ライフサイエンスコーパス: secretor

1 ting and therefore filamented bacteria (high secretors).

2 y (P < .001 for each variable, compared with secretors).

3 ve secretors, and 1 of 1 Lewis-negative weak secretor.

4 competent cytotoxic effectors and IFN-gamma secretors.

5 frequencies of cross-reactive IL-4 and IL-2 secretors.

6 ic E. coli isolates compared with cells from secretors.

7 f SpA patients where they act as major IL-17 secretors.

8 l P[8]/P[4] rotavirus infected children were secretors.

9 R that prepares cells to become professional secretors.

10 ed with growth and development, mostly among secretors.

11 pectrum to saliva samples of all A, B, and O secretors.

12 GII.4 norovirus exclusively infected secretors.

13 effector programs, but remained stable IL-17 secretors.

14 Of the 23 secretors, 16 (70%) were infected with norovirus, 13 (57

15 es were higher among infants of maternal non-secretors (39% vs 23%, P=0.001).

16 ative group); and in 25 of 28 Lewis-positive secretors (89%), 12 of 12 Lewis-positive nonsecretors (1

17 ildren of European or African ancestry to be secretors (96% vs 74%; P < .001).

18 The presence of histo-blood group antigens (secretor, ABO, and Lewis type) was determined in saliva.

19 ariations in maternal HMO profile, including secretor and Lewis phenotype, did not predict FIA.

20 The association between secretor and Lewis phenotypes and rotavirus vaccine fail

21 ainly because of the direct influence of the Secretor and Lewis phenotypes on HMOs biosynthesis.

22 out lactation and among women with different Secretor and Lewis phenotypes.

23 erences were observed for child UFE based on secretor and Lewis status of the mothers (p = 0.04).

24 We conducted a case-control study where secretor and Lewis status were ascertained from saliva s

25 Secretor and Lewis, but not A or B antigens, were presen

26 ocirculation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.

27 Forty healthy adults (23 secretors and 17 nonsecretors of HBGAs) were challenged

28 ells are capable of acting as both IFN-gamma secretors and cytotoxic T lymphocyte (CTL) effectors; ho

29 e (LNFP) I, and difucosyllacto-N-tetraose in secretors and lacto-N-tetraose and LNFP II in nonsecreto

30 ive status, including those with A, B, and O secretors and Lewis positive blood types, were sensitive

31 robability of death after bacteremia between secretors and nonsecretors (p = .02).

32 Secretors and nonsecretors were defined by the presence

33 HMO concentrations from women classified as secretors and nonsecretors, a phenotype that can be iden

34 , were sensitive to the virus, while the non-secretors and the Lewis negative individual were not.

35 elationship between maternal and child FUT2 (Secretor) and FUT3 (Lewis) status with growth, body comp

36 fferent histo-blood types, defined by Lewis, secretor, and ABO types.

37 he GI.7 strain bound to H- and A-type, Lewis secretor, and Lewis nonsecretor families of HBGAs, allow

38 arious types 1 and 2 HBGAs, including Lewis, secretor, and nonsecretor antigens, distributing on the

39 e nonsecretors (100%), 2 of 2 Lewis-negative secretors, and 1 of 1 Lewis-negative weak secretor.

40 ree patterns (VA387, NV, and MOH) recognized secretors, and 1 pattern (VA207) recognized Lewis-positi

41 (a+ b-) (nonsecretor) rather than Le(a- b+) (secretor) blood type.

42 Here, we combine producer/secretor cell libraries with whole-cell biosensors using

43 Secretor children were infected as early as 2 months of

44 thermore, all GII.4 AGE episodes occurred in secretor children.

45 Secretors comprised all 155 cases and 21 asymptomatic in

46 -Q elicited IL-4 and IL-2, but not IFN-gamma secretors cross-reactive with PLP-139-151.

47 s that do not secrete IL-9, as purified IL-9 secretors demonstrate the same loss of IL-9 in subsequen

48 mained elevated through day 180, and was not secretor dependent.

49 ions is determined by genetically controlled secretor-dependent expression of histo-blood group antig

50 re potent and biologically relevant cytokine secretors during stress-mediated hematopoiesis.

