ライフサイエンスコーパス: screening of

1 apeutic candidates for TNBC through in vitro screening of 1,363 drugs in patient-derived xenograft (P

2 In this study, we perform functional screening of 105 small molecules with pro-regenerative p

3 BD Max assay allows high-throughput C. auris screening of 180 surveillance samples in a 12-h workday.

4 At screening, of 190 participants (mean age, 47 years; 74%

5 dentified 100 candidate molecules by virtual screening of ~2 million small molecules for those predic

6 The use of infrared spectroscopy for the screening of 229 unprocessed durum wheat samples natural

7 Screening of 23 drugs used in the treatment of neuroblas

8 Screening of 289 targeted agents for the ability to incr

9 Screening of 367 kinase inhibitors in human neutrophils

10 Through a systematic screening of 39 analogues of SPD-304, a dual inhibitor o

11 Systematic RNA interference (RNAi) screening of 40 mosquito-specific genes was performed by

12 Functional screening of 47 species revealed 60% were competent for

13 rug candidates were identified by functional screening of 480 chemically diverse natural compounds in

14 Screening of 5 desmosomal genes was performed in proband

15 re we perform a CRISPR/Cas9-based functional screening of 59 membrane proteins expressed in the gamet

16 Screening of 6,633 citations was conducted.

17 Screening of 600 Victorian clinical isolates identified

18 After an initial potency screening of 7 U.S. Food and Drug Administration-approve

19 One-time screening of 90% of the 2018 population by 2030, with 80

20 high-throughput-screening of 997 LNA-MIR-inhibitors was performed in 6 C

21 Screening of a 48-variant library of the cytochrome P450

22 High-throughput screening of a chemical library yielded a small molecule

23 Screening of a collection of compounds revealed kojic ac

24 elopment, chemical synthesis, and biological screening of a compound library that led to the identifi

25 Screening of a GSK-proprietary library against intracell

26 loit such a toxicity to perform a functional screening of a human cDNA library, looking for cDNAs abl

27 lase activity was isolated during functional screening of a human gut metagenomic library using Lacto

28 Here, phenotypic screening of a human/hamster radiation hybrid panel iden

29 In a screening of a kinase inhibitor library, we identified t

30 An in vivo screening of a known drug library was performed to ident

31 of previously undiagnosed cases through mass screening of a large cohort of subjects with development

32 en, we applied the best models for a virtual screening of a large database of chemical compounds.

33 detected on polymerase chain reaction (PCR) screening of a large homeless shelter population in Bost

34 icability in a high-throughput computational screening of a large molecular database (GDB-9) with mor

35 In 2019, screening of a metagenomic library derived from the fece

36 routinely done by 14/23 (61%) and a systemic screening of a metastatic disease by 13/23 (57%).

37 Screening of a range of growth parameters led to the ide

38 Toward this goal, we began in vitro screening of a structurally diverse in-house library of

39 ided by this work may be useful for clinical screening of acylcarnitines as well as for studying rela

40 Screening of additional families will determine whether

41 Using high-throughput substrate screening of additional TrmA* mutants, we identified a t

42 a polymeric matrix is well suited for rapid screening of additives in efforts to identify more susta

43 n-AGE inpatient controls through prospective screening of admitted patients and passively identified

44 argeted metabolomics and CRISPR-Cas9 fitness screening of all known metabolic genes.

45 mp face shield (n = 57 [91.9%]), temperature screening of all persons entering clinical space (n = 34

46 his type of polaron allows efficient Coulomb screening of an electron or hole by extended ordering of

47 Screening of an extended PWD population confirmed perfec

48 thin/Neoaureothin as potent hits by anti-HIV screening of an extensive natural compound collection.

49 Through a loss-of-function screening of an M. tuberculosis transposon mutant librar

50 The screening of an NCI library of FDA-approved drugs using

51 Vision screening of an unselected middle school population inve

52 n effective platform for the high-throughput screening of anti-cancer drugs in 3D tumour spheroids.

