ライフサイエンスコーパス: scission

1 o cause the necessary curvature for membrane scission.

2 he ESCRT machinery mediates reverse membrane scission.

3 g new C-heteroatom bond formations via C-OMe scission.

4 rocycle followed by subsequent beta-hydrogen scission.

5 endocytic membrane invagination and vesicle scission.

6 PS4 assembly to enable neck constriction and scission.

7 eins involved in actin assembly and membrane scission.

8 ng the timing of ESCRT-III-mediated membrane scission.

9 clic alcohols to linear ketones via C-C bond scission.

10 spective sites of division where it mediates scission.

11 g by endoA2 and pulling-force-driven dynamic scission.

12 drial division dynamin also mediated vesicle scission.

13 UL34 are sufficient for membrane budding and scission.

14 dization that accompanies carbon-oxygen bond scission.

15 a role for the Vps1-actin interaction during scission.

16 es membrane deformation and perhaps membrane scission.

17 ipid diffusion and counteracts lipid-induced scission.

18 nificantly to the driving force for C-H bond scission.

19 rization to the membrane to drive successful scission.

20 ro systems, endoA2 reshapes membranes before scission.

21 dynamin-like protein (DLP)-mediated membrane scission.

22 vacuole, peroxisomal fission, and endocytic scission.

23 racil loss also does not compete with strand scission.

24 bly, which facilitates membrane invagination/scission.

25 dditional driving force for C-H and O-H bond scission.

26 dorse the nucleophilic assistance to the C-S scission.

27 -coding RNAs that catalyze single-strand RNA scission.

28 he plasma membrane to drive invagination and scission.

29 ud and constricting the neck to the point of scission.

30 bulk endosomes, indicating impaired membrane scission.

31 ding and that VP40 may be able to mediate PM scission.

32 of prototypical dynamin in endocytic vesicle scission.

33 r the mechanism of dynamin-mediated membrane scission.

34 rane constriction and COPII-directed vesicle scission.

35 rigger final events leading to mitochondrial scission.

36 mbrane recruitment and GTP-dependent vesicle scission.

37 volvement of spiraling filaments in membrane scission.

38 sition of the phenyl ring concerted with C-O scission.

39 at H addition occurs concerted with C-O bond scission.

40 cascade lactonization that results in chain scission.

41 nd templates ESCRT-III assembly for membrane scission.

42 ticularly those involving carbon-carbon bond scission.

43 he ESCRT complex and the control of envelope scission.

44 he plasma membrane to drive invagination and scission.

45 s GTPase activity, both required for vesicle scission.

46 and destabilizing the membrane neck, causing scission.

47 n via stereoelectronically assisted C-C bond scission.

48 MAPs in creating and/or stabilizing membrane scissions.

49 I/III) that promotes membrane remodeling and scission [3-5].

50 MoOx, Ir/VOx) demonstrate unusually high C-O scission activity at moderate temperatures.

51 urvature, potentially enabling Sar1 membrane scission activity to be spatially restricted to highly b

52 Delayed chain scission allows many eventual scission events to be init

53 hols from amides by the challenging N-C bond scission and (ii) synthesis of nitrogen-containing heter

54 echanophore that does not lead to main chain scission and an elastomeric polyurethane enabled consecu

55 T) gives insight into the mechanisms of C-Br scission and C-C coupling processes.

56 ding protein that controls endocytic vesicle scission and defines a whole class of dynamin-dependent

57 hway that requires dynamin-mediated membrane scission and endosomal acidification but is distinct fro

58 like mechanism to achieve efficient membrane scission and engulfment.

59 res determine the reaction pathways via bond scission and formation among weakly adsorbed water and r

60 equivalents result in full uranium-oxo bond scission and formation of UI4(1,4-dioxane)2 with extrusi

61 ons of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched

62 riteria of having only a single point of S-S scission and maximizing the ratio of S-S to the electroc

63 s-based perspective for the onset of vesicle scission and predict the shapes and composition of detac

64 pivaloyl chloride leads to U-O(uranyl) bond scission and reduction of U(VI) to U(IV) concomitant wit

65 ysin heterodimer Rvs161/Rvs167 to facilitate scission and release of vesicles.

