ライフサイエンスコーパス: selectivity

1 The major product was nontoxic ethane (94% selectivity).

2 te, in line with their higher activities and selectivity.

3 O) -rich N-SnO(2) NS, thus enhancing HCOO(-) selectivity.

4 may have a significant effect on the product selectivity.

5 ilability and enhanced receptor affinity and selectivity.

6 ferent equations and models used to quantify selectivity.

7 vesicles creates a crowded lumen that drives selectivity.

8 anol, causing low activity and poor methanol selectivity.

9 conditions, with up to 99 % yield and >20:1 selectivity.

10 ed Pyrox ligand in excellent yield and >20:1 selectivity.

11 er the channel's unitary conductance and ion selectivity.

12 nd photoablating(9,10) neurons with specific selectivity.

13 es are obtained with good to high yields and selectivity.

14 sign using volume gratings with polarization selectivity.

15 vity and dictates the outstanding gamma site-selectivity.

16 e of simpler assay optimization and improved selectivity.

17 al for the observed high reactivity and site selectivity.

18 y are the dominant contribution to substrate selectivity.

19 B(2)pin(2) in excellent yields and with high selectivity.

20 establish a constriction essential for K(+) selectivity.

21 ite interactions, and profiling of inhibitor selectivity.

22 hide yet unexplored catalytic activities and selectivity.

23 ial for alpha3beta4 nAChR subtype allosteric selectivity.

24 e products in good yields and complete trans selectivity.

25 role in determining chemical reactivity and selectivity.

26 e capacity and the highest C(2)H(6)/C(2)H(4) selectivity.

27 n rate is responsible for the enhanced CO2RR selectivity.

28 selectivity, enantioselectivity, and product selectivity.

29 igh potency and excellent JAK family subtype selectivity.

30 not present in human CLK1, thereby providing selectivity.

31 subtle, noncovalent interactions that drive selectivity.

32 hy photoreactivity, resulting in an enhanced selectivity.

33 on while modulating substrate reactivity and selectivity.

34 ell as an enhancement of the neurons' coding selectivity.

35 after stimulus presentation, followed by OMA selectivity.

36 mechanism which privileges sensitivity over selectivity.

37 ently in excellent yields and with high beta-selectivities.

38 High selectivity (1:1200, ovalbumin/BSA) and detection limit

39 17 kJ mol(-1) (alkene) ), high alkene:alkane selectivity (47; 29), and uptake capacity (>2.5 mol(alke

40 ) (100), and a factor of two higher pairwise selectivity (6.1 %) in the hydrogenation of propene than

41 e tested this prediction by mapping neuronal selectivity(7) and photoablating(9,10) neurons with spec

42 ties' guidelines and requirements, including selectivity, accuracy, precision, recovery, calibration

43 tonation capacity is associated with reduced selectivity against K(+) We conclude that optimization f

44 inhibition, and compounds demonstrated high selectivity against related proteases, good target engag

45 the lower pore is detrimental to gating and selectivity, although this interaction might occur in bo

46 s not only the binding affinity but also the selectivity among these mRNAs.

47 ave shown significant promise owing to their selectivity and ability to withstand harsh conditions.

48 Cargo selectivity and activation of processive motility depend

49 aining functional groups is key for the high selectivity and activity for 2e(-) ORR.

50 mics being successfully used to alter enzyme selectivity and activity.

51 s provide a blueprint for decoding signaling selectivity and advance our understanding of molecular r

52 loops as important structural motifs for ion selectivity and channel inhibition in Panx1.

53 tes at elevated temperatures, providing high selectivity and compatibility with polymerases.

54 offers unique opportunities to tailor shape selectivity and enhance catalyst performance.

55 g of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approach

56 MIP-7-hydroxycoumarin had greater selectivity and extraction efficiency (recoveries above

57 rom all known channels, predicting novel ion-selectivity and gating mechanisms.

58 between substrate deprotonation for optimal selectivity and high substrate affinity and transport ra

59 Feature selectivity and identity-sensitive activity in the two r

60 H53d-acid shows superior (>40-fold) affinity selectivity and is a positive modulator.

61 ing catalysts is an effective way to improve selectivity and kinetics of the oxygen reduction reactio

62 an be utilised, which greatly reduces device selectivity and offers much greater bitrates.

63 , aspartate 348, that determines both cation selectivity and pH gating.