53 n example application of this concept to the screening of antibacterial drugs that act at the major b

54 tform to facilitate rapid and cost-effective screening of antibody and toxin combinations for activit

55 at PRS mice may be useful in the preclinical screening of antipsychotic drugs acting to correct alter

56 Screening of Arabidopsis transcription factors identifie

57 commended when choosing diagnostic tests for screening of asymptomatic children.

58 ese results highlight the need for long-term screening of both childhood and early-adolescent and you

59 expensive, promising analytical tool for the screening of both the quality and safety of ketchup samp

60 ts into the usage of the MM-GBSA methods for screening of BRD inhibitors, substantiating the benefits

61 of breast MRI abbreviated protocols for the screening of breast cancer in high-risk patients compare

62 es the application of delta(13) C for WUE(i) screening of C(4) crops.

63 ach for such cell types and allows the early screening of candidate hiPSC seed stocks for clinical us

64 (PSMA)-ligand PET is potentially useful for screening of castration-resistant prostate cancer (CRPC)

65 the promising approaches for high-throughput screening of cell mechanotype is microfluidic deformabil

66 High-throughput screening of cell-secreted proteins is essential for var

67 High-throughput FACS screening of cellular picoreactors has the potential to

68 can be a general principle for the efficient screening of charge carriers from scattering with other

69 a-vital imaging, flow cytometry and scalable screening of chemical inhibitors and inhibitory antibodi

70 Using chemical genetics, the systematic screening of chemical matter for a biological outcome, h

71 Hence, screening of chemical modifications on DNA can be used t

72 iplex paper based platform for point-of-care screening of chicken carcasses for Campylobacter.

73 ay inform considerations of population-based screening of children for islet autoantibodies.

74 Screening of cilantro leaf metabolites revealed that one

75 The approach enables scaling up the screening of combinatorial libraries and, together with

76 wever, only a few have their origin from the screening of combinatorial peptidomimetic library.

77 We have performed the parallel screening of commercially available compounds against a

78 High-throughput screening of compound libraries against this enzyme enab

79 le end point detection method for cell-based screening of compound libraries for effects on PrP(C) pr

80 ional theory (DFT) has enabled computational screening of compounds with the goal of accelerated mate

81 The genome-wide screening of concordantly expressed genes (CEGs) elimina

82 Such an incomplete screening of contaminated samples substantially inflates

83 In-silico screening of CPEs in a rigorous skin model could speed u

84 hGRalpha, the biologically active isoform, a screening of current databases and publications revealed

85 developed a platform for rapid phage display screening of deep recombinant libraries consisting of as

86 widely applicable, preliminary yet accurate screening of dental lesions prior to dental clinics and

87 , PPARgamma-activation assays may enable the screening of dietary components and identification of ag

88 from this study suggest that the design and screening of different activation mechanisms may help to

89 nerally carried out by thorough experimental screening of different candidates.

90 ression, purification and activity profiling screening of different hABHD6 constructs and identified

91 ymography technique that can be used for the screening of disease-associated proteases in patient sam

92 d configurations, and long-ranged dielectric screening of distant charges, competing effects that are

93 ere we applied an automated pipeline for the screening of diverse monoterpene synthase libraries, emp

94 Technologies that enable rapid screening of diverse reaction conditions are of critical

95 Importantly, screening of DLBCL patient samples identified SIRT3 as a

96 1 KD in C. elegans is a useful model for the screening of drugs against motor neuron degeneration, an

97 is fast and is scalable for high-throughput screening of drugs targeting protein-protein interaction

98 WT is a powerful tool for the behavior-based screening of drugs.

99 ivariate FT-NIR spectroscopic method for the screening of durum wheat pasta samples adulterated with

100 Tn-seq screening of E. coli Tn10 insertion library revealed tha

101 ds targeting antibodies are not suitable for screening of early and asymptomatic cases since most pat

102 to colorectal cancer, supporting unselected screening of EC for LS.

