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1  ligand and the amino-terminal domain of the secretin receptor.
2 to complement this with other domains of the secretin receptor.
3 at the prototypic member of this family, the secretin receptor.
4 abeling a single protomer of the homodimeric secretin receptor.
5  calcitonin receptor with no activity at the secretin receptor.
6 the proposed third extracellular loop of the secretin receptor.
7  of four extracellular regions of the intact secretin receptor.
8 rther confirmed by mutagenesis of the intact secretin receptor.
9 ocumented, including the prototypic family B secretin receptor.
10 utive oligomers with themselves and with the secretin receptor.
11 a new molecular model of the ligand-occupied secretin receptor.
12  the glucagon-like peptide-1 receptor or the secretin receptor.
13  residues within secretin and the prototypic secretin receptor.
14 nd covalently labeled the Mr = 57,000-62,000 secretin receptor.
15 expressing wild-type and chimeric calcitonin-secretin receptors.
16 d sequencing of labeled wild-type and mutant secretin receptors.
17  been described for both cholecystokinin and secretin receptors.
18  to suppress hormone action at the wild-type secretin receptor (1).
19                                          The secretin receptor, a class II GPCR, is a GRK substrate,
20                 The endocytic pathway of the secretin receptor, a class II GPCR, is unknown.
21          Based primarily on studies with the secretin receptor, a prototype class B family member, th
22                                          The secretin receptor, a prototypic family B G protein-coupl
23 fuse pharmacophoric domain that binds to the secretin receptor, a prototypic member of the Class B fa
24                                        Since secretin receptors activate PKA, we tested the hypothesi
25 losest structurally related receptors to the secretin receptor also form constitutive oligomers with
26  beta-Intercalated cells express basolateral secretin receptors and apical CFTR and pendrin.
27 ibrosis transmembrane conductance regulator+/secretin receptor+) and activated phenotype (increased e
28 ibrosis transmembrane conductance regulator, secretin receptor, and nuclear receptors.
29 t the carboxyl terminus of VPAC1, VPAC2, and secretin receptors, and performed BRET and morphologic f
30                                              Secretin receptors are also expressed both in PC dendrit
31 ence complementation to demonstrate that the secretin receptor associates specifically with RAMP3, bu
32                    It covalently labeled the secretin receptor at a single site saturably and specifi
33 g a concentration-dependent cAMP response in secretin receptor-bearing cells.
34 s a potent stimulant of cAMP accumulation in secretin receptor-bearing Chinese hamster ovary-SecR cel
35           BRET studies showed that, like the secretin receptor, both VPAC receptors exhibited constit
36 de bonding pattern of the prototypic class B secretin receptor by applying the same paired cysteine m
37 ical sodium-dependent bile acid transporter, secretin receptor, cilia and cystic fibrosis transmembra
38  (CD44, CD24, EpCAM, aquaporin 5, claudin-4, secretin receptor, claudin-7, V-ros sarcoma virus oncoge
39          When these peptides probed 61 human secretin receptor cysteine-replacement mutants, a broad
40 on of PKCbetaII; and (iii) de novo expressed secretin receptor, cystic fibrosis transmembrane regulat
41                                              Secretin receptor-deficient mice are overtly normal and
42                                 Furthermore, secretin receptor-deficient mice show abnormal social an
43                            We have generated secretin receptor-deficient mice to explore the relation
44   Although GRK activity appears important in secretin receptor desensitization in HEK 293 cells, prot
45 ing this epitope act as full agonists on the secretin receptor despite their lack of amino acid homol
46  on adrenomedullin activity, with increasing secretin receptor expression competing for RAMP3 associa
47                                   Similarly, secretin receptor expression had functional effects on a
48 ation and differentiation (mucus production, secretin receptor expression, and primary cilia), reduce
49                                    Mth, like secretin receptor family members, has a large N-terminal
50 t mechanisms of desensitization exist in the secretin receptor family that should help protect recept
51 mologous to lectin, olfactomedin, mucin, the secretin receptor family, and a novel structural motif c
52  G-protein-coupled receptor, a member of the secretin receptor family.
53 elated to G protein-coupled receptors of the secretin receptor family.
54                                       As the secretin receptor forms constitutive homodimers, we expl
55  to demonstrate that the prototypic family B secretin receptor forms ligand-independent oligomeric co
56 chemical sequencing of photoaffinity-labeled secretin receptor fragments established that Val4 was th
57                            The expression of secretin receptor gene and secretin-induced cAMP levels
58 al secretion was estimated by measurement of secretin receptor gene expression and adenosine 3',5'-cy
59 merization of the Class II G protein-coupled secretin receptor has been reported, but the molecular b
60                    It covalently labeled the secretin receptor in a saturable and specific manner.
61                  Overexpression of wild-type secretin receptor in Panc-1 cells driven by transfection
62 entified a novel abnormal spliceoform of the secretin receptor in pancreatic and bile duct cancers an
63 sence and function of molecular forms of the secretin receptor in pancreatic cancer cell lines and in
64 oratory suggest expression of a low affinity secretin receptor in seven cell lines derived from human
65 the epidermal growth factor receptor and the secretin receptor in the presence and absence of their a
66            This represented a variant of the secretin receptor in which the third exon was spliced ou
67 receptors were observed for similarly tagged secretin receptors in which all or part of the amino-ter
68                      Thus, like the AT(1A)R, secretin receptor internalization is not inhibited by re
69 cence imaging, and compare the properties of secretin receptor internalization to that of the beta(2)
70 lasma membrane localized receptors; however, secretin receptor internalization was not reduced by exp
71                                          The secretin receptor is a member of a structurally distinct
72 onstrate that the agonist occupied wild-type secretin receptor is predominantly in a guanine nucleoti
73                                          The secretin receptor is prototypic of a recently described
74                                          The secretin receptor is prototypic of a recently described
75                                          The secretin receptor is prototypic of the class II family o
76 on-PCR and sequencing demonstrated wild-type secretin receptor mRNA in each of four cell lines and th
77 ogical FRET was utilized to demonstrate that secretin receptor oligomerization occurred at the cell s
78                             We conclude that secretin receptor oligomerization occurs through -GxxxG-
79 's membrane-spanning core is responsible for secretin receptor oligomerization.
