ライフサイエンスコーパス: selective advantage

1 e to hypoxia, with these events conferring a selective advantage.

2 viruses that acquire these mutations have a selective advantage.

3 lls with more robust SMAD5 expression have a selective advantage.

4 er periods of starvation, providing a strong selective advantage.

5 when retaining memory of the past provides a selective advantage.

6 CTL recognition, providing the virus with a selective advantage.

7 energy as fat between famines would be at a selective advantage.

8 y arise early during tumorigenesis or confer selective advantage.

9 ul conditions specific aneuploidies confer a selective advantage.

10 reduction in bicarbonate demand may confer a selective advantage.

11 ean populations, suggesting that they confer selective advantage.

12 ispensable residue that appears to confer no selective advantage.

13 aptation is due to new mutations of definite selective advantage.

14 y, a limited number of mutations that confer selective advantage.

15 or other properties of this motif, provide a selective advantage.

16 hancers in CRC tumor epigenomes to provide a selective advantage.

17 ility, whereby the PNH clone does not have a selective advantage.

18 iolent intrasexual competition giving them a selective advantage.

19 nments where biofilm formation may provide a selective advantage.

20 f the substrate that previously conferred no selective advantage.

21 sR mutant, loss of flagella did not confer a selective advantage.

22 in vivo, demonstrating tumor PD-L1 confers a selective advantage.

23 erved, suggesting that the process confers a selective advantage.

24 s were most frequently mutated, suggesting a selective advantage.

25 oss of chromosomes by cancer cells confers a selective advantage.

26 in the altered tumor environment, suggesting selective advantage.

27 y some treatment while some subclones gained selective advantage.

28 ether it may result from or confer an innate selective advantage.

29 f-function or regulatory mutations may be of selective advantage.

30 ns, suggesting that the P53 mutations confer selective advantage.

31 lative to 614D in a manner consistent with a selective advantage.

32 ier hypotheses that such diversity confers a selective advantage.

33 ge is minimal, faster growing fibrils have a selective advantage.

34 maintaining biological fitness and gaining a selective advantage?

35 might be driven by a cell-envelope mediated selective advantage across diverse chemical compounds.

36 how that, in addition, mecA provides a broad selective advantage across diverse chemical environments

37 of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators.

38 nd many American populations, would confer a selective advantage against vivax malaria.

39 tion and progression, cancer cells acquire a selective advantage, allowing them to outcompete their n

40 a model that virulent X. nematophila have a selective advantage and accumulate in aging IJs in advan

41 e persistent IL-15Ralpha expression are at a selective advantage and become founder cells, outgrow ot

42 The cells were isolated regardless of their selective advantage and differed only by the site of HPV

43 alled alginate provides P. aeruginosa with a selective advantage and facilitates survival in the CF l

44 We propose that this effect is linked to selective advantage and identify potential driver genes.

45 se "new" substitutions that enhance both the selective advantage and kinetic constants are positioned

46 We then discovered that the selective advantage and OSBS activity of the D297G mutan

47 tein, mediated by binding to GAGs, determine selective advantage and plaque size in BHK-21 cells, lev

48 Deletion of Trp53 in gastric cells confers a selective advantage and promotes the development of dysp

49 The pattern of reduction depends on the selective advantage and recurrence rate of the sweeps.

50 nd self-renewal in healthy tissue, promoting selective advantage and tissue colonization.

51 in which transgenes are predicted to confer selective advantages and disadvantages to recipient host

52 d fitnesses of clone variants, measure their selective advantages and order of appearance by fitting

53 ive to those that invoke external factors or selective advantage, and represents a null hypothesis fo

54 The selective advantages, and costs, of hornwort pyrenoids t

55 ate of the hypermutators was governed by the selective advantage arising from a reduced mutation rate

56 molecular mimicry (1) shows a key potential selective advantage arising from the partitioning of aaR

57 hat the new viral strains gained a potential selective advantage as a consequence of the acquired tra

58 rld to the New World and may have provided a selective advantage as begomoviruses adapted to a differ

59 Such chromosomal clustering may confer a selective advantage as it enables coordinated gene regul

60 ex chromosomes, or if it conveys a potential selective advantage aside from sexual antagonism.