103 er droplets to perform substrate specificity screening of eight model enzymes from the haloalkane deh

104 Standard state-of-the-art techniques for screening of electrogenic bacteria are inefficient, and

105 Chemical genetic screening of endothelial tube formation provides a robus

106 ques to isolate effective compounds based on screening of entire compound libraries based on desired

107 e solids in multichannel format and expedite screening of enzyme immobilization conditions.

108 quitoes using PCR, long-read sequencing, and screening of existing metagenomes.

109 Untargeted screening of extractable metabolites revealed that N-gly

110 this study, we have performed the mutational screening of EYA4 gene by DHLPC and NGS in a large cohor

111 racic aortic dissection, followed by cascade screening of family members, especially in patients with

112 roach consists of three steps: computational screening of FDA-approved drugs; in vitro and/or in vivo

113 A preliminary screening of fennel nsLTP1 suppressed the growth of MCF-

114 Parallel (multichip) screening of ferric ion concentration gradients (0-40 mM

115 Screening of five human chordoma cell lines revealed tha

116 nd miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was propos

117 es appropriate guidelines for cost-efficient screening of FMP products for adulterants to protect pub

118 Screening of food products for the presence of material

119 Initial screening of formulations considered the effect of charg

120 FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions

121 The solid form screening of galunisertib produced many solvates, prompt

122 ractive avenue to a sustainable economy, yet screening of genetically diverse strain libraries to ide

123 e that meets the need for de novo functional screening of genome-scale metabolic networks (GSMNs) at

124 pp.), following metabolomics-based diversity screening of global collections held within the CGIAR in

125 so more widely as a general approach for the screening of glycosyltransferases and other group-transf

126 We combined siRNA high-throughput screening of >20,000 genes with a multicohort analysis o

127 sed as a reporter system for high-throughput screening of HCMV inhibitors.

128 ta demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms.

129 An alternative to population-wide genetic screening of healthy individuals would exploit the trend

130 ent of high-throughput methodologies for the screening of heat tolerance.

131 oducible results that enable high-throughput screening of heterogeneous soil samples.

132 ations of dental caries, allowing convenient screening of hidden dental lesion sites that are oftenti

133 Prioritised screening of high prevalence groups (PWID and adults age

134 ing technique for the rapid optimization and screening of high-performance SSEs.

135 Radiologic screening of high-risk adults reduces lung-cancer-relate

136 Targeted screening of high-risk individuals is likely to be the m

137 n Durban, South Africa, through twice-weekly screening of high-risk participants.

138 e 1990s, however, indicates that low-dose CT screening of high-risk patients enables detection of lun

139 rhythmic drug mexiletine via high-throughput screening of hiPSC-CMs derived from patients with the ca

140 Through unbiased screening of histone H4 residues in the nucleosomal LRS

141 CrAg screening of HIV-infected persons in the blood prior to

142 ung (TEDDY) study enrolled 8,676 newborns by screening of HLA-DR-DQ genotypes at six clinical centers

143 nt a method for high-throughput, single-cell screening of IgG-secreting primary cells to characterize

144 gy provides an accurate approach for genetic screening of imprinting related disorders in newborns, o

145 It is thus technically adaptable to screening of individual differences in CYP enzyme functi

146 By a loss-of-function genetic screening of individual IFN-stimulated genes (ISGs) on h

147 Screening of individuals at risk may translate into elec

148 ith dengue seroprevalence rates above 80% or screening of individuals before vaccination, and vaccina

149 Guidelines suggest endoscopic screening of individuals who are at increased risk for B

150 reliable point-of-care diagnostics for early screening of infections especially in developing countri

151 Screening of just two ethnic-specific variants (p.Trp258

152 The compositional screening of K-Zn-Sb ternary system aided by machine lea

153 used the Expression2Kinase algorithm for the screening of kinase targets.

154 (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.

155 to meet drug discovery requirements for the screening of large and diverse compound libraries.

