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1 deuterium labels along the peptide (hydrogen scrambling).
2 d treated with miR-24 inhibitor or inhibitor scramble.
3 is function on ANO1, which normally does not scramble.
4 ent noise modulation segments was temporally scrambled.
5 mutant mice, in which neural positioning is scrambled.
6 impaired Ca(2+)-triggered phosphatidylserine scrambling.
7 usly involves both Ni-H moieties without H/D scrambling.
8 nels and regulators of membrane phospholipid scrambling.
9 brane-protein interactions involved in lipid scrambling.
10 insertion of loxPsym sites to enable genome scrambling.
11 ions (i.e., b/y ions) exhibit extensive H/D scrambling.
12 obular conformation and suppressed disulfide scrambling.
13 4) ions from ubiquitin exhibit extensive H/D scrambling.
14 rane expansion in parallel with phospholipid scrambling.
15 elationship between ion conduction and lipid scrambling.
16 bation time; it is accompanied by fast lipid scrambling.
17 ff' = 0 [0 to 25]%, 'On' = 69 [53 to 100]%, 'Scrambled' = 28 [13 to 63]%; Friedman Chi-squared test s
18 Off' = 0 [0 to 50]%, 'On' = 69 [67 to 95]%, 'Scrambled' = 59 [42 to 95]%; Friedman Chi-squared test s
21 imental LLPS data on the wild-type, a charge-scrambled, a phenylalanine-to-alanine (FtoA), and an arg
26 Our study further implicates TMEM16K lipid scrambling activity in endosomal sorting at these sites.
28 that the addition of PRD to hPLSCR2 restored scrambling activity, and deletion of PRD in hPLSCR1 (Del
29 SCR2 showed Ca(2+)-dependent aggregation and scrambling activity, whereas hPLSCR2 and DeltaPRD-hPLSCR
30 ghput gene synthesis, here we report a codon-scrambling algorithm that enables the PCR-based gene syn
32 ectivities is a necessity to avoid disulfide scrambled and incorrectly folded forms in the final prod
33 served regions of its primary structure were scrambled and the mutations were tested for the RD3 abil
34 require both TMEM16F-dependent phospholipid scrambling and calcium influx, as a kinetic assay to inv
36 and EGCG on inhibiting TMEM16F phospholipid scrambling and discourage the use of these polyphenols a
40 ), provides steric protection against ligand scrambling and metal complex oligomerization and electro
43 n inverse kinetic isotope effect, fast H2/D2 scrambling and slow alkene isomerizations pointing to an
44 ase fragment ion isomers related to sequence scrambling and the underlying fragmentation mechanism, w
47 d key amino acids necessary for phospholipid scrambling and validated the idea that ions permeate TME
48 membrane induced by oxidative stress, lipid scrambling, and artificial cell aging modulate the cell
49 sin to metarhodopsin II are not required for scrambling, and that the lipid translocation pathway eit
50 into a single peak over time, suggestive of scrambling, and the effect of the channel on the transbi
51 d, to determine the extent of disulfide bond scrambling, and to understand why scrambling occurs, we
53 e stage, an absence of corneal epithelium, a scrambled appearance of the anterior stroma and a hetero
54 icrobial attack), can help misconstrue lipid scrambling as the action of proteins or peptides, when i
55 eptide, we show that UVPD occurs without H/D scrambling as the peptide probe accurately retains its s
56 lisinopril (100 mg/kg/d), PBS (control), or scrambled ASO (66 mg/kg/wk) for 10 wk, followed by tissu
57 onucleotides (ASOs) to knockdown Mogat1 or a scrambled ASO control for 12 weeks while remaining on di
59 zing a (2)H-labeled silolane probe; complete scrambling at the silicon center was observed, consisten
60 ed Cu(I)Cu(II) pair; the Cu(II), however, is scrambled between the two locations within the dicopper
61 servations are likely the result of isotopic scrambling between transiently produced carbonyl-contain
62 observed both while viewing coherent versus scrambled biological motion, and while listening to happ
63 Synteny analysis uncovered localized but scrambled blocks of genes in putative orthologous relati
64 a path to experimental use FOTOCs to explore scrambling, bounds on quantum information processing and
67 maller autophagosomes, indicating that lipid scrambling by ATG9A is essential for membrane expansion.