61 We found that serotinous individuals have a selective advantage at high fire frequencies and low pre

62 New antigenic variants have a substantial selective advantage at the population level, but these v

63 (2) WASp(+) murine B cells exhibit a marked selective advantage beginning at the late transitional B

64 genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid im

65 ke protein variant D614G are suggestive of a selective advantage but may also be due to a random foun

66 e case of variants conferring a heterozygous selective advantage, but a homozygous disadvantage, as i

67 ns that exist in larger numbers experience a selective advantage by being more stochastically robust

68 This mechanism may confer a selective advantage by increasing cell population homoge

69 that a "synthetic" genetic code can confer a selective advantage by increasing the number of function

70 tibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing speci

71 this interaction might explain the mutant's selective advantage by means of repression of stem cell

72 Genetic mutations that provide a selective advantage by promoting these characteristics h

73 lon carcinoma, may confer tumor cells with a selective advantage by providing a mechanism for blockad

74 The magnitude of this selective advantage can then be estimated based on obser

75 codon reassignments would have a significant selective advantage compared to hosts utilizing the univ

76 gly, spirochetes containing lp28-3 were at a selective advantage compared to lp28-3-deficient spiroch

77 One possible selective advantage conferred by an encapsulated catalys

78 multiple spindles coupled with a subsequent selective advantage conferred by at least some aneuploid

79 enged with WT vs. H28-A2 escape mutants, the selective advantage conferred by glycan-mediated global

80 AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes i

81 uestions remain regarding the mechanisms and selective advantages conferred by both of these symplast

82 fundamental trade-off between the short-term selective advantages (Cope's rule) and long-term selecti

83 We asked what selective advantage could have driven the transition fro

84 g antigen stimulation-a mechanism conferring selective advantage during B-cell lymphoma development.

85 t whether T3SS-negative strains could have a selective advantage during in vivo infection.

86 suggests that some porin sequences confer a selective advantage during infection and/or transmission

87 , suggesting that the risk allele provides a selective advantage during tumor growth.

88 induced microtubule stabilization provides a selective advantage during tumor metastasis.

89 otoreceptors might have conferred particular selective advantages during evolution.

90 enhanced functional responses in vitro or to selective advantages during in vivo responses to cytomeg

91 ted hematologic defects that lack an in vivo selective advantage following gene correction may benefi

92 The strongest selective advantage for ADA-transduced cells occurred at

93 r events in different cells, contribute to a selective advantage for cancer cell proliferation.

94 flow cytometry-selected cells, demonstrating selective advantage for cells with multiple transposon i

95 penias that characterize AP syndrome and the selective advantage for clones that have lost the mutant

96 TrkC silencing by promoter methylation is a selective advantage for colorectal cell lines to limit t

97 uch of the low-latitude oceans, generating a selective advantage for diazotrophic organisms capable o

98 In patients with mixed chimerism, selective advantage for donor-derived T cells and switch

99 at inhibit rumen protozoa may provide such a selective advantage for EcO157 to proliferate in lagoons

100 ocytes, we obtained suggestive evidence of a selective advantage for increased GNAQ(Q209L) expression

101 d disruptions of F-pilus dynamics provides a selective advantage for infecting phages and thus may be

102 pression of XPC protein might also provide a selective advantage for initiation and progression of si

103 t during skin carcinogenesis that provides a selective advantage for initiation and progression of sq

104 o rewarding and aversive events, providing a selective advantage for maximizing the former while mini

105 ant-associated microbes, and thus provides a selective advantage for microbes such as P. syringae tha

106 model also successfully predicted a stronger selective advantage for more strongly activating gain-of

107 emostimuli called kairomones offers a strong selective advantage for potential prey animals.