64 ard with no nutritive value, initiating high selectivity and prolonged cravings for drug through rewa

65 hysical stability, low-cost production, high selectivity and rapid response, MIPs combined with minia

66 However, the trade-off between selectivity and sensitivity of such sensors remains a ke

67 H indicators, the ALISA exhibitssatisfactory selectivity and sensitivity, which demonstrated the grea

68 ects on NOP binding, intrinsic activity, and selectivity and showed that while the C(3)-substituted i

69 on in eukaryotic cells and achieve substrate selectivity and specificity through the interaction of d

70 examine this correspondence between category selectivity and the representation of multi-category sti

71 th restricted side chains that confer higher selectivity and/or affinity.

72 ld, >98:2 alpha:gamma selectivity, >98:2 Z:E selectivity, and >99:1 enantiomeric ratio.

73 ad optimization involved modulating potency, selectivity, and ADME properties which led to the identi

74 ifferentiation, design strategies to achieve selectivity, and applications in basic biology or in the

75 pharmacology, activation, inactivation, ion selectivity, and arrhythmias.

76 ent design strategy to modulate the potency, selectivity, and binding kinetics of Na(V) channel ligan

77 azidation methods highlights its unique site selectivity, and conversions of the benzyl azide product

78 gies are severely limited by the efficiency, selectivity, and durability of electrocatalysis.

79 control regioselectivity, induce spin-state selectivity, and elicit mechanistic crossovers.

80 higher methanol dehydrogenation activity and selectivity, and greater stability than that of some oth

81 mers over monomeric G-quadruplexes with high selectivity, and induced the formation of G-quadruplex D

82 Their high sequence similarity, low agonist selectivity, and lack of activation and G protein-coupli

83 ad optimization efforts focusing on potency, selectivity, and oral bioavailability led to the discove

84 Current methods present low ion selectivity, and require multistep processes to transfor

85 ies, but the determinants of ligand binding, selectivity, and signaling are still poorly understood.

86 ion signatures serve to predict the post-HAA selectivity, and since KED is affected by the free energ

87 guide to developing GDEs with high activity, selectivity, and stability, the three important performa

88 sodium hydroxide (NaOH) to increase membrane selectivity, and the particle size cutoff was reduced fr

89 Instead, selectivity appears to arise from the total number of sy

90 tudied for the ORR, but the origins of their selectivity are not well understood because the selectiv

91 e to insurmountable issues of reactivity and selectivity associated with all previously explored stra

92 zero-overpotential with near unity H(2)O(2) selectivity at 0.27 V vs. RHE.

93 se a new quantitative model for small object selectivity based on the physiology and anatomy of LC11

94 Studying selectivity between WNTs and FZDs has been hampered by t

95 ctions to a layer 2/3 neuron accord with its selectivity by obeying precise spatial patterns.

96 A fundamental understanding of substrate selectivity by SMR transporters is needed to identify th

97 peutic action, improved spatial and temporal selectivity can be achieved and subsequently harnessed f

98 ructural differences between receptor types, selectivity can be achieved in a number of different way

99 rtant to identify a platform with which high selectivity can be achieved.

100 This selectivity can be an advantage for their possible appli

101 pport the hypothesis that the enhancement of selectivity can be attributed to the distinct mechanism

102 Our findings indicate that social selectivity can emerge in the absence of complex future-

103 Chirality-induced spin selectivity (CISS), whereby helical molecules polarize t

104 P450 enzymes tend to have variable substrate selectivity compared with related extant forms, but they

105 ges, and found visual responses and category selectivity consistent with previous studies.

106 dified Chalk-Harrod mechanism, starting with selectivity-determining insertion into Ir-C(Aryl).

107 uggest a change in the turnover-limiting and selectivity-determining step induced by the optimal liga

108 ectivity are not well understood because the selectivity-determining step(s) usually occur after the

109 f five-membered heteroarenes that occur with selectivities dictated by steric effects, such as the bo

110 Their extraordinary efficiency and selectivity enable the development of flawless structure

111 decalin scaffold as the best moiety for the selectivity-enabling subpocket of FBKP51.

112 he formidable challenges of controlling site-selectivity, enantioselectivity, and product chemoselect

113 to multiple parallel columns with different selectivity enhances the power of compound identificatio

114 of magnitude fewer decoding errors than pure selectivity even when both forms of selectivity use the

115 ion mutation N629D at the outer mouth of the selectivity filter (SF) disrupts inactivation and K(+)-s

116 buted to a nonconductive conformation of the selectivity filter (SF).

117 and substituting one or two residues in the selectivity filter drastically increased the IC(50) valu

118 d external protons control intracellular and selectivity filter gates to modulate TASK2 activity.