66 T III-Vps4 complex assembly that facilitates scission and repair of the injured cell membrane.

67 eolae to the cell surface by restricting the scission and subsequent endocytosis of these membrane pi

68 by initial retro-hydroalkoxylation/beta-C-O scission and subsequent hydrogenolysis of the vinyl benz

69 rin contributes to the regularity of vesicle scission and thereby to controlling vesicle size.

70 of fragments generated by backbone C-C bond scissions and with the help of reference MS(2) spectra o

71 vided support for a kinetically relevant C-C scission, and a well-defined organometallic rhodium(III)

72 lates membrane trafficking through vesicular scission, and it is presumed that reducing this activity

73 All isomers are inert to thermal N(2) scission, and the trans,trans-isomer is also inert to ph

74 conjugation-driven radical-assisted C-O bond scission applies to any catalytic surface that preserves

75 , and subsequent R-loop formation and strand scission are driven by complementary base pairing betwee

76 The structural requirements for scission are even more stringent than those for budding,

77 port the proposed hypothesis that DNA strand scissions are caused by 1,4-benzenoid diradicals formed

78 ly proposed mechanisms describing amide link scission as a result of the hydrolysis of the N-chlorina

79 th S599V and S599D caused defects in vesicle scission, as shown by both live-cell imaging and electro

80 , consistent with the proposed role of M2 in scission at the end of budding.

81 ling steps, which lead to efficient membrane scission at the end of ILV biogenesis in vivo.

82 n promotes further chlorine uptake, and (vi) scission at the membrane surface is unrepresentative of

83 b-PLA micelles resisted backbiting chain end scission, based on reverse-phase HPLC analysis.

84 preconstriction of an organelle followed by scission by dynamin-related protein Drp1.

85 nucleotides in DNA results in direct strand scission by generating alkali-labile fragments from the

86 is significantly more susceptible to strand scission by ionizing radiation (hydroxyl radical) than i

87 ic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP and Sae2.

88 ular details and determinants impacting NEMO scission by PEDV nsp5 delineated in this study are funda

89 ir protection of supercoiled DNA strand from scission by peroxyl and hydroxyl radicals into the nicke

90 viously reported cleavage site E349 in NEMO, scission by PRRSV nsp4 took place at two additional site

91 budded vesicles, suggesting that it mediates scission by scaffolding the membrane bud and constrictin

92 d be a significant contributor to RNA strand scission by the hydroxyl radical, particularly under ana

93 by the stabilization of an enzyme-substrate scission complex via three distinct amino-acid-binding p

94 ter stages of endocytosis, consistent with a scission defect.

95 aptor protein that binds actin and modulates scission during endocytosis.

96 d protein 1 (Drp1), responsible for membrane scission during mitochondrial fission.

97 estigate the process of M2-mediated membrane scission during the budding of influenza viruses.

98 ESCRT-III executes membrane scission during the budding of intralumenal vesicles (IL

99 or transport III) filaments mediate membrane scission during the ostensibly disparate processes of mu

100 the activation energy of the CO and CH bond scission during the oxidation process.

101 c polymer fragmentation undergoes subsequent scission during the same high strain rate extensional ev

102 direct role for pUL51 in promoting membrane scission during virus assembly.

103 A subsequent beta-scission event liberates alkyl radicals for coupling wit

104 nophore activation and ~67 protons per chain scission event.

105 FtsA may be critical for the final membrane scission event.

106 CRT proteins mediate membrane remodeling and scission events and are essential for endosomal sorting

107 endocytosis of beta2AR occurs via quantized scission events hosted by clathrin spots and plaques of

108 Delayed chain scission allows many eventual scission events to be initiated within a single polymer

109 Radical cyclization and ring scission experiments are consistent with hydrogen atom t

110 They document that distinct scission factors operate in an additive manner, and pred

111 assays revealed that when endocytic vesicle scission fails, tubules are pulled into the cytoplasm an

112 We call this mechanism friction-driven scission (FDS).

113 Sonication experiments generate limiting scissioned fibrils with a well-defined length-to-width c

114 transport (ESCRT) machinery drives membrane scission for diverse cellular functions that require bud

115 By contrast, C-C bond scission for the linear and branched structures leads to

116 ong with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in t

117 erves as a source of methyl radical via beta-scission from a tertiary radical generated upon chlorine

118 sterol and glycosphingolipids drive caveolae scission from the PM.