108 potency and thus are not likely to provide a selective advantage for reprogramming.

109 accelerated evolution may be due to a larger selective advantage for resistance mutations in synergis

110 ation of a more robust biofilm may provide a selective advantage for strains that cause systemic dise

111 of HREs does not always provide an ultimate selective advantage for TEs, but may increase the probab

112 of a B cell for antigen is translated into a selective advantage for that B cell in immune responses

113 ed in the Wiskott-Aldrich syndrome, provides selective advantage for the development of naturally occ

114 ould be beneficial to therapy by providing a selective advantage for the expansion of stem cells.

115 end of the proto-spacer, suggesting a strong selective advantage for the phage that mutated in this r

116 imply defective phages and instead provide a selective advantage for the producing organisms.

117 mmation but host damage does not provide any selective advantage for these organisms.

118 (7,8), suggests that the volatiles provide a selective advantage for these soil microbes.

119 he hypothesis that small body size confers a selective advantage for tropical rainforest hunter-gathe

120 2 promotes aerobic glycolysis and provides a selective advantage for tumor formation.

121 ed RNA editing in cancer cells may provide a selective advantage for tumor growth and resistance to a

122 gous female WASp mice revealed a substantial selective advantage for WASp(+) vs WASp(-) iNKT cells.

123 munized individuals, identifying a potential selective advantage for wcjE inactivation and serotype 9

124 smids are extrachromosomal DNA that provides selective advantages for bacterial survival.

125 These experiments confirm that the selective advantages for viral yield and encapsidation s

126 nly accepted explanations for the individual selective advantages gained by shoaling.

127 at strategy A fixates in a B-population with selective advantage if the fitness of A is greater than

128 racteristic of individuals, and so may offer selective advantages if heritable.

129 Although these adaptations may confer some selective advantage, if they are not appropriately regul

130 in vivo or ex vivo but confers a significant selective advantage in competitive mosquito infections i

131 n truncated LEC1 proteins may have been of a selective advantage in creating somatic propagules, beca

132 rain-specific genes may provide an isolate a selective advantage in environments and contribute to th

133 persons expressing GM3/17 have potentially a selective advantage in HCMV defense.

134 an increased degree of placentation offers a selective advantage in high predation environments.

135 Selective advantage in host tissues can also be gained b

136 izontally acquired by pathogens to provide a selective advantage in host tissues.

137 s, such as nirS and cNor, appear to confer a selective advantage in microbial communities experiencin

138 osis-like death in pneumococci and confers a selective advantage in nasopharyngeal cocolonization.

139 ured environments, and thus likely confers a selective advantage in natural habitats of magnetotactic

140 clear whether cheating provides an important selective advantage in nature.

141 or viral replication but provide them with a selective advantage in nature.

142 n these five tumor types and likely confer a selective advantage in oncogenesis.

143 .IMPORTANCE Genetic alterations conferring a selective advantage in protecting from life-threating pa

144 or more gene clusters known to confer strong selective advantage in some environments.

145 panded "synthetic" genetic code can confer a selective advantage in the directed evolution of protein

146 no acid p-boronophenylalanine (BF) confers a selective advantage in the evolution of glycan-binding p

147 alizing antibodies did not bind, conferred a selective advantage in the immune systems of infected ho

148 TssM deubiquitinase may provide B. mallei a selective advantage in the intracellular environment dur

149 ll antigen receptor signaling and an in vivo selective advantage in the peripheral versus central B-c

150 table, amyloid-like aggregates that confer a selective advantage in the presence of specific antifung

151 hat grant spermatogonial stem cells (SSCs) a selective advantage in the testes of the father, but hav

152 Mutant FGFR3 may confer a selective advantage in the urothelium by overcoming norm

153 ical domain mutations in PIK3CA may confer a selective advantage in the urothelium in vivo by overcom

154 eling speculation that aneuploidy provides a selective advantage in these organs.