119 The scoop loop thereby acts as an additional selectivity filter in shaping the repertoire of presente

120 iments also suggest water is proximal to the selectivity filter of KirBac1.1 in the open-activated st

121 When ions occupy adjacent sites in the selectivity filter, the predicted spectra are significan

122 state but that it may not directly enter the selectivity filter.

123 probe specific ion binding sites within the selectivity filter.

124 was included in PKIS based on its promising selectivity following profiling against 260 human kinase

125 are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately

126 on kinetics, we show that divergent sequence selectivity for AB- and ABB-type copolymers can be achie

127 ved in the host/guest complexes and into the selectivity for acetylcholine over choline.

128 Using fMRI, we examined whether category selectivity for animals and tools would remain, when ima

129 iding Mycoplasma We observed high nucleotide selectivity for ATP driving motor rotation, negative coo

130 bond cleavage and, as a result, display high selectivity for borylation of aromatic C(sp(2))-H bonds

131 unds did not kill other bacteria, indicating selectivity for Chlamydia.

132 03.21 mmol g(cat) (-1) h(-1) with near-unity selectivity for CO generation and meanwhile excellent st

133 tion models exhibited distinctive functional selectivity for cognition and language.

134 The selectivity for different glycan types was studied using

135 typically reduced their visual responses and selectivity for direction and orientation.

136 ation of diverse mitophagic pathways and how selectivity for each of these pathways is conferred is j

137 om catalysts, and it has a high activity and selectivity for electrochemical CO(2) reduction (CO(2)R)

138 ed cavity found in 3 allows for an exclusive selectivity for fluoride over other competing halides.

139 310, a kainate receptor antagonist with high selectivity for GluK1 subunits, reduces the desensitizat

140 and 66 nM, respectively) and up to 410-fold selectivity for HDAC8 over the next targeted HDAC.

141 that the immune checkpoint 4-1BB had a high selectivity for human tumor Tregs and was associated wit

142 emonstrate that PUFA analogues vary in their selectivity for human voltage-gated ion channels involve

143 gyrus), and activations of layer-units with selectivity for image backgrounds were associated with c

144 ins nonequivalent gamma-methylenes, the site-selectivity for lactonization can be rationally predicte

145 s (SACs) have shown superior activity and/or selectivity for many energy- and environment-related rea

146 ansport, reduced cytotoxicity, and increased selectivity for Mn over calcium compared with two establ

147 orophene and bithionol exhibited significant selectivity for Nape-pld compared with nontarget lipase

148 activity against human nNOS, and only modest selectivity for nNOS over related enzymes.

149 eocortical cells were capable of forming the selectivity for ongoing events within a few minutes of n

150 Increased cation charge decreases selectivity for oxo-site bonding, leading to higher dime

151 ays represent category information, but that selectivity for sound classes emerges first in the front

152 Neurons exhibited selectivity for stimulus rank during learning, but not b

153 able to the state-of-art LC-MS but suggest a selectivity for the detection of a different subset of m

154 related compound CCG258208 also showed high selectivity for the GRK2 subfamily in a kinome panel of

155 cal structure-activity relationships driving selectivity for the Hsp90 isoforms expressed by Cryptoco

156 ied analogues that retained both potency and selectivity for the inhibition of prokaryotic translatio

157 are deployed to determine the origin of the selectivity for the syn diastereomer of the resultant te

158 A single population of neurons with mixed selectivity forms both subspaces, but the information is

159 As a result, we improve the CO selectivity from 74% for Ag/Zr-fcu-MOF-1,4-benzenedicarb

160 many advantages for analytical methods: high selectivity from the multiple spectral dimensions, line-

161 ducts in up to 91 % yield, >98:2 alpha:gamma selectivity, >98:2 Z:E selectivity, and >99:1 enantiomer

162 ronic interactions to control reactivity and selectivity has a long history in chemistry.

163 owever, the inherent issue of dictating site selectivity has cumbered the development of novel interm

164 es influence deacetylase activities and site-selectivities in chromatin is poorly understood.

165 Selectivities in such reactions are difficult to analyze

166 lucidation of the mechanisms conferring this selectivity in calcineurin signaling should reveal new s

167 t well for the known properties of direction selectivity in carnivores and primates.SIGNIFICANCE STAT

168 e alpha-ethereal C-H bonds, we observed site-selectivity in each case, prompting us to investigate po

169 are employed, although accompanied with poor selectivity in hydrotreatment.