156 The results of this study set the stage for screening of large chemical libraries for discovery of n

157 We use high throughput screening of large libraries of materials with differing

158 Here, we report the synthesis and screening of lipid derivatives inspired by granadaene, w

159 tients on these medicines require consistent screening of liver function.

160 We observe that screening of LO phonons is not as efficient as it would

161 Finally automated robotized screening of low-dimensional hybrid perovskite materials

162 targeting with MRI imaging for diagnosis and screening of lung cancers, (ii) magnetic drug targeting

163 nce for future attempts to achieve proximity screening of many-body phenomena in two-dimensional syst

164 thanol in spiked breath, promising for rapid screening of methanol poisoning and assessment of severi

165 Via screening of MHC-restricted libraries comprising ~2x10(8

166 e to (1) build/test a lab-scale platform for screening of microbial VOCs and (2) apply it to Mycobact

167 roposed method can be applied for an overall screening of migrants from these three simulants at even

168 (DI-SPME-GC-MS) was optimized for nontarget screening of migrants in 3% acetic acid, 10% ethanol, an

169 compound library, assay and future clinical screening of millions of samples within a reasonable tim

170 s towards high-throughput and ultrasensitive screening of miRNAs using labeling processes with focusi

171 neurodegeneration, we conducted a functional screening of mitochondria in neurons exposed to the CSF

172 We further demonstrated that rapid screening of mitochondria-specific therapeutic drugs to

173 Screening of ML417 against multiple G protein-coupled re

174 the sulfatide measurement in DBS for newborn screening of MLD.

175 d preparation of surface gradients and rapid screening of molecules in mixtures for a specific proper

176 framework offers a convenient route for fast screening of molecules prior to synthesis and testing.

177 system could only be discovered by empirical screening of molecules that either align or not within s

178 to multiplexed high-throughput platforms for screening of molecules that modulate the chemotaxis of d

179 Screening of more than 200 patients with autoimmune dise

180 Echocardiography is routinely used for screening of morphological malformations, but functional

181 for the expanded generation, enrichment, and screening of mouse hybridomas secreting mAb specific for

182 Simultaneous analysis/screening of multiple crucial system parameters during t

183 sequencing (NGS) technologies facilitate the screening of multiple genes linked to neurodegenerative

184 hips to be run in parallel, allowing for the screening of multiple therapeutic treatments (n = 690 to

185 hairy roots for rapid, reproducible efficacy screening of multiple therapies.

186 to evaluate different non-invasive tools for screening of NAFLD and fibrosis in obese patients.

187 APRI allows screening of NAFLD as well as fibrosis in obese patients

188 ed ex vivo stimulation of memory T cells and screening of naive and memory T cell libraries, combined

189 by thermal gel electrophoresis enabled rapid screening of native protein variants.

190 High-throughput screening of natural product extract and fraction librar

191 During an unbiased screening of natural product libraries, this novel compo

192 owever, applying protein-protein interaction screening of NCBP1, 2 and 3, we find that the interactio

193 This is a pioneer study on the in vitro screening of neuroactive properties of phlorotannin-targ

194 potential avenue for large-scale preclinical screening of neurocognitive decline as a new digital bio

195 and open-source OPERA application to enable screening of new chemicals with a defined applicability

196 control that can be applied to high-content screening of new more efficacious antiplatelet therapies

197 Concurrent hearing and genetic screening of newborns is expected to play important role

198 , these models can be utilized for efficient screening of novel antibiotics aiding in the discovery o

199 Screening of null mutants of 33 of those transcription f

200 able analytical tool for the high-throughput screening of nutrients and gut microbial components that

201 full-scan data sets for target and nontarget screening of OMPs in drinking and wastewater samples, re

202 etup shows limited ability to perform a true screening of oregano using the setup offered.