119 t an oxidative carbon-chlorine/fluorine bond scission has occurred during the autocatalytic process o

120 immediately after dynamin-mediated membrane scission has released the vesicle from the plasma membra

121 in proteins such as endophilin contribute to scission has remained unexplored.

122 e, yet the molecular cues that govern strand scission have not been elucidated.

123 es an intrinsically unstable domain prone to scission if not restrained by EHD2 at the caveolae neck.

124 a proton channel but also mediates membrane scission in a cholesterol-dependent manner to cause viru

125 ate that Sar1 alone is competent for vesicle scission in a manner that depends on the concentration o

126 and RNA aptamers, as well as catalytic bond scission in a ribozyme.

127 orination in acidic conditions or amide bond scission in alkaline conditions.

128 ynoid species provoke C(sp(2))-C(sp(2)) bond scission in alkenes by inserting a monovalent carbon uni

129 lain endocytic tubule elongation and vesicle scission in fission yeast.

130 timing of ESCRT-III recruitment and membrane scission in HIV-1 budding.

131 The ESCRT complexes drive membrane scission in HIV-1 release, autophagosome closure, multiv

132 echanoradicals originate from homolytic bond scission in polymers.

133 rface is unrepresentative of volume-averaged scission in the active layer.

134 The volume-averaged amide link scission in the aromatic polyamide active layer of a rev

135 ulations show that the radicals form by bond scission in the direct vicinity of crosslinks in collage

136 ular bonding, leading to intramolecular bond scission in the formation of secondary ions.

137 tion of the directing functionality via beta-scission in the last step of the cascade.

138 nd-order rate constants for C-H and O-H bond scission in the range of 10-10(7) M(-1)s(-1).

139 Catalysis of bond scission in these hammerhead ribozymes could be restored

140 Wet self-mending of scission in these polymers is initiated and accelerated

141 on intermediate that catalyzes carbon-carbon scission in this key enzyme.

142 toethanol (1 M) does not compete with strand scission, indicating that phosphate elimination is >10(6

143 cyclin C directs the extensive mitochondrial scission induced by the anticancer drug cisplatin or oxi

144 as9, as well as individual single-strand DNA scissions induced by the nickase version of Cas9, can be

145 ring the first oxidation step, with C-C bond scission instead leading to ring opening, efficient func

146 here is evidence that envelope formation and scission involve the participation of multiple viral pro

147 aled that the initial step of CO binding and scission involved CO acting as a Lewis acid (four-electr

148 Membrane scission is a crucial step in all budding processes, fro

149 Heterolytic bond scission is a staple of chemical reactions.

150 to occur, (ii) hydroxide-induced amide link scission is a strong function of exposure to hypochlorou

151 ough the underlying molecular details of how scission is accomplished often remain unknown.

152 This scission is defective in cells expressing a centronuclea

153 II complexes are stabilized and ILV membrane scission is delayed by Doa4, which is the ubiquitin hydr

154 Membrane scission is essential for intracellular trafficking.

155 the alpha-ribo-furanose; therefore, the beta-scission is highly delayed, and due to the reversibly na

156 naling at the plasma membrane before vesicle scission is poorly understood.

157 menting step, followed by loss of R-OH, beta-scission is preferred for the formation of alkoxy radica

158 The barrier for O-O bond scission is sensitive to Pd surface structure and is con

159 s suggests that the rate constant for strand scission is significantly greater than 10(6) s(-1) at pH

160 N-glycosidic bond scission is then facilitated by a backbone phosphate gro

161 dies that suggest that the barrier to strand scission is very low and that synchronous proton transfe

162 protein that is required to mediate particle scission, is recruited to HIV-1 assembly sites approxima

163 Thermal analysis and evaluation of chain-scission kinetics suggest that sonication of VA-PNB resu

164 rinsic to the broad distribution of limiting scission lengths.