73 developed elaborate eccentricities, such as scrambled coding regions, nonstandard genetic codes, and
76 se oligodeoxynucleotides targeting Notch3 or scramble control oligodeoxynucleotides in wild-type mice
77 obscurin short hairpin RNA (shRNA), but not scramble control shRNA, exhibit increased primary tumor
81 o be in the Cdc42/ciliogenesis pathway and a scrambled control morpholino showed no phenotypic effect
84 ased baseline Tshb mRNA levels compared with scrambled control, but surprisingly had no affect on the
85 al and histological endpoints, compared with scrambled control-treated IL-15 transgenic CTCL mice.
86 rostate cancer cell xenografts compared with scrambled controls, suggesting HIP1R is a key functional
87 oron-dipyrromethene (IYIY-I2-BODIPY) and its scrambled counterpart YIYI-I2-BODIPY have been prepared.
89 unmodified or lesion-containing CRE, but not scrambled CRE or scrambled CRE with a G/U mispair, resul
90 ion-containing CRE, but not scrambled CRE or scrambled CRE with a G/U mispair, resulted in increased
91 Gly(6)-Gln(7) residues or by random sequence scrambling demonstrated a crucial role for this structur
93 ium-labeling studies indicate that deuterium scrambling does not take place in this sp(2) -sp(3) cros
95 ly, a/x and c/z ions have also undergone H/D scrambling due to UV-induced heating of the precursor io
96 considered as a competition in which neurons scramble during a critical selection period for integrat
98 r use in RT-PCR diagnostics: we encapsulated scrambled Ebola RNA sequences inside of tobacco mosaic v
99 owder reached 1g, it was replaced with 8g of scrambled egg, after then subsequent doses were increase
100 e top-down routine does not trigger hydrogen scrambling either during the electrospray ionization pro
102 s (FOTOCs) can elucidate connections between scrambling, entanglement, ergodicity and quantum chaos (
103 urements appear to be unaffected by hydrogen scrambling, even when high collisional energies are util
105 of the reaction were further confirmed by a scrambling experiment, involving pillar[5]arene and per-
109 oveated face under three preview conditions: scrambled face, incongruent face (different identity fro
112 inferior temporal (IT) cortex to intact and scrambled faces that were filtered to selectively preser
113 longitudinally the responsiveness to faces, scrambled faces, and objects in macaque inferotemporal c
114 ircuit that provides a positive test for the scrambling features of a given unitary process(5,6).
116 a detailed investigation of the level of H/D scrambling for all fragment ion types upon UVPD of the p
119 Using this rule, we were able to reduce scrambling from 75% to below 5% on average using the hig
120 the genetics by removing or recoding genes, scrambling gene order and replacing all non-coding DNA w
122 and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity thro
123 ncrypted genome architecture contains >3,500 scrambled genes, as well as >800 predicted germline-limi
124 This genome assembly provides a draft of a scrambled genome and a powerful model for studies of gen
125 t, providing an unambiguous test for whether scrambling has occurred, while simultaneously measuring
128 face-selective response is absent for phase-scrambled images and therefore not due to low-level info
129 en category correlations for both intact and scrambled images demonstrating distinct patterns of resp
133 rithms are utilized to convert the spatially scrambled images into fluorescent images and video.
136 However, the difference between intact and scrambled images was smaller in V3 compared to V1 and V2
138 -irradiation of ubiquitin did not induce H/D scrambling in the nonfragmented precursor ion population
139 ormations resemble their counterparts of the scrambling-incompetent anion channel mTMEM16A, yet with
140 t, and enable us to experimentally bound the scrambling-induced decay of the corresponding OTOC measu
141 ane permeabilization, blebbing, phospholipid scrambling, inflammasome activation, and IL-1beta releas
143 m CO(2) and that electrochemical nanocrystal scrambling is an avenue toward creating such catalysts.
