ライフサイエンスコーパス: scramblase

1 porozoite ligand (identified as phospholipid scramblase).

2 ain-containing protein (HIC), epithelin, and scramblase.

3 ough different pathways to activate the same scramblase.

4 ectly enhancing the activity of phospholipid scramblase.

5 rotein 16F, a calcium-dependent phospholipid scramblase.

6 the cell surface related to expression of PL scramblase.

7 dentity of the cloned cDNA to erythrocyte PL scramblase.

8 ing an underlying defect or deficiency of PL scramblase.

9 t platelets requires TMEM16F, a phospholipid scramblase.

10 icated that QUAD opsin is a fully functional scramblase.

11 vated Cl(-) channel convert it into a robust scramblase.

12 G protein-coupled receptor and phospholipid scramblase.

13 onductance ion channel and as a phospholipid scramblase.

14 annels and operates as membrane phospholipid scramblase.

15 s, suggesting that this homologue might be a scramblase.

16 ion of Notch and epithelin but not of HIC or scramblase.

17 nlight as constitutively active phospholipid scramblases.

18 tro assays reveal TMEM41B, VMP1, and ATG9 as scramblases.

19 branes might be a general property of active scramblases.

20 ike flippases and floppases and channel-like scramblases.

21 ip between bulk lipid transport proteins and scramblases.

22 nteracts directly with human VPS13A, XK, are scramblases.

23 -far-overlooked role in membrane dynamics as scramblases.

24 family that comprises ion channels and lipid scramblases.

25 +)-activated Cl(-) channels and phospholipid scramblases.

26 nnels, scramblases and dual-function channel/scramblases.

27 he family diverged into channels and channel/scramblases.

28 with the expected properties of mammalian PL scramblases.

29 TMEM16F, might also be dual-function channel/scramblases.

30 LSC-1, a homologue of mammalian phospholipid scramblases.

31 of calcium-dependent ion channels and lipid scramblases.

32 Human phospholipid scramblase 1 (hPLSCR1), a type II integral class membran

33 We show that inhibition of phospholipid scramblase 1 (PLSCR1) activity reduces intracellular cal

34 identified phospholipid scramblase 1 (PLSCR1) as a novel ISG that restricts seve

35 Here we identify phospholipid scramblase 1 (PLSCR1) as a potent cell-autonomous restri

36 Phospholipid scramblase 1 (PLSCR1) is a Ca(2+)-binding, endofacial pl

37 Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated, Ca(2+

38 Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated, endof

39 Phospholipid scramblase 1 (PLSCR1) is a plasma membrane protein that

40 Phospholipid scramblase 1 (PLSCR1) is an endofacial plasma membrane p

41 Phospholipid scramblase 1 (PLSCR1) is an IFN-inducible, endofacial pl

42 Phospholipid scramblase 1 (PLSCR1) is an interferon (IFN)- and growth

43 Human phospholipid scramblase 1 (PLSCR1) is an interferon-stimulated gene (

44 Phospholipid scramblase 1 (PLSCR1) is an interferon-stimulated gene (

45 While the role of phospholipid scramblase 1 (PLSCR1) is controversial in flip-flop, we

46 As phospholipid scramblase 1 (PLSCR1) randomizes PL distribution between

47 e have characterized the NLS of phospholipid scramblase 1 (PLSCR1), a lipid-binding protein that ente

48 racting proteins and identified phospholipid scramblase 1 (PLSCR1), an endofacial membrane protein, w

49 rowth factor (EGF) receptor and phospholipid scramblase 1 (PLSCR1), an endofacial plasma membrane pro

50 palmitoylation and induction of phospholipid scramblase 1 (PLSCR1).

51 Human phospholipid scramblase 1 (SCR) catalyzes phospholipid transmembrane

52 e motif containing 14), PLSCR1 (phospholipid scramblase 1), and NOS2 (nitric oxide synthase 2, induci

53 ed neuropilin-like protein, and phospholipid scramblase 1.

54 at altering the function of the phospholipid scramblase-1 (PLSCR-1) by expressing a PLSCR-1 calcium-i

55 ary IT2IR, we demonstrated that phospholipid scramblase-1 (PLSCR1), a type II transmembrane protein t

56 lipid scramblases, particularly phospholipid scramblase-1 (PLSCR1), and their role in regulated exocy

57 eracted with and phosphorylated phospholipid scramblase 3 (PLS3) after UV irradiation.