51 This "social insulation" protects secretors from competition with nonsecretors of the same

52 Children of secretor (FUT2 positive) mothers had a 38% increased adj

53 uals with a functional FUT2 gene are termed "secretors." FUT2 polymorphisms may influence viral bindi

54 ave been shown to interact specifically with secretor gene-dependent GSLs embedded in lipid membranes

55 viduals have a functional copy of the FUT2 ("secretor") gene required for gut HBGA expression; these

56 ABO non-secretor genotypes for two ancestry-specific FUT2 SNPs s

57 x individuals with different ABO, Lewis, and secretor genotypes.

58 sion to estimate magnitude of the population secretor-GII.4 proportion association.

59 who expressed a functional FUT2 enzyme (the secretor group), 13 of 13 (100%) who were FUT2 null (the

60 Secretors had higher amounts of total oligosaccharides t

61 (n=843) expressing the combined MBL2 5' LYQA secretor haplotype (CGTCGG) and 3' haplotype (CGGGT) was

62 Inclusion of the combined MBL2 LYQA secretor haplotype improved prediction models for PMI ba

63 The combined MBL2 LYQA secretor haplotype in whites was also an independent pre

64 The combined MBL2 LYQA secretor haplotype is a novel independent predictor of P

65 Moreover, the combined MBL2 LYQA secretor haplotype was an independent predictor of PMI i

66 ntraoperative variables to determine if MBL2 secretor haplotypes are independent predictors of PMI in

67 We found that 5' secretor haplotypes known to correlate with moderate and

68 Within the MBL2 gene are seven 5' "secretor" haplotypes that code for altered serum MBL lev

69 nctional fucosyltransferase-2 gene, known as secretors, have increased susceptibility to GII.4 norovi

70 P genotypes of human RVs interacts with the secretor histo-blood group antigens (HBGAs).

71 children with gastroenteritis associate with secretor histo-blood group phenotype.

72 exchanger 2 (AE2), the principal bicarbonate secretor in the human biliary tree, is down-regulated in

73 certain Mm non-producing mutants to act as 'secretors' in cosynthesis with other 'convertor' mutants

74 f 1 with reduced FUT2 activity (i.e., a weak secretor); in 37 of 40 individuals (93%) who expressed a

75 enhanced functionality (i.e., multicytokine secretors, including IL-2; enhanced CD137 and CD107a exp

76 ]/P[4] rotaviruses bound saliva samples from secretor individuals.

77 sceptibility to rotavirus diarrhea, with non-secretors less susceptible to symptomatic infection.

78 ain structure of a 2004 variant with ABH and secretor Lewis HBGAs and compared it with the previously

79 hat all P[8]-infected children (n = 22) were secretor Lewis positive.

80 also in age and sex adjusted model among non-secretor mothers (aOR = 2.86, 90% CI 1.07, 7.62).

81 Of the infants with SAM, 14 (53.85%) had secretor mothers, and 11 (57.89%) of the non-malnourishe

82 (57.89%) of the non-malnourished infants had secretor mothers.

83 during the first 5 y of life in children of secretor mothers.

84 frequency of subtotal villous atrophy among secretor negative and Lewis positive children (p = 0.09

85 d to be nonsusceptible on the basis of being secretor negative.

86 10 of 12 secretor-positive (83%) and 4 of 8 secretor-negative (50%) becoming ill.

87 rates of non-GII.4 infections were found in secretor-negative children (relative risk, 0.56; P = .02

88 on-GII.4 infections were more often found in secretor-negative children.

89 r healthy adults (36 secretor-positive and 8 secretor-negative for histo-blood group antigens) were c

90 tion, cases of NoV infection associated with secretor-negative individuals are reported.

91 were observed in both secretor-positive and secretor-negative subjects in this challenge study.

92 Neither Secretor nor Lewis status distinguished between transmit

93 tzii A2-165 and Clostridium hathewayi, a low secretor of IL-10, on the Th1-driven inflammatory respon

94 thcare-acquired infections and is a prolific secretor of proteins, including three chitinases (ChiA,

95 ells (pDCs) have been identified as a potent secretor of the type I interferons (IFNs) in response to

96 y in a cell line (UM-SCC-1) which is an avid secretor of this collagenase.