144 e direct experimental measurement of quantum scrambling is difficult, owing to the exponential comple
145 is asymmetry by ATP-independent phospholipid scrambling is important in cellular signaling, but its m
148 A major consequence of Ca(2+)-dependent scrambling is the release of extracellular vesicles that
150 compare native cytotoxin 3 (CTX III) and its scrambled isomer, another category of protein mixture, f
153 83%), TNFA (by 77%), and PI3 (by 65%) versus scrambled L-SNA and vehicle controls (all P < 0.001).
154 cterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine (PS) externaliz
155 orrelation function (OTOC); however, because scrambling leads to their decay, OTOCs do not generally
156 beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that rhodopsin-like G protei
159 rovide a possible mechanism for phospholipid scrambling mediated by PLSCRs and the importance of PRD
160 hat target Foxp3 and IL-17, respectively, or scrambled miR (mock) or inhibitors confirmed that these
164 ion, we designed a series of linker sequence scrambling mutants to suppress potential complex interpl
166 containing bodies, faces, objects, scenes or scrambled objects, and static pictures from the beginnin
168 lfide bond scrambling, and to understand why scrambling occurs, we determined the disulfide bond prof
169 ducts of deuterated retinol showed a lack of scrambling of a putative allylic radical at C-3 and C-4.
175 e protein, is known to mediate bidirectional scrambling of phospholipids in a Ca(2+)-dependent manner
179 ias-induced rapid fusion or "electrochemical scrambling" of Cu NPs creates disordered structures intr
180 serve as channels facilitating the movement (scrambling) of phospholipids between leaflets of the mem
181 tubule cell lines compared with wild-type or scrambled oligonucleotide-treated cells, respectively.
182 parison with Match oligonucleotides, (111)In-Scramble or (111)In-Mismatch oligonucleotides demonstrat
184 complementary (Match) and noncomplementary (Scramble or Mismatch) to hTR were conjugated to diethyle
185 in levels in MC3T3-E1 cells transfected with scrambled or protein kinase B (Akt) small interfering RN
186 ble for peptides that are prone to disulfide scrambling or are unstable in solution with partly reduc
187 TA and EGCG do not inhibit the phospholipid-scrambling or ion conduction activities of the dual-func
190 zed by profound epigenetic changes including scrambled patterns of DNA methylation, deregulated histo
191 n, TAT-CBD3, but not CBD3 without TAT or TAT-scramble peptide, inhibited increases in cytosolic Ca(2+
193 t surgery, the Cx43 mimetic peptide Gap27 or scrambled peptide, were administered via osmotic minipum
194 -dependent and saturable manner, whereas the scrambled peptides showed highly reduced or no binding t
195 ing our scattering experiments, we identify 'scrambles' (periods of time in which no pairwise binarie
196 onclude that an engineered opsin monomer can scramble phospholipids, and that the lipid-exposed face
202 multigram scale-up route for highly soluble 'scrambled' porous cages prepared from a mixture of comme
203 mbly behavior in a predictable manner, while scrambling primary sequence has little effect on PrLD as
204 fragment ion types upon UVPD of the peptide scrambling probe P1 (HHHHHHIIKIIK) using an Orbitrap tri
205 bling-sensitive quadruply charged P1 peptide scrambling probe resulting in a minor 33% transmission l
210 he design of negative controls by permitting scrambling, reversing, complementing or introducing mult
212 e.g. OnRS/miR-124, OnRS/GFP-siRNA, OnRS/Neg (scrambled RNA) and OnRS/MGA (malachite green aptamer)) w
213 hat the plasma membrane cell fate regulator, SCRAMBLED (SCM), is mislocalized in ugt80B1 mutants, und
214 s one- and two-base mismatches (1MM, 2MM) or scrambled (SCR) sequences was highlighted and the applic
216 75% to below 5% on average using the highly scrambling-sensitive quadruply charged P1 peptide scramb
217 rgeting catenin beta 1 (CTNNB1; CTNNB1-LNP), scrambled sequence (Scr-LNP), or phosphate-buffered sali
218 plementary target sequence exceeds that of a scrambled sequence by nearly 3 orders of magnitude.
