmic reticulum-entrapped Ca(2+) indicator demons

146 ntain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane i

147 omal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear

148 lcium (Ca(2+) ) release channels on the endo/sarcoplasmic reticulum (ER/SR).

149 VT VMs and PCs than respective controls, and sarcoplasmic reticulum fractional release was greater in

150 ]i is increased by manoeuvres that decrease sarcoplasmic reticulum function.

151 ut negligible inotropic response, suggesting sarcoplasmic reticulum immaturity.

152 t to prevent global calcium release from the sarcoplasmic reticulum in LV myocytes, without affecting

153 rastructural alterations of mitochondria and sarcoplasmic reticulum in muscle and abnormal collagen f

154 l role of abnormal calcium releases from the sarcoplasmic reticulum in producing repetitive electrica

155 rotein, obscurin, and stabilizes the network sarcoplasmic reticulum in skeletal muscle.

156 rm shape show changes in the location of the sarcoplasmic reticulum, inter-organelle distances, and d

157 Orai1 channels in complex with STIM1 in the sarcoplasmic reticulum is one such potential disease mec

158 tructural bridge between the plasmalemma and sarcoplasmic reticulum, is essential for precise Ca(2+)-

159 efine a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major

160 Importantly, a mismatch between sarcoplasmic reticulum load and L-type Ca(2+) trigger ca

161 nm) pore connects the transport sites to the sarcoplasmic reticulum lumen through a chain of water mo

162 and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum lumen.

163 nd nearly fully opened at 2 mum cytosolic or sarcoplasmic reticulum luminal Ca(2+), and Ca(2+)- and v

164 d sarcoplasmic reticulum calcium content and sarcoplasmic reticulum-mediated calcium release, preserv

165 rs of Ca(2+) release channels located in the sarcoplasmic reticulum membrane (ryanodine receptors and

166 ated that sAnk1 and SLN can associate in the sarcoplasmic reticulum membrane and after exogenous expr

167 g sites (ECC couplons) comprising plasma and sarcoplasmic reticulum membrane calcium channels are imp

168 Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting

169 he intracellular calcium gradient across the sarcoplasmic reticulum membrane.

170 a lattice to form clusters in the junctional sarcoplasmic reticulum membrane.

171 under conditions that mimic environments in sarcoplasmic reticulum membranes.

172 initiated by the release of calcium from the sarcoplasmic reticulum, muscle relaxation involves the a

173 ease from intracellular Ca(2+) stores (e.g., sarcoplasmic reticulum) need to be examined.

174 spryn and RyR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes.

175 dantrolene inhibits Ca(2+) release from the sarcoplasmic reticulum of skeletal and cardiac muscle pr

176 the principal Ca(2+) storage protein of the sarcoplasmic reticulum of skeletal muscle.

177 A2a, the protein that pumps calcium into the sarcoplasmic reticulum of the cardiomyocyte, seems promi

178 tivity of channels in the plasma membrane or sarcoplasmic reticulum of vascular cells.

179 increased distance between mitochondria and sarcoplasmic reticulum on electron microscopy, and 3) ni

180 Immunostaining showed mislocalization of the sarcoplasmic reticulum proteins Serca1 and Ryr1 in a pat

181 nger function, reduction of Ca(2+) uptake to sarcoplasmic reticulum, reduced K(+) currents, and incre

182 dine receptor would lead to Ca leak from the sarcoplasmic reticulum, reducing sarcoplasmic reticulum

183 o RyR1 that triggers Ca(2+) release from the sarcoplasmic reticulum, retrograde signaling from RyR1 t

184 e include the Ca(2+) release channels of the sarcoplasmic reticulum (ryanodine receptors or RyR2s) an

185 type channel, in contrast to that of cardiac sarcoplasmic reticulum RyR.

186 that lysosomes form close contacts with the sarcoplasmic reticulum (separation approximately 25 nm).

187 sed on the activity of an ATPase pump in the sarcoplasmic reticulum (SERCA1a) and is controlled by th

188 arcolemma triggering Ca(2+) release from the sarcoplasmic reticulum (SR) - a process termed Ca(2+) -i

189 d Ca(2+) release from central non-junctional sarcoplasmic reticulum (SR) and centripetal propagation

190 action depends on release of Ca(2+) from the sarcoplasmic reticulum (SR) and reuptake by the Ca(2+)ad

191 ]i , in particular the relative roles of the sarcoplasmic reticulum (SR) and surface membrane, are un

192 Calcium cycling between the sarcoplasmic reticulum (SR) and the cytosol via the sarc

193 associated membrane (MAM) signaling from the sarcoplasmic reticulum (SR) and the endoplasmic reticulu

194 reviously unidentified junctions between the sarcoplasmic reticulum (SR) and transverse-tubules (TTs)

195 d spontaneous Ca(2+) release events from the sarcoplasmic reticulum (SR) as a potential cause of proa

196 unction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine recept

197 f systolic Ca(2+) decrease with age, whereas sarcoplasmic reticulum (SR) Ca content increases.