165 oss of stress transfer that results from the scission limits the extent of degradation that can be ac

166 presents a complete membrane deformation and scission machinery.

167 The scission mechanism is unknown but appears to be linked t

168 ts were consistent with a free radical chain scission mechanism, supported by measurements of sub-muM

169 imulations are consistent with a heterolytic scission mechanism.

170 ake it imperative to understand the membrane scission mechanism.

171 g NEMO for proteolytic cleavage and that the scission occurred at four sites: E166, E171, glutamine 2

172 Less intramolecular scission occurred in the amorphous form, resulting in a

173 y in the presence O(2), suggesting that bond scission occurs from a triplet excited state.

174 elegans Our findings indicate that membrane scission occurs on both sides of the midbody ring with r

175 mily of natural products and features a beta scission of a 14-alkoxy radical with concomitant generat

176 ements, which both appear to operate through scission of a C-H bond.

177 the intermediate 5-exo-trig product via beta-scission of a properly positioned weak C-S bond provides

178 uch as an exchange of a sulfur to an oxygen, scission of a single bond in P2'-cyclopropylaminobenzoth

179 sp(3)-sp(3) carbon bonds via catalytic beta-scission of aliphatic alcohol derivatives with both aryl

180 catalyzed sequence for the formal two-carbon scission of allyl groups to carboxylic acids has been de

181 mation is likely to proceed through the beta-scission of an alkoxy radical, followed by oxidation and

182 ously unrecognized role for dynamin-2 in the scission of apical carrier vesicles from AREs.

183 The scission of biological membranes is facilitated by a var

184 her Ag(111) or Ag(110) surfaces leads to the scission of C-I bonds followed by the formation of organ

185 For ether and thioether-terminated layers, scission of C-O or C-S bonds also led to the release of

186 ite that can efficiently induce the required scission of carbon-oxygen bonds and generate carbon-carb

187 rious membrane fission events, including the scission of clathrin-coated vesicles.

188 mbrane curvature and fluidity, mediating the scission of constricted membrane necks in multiple biolo

189 echanical stress through the mechanochemical scission of covalent bonds in the backbone.

190 dissociation from the MSW core, followed by scission of covalent bonds in the bottlebrush backbones.

191 doxorubicin, by ultrasound-induced selective scission of disulfide-centered polymers in solution.

192 in we report studies that reveal binding and scission of double-stranded DNA by shishijimicin A.

193 canning large DNA molecules, and to regulate scission of double-stranded DNA.

194 en lipids and BAR-domain proteins drives the scission of elongating membrane tubules.

195 alesce, thereby leading to the detachment by scission of endocytic uptake carriers.

196 sculpt single cells, repair neurons, promote scission of endocytic vesicles, and seal phagosomes.

197 thin a single polymer chain between the bond scission of interest and the nonscissile mechanochemical

198 in that participates in vesicle formation by scission of invaginated membranes.

199 remains stagnated mainly due to the sluggish scission of magnesium-chloride bond and slow diffusion o

200 cs of magnesium monochloride cations without scission of magnesium-chloride bond.

201 s vacuolar protein sorting 4 (VPS4) mediates scission of microvesicles from the T-cell plasma membran

202 gagement of OCRL1 with pacsin 2 and promotes scission of MPR-containing carriers.

203 xy)benzene (M10) molecules, dominates direct scission of O-CH2 bonds up to a temperature of approxima

204 Copper-catalyzed bond scission of pentafluorobutane-1,3-diones generates diflu

205 icating a second degradation process through scission of PES chains.

206 in vivo tracking of drug delivery and chain scission of polymeric conjugates by FRET imaging.

207 amin and actin contribute in parallel to the scission of Shiga-toxin-induced tubules.

208 ablishes the basic mechanism for budding and scission of tailored vesicles at the INM.

209 leading to an intein-succinimide product and scission of that peptide bond.