80                                       Unlike secretin receptor oligomers that were unaffected by liga
81             We demonstrate agonist-dependent secretin receptor phosphorylation coincident with profou
82  with a model of secretin occupying a single secretin receptor protomer within the homodimeric recept
83 g cholecystokinin and acetylcholine, whereas secretin receptors regulate duct cells.
84 functionally important amino terminus of the secretin receptor represents a structurally independent,
85 hly aggressive malignancies that evolve from secretin receptor-rich ductular cells.
86                    It covalently labeled the secretin receptor saturably in a single site.
87                           The secretin (SCT)/secretin receptor (SCTR) axis promotes biliary senescenc
88 cholestatic age-matched controls at PE, only secretin receptor (SCTR) expression predicted cumulative
89 els increase during acute alkalosis, and the secretin receptor (SCTR) is functionally expressed in be
90                                          The secretin receptor (SCTR) is functionally expressed in th
91                                       In the secretin receptor (SecR) structure, interactions are obs
92 ells and membranes expressing the prototypic secretin receptor (SecR) to gain insights into secretin
93                  The molecular mechanisms of secretin receptor signal termination are unknown.
94 phorylation appeared to be less important in secretin receptor signal termination.
95                                     Secretin/secretin receptor signaling mediates biliary damage and
96  cysteine residues within this region of the secretin receptor singly and in pairs resulted in loss o
97 nist (EC(50) = 72 +/- 6 pm) and bound to the secretin receptor specifically and with high affinity (K
98  in cancer, we evaluated whether an abnormal secretin receptor spliceoform were present, characterize
99 mulates ductal secretion by interacting with secretin receptor (SR) activating cyclic adenosine 3',5'
100                                 The secretin/secretin receptor (SR) axis is up-regulated by prolifera
101             Activation of the secretin (Sct)/secretin receptor (SR) axis, expressed only by cholangio
102 way and is closely associated with increased secretin receptor (SR) expression.
103 tal secretion was assessed by measurement of secretin receptor (SR) gene expression and secretin-indu
104 al cholangiocytes, increasing DNA synthesis, secretin receptor (SR) gene expression, and adenosine 3'
105  measurement of secretin-induced choleresis, secretin receptor (SR) gene expression, and cyclic adeno
106 eptide hormone, secretin (SCT) that binds to secretin receptor (SR), is a key mediator in cholangiocy
107                           Secretin (SCT) and secretin receptor (SR, only expressed on cholangiocytes
108  (1) secrete bicarbonate by interaction with secretin receptors (SRs) through activation of cystic fi
109              These findings suggest that the secretin receptor system has an important role in the ce
110 a new radioiodinatable agonist ligand of the secretin receptor that incorporates a photolabile p-benz
111                                              Secretin receptors that are key for regulation of health
112 eloped a new probe for affinity labeling the secretin receptor through a photolabile benzoyl-phenylal
113  a single amino acid in the second TM of the secretin receptor to the corresponding residue in the PT
114  This study demonstrates that the ability of secretin receptor to undergo GRK phosphorylation and bet
115 of exogenous RAMP transfection, although the secretin receptor trafficks normally to the cell surface
116 This was attached to a homology model of the secretin receptor transmembrane bundle, with the two dom
117  carboxyl-terminal (COOH-terminal) truncated secretin receptor using flow cytometry and fluorescence
118 progressive cleavage of wild type and mutant secretin receptors (V13M and V16M) and sequence analysis
119 ssplicing is responsible for expression of a secretin receptor variant having the ability to suppress
120 r specimens and no normal tissue expressed a secretin receptor variant with exons 3 and 4 deleted.
121 gy model of the amino-terminal domain of the secretin receptor was developed using the NMR structure
122 tor-bearing Chinese hamster ovary cells, the secretin receptor was shown to have growth-inhibitory ef
123 n of a functional, N-terminal epitope-tagged secretin receptor was used to demonstrate agonist-depend
124 th the wild-type and COOH-terminal truncated secretin receptors was unaffected by GRK phosphorylation
125 tly transfected HEK 293 cells expressing the secretin receptor, we investigated its mechanisms of des
126 e first 10 residues of the N terminus of the secretin receptor were critical.
127  specific high-affinity dimeric state of the secretin receptor, which may be typical of family B G pr
128 ct cells expressing wild-type or C11A mutant secretin receptor with a cell-impermeant sulfhydryl-reac
129         This probe specifically bound to the secretin receptor with high affinity (IC50 = 13.2 +/- 2.
130                     However, coexpression of secretin receptors with either type of VPAC receptor res
131 ide cleaved a series of wild type and mutant secretin receptors, yielding patterns that agreed with o

 
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