97 only as a permeability barrier but also as a secretor of urinary proteins that can play physiological

98 only 2 (5%) of 44 consistent or intermittent secretors of acid had ratios in this range (P<.001).

99 ing tumour was a prolactinoma; three ectopic secretors of ACTH (two bronchial and one thymic carcinoi

100 resenting cells for T cell activation and as secretors of antigen-specific antibodies.

101 rms, including Fasciola hepatica, are active secretors of extracellular vesicles (EVs), but research

102 0 aa not linked to a signal peptide are poor secretors of IL-16 and show little if any resistance to

103 Filamentous fungi are native secretors of lignocellulolytic enzymes and are used as p

104 potential roles in multiple sclerosis (MS): secretors of proinflammatory cytokines and chemokines, p

105 tional CD4(+) effector T cells identified as secretors of prototypical cytokines IFNgamma, IL4, IL9,

106 transplant recipients studied who were high secretors of S-HLA-I postoperatively carried HLA-A24 or

107 n subjects with HLA-A23 or HLA-A24 were high secretors of S-HLA-I.

108 -SCC-1 and MDA-TU-138) characterized as avid secretors of the plasminogen activator.

109 Among secretors only [fucosyltransferase 2 gene (FUT2) positiv

110 Among secretors only [fucosyltransferase 2 gene (FUT2) positiv

111 whereas strain MOH binds to HBGAs of A and B secretors only.

112 Because the liver is the main TTR protein secretor organ, it has been the main target of treatment

113 ikely than norovirus-negative controls to be secretors (P < .001) in a logistic regression model adju

114 The relationship between ABO-Le secretor phenotype and susceptibility to recurrent idiop

115 This allele determines the secretor phenotype in which blood group antigens are fou

116 ltransferase gene (FUT2) responsible for the secretor phenotype is required for susceptibility to Nor

117 Overall, the frequency of the secretor phenotype was 93%.

118 In 147 of 164 participants, Lewis and secretor phenotype were determined.

119 sk by HMO concentrations, maternal and child secretor phenotype, and with censoring of weaned childre

120 um P[8]/P[4]-specific IgG and host Lewis and secretor phenotypes has been found among 206 studied ser

121 Histo-blood group antigen (HBGA) Lewis/secretor phenotypes predict genotype-specific susceptibi

122 Fecal Reg1B was elevated in secretor positive children compared to their counterpart

123 atic patients showed that individuals with a secretor positive status, including those with A, B, and

124 and illness in 70% of subjects with 10 of 12 secretor-positive (83%) and 4 of 8 secretor-negative (50

125 Forty-four healthy adults (36 secretor-positive and 8 secretor-negative for histo-bloo

126 infection and illness were observed in both secretor-positive and secretor-negative subjects in this

127 ximately 1320 genomic equivalents [gEq]) for secretor-positive blood group O or A persons and 7.0 (ap

128 RV strains (n = 27) infected only Lewis- and secretor-positive children (27/27; P < .0001), but no Le

129 II, genotype 4 (GII.4) infections were among secretor-positive children (P < .001), but higher rates

130 GII.4 infections were uniquely detected in secretor-positive children, while non-GII.4 infections w

131 norovirus strains infected various types of secretor-positive individuals (types A, B, and O).

132 Among 18 infected secretor-positive individuals, blocking titers peaked by

133 targeting of new variants to Lewis-positive, secretor-positive individuals.

134 Only secretor-positive participants maintained high avidity b

135 ons and 7.0 (approximately 2800 gEq) for all secretor-positive persons.

136 Although secretor-positive status is strongly correlated with NoV

137 Secretor prevalence was 75% (89 of 118) in infants who s

138 Country secretor proportion ranged from 43.8% to 93.9%.

139 ortion for each percentage increase in human secretor proportion, controlling for Human Development I

140 The 3 secretor-recognizing patterns were defined as A/B (MOH),

141 Infection occurred in secretors regardless of ABO blood group.

142 ls and increased ratios of IFN-gamma to IL-4 secretors responsive to PLP-139-151.