210 showed that directed expression or selective scission of the ACE2 protein had no measurable effect on

211 w the system to overcome the high barrier of scission of the actinide-oxygen bond.

212 d N-methylphthalimide (Me-phth) from beta-Me scission of the alkoxy radicals to form a methyl radical

213 A complete scission of the B horizontal lineB double bond in 6 was

214 Subsequent scission of the beta'-C-H bond takes place via a proton-

215 ated unambiguously that this unusual mode of scission of the biaryl bond can occur in the C1,C1'-dipr

216 rom eta(2)-(C,O) to eta(2)-(C,C) followed by scission of the C horizontal lineC bond, which is usuall

217 control the reactivity and how the concerted scission of the central sigma bond is prevented in the b

218 to capture long-wavelength light to promote scission of the Co-C bond at wavelengths up to 800 nm.

219 but they often suffer from the unintentional scission of the degradable functionalities on the polyme

220 rnal heat stimulus is applied to trigger the scission of the dimerized anthracene, which reduces the

221 ls and organic bulk chemicals) via reductive scission of the enormously strong CO bond is dominated b

222 ialyl hydroxylamines by reversible homolytic scission of the glycosidic bond following the dictates o

223 tion proceeds via UV light-induced C-Br bond scission of the initiator, giving rise to propagating ra

224 NO-induced scission of the iron-histidine bond triggers structural

225 iation of COPII-coated vesicle formation and scission of the nascent vesicle from the endoplasmic ret

226 KIE leads to the inference that hole-driven scission of the O-H bond in H(2) O is a critical, limiti

227 that the ultrasound-induced mechanochemical scission of the oxime sulfonate mechanophore also genera

228 just two (for R = CH(2)OAc) or three steps (scission of the pyrrolidine ring, manipulation of the al

229 ol O-H bonds followed by subsequent C-C beta-scission of the resulting alkoxy radical intermediates.

230 radical to the ester carbonyl group; 3) beta-scission of the so-formed alkoxy radical to provide the

231 The direct scission of the triple bond of dinitrogen (N(2)) by a me

232 Oxidative scission of the vinyl substituent of this cyclobutane ga

233 and other ESCRT complex proteins to promote scission of the virus particle from the plasma membrane.

234 ar olefins in the lubricating oil and random scission of their carbon-carbon backbones; the products

235 ling endosomes is mediated by DNM2-dependent scission of these tubules.

236 in have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanis

237 2.9 x 10(10) s(-1) at 25 degrees C) through scission of two bonds of the cube.

238 dynamin (DNM2), a GTPase regulating membrane scission of vesicles in endocytosis, in NME1 and NME2 re

239 Delayed scission offers a strategy to enhanced mechanical degrad

240 e that can measure mechanically induced bond scission on graphene in real time with sensitivity to at

241 thioether bond is accompanied by a C-H bond scission on Tyr272 with few details known thus far.

242 reoelectronic gating delays the central bond scission, opening access to the interrupted Cope rearran

243 either hydrogen atom abstraction or C-S bond scission or allowed to proceed further to the formal 6-e

244 tep for aldol cleavage shifted from C-C bond scission (or an earlier step in the pathway) for the com

245 ymers is typically limited to a single chain scission per triggering chain stretching event, and the

246 ration of the Treibs type, an oxidative bond scission preluding a dioxa-[4+2]-cycloaddition of an ald

247 ximal amphipathic helix that facilitates the scission process and is also required for filamentous pa

248 Interestingly, this strand scission process leaves an electrophilic alpha,beta-unsa

249 with random order and that completion of the scission process requires actomyosin-driven membrane rem

250 st, which enables up to 76% yield of the C-O scission product (2-methyl furan) in catalytic transfer

251 tration with a concomitant yield decrease of scission product, protocatechuic acid.

252 Degradation of these anthocyanins formed scission products (gallic and protocatechuic acids respe

253 analysis was used to identify possible chain-scission products of polymer degradation, which were the

254 Scission products tentatively annotated with MS(2) and M

255 of degradation products, LO-radicals, their scission products were detected with (1)H NMR and indica

256 e polymers from anthocyanin condensation and scission products.

