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1 ng cycle, featuring two enzymes and a single scaffolding protein.
2 tial for tumor growth through one individual scaffolding protein.
3 cascade without the involvement of the RACK1 scaffolding protein.
4 ubiquitously expressed lipid raft-associated scaffolding protein.
5 interaction with Ajuba, an actin binding and scaffolding protein.
6 eneous aberrant structures in the absence of scaffolding proteins.
7 ibitory, and experimentally evolved coat and scaffolding proteins.
8 natorial interactions among many enzymes and scaffolding proteins.
9 ion, triggered by limited proteolysis of the scaffolding proteins.
10 ytic enzymes with regulatory, accessory, and scaffolding proteins.
11 G proteins and an MAPK cascade via the RACK1 scaffolding proteins.
12 arallel to the Scribble module of junctional scaffolding proteins.
13 endrites by interaction with AKAP5 and other scaffolding proteins.
14 cognate transport machinery and specific AZ-scaffolding proteins.
15 n of G protein-coupled receptor signaling by scaffolding proteins.
18 ring development where it interacts with the scaffolding protein 4.1B and the dynein regulator lissen
19 d G protein-coupled receptors coupled by the scaffolding protein A-kinase-anchoring protein (AKAP)79/
20 Synapse-associated protein 102 (SAP102) is a scaffolding protein abundantly expressed early in develo
21 During varphiX174 assembly, the external scaffolding protein acts like a coat protein, self-assoc
22 ins constitute a highly conserved network of scaffolding proteins, adaptors and enzymes that form and
24 total mGlu1 protein or its coupling to Homer scaffolding proteins after methamphetamine withdrawal, n
26 smaller than a Golgi subdomain positive for scaffolding protein AKAP450, which is thought to recruit
29 guanylate kinase (MAGUK) family of synaptic scaffolding proteins anchor glutamate receptors at CNS s
30 +) exchange regulatory cofactor (NHERF)-1, a scaffolding protein, anchors multiple membrane proteins
32 ite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal
33 pacity, MALT1 has two functions, acting as a scaffolding protein and as a substrate-specific protease
34 apsid') built by multiple copies of coat and scaffolding protein and by one dodecameric portal protei
35 mponent, has been broadly characterized as a scaffolding protein and is required for the recruitment
36 dditionally, we explored the function of the scaffolding protein and main component of caveolae, cave
38 n domains in the kinase or via anchoring and scaffolding proteins and can drastically increase the ki
39 ely form via interactions among postsynaptic scaffolding proteins and receptors and align with putati
40 ion, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-s
41 as associated with reduced recruitment of TZ scaffolding proteins and reduced Smoothened levels at ci
43 nding of CCCTC-binding factor, a chromosomal scaffolding protein, and increases histone and DNA methy
44 of protein levels of PSD-95, a postsynaptic scaffolding protein, and the AMPAR subunits GluR1 and Gl
45 olytic metabolon is dependent on presynaptic scaffolding proteins, and disruption of the glycolytic m
46 ls, including enzymes, channels, adaptor and scaffolding proteins, and proteins of uncharacterized fu
49 l Cell, Budnar and colleagues report how the scaffolding protein anillin uses cycles of transient bin
52 r components of the node is the cytoskeletal scaffolding protein, ankyrin G (AnkG), which interacts w
56 at appears to contain substantial amounts of scaffolding protein as well as DNA, suggesting that DNA
57 taining for PSD-95 and gephyrin postsynaptic scaffolding proteins as proxies for excitatory and inhib
59 ule dynamics at both locations, but how this scaffolding protein assembles microtubule nucleation mac
60 ne-associated guanylate kinase, is the major scaffolding protein at excitatory postsynaptic densities
61 K3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory synapses in which muta
62 n-immunoreactive (IR) puncta, a postsynaptic scaffolding protein at inhibitory synapses used here as
64 ociated guanylate kinases (MAGUKs) are major scaffolding proteins at the PSD in glutamatergic excitat
66 bstitutions ranged from inefficient internal scaffolding protein B binding to faulty procapsid elonga
70 a interaction protein (GSKIP) is a cytosolic scaffolding protein binding protein kinase A (PKA) and g
71 The C domain instead appears to serve as a scaffolding protein, bringing the catalytic YcaO domain
76 ventricular myocyte with a reduction in the scaffolding protein caveolin-3 (Cav-3), altered Ca(2+) c
80 nalling domain interacts with the chemotaxis scaffolding proteins CheV and CheW, and comparative geno