225 t with the prosthesis in the 'On', 'Off' or 'Scrambled' setting presented in a randomised order.
229 ced diabetic C57BL/6 mice were injected with scramble shRNA and PRR shRNA and followed for a period o
230 d with eIF5A shRNA was compared with that of scramble shRNA-transduced counterpart by the iTRAQ metho
231 aH2AX by H2O2 treatment (20 mum) subsided in scrambled shRNA but exacerbated in SelH shRNA MRC-5 cell
233 utathione level was lower in SelH shRNA than scrambled shRNA HeLa cells, and the H2O2-induced cell de
235 migrate faster than the ones expressing the scrambled shRNA on a collagen I gel (two-dimensional) al
236 pression did not change in similarly treated scrambled shRNA transgenic kidneys, and we observed no C
237 c mice that express stanniocalcin-1 shRNA or scrambled shRNA upon removal of a floxed reporter (phosp
238 lk1 knockouts, as well as with a fraction of scrambled shRNAs, suggesting a sequence-dependent but no
243 cted by TNF-alpha, whereas NPSCs loaded with scrambled siRNA do not cause the predicted changes.
246 , Il17c, S100a7, Pi3, Krt16, and Tnfa versus scrambled spherical nucleic acid (Scr SNA) controls.
247 situ, and in situ analyses reveals that the scrambled state exhibits several structural signatures:
251 the Pd(0) pathway, as evident from deuterium scrambling studies that could reveal differentiating pro
252 ng to transient or, in the case of apoptotic scrambling, sustained collapse of membrane asymmetry.
255 act maps to detect rearrangements induced in SCRaMbLE (synthetic chromosome rearrangement and modific
257 ically, we created a series of truncated and scrambled tau constructs and characterized the size and
258 ials to 3 Hz alternations between intact and scrambled text comprised of letters of varying size.
260 ssion of these factors and, thereby, lineage scrambling that is disconnected from TCR restriction by
262 ctions in disordered media are well-known to scramble the information content of light by complex but
263 ttering, in which multiple scattering events scramble the recorded electron diffraction intensities s
265 dex distribution of biological tissue, which scrambles the incident light and destroys the optical fo
267 A related, detergent-based protocol for scrambling the lipid asymmetry of liposomes and maybe ce
269 mplications of Ca(2+)-dependent phospholipid scrambling, the extracellular vesicles associated with t
271 ystems at infinite temperature, bounding the scrambling time by a finite decay time of local quantum
272 tary circuits, we propose that a logarithmic scrambling time can be achieved in most quantum systems
275 positive results is partly attributable to a scramble to find simple solutions for complex problems t
276 ents, regulators, and dialysis organizations scramble to keep up with the frequent release of wide-ra
281 g different tpy "heads" and thiolate "tails" scrambles to afford up to 10 ternary assemblies via two
282 scribe an optimization strategy for reducing scrambling to a negligible level while minimizing the im
283 HN(SiMe(3))(2), followed by silyloxy ligand scrambling, to form 1 and the U(VI) bis(silsesquioxane)
284 Hep3B alpha3-positive, but not wild-type and scramble transfected, cells acquired protection by soraf
289 ly support the mechanism of peptide sequence scrambling via b ion cyclization, and provide the first
290 al form and the other with a partially phase-scrambled visual form, were completely irrelevant to the
291 range of nonvocal control sounds, including scrambled voices, environmental noises, and animal cries
292 employed in this key step, no conformational scrambling was observed during the asymmetric synthesis
295 quantum chaos is not universally related to scrambling: We construct random few-body circuits with i
296 embrane suffice for virtually complete lipid scrambling, whereas leakage remains below 10% for up to
297 and suggest methods to experimentally study scrambling with as many as 100 sparsely connected quantu
299 ort that ZIP as well as its inactive analog, scrambled ZIP, induced a dose-dependent increase in spon
300 ort that ZIP as well as its inactive analog, scrambled ZIP, induced a dose-dependent increase in spon