155 F10 carriage gives E. faecalis a significant selective advantage in this environment.

156 ation of the PTAP motif in p6(Gag) confers a selective advantage in viral replication by increasing G

157 se immunodeficiencies corrected cells have a selective advantage in vivo, and low numbers of gene-mod

158 19A) and CC695(19A) could reflect additional selective advantages in addition to resistance.

159 atures unique to each myosin type may confer selective advantages in cellular functions.

160 SAgs offer selective advantages in facilitating DFU infections and

161 mone receptors, suggesting that they provide selective advantages in natural environments.

162 dengue viruses, and the critical role of the selective advantages in the mosquito vector.

163 ost significant determinant of the threshold selective advantage is compartment size, with the thresh

164 explanation for these findings, whereby the selective advantage is driven by the competing risks of

165 onal B-cell stage; and (3) a similar in vivo selective advantage is manifest by mature WASp(+) human

166 This selective advantage is paired with a tradeoff in which m

167 Strength of selective advantage is presented for a range of disorder

168 This selective advantage is surprisingly small--0.004 +/- 0.0

169 mage the host, if this capability provides a selective advantage, is not understood.

170 of a lipid droplet, which despite the clear selective advantage it confers is also a harbinger of ce

171 us consequences, possibly as a result of the selective advantage it originally provided to either a h

172 ive evidence supports two hypotheses for the selective advantages leading to the origin of vocal lear

173 tations that provide the mutant cells with a selective advantage, leading to the clonal expansions re

174 ond distinct cell population that may have a selective advantage, leading to variation of LOI in norm

175 This selective advantage occurs at the expense of resident in

176 ed with low Igmu-chain and can eliminate the selective advantage of "double-producers" that achieve h

177 We find no evidence for a selective advantage of a high polygenic risk of schizoph

178 es are used to quantify the magnitude of the selective advantage of a monogenic heterozygous variant

179 We show that even a small selective advantage of a single cell within a large tumo

180 e disequilibrium generated by migration; the selective advantage of an inversion is dependent on the

181 By virtue of the acquired selective advantage of blocking virus-induced apoptosis,

182 other diseases, is confounded by the strong selective advantage of cells in which shRNA expression i

183 been the subject of much speculation, and a selective advantage of clusters of functionally related

184 For tumor growth, one selective advantage of concurrent mutation of RAS and PT

185 ers are more evenly spaced, which suggests a selective advantage of crossover interference.

186 ropose that CsrD evolution was driven by the selective advantage of decoupling Csr sRNA decay from Cs

187 Targeting these proteins blunted the selective advantage of ER-mutant tumor cells to survive

188 However, the selective advantage of female-biased sex ratios comes fr

189 To understand the selective advantage of genetically encoding more than 20

190 Two hypotheses have been proposed: A selective advantage of GPI(-) cells because of a second

191 s can ensure correlated gene expression, the selective advantage of maintaining adjacent gene pairs r

192 tes mitochondrial DNA (mtDNA), can alter the selective advantage of one mtDNA type over another.

193 Our results further reveal a potential selective advantage of Phe in certain situations, relati

194 ips among species in order to understand the selective advantage of producing milk with specific nutr

195 Furthermore, this finding suggests the selective advantage of specific combinations of genetic

196 n capability, leading to questions about the selective advantage of this activity.

197 ufficient for symbiosis, thus explaining the selective advantage of this allele at the mechanistic le

198 s in saturniid moths, further supporting the selective advantage of this anti-bat strategy.

199 However, the selective advantage of this enzyme is not known.

200 ation for both progressive emphysema and the selective advantage of this mutant allele.

201 The proposed selective advantage of this mutation for these primates

202 The selective advantage of this variation is not clear.

203 -dependent hematopoiesis consistent with the selective advantage of WASP-positive hematopoietic cells

204 nsion of a dominant homozygous subclone, the selective advantage of which is likely to reflect additi

205 One of the major selective advantages of GC-rich DNA is hypothesized to b

206 heterogeneity allowing to study and quantify selective advantages of individual clones.

