ライフサイエンスコーパス: segment polarity

1 pointing lateral lobes, indicating body and segment polarity.

2 and nerves is perturbed, indicating loss of segment polarity.

3 opus development and establishing Drosophila segment polarity.

4 s (fss), because its paraxial mesoderm lacks segment polarity.

5 ream of Hh signaling in the establishment of segment polarity.

6 The mutants also display evidence of segment polarity.

7 that oro functions in determining embryonic segment polarity.

8 ecursor has a distinct identity conferred by segment polarity and dorso-ventral patterning genes that

9 protein, Cubitus interuptus (Ci), regulates segment polarity and wing and leg development.

10 tantly related insects, including pair-rule, segment polarity, and neural patterns.

11 nkd loss of function results in segment polarity defects and embryonic death, but how nk

12 ophila Chibby by RNA interference results in segment polarity defects that mimick a wingless gain-of-

13 the Xenopus gastrula organizer region and a segment-polarity determinant in Drosophila.

14 recently published Boolean network model of segment polarity development in Drosophila melanogaster.

15 red flour beetle (Tribolium castaneum), the segment-polarity function of wg is conserved [1].

16 The Drosophila segment polarity gene cubitus interruptus (ci) encodes a

17 The segment polarity gene cubitus interruptus (ci) maps to t

18 Hh signaling is thought to involve the segment polarity gene cubitus interruptus (ci).

19 (Dvl2) gene is an ortholog of the Drosophila segment polarity gene Dishevelled, a member of the highl

20 ne of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene

21 The expression domains of the segment polarity gene engrailed (en) allow one to subdiv

22 characterizing the expression pattern of the segment polarity gene engrailed (en) in a basal annelid,

23 es En-1 and En-2, homologs of the Drosophila segment polarity gene engrailed, in regulating the devel

24 One example is the expression of the segment polarity gene engrailed, which at embryonic and

25 To determine whether segment polarity gene expression is established differen

26 These results show that segment polarity gene expression is necessary for the su

27 and stripe-specific defects in pair-rule and segment polarity gene expression.fish mutant embryos als

28 Previous studies of segment polarity gene function largely focused on neurob

29 en the embryos, a hierarchy of gap/pair-rule/segment polarity gene function may be a shared and ances

30 growth factors); Wnt 7a and Shh (Drosophila segment polarity gene homologs); Msx-1 and Msx-2 (Msx cl

31 The segment polarity gene homologues have a conserved role i

32 a hierarchy of maternal, gap, pair-rule, and segment polarity gene interactions regulates virtually s

33 ch head segment exhibits a unique network of segment polarity gene interactions.

34 n somite is repressed in mice mutant for the segment polarity gene Mesp2 and expanded in Splotch muta

35 Here we show that the segment polarity gene midline is required for neuroblast

36 The Drosophila segment polarity gene naked cuticle (nkd) encodes an EF

37 Drosophila melanogaster, was identified as a segment polarity gene necessary for the transduction of

38 portant insights into the functioning of the segment polarity gene network, such as the crucial role

39 Here we describe a new segment polarity gene of Drosophila melanogaster, oroshi

40 esent genetic evidence showing that lines, a segment polarity gene of Drosophila, is required for the

41 tions of the human homolog of the drosophila segment polarity gene patched (ptc).

42 the human homologue (PTCH) of the Drosophila segment polarity gene patched have been identified in NB

43 of the mammalian homologue of the Drosophila segment polarity gene patched, is a receptor for hedgeho

44 y of protein kinase A and the product of the segment polarity gene patched.

45 e proteins closely related to the Drosophila segment polarity gene product armadillo.

46 Drosophila patched is a segment polarity gene required for the correct patternin

47 We have expressed the segment polarity gene wingless (wg) ectopically in imagi

48 The Drosophila segment polarity gene wingless (wg) is essential for cel

49 Dvl genes are homologs of the Drosophila dsh segment polarity gene, and are involved in the Wnt/wingl

50 others have recently characterized a second segment polarity gene, dTCF or pan, 12 kb upstream of ci

51 lving mammalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, son

52 luding the human homologue of the Drosophila segment polarity gene, patched (PTCH), the adenomatous p

53 otein with strong homology to the Drosophila segment polarity gene, patched.

54 arity to the hereditary basal cell carcinoma/segment polarity gene, patched.

55 we have identified rasp, a novel Drosophila segment polarity gene.

56 The segment-polarity gene Engrailed and the homeotic genes U

57 tern resembles the expression stripes of the segment-polarity gene engrailed, which has a key role in

58 rect role in repressing transcription of the segment-polarity gene engrailed.

59 h), a vertebrate homologue of the Drosophila segment-polarity gene hedgehog, has been reported to pla

60 imary pair-rule transcription factor Runt in segment-polarity gene regulation.

61 Here we show that the segment-polarity gene smoothened is required for the res

62 show that naked cuticle (nkd), a Drosophila segment-polarity gene, encodes an inducible antagonist f

63 We also provide evidence that the segment-polarity gene, gooseberry (gsb), controls expres

64 We report that primary segment polarity genes (engrailed, hedgehog and wingless

65 Along the anterior-posterior axis, several segment polarity genes (wingless, engrailed, hedgehog, a

66 parallel: a cell fate programme mediated by segment polarity genes and a boundary/epithelial integri

67 omologues may not control segmentation, some segment polarity genes and their interactions are conser

68 These segment polarity genes are expressed in some, but not al

69 In the trunk of the Drosophila embryo, the segment polarity genes are initially activated by the pa

70 To understand how these segment polarity genes are regulated, we examined the re

71 ng computer simulations, that the Drosophila segment polarity genes constitute such a module, and tha

72 ectly control the periodic expression of the segment polarity genes engrailed (en) and wingless (wg)

73 tory effects of otd on the expression of the segment polarity genes engrailed (en) and wingless (wg).