170 contrast, high flux comes at the expense of selectivity in many synthetic filters.

171 erein, we report a concept of creating shape selectivity in MNPs/porous nanomaterials through intenti

172 The ability to control reaction selectivity in supramolecular structures beyond traditio

173 e an accurate prediction of the experimental selectivity in the addition of HCl to 1,3-pentadiene.

174 The results reveal that the selectivity in the formation of products was obtained by

175 How does face-selectivity in the fusiform arise in development, and wh

176 While some dSTACs elicit ER subtype-selectivity in the presence of hormone, most synergize w

177 Selectivity in these reactions is attributed to the abil

178 s necessary for the development of direction selectivity in visual cortex of carnivores, it is unclea

179 ies identified patterns driving affinity and selectivity, including limited ligand flexibility, as ob

180 demonstrate that inhibition shapes direction selectivity independently within small dendritic segment

181 e nanomolar range (IC(50) = 74 nM) with high selectivity index (SI > 1350).

182 gically realistic estimates of the direction selectivity index, and it reproduces the critical findin

183 d catalysts, and a totally unexpected facial selectivity inversion was also noticed.

184 novel chemical structures can thus be found, selectivity is a challenge owing to the largely identica

185 Selectivity is achieved by exploiting the lower barrier

186 We uncover that this substrate selectivity is based on the ability of nestin to interac

187 eske oxygenases responsible for control over selectivity is essential to enable the development of th

188 Endo selectivity is predicted for both uncatalyzed and cataly

189 the main substrate classifier distinguishing selectivity is the magnitude of change in local compacti

190 For selectivity, it successfully rejected signals from pH ch

191 or intra-pipette Na(+) had no effect on the selectivity, kinetics, amplitude, rectification or rever

192 In contrast, changes in selectivity made gluconate permeant in L46P EAAT2, and n

193 substrate activation modes and unprecedented selectivity manifolds.

194 This suggests that nonlinear mixed selectivity may be a general coding scheme exploited by

195 lack of stereoselectivity, and evaluates why selectivity may not occur and when it will likely occur.

196 r understanding about ligand recognition and selectivity mechanisms of the formyl peptide receptor fa

197 g uridine/cytidine kinase 2 and characterize selectivity mechanisms using molecular dynamics and X-ra

198 Although the field is well developed and selectivity models have been proposed for a number of ca

199 tures, with unprecedented dynamic separation selectivities of 100, 92, and 83, respectively.

200 on ranges of 0-100 and 0-50 mmol L(-1) , and selectivities of 15.6 and 8.1 mmol L(-1) , respectively.

201 The selectivities of many HIs for HIF hydroxylases and possi

202 s a glycan microarray to examine the binding selectivities of several HS-binding proteins.

203 The selectivities of this reaction are up to >20:1 ortho/par

204 subsequent C-N bond forming step, achieving selectivities of up to 98:2 er.

205 analysis of the FeAg NPs revealed a faradaic selectivity of 36 % for CO in 0.1 M KHCO(3) at -1.1 V vs

206 ss yields of 58 % are observed at a fructose selectivity of 94 %, and continuous operation for over 1

207 on of this reaction by water when tuning the selectivity of a well-defined CeO(2)/Cu(2)O/Cu(111) cata

208 us heart valve defect, affects the substrate selectivity of ADAM17 toward Heparin-binding epidermal g

209 Moreover, the ion selectivity of bBest2 is controlled by multiple residues

210 f bistability during auditory streaming: the selectivity of bistability to specific stimulus configur

211 In vivo testing confirmed the selectivity of C(3)-ZIF(MCF) to accumulate in MCF-7 tumo

212 ible for substrate specificity and catalytic selectivity of C4H.

213 Controlling the selectivity of catalytic reactions is a critical aspect

214 e catalyst Pt(1)/CeO(2) greatly enhances the selectivity of cyclization and aromatization in the n-he

215 and functionalities impact the activity and selectivity of ECH?(2)What material properties cause an

216 The selectivity of excitatory and inhibitory neurons within

217 odeling was found to define the kinetics and selectivity of gene activation in response to microbial

218 High sensitivity and selectivity of hearing require an active cochlea.

219 rsal and diversification rates and taxonomic selectivity of immigrants.

220 ovements leading to a higher sensitivity and selectivity of instruments.

221 Significant selectivity of MMP 13 versus MMP-2 can be achieved by su

222 ) via a 2 e(-) pathway with a high H(2) O(2) selectivity of over 95 % in 0.10 m KOH.