81 called MAGI-2), which encodes a postsynaptic scaffolding protein controlling synaptic AMPA receptor l
83 the receptor or recruitment of beta-arrestin scaffolding proteins could preserve the analgesic proper
84 74 morphogenesis, 240 copies of the external scaffolding protein D organize 12 pentameric assembly in
85 assembly intermediates, whereas the external scaffolding protein D organizes 12 of these intermediate
87 neuromuscular junction (NMJ), the endocytic scaffolding protein Dap160 colocalizes during the SV cyc
88 multiple ankyrin repeat domains 3 (SHANK3B) scaffolding protein, defective expression of which has b
89 -CDF) of CaV1.3 channels that depends on the scaffolding protein densin and CaMKII and that outlasts
90 orted interaction among CaV1.3 channels, the scaffolding protein densin, and CaMKII could generate a
91 HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodies
92 Assess occurrence of the dendritic spine scaffolding protein Drebrin as a pathophysiologically re
94 ndicate that fibulin-4 serves as a potential scaffolding protein during collagen maturation in the ex
95 mine the dynamics and function of the apical scaffolding protein E3KARP/NHERF2, which consists of two
96 tute for the function of the closely related scaffolding protein EBP50/NHERF1 in the formation of int
102 egradation and, in yeast, recruit Atg11, the scaffolding protein for selective autophagy initiation.
103 tein likely acting as a dynamic cell surface scaffolding protein for the assembly of different signal
104 In the central nervous system (CNS), Homer scaffolding proteins form signaling complexes with two C
105 r biogenesis by this large family of cluster scaffolding proteins found across all domains of life.
106 a suggest that aphthoviruses actively target scaffolding proteins G3BP1 and G3BP2 and antagonize SG f
108 basolateral amygdala, the clustering of the scaffolding protein Gephyrin and of gamma-aminobutyric a
109 otein collybistin (CB) recruits the receptor-scaffolding protein gephyrin to mammalian inhibitory gly
112 ere we show that the conserved signaling and scaffolding protein Girdin localizes to the proximal reg
113 iscover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinase
114 P2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (G
119 l-drinking elevates BNST levels of the mGlu5-scaffolding protein Homer2 and activated extracellular s
120 domain and PHD finger-containing) family are scaffolding proteins important for the recruitment of hi
121 eodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of hi
122 came aware of this issue in our studies of a scaffolding protein in microvilli, which forced us to re
123 rtant new insights into the role of FAK as a scaffolding protein in molecular complexes that regulate
124 omplementation group A (XPA) is an essential scaffolding protein in the multiprotein nucleotide excis
125 nteract with beta-arrestin, implicating this scaffolding protein in the receptor's subcellular redist
128 iated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin signaling, we studi
132 multiple pre- and post-synaptic membrane or scaffolding proteins including glutamatergic ion channel
133 repeat proteins, as well as their associated scaffolding proteins, including SHANKs and others, on so
134 the CAV3 gene encoding caveolin-3 (Cav3), a scaffolding protein integral to caveolae in cardiomyocyt
136 dates, MPP7 (MAGUK p55 subfamily member 7, a scaffolding protein involved in cell-cell contacts) and
137 previously shown that Huntingtin (HTT), the scaffolding protein involved in Huntington's disease, re
138 STATEMENT: Integrin-linked kinase (ILK) is a scaffolding protein involved in integrating signals from
139 ozygous mutations in CARD11, which encodes a scaffolding protein involved in lymphocyte receptor sign
140 protein (CD2AP), a slit diaphragm-associated scaffolding protein involved in survival and regulation
141 1; also known as p62) encodes a multidomain scaffolding protein involved in various key cellular pro
142 ac1 and nuclear ERK activity depended on the scaffolding proteins IQ motif-containing GTPase-activati
144 our capsids, aided by the discovery that the scaffolding protein is exceptionally prone to radiation-
148 guanylate kinase (MAGUK) family of synaptic scaffolding proteins is critical for localization of glu
149 ts suggest that enzyme sequestration through scaffolding proteins is exploited by evolution to genera
150 uitously expressed cytoplasmic lipid droplet scaffolding protein, is hypothesized to contribute to NA
151 ighly conserved double-PDZ domain-containing scaffolding protein, is robustly expressed in human-deri
152 Previous studies found that Asl acts as a scaffolding protein; its N terminus binds Plk4's tandem