203 One of the most critical steps in nontarget screening of organic micropollutants (OMP) in complex en

204 nt work, we address the issue of nontargeted screening of organohalogenated chemicals in complex matr

205 In the derivation cohort, screening of OSA(>=5), OSA(>=15), and OSA(>=30) revealed

206 riminatory ability of GOAL questionnaire for screening of OSA(>=5), OSA(>=15), and OSA(>=30) was simi

207 In the validation cohort, screening of OSA(>=5), OSA(>=15), and OSA(>=30), corrobo

208 A screening of our in-house chemical library against polio

209 n 17 neurons in one human cortical slice and screening of over 600 connections in tissue from a singl

210 ed by a model that accounts for hydrodynamic screening of packed cilia and the chemomechanical energy

211 compelling argument for direct, quantitative screening of PAHs in soils by CP-MIMS-LEI/CI, particular

212 d C. auris real-time PCR assay for the rapid screening of patient and environmental surveillance samp

213 e case calculation shows that MR angiography screening of patients with ADPKD every 5 years and annua

214 se and glucosidase inhibition) were used for screening of peppermint bioactivity.

215 n A(b)-peptide library that enabled unbiased screening of peptides recognized by a bona fide murine T

216 e RTgill-W1 in vitro assay is useful for the screening of pH-dependent uptake of IOCs in fish, and ha

217 to conduct a high-throughput and systematic screening of PI5P-interacting proteins with PI5P-tagged

218 ce in plants, we performed a forward genetic screening of PIN2:PIN1-HA;pin2 Arabidopsis (Arabidopsis

219 the utility of LAESI-MS for high-throughput screening of plant phenotypes.

220 When implementing the bioassay for the screening of plasma, a pronounced receptor activation wa

221 existing screening strategy involves routine screening of PLD who indicate they are from HCV high-ris

222 The rapid screening of plutonium from aqueous sources remains a cr

223 Compared with no screening, combined screening of POAG and PACG in rural China is predicted t

224 nn et al. used high-throughput synthesis and screening of polyacrylamide-based excipients to yield a

225 uating hepatic IRI, and suggest a diagnostic screening of portal blood for reactivity to these PRRs m

226 es, abdominal US is needed for diagnosis and screening of portal hypertension.

227 foundation to design rational strategies for screening of potential analgesics.

228 ach is being adopted for high-throughput pre-screening of potential bushmeat samples in East African

229 Despite clinical and laboratory screening of potential donors for transmissible disease,

230 Universal screening of potential organ donors and recipients for s

231 se (HD) and for high throughput pre-clinical screening of potential therapeutic compounds.

232 seful diagnostic tool for rapid and reliable screening of potentially exposed individuals to aid earl

233 Multiplexed cell-based screening of promoters for three TetR-like aTFs generate

234 , yet accurate assays (e.g., high-throughput screening) of proteins.

235 Screening of publicly available metagenomes revealed tha

236 his encapsulation methodology simplifies the screening of reaction conditions and the preparation of

237 ers key advantages including high throughput screening of reaction conditions, better spatiotemporal

238 y electrodes in the system impedes efficient screening of reaction conditions.

239 Retrospective DNA and cardiac screening of relatives of 113 families from 143 index pa

240 Predictive genetic screening of relatives of patients with hypertrophic car

241 ficient evidence to recommend for or against screening of renal transplant recipients within 1 month,

242 ent rice samples and can also be applied for screening of rice for toxicity with respect to Cr.

243 time to perform comprehensive and systematic screening of RNA virome in medically important mites inc

244 Therefore, genetic screening of SCN9A, SCN10A and SCN11A should be consider

245 xinus excelsior), we undertook comprehensive screening of secoiridoid glycosides in leaf extracts of

246 Using high-throughput library screening of secreted peptides, we identify two fibrobla

247 e searched for new agents by high-throughput screening of selected targeted compounds and identified

248 ll miniaturized version of the assay for the screening of SHP2 inhibitors targeting either WT SHP2 or

249 tional analysis step enables high-throughput screening of shRNA or CRISPR-Cas9 constructs to identify

250 lication, the selector is used for automated screening of single-molecule Forster resonance energy tr

251 ensity functional theory, and by theoretical screening of six other molecules, here we show the intra

252 lly functional (ATP EC(50) 8.7 uM), and that screening of small (2 ul) volumes of a library of 80 ade

253 ne application of cryo-EM in high-throughput screening of small molecule modulators and structure-bas

254 hieved by a method that enables simultaneous screening of small sample amounts and detailed dissoluti

255 pective on the high-throughput synthesis and screening of small-molecule libraries.