143 Fifty-four women were secretors (Se+), and 6 were nonsecretors (Se-).

144 EC and determined that nonsecretors (but not secretors) selectively express two extended globoseries

145 ferentiation (BCL11A) and blood-type antigen secretor status (FUT2).

146 e take was not significantly associated with secretor status (relative risk, 1.00 [95% CI, .94-1.06];

147 = 2.00, 90% CI 1.30, 3.06), in age, sex, and secretor status adjusted model (aOR = 1.96, 90% CI 1.29,

148 lyses assessed the preventive association of secretor status against severe rotavirus gastroenteritis

149 Salivary DNA was collected to determine secretor status and genetic ancestry.

150 le to replicate in HIEs independent of their secretor status and histo-blood group antigen expression

151 d whether an association exists between FUT2 secretor status and laboratory-confirmed rotavirus infec

152 Secretor status controls mucosal histoblood group antige

153 Secretor status determined the susceptibility to norovir

154 A genetic polymorphism affecting FUT2 secretor status in approximately one-quarter of humans o

155 Secretor status in children strongly influences the inci

156 A24 or HLA-A29 resulted in the observed high secretor status in liver transplant recipients after tra

157 erged this with data on proportions of human secretor status in various countries from a separate sys

158 Secretor status in women (based on HMO profile) was not

159 Secretor status influences susceptibility to enteric vir

160 The role of breast milk secretor status on oral live-attenuated rotavirus vaccin

161 pistatic effects of ABO blood group and FUT2 secretor status on proteins with gastrointestinal tissue

162 These results show the importance of secretor status on rotavirus risk, even in vaccinated ch

163 Maternal secretor status should be considered when interpreting o

164 Only secretor status was associated with seroconversion: 41%

165 , prevaccination IgG and maternal and infant secretor status were associated with rotavirus vaccine r

166 Prevaccination IgG and secretor status were significantly associated with seroc

167 tibility to some noroviruses depends on FUT2 secretor status, but the population impact of this assoc

168 cosyltransferase that determines blood group secretor status.

169 infection was not dependent upon blood group secretor status.

170 de polymorphisms analyzed to infer Lewis and secretor status.

171 rom saliva samples regardless of the donor's secretor status.

172 were marginally influenced by their mother's secretor status.

173 ther according to their lactation period and secretor status.

174 specimens were tested for rotavirus and for secretor status.

175 sociation of infection and disease with FUT2 secretor status.

176 wis-positive children, irrespective of their secretor status.

177 d find mother's fucosyltransferase-dependent secretor-status indirectly impact the sialylation.

178 Secretor statuses were found to correlate with the risk

179 nvironment, however, our model predicts that secretor strains of any one species will be surrounded b

180 Two hundred nineteen genotype and 112 secretor studies with data from 38 countries were includ

181 expression; these individuals are known as "secretors." Susceptibility to some noroviruses depends o

182 child-years, and was significantly higher in secretor than nonsecretor children (9.8 vs 3.5/100 child

183 igh proportion of nonsecreting bacteria (low secretors) than from populations with a high proportion

184 CA11 gene appears to be located between the secretor type alpha(1,2)-fucosyltransferase gene cluster

185 or substrate specificity resembles the human Secretor-type alpha1,2- FTase.

186 with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (9

187 We found that secretors were 9.9 times (95% confidence interval [CI],

188 Secretors were also 26.6 times more susceptible to infec

189 IgA secretors were prominent in the early AFC response to in

190 Strain VA387 binds to HBGAs of A, B, and O secretors, whereas strain MOH binds to HBGAs of A and B

191 Twenty percent of Caucasians are 'non-secretors' who do not express ABO antigens in saliva as

192 s Pseudomonas aeruginosa, a prolific protein secretor with the potential to produce seven different s

193 d by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (

194 od group O, and the highest rate (51%) among secretors with O blood group.

195 metabolome between Finnish mothers (n = 120, secretors) with symptoms of prenatal symptoms of psychol

196 higher in samples from HW than from MW among Secretor women.