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1 vels of deoxycholic acid, a pro-inflammatory secondary bile acid.
2 bundance, and a longer duration of decreased secondary bile acids.
3 infection (rCDI) may be mediated in part by secondary bile acids.
4 s of short-chain fatty acid biosynthesis and secondary bile acids.
5 nsistent with accumulation of TLCA and other secondary bile acids.
6 ficant shift in the abundance of primary and secondary bile acids.
7 potentially carcinogenic metabolites such as secondary bile acids.
8 echanism underlying the oncogenic effects of secondary bile acids.
9 nd changes in the composition of primary and secondary bile acids.
10 apable of 7a/B-dehydroxylation of primary to secondary bile acids.
11 ivity including the conversion of primary to secondary bile acids.
12 ely lower plasma concentrations of SCFAs and secondary bile acids.
13 ances microbial sensitivity to vitamin A and secondary bile acids.
14 in particular branched-chain fatty acids and secondary bile acids.
15 patic recirculation and an increase of toxic secondary bile acids.
17 lationship between polyp reduction and fecal secondary bile acids after feeding UDCA to these rats.
18 ng isolithocholic acid (isoLCA), a microbial secondary bile acid and RORgammat inverse agonist, we co
19 s with increases in short-chain fatty acids, secondary bile acids and bile salt hydrolase genes after
21 abolic profile (MMP) that accounts for fecal secondary bile acids and desaminotyrosine concentrations
23 ammatory short-chain fatty acids (SCFAs) and secondary bile acids and lower relative abundances of sp
24 focused on profiling 5 canonical primary and secondary bile acids and their glycine and taurine amino
25 olecules, including short-chain fatty acids, secondary bile acids and tryptophan metabolites, as pote
26 ected microbially modified molecules such as secondary bile acids and unexpected microbial molecules
27 ween sleep, alpha diversity, and pyrimidine, secondary bile acid, and neuroactive glucocorticoid/preg
28 rial 7 alpha-dehydroxylase and PI-PLC, fecal secondary bile acids, and colonic mucosal DAG kinase and
29 ort-chain fatty acids, converting primary to secondary bile acids, and facilitating colonization resi
30 regulatory nodes, including the microbiota, secondary bile acids, and humoral immunity to vaccinatio
31 ns of short- and branched-chain fatty acids, secondary bile acids, and tryptophan metabolites correla
32 accompanied by decreased free and conjugated secondary bile acids as well as changes in gut microbiot
34 that accumulation of primary conjugated and secondary bile acids (BAs) are metabolic features of hum
35 his concept, we focused on the generation of secondary bile acids by 7alpha-dehydroxylating bacteria
36 of dietary fat on colonic bacterial enzymes, secondary bile acids, colonic mucosal and tumor DAG kina
40 novel role for specific bile acids, and the secondary bile acid DCA in particular, in the regulation
42 enzyme also activates chenodeoxycholate, the secondary bile acids deoxycholate and lithocholate, and
43 idium scindens converts cholic acid into the secondary bile acid deoxycholic acid (DCA) very efficien
44 ed that the microbial metabolic byproduct of secondary bile acid deoxycholic acid (DCA), at as low as
45 junction with Clostridium spp. increased the secondary bile acid deoxycholic acid levels in the ileum
46 ium scindens, or its derived metabolite, the secondary bile acid deoxycholic acid, can restore pDC- a
47 Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocho
49 cale pharmacological database and identify a secondary bile acid, deoxycholic acid, as a potential th
52 Moreover, we inferred elevated production of secondary bile acids from CRC metagenomes, suggesting a
60 carcinogenesis may include the production of secondary bile acids in the colon and the modulation of
61 Subsequently, mice were treated with these secondary bile acids in vivo to assess their ability to
62 anisms that are capable of generating unique secondary bile acids, including various isoforms of lith
63 alyses with microbial-origin (phenyllactate, secondary bile acids, indoles), choline moieties, and po
64 t flora modify primary bile acids to produce secondary bile acids leading to a chemically diverse bil
68 hat VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA), which is hep
69 a and corresponding enzymes that convert the secondary bile acid lithocholic acid into 3-oxoLCA as we
70 and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty ac
71 biosis, in which lower circulating SCFAs and secondary bile acids may facilitate pulmonary vascular d
72 drate, amino acid, long chain fatty acid and secondary bile acid metabolism at 6 weeks with changes i
74 ed restoration of commensal bacteria-derived secondary bile acid metabolites in the large intestine.
75 mensal-derived indole derivatives as well as secondary bile acids modulate astrocyte function during
76 partially mediated by indole derivatives and secondary bile acids modulating the expression of mTOR p
80 dehydroxylase that is involved in generating secondary bile acids, phosphatidylinositol-specific phos
81 GPBAR1 is a G protein-coupled receptor for secondary bile acids placed at the interface between liv
82 We discovered that lithocholic acid (LCA), a secondary bile acid prevalent in the cecum and colon of
84 tory Escherichia and depletion of beneficial secondary bile-acid producing bacteria in the ileal muco
85 s) and Clostridium hylemonae (Ch) eliminates secondary bile acid production and reshapes the communit
87 rial and colonic mucosal enzymes and colonic secondary bile acids relevant to colon tumor promotion.
89 lower lithocholic acid (P = 0.01) and total secondary bile acid (SBA) concentrations (P = 0.04) than
92 ter and reduced plasma cholesterol and toxic secondary bile acids (SBAs), thus improving cholesterol
93 or) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by i
94 fed the HFCO diet excreted higher levels of secondary bile acids, such as deoxycholic acid and litho
95 luster also was predicted to exhibit reduced secondary bile acid synthesis and elevated aromatic amin
96 have significantly reduced capabilities for secondary bile acid synthesis but elevated capabilities
97 rmentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.
98 etagenome analyses revealed that pathways of secondary bile-acid synthesis and biotin metabolism were
99 r M-BAR) is a G protein-coupled receptor for secondary bile acids that is highly expressed in monocyt
100 lamine N-oxide, short-chain fatty acids, and secondary bile acids, that seem to participate in the de
101 erol is converted into dozens of primary and secondary bile acids through pathways subject to negativ
102 human livers were incubated with primary and secondary bile acids to determine their effects on LCFA
103 c attention paid to short-chain fatty acids, secondary bile acids, trimethylamine N-oxide, and phenyl
104 is (p = 0.018) and the concentrations of the secondary bile acid ursodeoxycholic acid (p = 0.033) and
107 Primary bile acids were similar, whereas secondary bile acids were absent, in GF mdr2(-/-) mice.
109 s of microbial diversity and microbe-derived secondary bile acids, which inhibit C. difficile germina
110 tories, with a 1,000-fold reduction in serum secondary bile acids, which was highly correlated with A