256 ELISA screening of soluble VEGFR2 in the blood of LZTR1-mutate

257 ns has important implications on lipases for screening of stilbenoid.

258 develop a strategy termed PROSPECT (primary screening of strains to prioritize expanded chemistry an

259 Remote and unobtrusive screening of subtle FMI via natural smartphone usage, ma

260 y SSc patient lung cells for high-throughput screening of TGF-beta signaling via high-content imaging

261 erges as a promising tool to provide a rapid screening of the beverages authenticity and it may be us

262 he presence of mobile ions, enabled by ionic screening of the carbon electrode.

263 of these sensors is determined by the Debye screening of the charges from counter ions in solutions.

264 Screening of the compound library identified kenpaullone

265 a quantitative model involving the dynamical screening of the Coulomb interaction and show that an en

266 ns may occur in metals, despite the expected screening of the Coulomb interactions that often drive p

267 uld be discovered by structure-based virtual screening of the dark chemical matter.

268 tangled effects leads to partial or complete screening of the EEF, with the extent of screening being

269 n increase in carrier density resulting in a screening of the electron-electron interactions in the Q

270 Despite modest sensitivity, low-cost, repeat screening of the entire population could be cost-effecti

271 tor interactions increased the electrostatic screening of the exciton, in turn lowering its binding e

272 Toxicity screening of the extracts showed that bioactivity was no

273 Focused in vitro screening of the GSK Kinetobox library and structure-act

274 Large-scale combinatorial screening of the Human TFome will complement other strat

275 Our assay enables accurate and efficient screening of the ligand-binding profiles of individual a

276 aphene oxide (GO) was used as a platform for screening of the minimal-length aptamer sequence require

277 A recent in vitro screening of the Phoneutria nigriventer spider venom (Pn

278 In most cases, the many-body screening of the quasi-2DEGs dramatically reduces the Fr

279 Phenotypic screening of the resulting oxazonine collection identifi

280 ate in research studies that include genomic screening of their patients.

281 These animals may facilitate preclinical screening of therapeutic agents that counter against NAF

282 the same approach could be employed for the screening of therapeutic candidates to regulate specific

283 validation of the system for high-throughput screening of therapeutic compounds.

284 zation of serotonergic hallucinogens and the screening of these compounds in biofluids based on their

285 Screening of these siRNAs against their corresponding mR

286 med to develop a new analytical approach for screening of thiols in plants, using four vegetal exampl

287 Rapid and facile screening of this disease is in high demand.

288 erm monitoring program, we performed genetic screening of thousands of non-invasive samples collected

289 resolution mass spectrometers (UHRMS) allows screening of thousands of organic species in complex sam

290 Screening of titles and abstracts followed the MOOSE gui

291 Methods for rapid and high-throughput screening of transcription in vitro to examine reaction

292 Screening of tumor extracts with a hybrid combinatorial

293 This work describes the screening of twenty three per- and polyfluoroalkyl subst

294 sent work is the first study to focus on the screening of umami peptides from tempeh.

295 edictor variables, our results indicate that screening of unimpaired individuals for potential inclus

296 osensors attract attention as they allow the screening of vast libraries when used in combination wit

297 ected cancers (6.8 cancers detected per 1000 screenings), of which 26 (0.8% of screening-detected can

298 ce (FT-ICR)-MS approach was used for initial screening of wild-type and feronia (fer) mutant plant ex

299 t of this aim implies relatively large scale screening of women at an age of clinically significance

300 Screening of women in households continued until 20-30 e