257 exposure times are combined, (v) amide link scission promotes further chlorine uptake, and (vi) scis

258 ytic triad is protonated upon 5'-splice-site scission, promoting a reversible structural rearrangemen

259 ates cortactin association with the membrane scission protein dynamin-2.

260 , provides a rationale for the carbon-carbon scission reaction catalyzed by OleT.

261 ol(-1)) has been calculated for the C-S bond scission reaction in 1(+*)-4(+*).

262 ADPH, the azobenzene linkages undergo a bond scission reaction.

263 t (ESCRT) machinery carries out the membrane scission reactions that are required for many biological

264 uid-phase HDH of single HACs, hydrogenolytic scission reactivity of C-X bonds decreases in order of C

265 To clarify the reason why hydrogenolytic scission reactivity of C-X bonds over Pd/C and Raney Ni

266 n mutants, affecting endocytosis and vesicle scission, resolving 100nm vesicles was delayed (>20 s).

267 ransformations (C-chlorination or amide bond scission) result in an irreversible increase in membrane

268 Spontaneous scission results in the formation of the stable nitroxyl

269 ns to five classes - kDNA synthesis, site of scission selection, scission, separation, and partitioni

270 kDNA synthesis, site of scission selection, scission, separation, and partitioning.

271 for other genes required either for membrane scission (shibire) or for early endosome formation (Rab5

272 hout the deleterious chain-coupling or chain-scission side reactions inherent to previous methods.

273 cle is predicted to flow through an O-O bond scission step in either H2O2 or OOH, followed by rapid H

274 This "scission" step is, thus, critical for autophagosome form

275 The calculations showed that the scission takes place by nucleophilic attack of hydroxide

276 s within the CD framework via a 1,8-HAT-beta-scission tandem mechanism.

277 and spillover but are incapable of C-C bond scission that leads to loss of selectivity and catalyst

278 on-stabilized furfuryl radical upon C-O bond scission, the strong hydroxyl affinity of oxygen vacanci

279 However, two factors can make the C-S scissions thermodynamically favorable: increased entropy

280 dependent on the presence of Drp1, and after scission they are distributed to daughter organelles, su

281 Many proteins have been associated with scission, though the underlying molecular details of how

282 embrane tension until the membrane undergoes scission through lysis.

283 sine and water as the nucleophile for strand scission, thus between productive recombination and futi

284 using restriction enzymes or sgRNA/Cas9 DNA scission to capitalize on the many benefits of plasmids

285 generating an SP radical that undergoes beta scission to form a repaired 5'-thymine and a 3'-thymine

286 activation proceeds via rate-determining C-H scission to form a surface-bound C(1) intermediate that

287 O fragments resulting from EAV or PRRSV nsp4 scission to induce IFN-beta production, we serendipitous

288 showed that (i) hydroxyl ions are needed for scission to occur, (ii) hydroxide-induced amide link sci

289 rengths are assessed in the context of chain scission triggered by pulsed sonication of polymer solut

290 rylmethyl, undergo facile homolytic C-N bond scission under mild conditions to give products of forma

291 g GTPase dynamin catalyzes endocytic vesicle scission via membrane insertion of its pleckstrin homolo

292 cks short enough to avoid hydrodynamic chain scission (weight-average molecular weights of 400 to 100

293 cross-link intermediates prior to the strand scission were also observed upon treating AP-DNA with mi

294 sible oxygen electrodes by oxidative thermal scission, where we concurrently rupture nitrogen-doped c

295 idation followed by condensation and a minor scission which represents about 10% of degraded anthocya

296 ation of the latter occurs via beta-C-C bond scission, which is facilitated by 2c,3e through-bond int

297 Thermolysis is shown to affect C-N bond scission while reactions with C6Cl4O2 or (tht)AuCl affor

298 h facilitate reaction of methoxy through C-H scission with the bridge oxygen atoms that are readily a

299 Whereas the C-C scission with the loss of CO(2) is usually exothermic, t

300 loss of CO(2) is usually exothermic, the C-S scission with the loss of SO(2) is generally endothermic