58 Phospholipid scramblase 3 (PLS3) is an enzyme that plays a critical r

59 rome c release and apoptosis by phospholipid scramblase 3 (PLS3).

60 ar epithelial cells showed that phospholipid scramblase 3 (PLSCR3), an understudied inner mitochondri

61 Phospholipid scramblase 3 is required for recovery after AKI.

62 r-31-mediated mitoprotection is phospholipid scramblase 3-dependent.

63 Phospholipid scramblase-3 (PLSCR3) deficiency in a tumor compromised

64 inates in a short exoplasmic tail, murine PL scramblase (307 AA) terminates in the predicted membrane

65 Whereas human PL scramblase (318 AA) terminates in a short exoplasmic tai

66 cellular localization of human phospholipid scramblase 4 (hPLSCR4), a member of the phospholipid scr

67 is facilitated by membrane proteins known as scramblases, a few of which have recently been identifie

68 Although ANO5 is a phospholipid scramblase, abnormal repair is rescued by overexpression

69 utic agents induce overexpression of Xkr8, a scramblase activated during apoptosis, at the transcript

70 The additional requirement of scramblase activation may occur during transient increas

71 TMEM16 homologue with intrinsic channel and scramblase activities supports this hypothesis.

72 is dependent on an increase in phospholipid scramblase activity and a decrease in APLT activity.

73 ATG9 harbors scramblase activity and is essential to autophagosome fo

74 gions, a property that correlates with lipid scramblase activity and possibly with FtsH's function in

75 scuss the physiological significance of GPCR scramblase activity and the modes of its regulation in c

76 nt to stimulate plasma membrane phospholipid scramblase activity and to mobilize phosphatidylserine t

77 ows for quick, reproducible data analysis of scramblase activity assays and provides a platform for r

78 This PL scramblase activity co-eluted through multiple chromatog

79 to Ca(2+) and critical for Ca(2+)-dependent scramblase activity during blood coagulation.

80 tivation of a calcium-dependent phospholipid scramblase activity in concert with inactivation of the

81 While the assay has yielded insight into the scramblase activity in crude membrane preparations, func

82 Building on our ability to recapitulate scramblase activity in proteoliposomes reconstituted wit

83 results instead strongly suggest that M5-DLO scramblase activity is due to a protein, or protein comp

84 We attribute this absence of scramblase activity of hPLSCR2 to the lack of N-terminal

85 scopy-based assay for detecting phospholipid scramblase activity of membrane proteins upon their reco

86 The lipid scramblase activity of PLSCR1 was found to be dispensabl

87 cell), consistent with apparent increased PL scramblase activity of the platelet plasma membrane.

88 methodology is suitable for the study of the scramblase activity of the yeast endoplasmic reticulum a

89 hat of the plasma membrane and show that the scramblase activity of two prototypical GPCRs, opsin and

90 Blocking ATG9B's scramblase activity or depleting ANXA1 decreased niche m

91 flippase activity coupled with phospholipid scramblase activity results in the exposure of phosphati

92 ipid synthesis is restricted to one leaflet, scramblase activity should be essential for equilibrated

93 However, tests of scramblase activity show that unlike wild-type rhodopsin

94 gy to the TMEM16 proteins, possesses a lipid scramblase activity that is not regulated by Ca2+.

95 Ca2+-dependent PL scramblase activity was also demonstrated in recombinant

96 ramblase at neutral pH, apparently normal PL scramblase activity was induced at pH < 6.0.

97 to hPLSCR2 (PRD-hPLSCR2) and checked whether scramblase activity was restored.

98 om the Scott cells which exhibited normal PL scramblase activity when reconstituted in vesicles with

99 ssociation of tissue factor and phospholipid scramblase activity with lipid rafts, we have explored t

100 37-kDa red blood cell protein and absorb PL scramblase activity, confirming the identity of the clon

101 tereociliary PMCA2 Ca(2+) pump both elicited scramblase activity, suggesting that apoptosis is promot

102 d BR trimers exhibit light-independent lipid scramblase activity, thereby facilitating transbilayer e

103 C-terminal beta-barrel domain-but not lipid scramblase activity-was essential for this fusogenic blo

104 (++) levels that have been shown to activate scramblase activity.