207 evolutionary selection, including potential selective advantages of mutation carriers in genes affec

208 lead to differing conclusions related to the selective advantages of sexual reproduction.

209 n be classified across species, and what the selective advantages of the capacity for mood are.

210 suggests that Myc heterogeneity confers some selective advantage on breast tumor growth and progressi

211 et, known as driver mutations, confer clonal selective advantage on cancer cells and are causally imp

212 elegans with metabolic plasticity and thus a selective advantage on different diets in the wild.

213 w can significantly diminish the effect of a selective advantage on fixation probabilities.

214 ogues of known accessory modules that confer selective advantage on host bacteria.

215 sults suggest that type IV pili may confer a selective advantage on K. kingae early in infection and

216 bility of most therapeutic genes to confer a selective advantage on the gene-corrected cells.

217 al breast epithelial cells, which provides a selective advantage once tumorigenesis has begun.

218 d and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resist

219 t-hedging, or adaptive tracking) has a clear selective advantage over all others.

220 duals that do not contribute socially have a selective advantage over altruists if both types receive

221 ssume that modern humans benefited from some selective advantage over Neanderthals, which led to the

222 ssary mutations the transformed cell gains a selective advantage over normal cells, and the mutation

223 e ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells thro

224 ning elevated levels of plasticity acquire a selective advantage over other clonal populations within

225 he surfactant provides L. pneumophila with a selective advantage over other legionellae in the natura

226 talytic transformations would have enjoyed a selective advantage over other protocells in high Mg(2+)

227 bial pressure, 6 out of 11 mutants carried a selective advantage over the antimicrobial-sensitive par

228 eads to DSBs, and whether sleep provides any selective advantage over wake in their repair.

229 t that the HBeAg-negative variant may have a selective advantage over wild-type HBV within the livers

230 Our findings reveal a potential selective advantage possessed by multidrug-resistant-A.

231 Our results imply that the selective advantage produced by human chromosome 17p del

232 he molecular (sequence) pathway by which the selective advantage provided by this protein can be impr

233 the model allows us to calculate the actual selective advantage provided by typical somatic mutation

234 s paper, we build on our recent work on the "selective advantage" relation among driver mutations in

235 ple cognitive abilities (each with their own selective advantage) requires no additional evolutionary

236 fraction exceeded 50%, suggesting additional selective advantage resulting from the loss of heterozyg

237 lthough the mechanisms of regulation and the selective advantage(s) of regulating cellular shape are

238 how that viruses with these mutations have a selective advantage since they are preferentially locate

239 expression of particular genes may provide a selective advantage such that it is conserved across spe

240 ge transaldolase may be a tradeoff for other selective advantages such as reduced gene size: we show

241 tion, we predict that revertant cells have a selective advantage that allows their clonal expansion a

242 e latter case, heterogeneity should confer a selective advantage that benefits the entire population.

243 kinase gene, which conferred an exceptional selective advantage that could be demonstrated through b

244 l chromosomes(1,2,5,6,9), but the sources of selective advantage that drive the expansion of most clo

245 thelium plays a unique function, providing a selective advantage that gives rise to transgene-positiv

246 er or not this exclusion activity provides a selective advantage through maintenance of Stk activity

247 Therefore, Hsp72 provides a selective advantage to cancer cells by suppressing defau

248 investigate whether aneuploidy may confer a selective advantage to cancer cells, we employed a contr

249 pression of light-inducible genes provides a selective advantage to cavefish at the expense of a damp

250 es that disrupt normal biology and provide a selective advantage to cells during tumorigenesis.

251 ity suggests that they confer as yet unknown selective advantage to DNA.

252 s do not have the necessary proliferative or selective advantage to evolve into a disease-relevant re

253 , suggesting that GTAC methylation confers a selective advantage to H. pylori.