153 l autophagosome transport is mediated by the scaffolding protein JIP1, which not only inhibits antero
155 cond WW domain (WW2) of the kidney and brain scaffolding protein, KIBRA, has an isoleucine (Ile-81) r
157 containing CaMKII and Shank3, a postsynaptic scaffolding protein known to interact with L-type calciu
158 ptors (L-AChRs) requires the muscle-secreted scaffolding protein LEV-9, a multidomain factor containi
160 es, MAP17 is known to interact with PDZK1, a scaffolding protein linked to other transporters, includ
161 which otoferlin acts as a calcium-sensitive scaffolding protein, localizing SNARE proteins proximal
162 also called AKAP450/CG-NAP/AKAP9) is a large scaffolding protein located at both the centrosome and G
163 Here, we show that loss of function of a scaffolding protein Mask, also known as ANKHD1 (Ankyrin
164 ned with RNA-induced phase separation of key scaffolding proteins, may be a general mechanism for con
165 sis of human metastatic genes identified the scaffolding protein metastasis suppressor 1 (MTSS1) as a
167 DZ-binding motif allowing for binding of the scaffolding proteins Na(+)/H(+) exchanger regulatory fac
168 Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet
169 immunofluorescence is coassociated with the scaffolding protein NHERF-1 and PLCbeta2 in microvilli.
170 nsically disordered tail of the multi-domain scaffolding protein NHERF1, which affects the intracellu
172 ptic scaffold organized by gephyrin-the main scaffolding protein of GABAergic synapses, which anchors
173 milar to mice overexpressing PSD-95, a major scaffolding protein of postsynaptic density involved in
174 Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurod
178 teins BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex
179 ere we used tagged gephyrin, one of the main scaffolding proteins of the postsynaptic density at GABA
182 MAGUK (membrane-associated guanylate kinase) scaffolding proteins or NMDA receptors, it is necessary
189 ating cell nuclear antigen (PCNA), a nuclear scaffolding protein pivotal in DNA synthesis, controls n
190 n into dodecameric rings, possibly forming a scaffolding protein-portal protein nucleation complex th
191 lation of GluN2B Y1472, whereas the synaptic scaffolding protein postsynaptic density protein 95 (PSD
192 findings reveal that modular regulation by a scaffolding protein provides a simple, yet effective, me
193 s a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors
194 = 0.68) when overexpressing the postsynaptic scaffolding protein PSD-95, which increased receptor clu
195 m increase in the expression of the synaptic scaffolding proteins PSD-95 and SAP90/PSD-95-associated
196 where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine mat
198 ession from clinical samples, and found that scaffolding protein RACK1 deficiency plays a significant
200 than tightly clustered by the intracellular scaffolding protein, rapsyn, as at the intact neuromuscu
201 containing GTPase-activating protein (IQGAP) scaffolding proteins regulate many essential cellular pr
203 eomic and MS study, we demonstrate that this scaffolding protein regulates a shift in protein kinase
204 ogene required for development, and DCAF7, a scaffolding protein required for craniofacial developmen
205 with poor patient prognosis, and BRPF1 is a scaffolding protein required for the assembly of histone
207 4 is shown by cross-linking to interact with scaffolding protein residue R293 and, thus, is intimatel
209 rangement of the coat protein and release of scaffolding protein, resulting in dramatic procapsid lat
211 me through direct interaction with the large scaffolding protein RPN2 within the 19S regulatory parti
214 roteins 1 and 2 and with the multifunctional scaffolding protein sequestosome-1 (SQSTM1/p62) confirme
217 IFICANCE STATEMENT Mutations in the synaptic scaffolding protein SHANK3 are commonly associated with
218 s the interaction between membrane proteins, scaffolding proteins, signalling proteins and enzymes to
219 of the HDAC interaction domain (HID) of the scaffolding protein Sin3A through a bipartite motif comp
221 ises the NAD-dependent deacetylase Sir2, the scaffolding protein Sir4, and the nucleosome-binding pro
224 and show that CpmB competes with the 80alpha scaffolding protein (SP) for a binding site on the capsi
226 rrent study, we identify the multifunctional scaffolding protein spinophilin as a novel Group I mGluR
227 capacity, but altering the binding with the scaffolding protein spinophilin upon neurotransmitter ac
229 , the portal forms a nucleation complex with scaffolding proteins (SPs) to initiate procapsid (PC) as
231 cultured astrocytes, suggesting that the DLG scaffolding protein stabilizes EAAT2b at the surface.