105 se hamster ovary cells demonstrated enhanced scramblase activity.

106 ented both apoptosis- and activation-induced scramblase activity.

107 ized N-terminal domain and stimulates PLSCR3 scramblase activity.

108 ne of these proteins is necessary for M5-DLO scramblase activity.

109 le, full membrane growth also requires lipid scramblase activity.

110 ctivity but instead evoke constitutive lipid scramblase activity.

111 also bend the membrane-even those that lack scramblase activity.

112 inal proline-rich domain (PRD), did not show scramblase activity.

113 he open-groove conformation is necessary for scramblase activity.

114 aturing chondrocytes express PLSCR1 and have scramblase activity.

115 mbrane that mediates this Ca2+-dependent "PL scramblase" activity, we undertook purification and reco

116 Lipid scramblases allow passive flip-flop of phospholipids bet

117 ry can be dissipated by various phospholipid scramblases, allowing cells to respond to stimuli and ad

118 n of a nonspecific lipid flipsite termed the scramblase allows rapid, bidirectional transbilayer move

119 EM16F) that underlie its function as a lipid scramblase and an ion channel.

120 nctioning as a Ca(2+)-dependent phospholipid scramblase and Ca(2+)-activated chloride channel.

121 TMEM16F is a calcium-activated phospholipid scramblase and nonselective ion channel, which allows th

122 leton bridges, stimulation of a phospholipid scramblase and phospholipase C, and induction of transgl

123 How Atg9, a lipid scramblase and the only conserved transmembrane protein

124 two or three different subclasses, channels, scramblases and dual-function channel/scramblases.

125 lipids in each leaflet, controlled by lipid scramblases and flip/floppases.

126 ily of membrane proteins includes both lipid scramblases and ion channels involved in olfaction, noci

127 e a general functional feature of the TMEM16 scramblases and therefore of general importance in under

128 NCEE also strongly inhibited APLT, activated scramblase, and caused PS externalization.

129 optosis (including RAP46/Bag-1, phospholipid scramblase, and hypoxia inducible factor-1alpha).

130 ns utilize P-type ATPases, ABC transporters, scramblases, and Niemann-Pick type C (NPC) family protei

131 Both human and murine PL scramblase are acidic proteins (pI = 4.9) with a predict

132 Scramblases are a family of single-pass plasma membrane

133 e that flies lacking either or both of these Scramblases are not compromised in vivo in processes req

134 he identity of the covalently bound 3H in PL scramblase as a thioester-linked [3H]palmitate was confi

135 atococca that functions primarily as a lipid scramblase, as well as subnanometre-resolution electron

136 n-grade graphical presentation of dithionite scramblase assays and demonstrate its utility in revisit

137 When applied to lymphoid cells, scramblase assays reveal a similar activity, with scramb

138 nresponsive to Ca2+-induced activation of PL scramblase at neutral pH, apparently normal PL scramblas

139 ific threshold concentration to disable GPCR scramblases at the plasma membrane.

140 , NRF2 increased the expression of the lipid scramblase ATG9B, which exposed an "eat me" signal on th

141 Furthermore, reconstitution of PKCdelta and scramblase, but not scramblase or PKCdelta alone in Chin

142 Scramblases can re-equilibrate lipids between membrane l

143 correlation profiling' approach to identify scramblase candidates in the yeast Saccharomyces cerevis

144 itized six polytopic ER membrane proteins as scramblase candidates, but reconstitution-based assays a

145 id cells from a patient with Scott syndrome, scramblase cannot be activated by Ca(2+), but is induced

146 eins with both Ca(2+)-activated phospholipid scramblase (CaPLSase) and Ca(2+)-activated, nonselective

147 Although a calcium-activated phospholipid scramblase (CaPLSase) has long been proposed to mediate

148 s an enigmatic Ca(2+)-activated phospholipid scramblase (CaPLSase) that passively transports phosphol

149 TMEM16 Ca(2+)-activated phospholipid scramblases (CaPLSases) mediate rapid transmembrane phos

150 Scramblases catalyze the movement of lipids between both

151 that TMEM16K, an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia (SCAR10)

152 [Ca2+]c, Raji cells were transfected with PL scramblase cDNA in pEGFP-C2, and stable transformants ex