198 We find that when CRU firings are sparse and sarcoplasmic reticulum (SR) Ca load is high, increasing

199 f Ca wave initiation sites), cellular scale (sarcoplasmic reticulum (SR) Ca load), and tissue scale (

200 Calcium (Ca) sparks are the fundamental sarcoplasmic reticulum (SR) Ca release events in cardiac

201 neity of RyR cluster size alters spontaneous sarcoplasmic reticulum (SR) Ca releases (Ca sparks) and

202 y of beta-adrenergic stimulation to regulate sarcoplasmic reticulum (SR) Ca(2+) -release.

203 ial cardiomyocytes are caused by a decreased sarcoplasmic reticulum (SR) Ca(2+) ATPase (SERCA2)-media

204 Sarcoplasmic reticulum (SR) Ca(2+) content increased dur

205 Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to nor

206 nts started to appear, eventually leading to sarcoplasmic reticulum (SR) Ca(2+) depletion.

207 isoproterenol were associated with increased sarcoplasmic reticulum (SR) Ca(2+) leak and frequent dia

208 it a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) Ca(2+) leak in diastole and

209 Abnormal sarcoplasmic reticulum (SR) Ca(2+) leak via the ryanodin

210 nodine receptor 2 (RyR2) phosphorylation and sarcoplasmic reticulum (SR) Ca(2+) leak.

211 ased intracellular Ca(2+) leak and increased sarcoplasmic reticulum (SR) Ca(2+) load compared with ag

212 ise showed an extensive fragmentation of the sarcoplasmic reticulum (SR) Ca(2+) release channel, the

213 V is associated with rapid remodeling of the sarcoplasmic reticulum (SR) Ca(2+) release channel/ryano

214 KEY POINTS: Spontaneous sarcoplasmic reticulum (SR) Ca(2+) release events increa

215 o explore whether subclinical alterations of sarcoplasmic reticulum (SR) Ca(2+) release through cardi

216 ransverse (t) tubule depolarization triggers sarcoplasmic reticulum (SR) Ca(2+) release through ryano

217 ack a transverse tubule system, dividing the sarcoplasmic reticulum (SR) Ca(2+) store into the periph

218 e by Ca(2+) -induced Ca(2+) release from the sarcoplasmic reticulum (SR) Ca(2+) store.

219 Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates stor

220 on of STIM1 in mice resulted in depletion of sarcoplasmic reticulum (SR) Ca(2+) stores of SANCs and l

221 ation in RyR1 decreases the amplitude of the sarcoplasmic reticulum (SR) Ca(2+) transient, resting cy

222 Ang II-stimulated Nox2 activity increased sarcoplasmic reticulum (SR) Ca(2+) uptake in transgenic

223 Sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) and ph

224 ulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum (SR) Ca(2+)-release channel in th

225 amplitude was smaller, although spontaneous sarcoplasmic reticulum (SR) Ca(2+)-release events and L-

226 ation, which was accompanied by an increased sarcoplasmic reticulum (SR) Ca2+ content and Ca2+ transi

227 alaemia, increased Ca2+ transient amplitude, sarcoplasmic reticulum (SR) Ca2+ load, SR Ca2+ leak and

228 tion which led to increased steepness of the sarcoplasmic reticulum (SR) Ca2+ release slope.

229 Sarcoplasmic reticulum (SR) calcium (Ca(2+) ) release is

230 Because sarcoplasmic reticulum (SR) calcium has been shown to pl

231 to modulate activity of the skeletal muscle sarcoplasmic reticulum (SR) calcium release channel (rya

232 To address this question, sarcoplasmic reticulum (SR) calcium release in a mouse s

233 nctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of

234 Abnormal calcium (Ca(2+)) release from the sarcoplasmic reticulum (SR) contributes to the pathogene

235 l to the amount of calcium released from the Sarcoplasmic Reticulum (SR) during systole.

236 Although abnormal Ca(2+) release from the sarcoplasmic reticulum (SR) has been linked to arrhythmo

237 tion is triggered by Ca(2+) release from the sarcoplasmic reticulum (SR) in response to plasma membra

238 nhancement of Ca(2+) uptake and release from sarcoplasmic reticulum (SR) in sinoatrial nodal cells (S

239 X-1 (HS-associated protein X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts w

240 9) may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and sk

241 lysosomes are intimately associated with the sarcoplasmic reticulum (SR) in ventricular myocytes; a m

242 Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation-co

243 and type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum (SR) is thought to underlie both

244 Imaging at ~100 nm resolution located GPa at sarcoplasmic reticulum (SR) junctional cisternae, and ap

245 ith the nucleus at its centre, demarcated by sarcoplasmic reticulum (SR) junctions (<=400 nm across)

246 TRIC-A and TRIC-B, represent two subtypes of sarcoplasmic reticulum (SR) K(+) -channel but their indi

247 s in function between native skeletal muscle sarcoplasmic reticulum (SR) K(+) -channels from wild-typ

248 contribute to heart failure by rendering the sarcoplasmic reticulum (SR) leaky for Ca(2+).