254 rovides a path to tumor development, with no selective advantage to having both mutations.

255 , the DNE of p53 missense variants confers a selective advantage to hematopoietic cells on DNA damage

256 of heterozygotes, may result in an apparent selective advantage to heterozygotes at the neutral locu

257 common MHC alleles, which in turn provides a selective advantage to hosts carrying rare MHC alleles.

258 ll, our data show that aneuploidy can confer selective advantage to human cells cultured under non-st

259 iversity acts as a mechanism that provides a selective advantage to individual cells within otherwise

260 ated nuclear antigen (LANA/orf73) provides a selective advantage to infected B cells by driving proli

261 sure to inflammatory cytokines can provide a selective advantage to infiltrating CD8(+) T cells by tr

262 n this model, each genetic polymer imparts a selective advantage to its protocell by, for example, co

263 ever, the PS was found to provide a distinct selective advantage to MHV.

264 age or death of their host offers no obvious selective advantage to microbial growth or survival.

265 ive virulence determinants may both confer a selective advantage to mucA mutant strains of P. aerugin

266 mutations and biological processes that give selective advantage to mutant clones, we analysed genoty

267 ic mutations in a single HSC that provides a selective advantage to mutant HSC over normal HSC and pr

268 owever, very high seed predation shifted the selective advantage to nonserotinous individuals even at

269 ations on space and/or growth factors gave a selective advantage to phenotypes derived from tumorigen

270 clock, acting with hormone signals, provides selective advantage to plants through anticipation of an

271 ibiotic production can actually decrease the selective advantage to producers.

272 sitive to COP1, implying that this confers a selective advantage to prostate epithelial cells.

273 lution, our findings suggest that there is a selective advantage to retaining polar, uncharged residu

274 d corresponding stress resistance provides a selective advantage to Runx1-deficient HSPCs, allowing t

275 ly unrecognized role in providing a germline-selective advantage to spermatogonia for the recurrent m

276 trains and biofilm formation seems to give a selective advantage to the bacterium.

277 Thus, WASP expression conferred a selective advantage to the development of Kit-dependent

278 at support conjugation, exclusion provides a selective advantage to the element and its host cells.

279 housekeeping genes suggests that they offer selective advantage to the genomes and ecosystems they i

280 t of large supergene complexes that confer a selective advantage to the individual.

281 lly, the resistance gene must confer a large selective advantage to the vector to surmount the effect

282 us-encoded miRNAs are likely to be of little selective advantage to the virus, and our approach provi

283 2013-16 epidemic, are suspected to confer a selective advantage to the virus.

284 ype p53 in glioblastoma cells could confer a selective advantage to these cells under the adverse con

285 These contexts gave a selective advantage to traits, such as dietary flexibili

286 inherent to viral populations may provide a selective advantage to viruses that can be fully exploit

287 ration of genome rearrangements that provide selective advantages to the invading microbe.

288 hway; yet their accumulation must have given selective advantages to the parasite.

289 a unique family of retroelements that confer selective advantages to their hosts by facilitating loca

290 onse to specific challenges and can confer a selective advantage under certain environmental stresses

291 ncoded by TP53) provides cancer cells with a selective advantage under conditions of hypoxia, but lit

292 de that LeuRS-I may have evolved to confer a selective advantage under the extreme and fluctuating en

293 This study demonstrates the selective advantage underground metabolism offers, provi

294 changes in amino acid function provided the selective advantage underlying the expansion of the gene

295 Defectors have a selective advantage unless a mechanism for evolution of

296 This trade-off may have provided a selective advantage when Homo transitioned to butchery u

297 t certain environment-altering traits have a selective advantage when those traits also contribute to

298 equence of behaviors that evolved to provide selective advantages when elicited by tall trees, but ar

299 ing development might offer dosage-dependent selective advantage, whereas rapid expression divergence

300 ) Initially, the two linked mutations have a selective advantage while rare and will increase in freq