153 Human Raji cells transformed with PL scramblase cDNA in the expression vector pEGFP-C2 were m

154 hese data indicate that transfection with PL scramblase cDNA promotes movement of PS to cell surfaces

155 n of candidate scramblases, stoichiometry of scramblase complexes as well as ATP-dependence of flippa

156 mal repair is rescued by overexpression of a scramblase-defective ANO5 mutant, suggesting a novel, sc

157 Phospholipid (PL) scramblases disrupt the lipid asymmetry of the plasma me

158 TMEM16 scramblases dissipate the plasma membrane lipid asymmetr

159 oteins, moonlight as a class of phospholipid scramblases - distinct from alpha-helical scramblase pro

160 Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft tha

161 The combination of NEM and synthetic PS scramblase enhances the ability of erythrocytes to promo

162 Activation of PL scramblase entails coordination of Ca2+ by a 12 residue

163 Scramblase enzymes carry out cellular PS externalization

164 ization of this phospholipid is catalysed by scramblase enzymes, several of which are activated by ca

165 Thus we conclude that scramblases exhibit Ca(2+)-dependent scrambling activity

166 confirm this apparent correlation between PL scramblase expression and PS egress at elevated [Ca2+]c,

167 oTracker, and Annexin V, the latter labeling scramblase externalization of phosphatidyl serine.

168 iated calcium influx activates TMEM16F lipid scramblase, facilitating the externalization of phosphat

169 Among 49 phospholipid scramblases, flippases, and floppases we analyzed, only

170 Crystal structures of TMEM16K show a scramblase fold, with an open lipid transporting groove.

171 We have now cloned murine PL scramblase for comparison with the human polypeptide.

172 Like PL scramblase from normal erythrocytes, PL scramblase from

173 on, addition of Ca2+ was found to protect PL scramblase from proteolysis by trypsin both in detergent

174 e PL scramblase from normal erythrocytes, PL scramblase from Scott erythrocytes was maximally activat

175 for normal expression of plasma membrane PL scramblase function in situ, or alternatively, reflects

176 pressing GFP alone, clones expressing GFP-PL scramblase fusion protein showed increased exposure of P

177 ormants expressing various amounts of GFP-PL scramblase fusion protein were obtained.

178 ng furrow that provides a path for lipids in scramblases has changed to form an enclosed aqueous pore

179 expansion and dynamics, the identity of most scramblases has remained elusive.

180 d, we show that D. melanogaster lacking both Scramblases have more vesicles and display enhanced recr

181 s such as the endoplasmic reticulum (ER) the scramblases have not been identified.

182 n those cell lines constitutively high in PL scramblase (HEL, Epstein-Barr virus-transformed B-lympho

183 eration and isolation of null mutants of two Scramblases identified in Drosophila melanogaster.

184 ated cells) and could directly phosphorylate scramblase immunoprecipitated from Jurkat cells.

185 Upon activating the plasma membrane scramblase in intact human red cells by introducing iono

186 approximately 10-fold higher abundance of PL scramblase in platelet ( approximately 10(4) molecules/c

187 protein, and that the deduced sequence of PL scramblase in Scott cells is identical to that of normal

188 cular basis of this disorder, we compared PL scramblase in Scott erythrocyte membranes to those of no

189 y, we identify TMEM16F as the dominant lipid scramblase in T lymphocytes that transports phospholipid

190 ugated opsin apoproteins act as phospholipid scramblases in mammalian photoreceptor disks [16], yet c

191 oprotein opsin, are constitutively active as scramblases in vitro.

192 is comparable to that of recently described scramblases including bovine rhodopsin and fungal TMEM16

193 In addition, the synthetic PS scramblase increases the levels of endogenous PS on the

194 e-defective ANO5 mutant, suggesting a novel, scramblase-independent role of ANO5 in repair.