249 eceptor Ca(2+) release channel (RyR2) in the sarcoplasmic reticulum (SR) membrane and the SR Ca(2+) b

250 C-A) is a major component of the nuclear and sarcoplasmic reticulum (SR) membranes of cardiac and ske

251 Does this rule apply inside the sarcoplasmic reticulum (SR) of a working cell?

252 ry of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractori

253 ry of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractori

254 Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker c

255 l matrix includes local Ca(2+) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) t

256 RC protein triadin (T95) is localized in the sarcoplasmic reticulum (SR) subdomain of triads where it

257 zed membrane network of smooth ER called the sarcoplasmic reticulum (SR) surrounding myofibrils and s

258 ubules (ATs) with extensive junctions to the sarcoplasmic reticulum (SR) that include ryanodine recep

259 ous intracellular release of Ca(2+) from the sarcoplasmic reticulum (SR) through RyR2 generates local

260 s mediated by increased Ca(2+) leak from the sarcoplasmic reticulum (SR) through the RyR1.

261 Altered calcium transfer from sarcoplasmic reticulum (SR) to mitochondria has been cau

262 tophilin isoforms (JPH1 and JPH2) tether the sarcoplasmic reticulum (SR) to transverse tubule (T-tubu

263 ibited Ca(2+) release from intact fibers and sarcoplasmic reticulum (SR) vesicles, but failed to inhi

264 ne receptors (RyR2s) release Ca(2+) from the sarcoplasmic reticulum (SR) via a positive feedback mech

265 P(i) diffuses into the sarcoplasmic reticulum (SR) where it is believed to form

266 Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is

267 activated by a synchronized Ca release from sarcoplasmic reticulum (SR), a major intracellular Ca st

268 ) and most calcium in the cell stored in the sarcoplasmic reticulum (SR), and another, with open RyRs

269 R2), a Ca(2+) release channel located in the sarcoplasmic reticulum (SR), or calsequestrin 2 (CASQ2),

270 ated 'pathological' calcium release from the sarcoplasmic reticulum (SR), the major calcium storage o

271 coupling of the contractile apparatus to the sarcoplasmic reticulum (SR), which serves as the reservo

272 e channel ryanodine receptor 1 (RyR1) in the sarcoplasmic reticulum (SR).

273 in muscle and alters the composition of the sarcoplasmic reticulum (SR).

274 KAP18 in a multiprotein signalosome in human sarcoplasmic reticulum (SR).

275 -mediated calcium (Ca(2+) ) release from the sarcoplasmic reticulum (SR).

276 axation by regulating Ca(2+) uptake into the sarcoplasmic reticulum (SR).

277 ults in markedly increased Ca content of the sarcoplasmic reticulum (SR).

278 ibrillar space (MS) and a calcium store, the sarcoplasmic reticulum (SR).

279 o induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR).

280 ue by precipitating calcium salts inside the sarcoplasmic reticulum (SR).

281 ith type 2 ryanodine receptors (RyR2) on the sarcoplasmic reticulum (SR).

282 ainide or riluzole) acting primarily through sarcoplasmic reticulum stabilization.

283 rtly results from increased Ca(2+) leak from sarcoplasmic reticulum stores via dysregulated ryanodine

284 An approach was developed to model the sarcoplasmic reticulum structure at the whole-cell scale

285 urce of reactive oxygen species (ROS) in the sarcoplasmic reticulum that may reduce SERCA2a function.

286 of the calcium release channel (RyR1) in the sarcoplasmic reticulum that supplies the calcium signal

287 Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (R

288 ciation between T-tubules and the junctional sarcoplasmic reticulum to ensure efficient CICR.

289 ne receptors (RyR1s) release Ca(2+) from the sarcoplasmic reticulum to initiate skeletal muscle contr

290 ptor (RyR1) mediates Ca(2+) release from the sarcoplasmic reticulum to initiate skeletal muscle contr

291 es bidirectional proton transport across the sarcoplasmic reticulum to maintain the charge balance of

292 e receptor (IP3R), thereby linking the endo-/sarcoplasmic reticulum to the plasma membrane.

293 Ca(2+) uptake into sarcoplasmic reticulum vesicles by SERCA2A was inhibited

294 on RyR1 channel activity after incorporating sarcoplasmic reticulum vesicles into lipid bilayers.

295 sAnk1 interacts specifically with SERCA1 in sarcoplasmic reticulum vesicles isolated from rabbit ske

296 on the cytoplasmic domain of RyR in isolated sarcoplasmic reticulum vesicles.

297 The Ca(2+) pool in the sarcoplasmic reticulum was increased, the activity of ca

298 adic junctions between the cell membrane and sarcoplasmic reticulum were progressively 'packed' with

299 KCNQ1 mainly resides in the jSR (junctional sarcoplasmic reticulum), whereas KCNE1 resides on the ce

300 se during systole, gradually overloading the sarcoplasmic reticulum with Ca(2+).