74 l expression of orthologues of the arthropod segment polarity genes engrailed (en), hedgehog (hh), an

75 e mutants fail to maintain expression of the segment polarity genes engrailed (en), wingless (wg), an

76 Segment polarity genes have a dual function in early neu

77 roduction of secreted signals encoded by the segment polarity genes hedgehog (hh) and wingless (wg) a

78 We show that the segment polarity genes hedgehog and wingless specify the

79 of the Drosophila melanogaster pair rule and segment polarity genes in a range of arthropods.

80 secondary pair-rule genes directly regulate segment polarity genes in Drosophila, we analyzed Tc-prd

81 Expression of the Drosophila segment polarity genes is initiated by a pre-pattern of

82 Hence, the segment polarity genes midline and H15 play an important

83 rovided by its genetic interactions with the segment polarity genes patched (ptc) and fused (fu).

84 While the expression patterns of segment polarity genes such as engrailed have been shown

85 segments and segments, via the regulation of segment polarity genes such as gooseberry, which in turn

86 The expression patterns of the segment polarity genes wingless and engrailed are conser

87 s required for the correct expression of the segment polarity genes wingless, engrailed and gooseberr

88 ir-rule gene products subsequently 'imprint' segment polarity genes with reiterated patterns, thus de

89 the expression of the gap, segmentation and segment polarity genes, as well as changes in early morp

90 e epidermal pattern in each segment, several segment polarity genes, including gooseberry (gsb), spec

91 our methods to the regulatory network of the segment polarity genes, thus gaining novel insights into

92 subsequent action of the gap, pair-rule, and segment polarity genes.

93 d gap genes into the segmental expression of segment polarity genes.

94 ised of maternal effect, gap, pair-rule, and segment polarity genes.

95 x-3, is key to the coordinated regulation of segment-polarity genes during embryogenesis.

96 dulates the Runt-dependent regulation of the segment-polarity genes wingless (wg) and engrailed (en).

97 In Drosophila, hedgehog is one of the segment-polarity genes, mutations of which disrupt the p

98 lishing stripes of expression of several key segment-polarity genes, one stripe for each parasegment,

99 nvey positional information to pair-rule and segment-polarity genes, the latter forming a segmental p

100 segments has not been defined for any of the segment-polarity genes.

101 rotein and is known to regulate genes of the segment polarity, homeotic, and pair-rule classes.

102 presentatives of coordinate, gap, pair-rule, segment polarity, homeotic, and Polycomb group functions

103 the leech primary blast cell clones acquire segment polarity - i.e. a fixed sequence of positional v

104 results demonstrate the molecular basis for segment polarity in a non-bilaterian animal, suggesting

105 ventral axis in Xenopus and determination of segment polarity in Drosophila.

106 s study by showing that the establishment of segment polarity in the leech ectoderm is largely indepe

107 gs gave rise to a model for the formation of segment polarity in the zebrafish in which caudal is the

108 To better understand the generation of segment polarity in vertebrates, we have studied the zeb

109 These new data suggest that segment polarity is created in a three-step process in w

110 n addition to its roles at the pair-rule and segment polarity levels of the hierarchy.

111 at these genes function at the pair-rule and segment polarity levels to establish the spacing and pol

112 even pair-rule stripes, but later exhibits a segment polarity-like pattern for which no phenotypic co

113 ular mechanisms underlying somite formation, segment polarity, maintenance of segment borders, and th

114 Previous studies have suggested that segment polarity mutant phenotypes are partially the res

115 We showed previously that a model of the segment polarity network in Drosophila is robust to para

116 three models of biochemical regulation: the segment polarity network in Drosophila melanogaster, the

117 Nevertheless, precisely how and when segment polarity pathways arose remains obscure.

118 nd directly regulate different components of segment polarity pathways in parallel.

119 omparable to the highly conserved ectodermal segment polarity pattern observed in arthropods at any l

120 We do not observe a segment polarity pattern of expression of Ch-en in the e

121 expression, and how this is converted into a segment-polarity pattern by 'timing factor' wavefronts a

122 encing of dally-like, but not dally, gives a segment polarity phenotype identical to that of null mut

123 We propose that the nkd segment polarity phenotype results from unregulated post

124 es of this gene, mutant embryos develop with segment polarity phenotypes reminiscent to loss of eithe

125 y late morphogenetic role for this and other segment polarity proteins, mainly oriented at lobule jun

126 led expression play an important role in the segment polarity specification of the Drosophila embryo,

127 owever, while we observe nmr1 transcripts in segment polarity stripes and specific neural precursors

128 otein are expressed in identical patterns of segment polarity stripes, defined sets of neuroblasts, m

129 omplications for dissecting the pair-rule to segment-polarity transition are the regulatory interacti

130 the combinatorial logic of the pair-rule to segment-polarity transition.