195 s does not affect the activity of flipase or scramblase, indicating that these proteins are not regul

196 Phospholipid scramblase induces nonspecific bidirectional movement of

197 ne 540, the calpain inhibitor E-64d, and the scramblase inhibitor R5421 revealed that neither phospho

198 homologues were reported to be phospholipid scramblases, ion channels, to have both functions or to

199 Phospholipid (PL) scramblase is a 35.1 kDa plasma membrane protein that me

200 Phospholipid (PL) scramblase is a plasma membrane protein that mediates ac

201 dylcholine analogues are similar whether the scramblase is activated by elevated internal Ca(2+) or b

202 We also presented evidence that this PL scramblase is expressed in a variety of other cells and

203 Activation of scramblases is one of the mechanisms that regulates the

204 ng activity of protein extracts and purified scramblases is typically measured using a fluorescence-b

205 rine on the cell surface, catalyzed by lipid scramblases, is an important signal for the clearance of

206 the architecture of a Ca(2+)-dependent lipid scramblase, its regulation mechanism has remained elusiv

207 This mechanism could be extended to other scramblases lacking a hydrophilic groove.

208 f thioester bonds in purified erythrocyte PL scramblase markedly reduced the Ca2+-dependent activity

209 TMEM16 phospholipid scramblases may be a therapeutic target for thrombotic c

210 Calcium-activated phospholipid scramblase mediates the energy-independent bidirectional

211 Ca2+, and we presented evidence that this PL scramblase mediates the transbilayer movement of plasma

212 y the upregulation of PLSCR1, a phospholipid scramblase mediating endosomal TLR-9 translocation.

213 t lymphoblasts expressed normal levels of PL scramblase mRNA and protein, and that the deduced sequen

214 PL scramblase mRNA was found in a variety of hematologic an

215 Although the structure of the scramblase nhTMEM16 has defined the architecture of the

216 y exposed to the lipid bilayer on the fungal scramblase nhTMEM16 serves as the pathway for both lipid

217 ed to an altered interaction of Ca2+ with PL scramblase on the endofacial surface of the cell membran

218 iling view in the field is that phospholipid scramblases on the plasma membrane act without headgroup

219 rsy surrounds whether ANO6 is a phospholipid scramblase or an ion channel like other ANO/TMEM16 famil

220 mbers of the TMEM16 family have either lipid scramblase or chloride channel activity.

221 titution of PKCdelta and scramblase, but not scramblase or PKCdelta alone in Chinese hamster ovary ce

222 It is however controversial whether they are scramblases or channels regulating scrambling.

223 phospholipid transporters, such as specific scramblases or proteins from the family of multidrug res

224 nally, we highlight recent findings on lipid scramblases, particularly phospholipid scramblase-1 (PLS

225 tive to activation of the plasma membrane PL scramblase pathway, it had been shown that PL scramblase

226 ysiological analysis lead us to propose that Scramblases play a modulatory role in the process of neu

227 dependent, but instead requires phospholipid scramblase PLSC-1, a homologue of mammalian phospholipid

228 Phospholipid scramblase (PLSCR1) is a multiply palmitoylated, calcium

229 pholipid translocase (APLT) and phospholipid scramblase (PLSCR1), during maturation of a murine chond

230 The phospholipid scramblases (PLSCR1 to PLSCR4) are a structurally and fu

231 ation of cardiolipin synthase (Crls1) or the scramblase (Plscr3) that transfers cardiolipin to the OM

232 Phospholipid scramblases (PLSCRs) constitute a family of cytoplasmic

233 tly identified a conserved segment in the PL scramblase polypeptide (residues Asp273 to Asp284) that

234 rrant posttranslational processing of the PL scramblase polypeptide or to a defect or deficiency in a

235 We investigated two scramblases previously identified to be involved in EBOV

236 ewly identified PLSCR1 gene for phospholipid scramblase, previously implicated in remodeling of plasm

237 se 4 (hPLSCR4), a member of the phospholipid scramblase protein family.

238 cramblase pathway, it had been shown that PL scramblase protein isolated from detergent-solubilized S

239 The deduced "PL scramblase" protein is a proline-rich, type II plasma me

240 id scramblases - distinct from alpha-helical scramblase proteins - that act to import lipids into mit

241 6F as Ca(2+)-activated ion channel and lipid scramblase raise intriguing questions regarding their mo

242 TMEM16F, maintain an additional function as scramblases, rapidly exchanging phospholipids between le

243 oposed that activation of the Xkr4 apoptotic scramblase requires caspase cleavage, followed by dimeri

244 Our results demonstrate that scramblase restricts TCR responses to avoid overactivati

245 within the putative EF hand loop of human PL scramblase resulted in loss of its PL mobilizing functio

246 Clones expressing GFP-PL scramblase showed distinctly plasma membrane-localized f

247 nanodisc-reconstituted Ca(2+)-bound afTMEM16 scramblase showing how rearrangement of individual lipid

248 ved sequence in the cytoplasmic domain of PL scramblase shows similarity to Ca2+-binding loop motifs

249 Our data indicate that calcium-activated scramblases, sphingomyelin, and neutral sphingomyelinase

250 arations, functional validation of candidate scramblases, stoichiometry of scramblase complexes as we

251 outer cell membrane leaflet by phospholipid "scramblases," such as TMEM16F.