233 itic instability and alterations in synaptic scaffolding proteins, studies of glutamate receptor leve
235 ignal through Gi/o-coupled G-proteins and/or scaffolding proteins, such as beta-arrestin, we find tha
237 isoform was recruited to nascent AZs by the scaffolding proteins Syd-1 and Liprin-alpha, and Unc13A
243 y reported that the immunophilin FKBP51 is a scaffolding protein that can enhance PHLPP-AKT interacti
244 ation of the Mdm2 pathway degrades PSD-95, a scaffolding protein that clusters NMDARs at the synapse
245 s sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein
246 signaling is negatively regulated by Axin, a scaffolding protein that controls a rate-limiting step i
248 chizophrenia 1 (DISC1) is a multi-functional scaffolding protein that has been associated with neurop
250 (JNK-associated leucine zipper protein) is a scaffolding protein that interacts with various signalin
253 Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functio
256 ptic density 95 (PSD-95) is a major synaptic scaffolding protein that plays a key role in bidirection
257 cells by knocking down ANLN, a cytoskeletal scaffolding protein that regulates cytokinesis and might
258 associated with its binding partner Homer, a scaffolding protein that regulates mGlu5 localization to
260 n together, our data suggest that CPTL2 is a scaffolding protein that tethers CPT3 on endoplasmic ret
261 d guanylate kinases (MAGUKs) are a family of scaffolding proteins that are expressed in excitatory gl
262 ) exchanger regulatory factor (NHERF) family scaffolding proteins that are required for many aspects
264 T The presynaptic active zone is composed of scaffolding proteins that functionally interact to local
265 hatases and kinases complex, are multidomain scaffolding proteins that play important biologic roles.
266 regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor traffic
267 s mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins that regulate the establishment of
268 s enriched in sphingolipids, cholesterol and scaffolding proteins; they serve as a platform for signa
269 exclusively to wag31, a gene that encodes a scaffolding protein thought to orchestrate cell elongati
270 alizes and interacts with the tight junction scaffolding proteins TJP1 and TJP2 in polarized epitheli
271 t occurs through initial mobilization of the scaffolding protein Tks5 and F-actin accumulation, follo
272 t RA T cells abundantly express the podosome scaffolding protein TKS5, which enables them to form tis
275 igher-order protein complexes containing K-H scaffolding protein to gain insight into its cellular fu
277 3 "writer," and with TRIM28, an abundant HP1 scaffolding protein, to form complexes with increased mu
278 4-3-3 proteins, a family of highly conserved scaffolding proteins ubiquitously expressed in all eukar
279 1 bound, phosphorylated, and inactivated KSR scaffolding proteins ultimately inhibited Ras/ERK signal
280 al cellulosome assembly, including conserved scaffolding proteins unique to the Neocallimastigomycota
281 PIKfyve complex comprises five copies of the scaffolding protein Vac14 and one copy each of the lipid
283 nhibitor, pointed to a mechanism involving a scaffolding protein, Wag31, involved in polar elongation
284 parate study, we reported that the autophagy scaffolding protein WDFY3 is required for cerebral corti
285 e activating protein, and SHANK3, a synaptic scaffolding protein, were chosen because of mounting evi
287 mes are spatially controlled by cytoskeletal scaffolding proteins, which both recruit and organize th
288 hogen effectors by partnering with different scaffolding proteins, which can each recognize distinct
290 xes and contain cytoskeletal, regulatory and scaffolding proteins, which regulate channel conductance
291 bule actin cross linking factor 1 (MACF1), a scaffolding protein with binding sites for microtubules
292 se disorders are those encoding postsynaptic scaffolding proteins with roles in synaptic transmission
294 ganization of neurotransmitter receptors and scaffolding proteins within the postsynaptic density.
295 protein (also known as KAP1 and TIF1beta), a scaffolding protein without intrinsic repressive or DNA-
296 mplex comprising DNA ligase IIIalpha and the scaffolding protein X-ray repair cross-complementing pro
297 ng of DNA from the histone octamer; that the scaffolding protein XRCC1 enhances the ligation; that th
299 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in he
300 y a novel functional complex of the junction scaffolding protein ZO-1 and the F-BAR-domain protein TO