252 BC transporter) and germ cells (phospholipid scramblase) suggest an increased complexity in the regul

253 ungal Nectria haematococca TMEM16 (nhTMEM16) scramblase suggested a putative mechanism of lipid trans

254 proteins belong to the Transmembrane Channel/Scramblase (TCS) superfamily.

255 ATG9A is a lipid scramblase that allows equilibration of lipids across a

256 ein-coupled receptor opsin is a phospholipid scramblase that facilitates rapid transbilayer phospholi

257 he multispanning membrane protein ATG9A is a scramblase that flips phospholipids between the two memb

258 amin 6), a calcium-activated ion channel and scramblase that is responsible for exposure of phosphati

259 colleagues identifies Any1 as a phospholipid scramblase that plays an important role in MVB biogenesi

260 rise in intracellular Ca2+ activates a lipid scramblase that translocates PS from the inner to the ou

261 We identify the OSN scramblase that transports phosphatidylserine from the s

262 Among them are scramblases that facilitate a rapid bi-directional movem

263 ytosolic leaflets of apposed organelles, and scramblases that reequilibrate the leaflets of donor and

264 O paralogs are Ca(2+)-dependent phospholipid scramblases that serve as channels facilitating the move

265 externalize PS has been assumed to involve "scramblases" that randomize phospholipids across the PM

266 shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photo

267 The membrane protein (M5-DLO scramblase) that mediates M5-DLO translocation across th

268 a erythrocyte membrane protein, phospholipid scramblase, that promotes Ca2+-dependent transbilayer mo

269 ugmented by the deletion of another putative scramblase, the protein insertase Get1, suggesting that

270 itated by integral membrane proteins called "scramblases." These proteins feature a hydrophilic groov

271 I, Schmaier et al. identify the phospholipid scramblases TMEM16E and TMEM16F, which support endotheli

272 Furthermore, SERINC3, SERINC5 and the scramblase TMEM16F expose PS on the surface of HIV-1 and

273 The lipid scramblase TMEM16F initiates blood coagulation by cataly

274 confirmed that lipid scrambling through the scramblase TMEM16F is essential for chemically induced m

275 rane-residing calcium-activated phospholipid scramblase TMEM16F preferentially acts on phosphatidylse

276 receptor interactions and involves the lipid scramblase TMEM16F.

277 Thus far, host cell scramblases TMEM16F and XKR8 have been implicated in Ebo

278 ompartments open when Ca activates the lipid scramblase, TMEM16F, anionic phospholipids escape from t

279 n enriched in another multispanning membrane scramblase, TMEM41B, and also in close proximity to phag

280 sts that PaMprF is the first dedicated lipid scramblase to be characterized in bacteria.

281 C), an abundant outer membrane protein, as a scramblase-type lipid transporter that catalyzes lipid e

282 Metal binding to PL scramblase was accompanied by increased right-angle ligh

283 on by Ca2+, the PL-mobilizing function of PL scramblase was found to be activated by other ions, with

284 unoprecipitated with antibody against GFP-PL scramblase was found to covalently incorporate 3H, where

285 + activates the PL-mobilizing function of PL scramblase, we analyzed conformational changes associate

286 this lipid asymmetry in the presence of GPCR scramblases, we hypothesized that GPCR-mediated lipid sc

287 Recombinant murine and human PL scramblase were each expressed in Escherichia coli and i

288 re, we identify Any1 as a novel phospholipid scramblase, which functions with the lipid transfer prot

289 gs to a family of plasma membrane (PM) lipid scramblases whose action results in exposure of PtdSer a

290 we show that TMEM16K is an ER-resident lipid scramblase with a requirement for short chain lipids and

291 er TMEM16 homologues, and a Ca(2+)-dependent scramblase, with the expected properties of mammalian PL

292 Scramblase Xk-related protein 8 (Xkr8) regulates the ext

293 Scramblase Xkr8 regulates the externalization of phospha