223 The idea of combining the size and shape selectivity of porous domains with the fluidity of liqui

224 e properties well explain the reactivity and selectivity of SNZVI during the reductive dechlorination

225 interpreting data in the context of receptor selectivity of such agonists.

226 kills liver cancer cells in culture, as the selectivity of the aptamer binding directs doxorubicin i

227 rovides a powerful avenue to investigate the selectivity of the binding sites along the pore of potas

228 ty and magnitude of this flow depends on the selectivity of the channel.

229 e of GABA(A) receptors strongly improved the selectivity of the neurons' delay activity, causing an i

230 clization step is a key step controlling the selectivity of the process.

231 ic aspects that influence the reactivity and selectivity of the reaction, comparing the involvement o

232 Because of the high selectivity of the sensor, we were able to quantify gluc

233 As a consequence, the selectivity of the silylation of substituted arenes is g

234 role of ligand-receptor dissociation in the selectivity of the weak multivalent binding.

235 The selectivity of this process can be diverted to exclusive

236 th over 50% Faradaic efficiency and over 90% selectivity on a carbon basis at a modest electrode pote

237 Selectivity on model substrates and deuterium-labeling e

238 JH112 exhibits high selectivity over a panel of different GPCRs, is able to

239 toward integrin alpha(v)beta(3) and enhanced selectivity over integrin alpha(5)beta(1).

240 with significant improvement in solubility, selectivity over Na(V)1.5, and CYP2C9 inhibition.

241 an IC(50) of 72 nM and greater than 200-fold selectivity over off-target sodium channel isoforms, Na(

242 m protein pores with ultrahigh proton (H(+)) selectivity over other ions.

243 nanomolar potency against GRK2 and excellent selectivity over other kinases.

244 antages over genetic approaches and improved selectivity over small molecule inhibitors.

245 gonists displaying high affinity and subtype selectivity over the antitarget M(2) are valuable pharma

246 retain high potency for FKBP51 and excellent selectivity over the close homologue FKBP52.

247 he first step in GPI biosynthesis, with good selectivity over the human functional homolog PIG-A.

248 rd highly substituted bisperoxides with high selectivity over the oxidative cleavage of C=C bond that

249 ates: weak binding of CO is desirable from a selectivity perspective, but weak binding of CO(2) leads

250 n terms of their sensitivity, dynamic range, selectivity, precision, and simplicity.

251 , by virtue of the increased sensitivity and selectivity provided with LC-MS, yielded additional site

252 stablishing the guidelines for enhancing the selectivity: reactor studies of complex catalyst materia

253 ar concentrations and greater than 1000-fold selectivity relative to other serine hydrolases.

254 Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practic

255 Selectivity remains a challenge for ATP-mimetic kinase i

256 Site selectivity represents a key challenge for non-directed

257 ompound 3a that displayed excellent potency, selectivity, safety profile, and efficacy in vivo.

258 The proposed biosensor exhibited high selectivity, sensitivity, and good stability.

259 rength on pH values and pK(a) values, on the selectivity, sensitivity, precision, dynamic ranges, and

260 showed the sensor can be reused and has good selectivity; sensitivity and dynamic range can be tuned

261 of membranes are covered, such as diffusion-selectivity separation, adsorption-selectivity separatio

262 diffusion-selectivity separation, adsorption-selectivity separation, and synergetic adsorption-diffus

263 aration, and synergetic adsorption-diffusion-selectivity separation.

264 Furthermore, considerable selectivity, stability and reliability of the aptasensor

265 of ephaptic interactions on recruitment and selectivity stemming from artificial (i.e., neural impla

266 180 % higher in activity and 22 % higher in selectivity than its counterpart with numerous internal

267 were more likely to affect gating and/or ion selectivity than those in the upper pore.

268 (pre-miR-21) for enzymatic destruction with selectivity that can exceed that for protein-targeted me

269 H KIEs, LFERs, CF(2) transfer efficiency and selectivity, the effect of inhibitors, and density funct

270 emperature in excellent yields and with high selectivity, thereby demonstrating its broad utility and

271 at proceeds with fast kinetics and exquisite selectivity, thereby enabling facile modification of NCy

272 to its high boron loading and excellent GRPR selectivity, this conjugate can be considered as a promi

273 measurement in triplicate, and of the device selectivity through the presence of an internal referenc

274 <10 wt %) exhibited stable (for 60 h) > 93% selectivity to AA with single pass conversion >60%.

275 e design parameters for enhancement of tumor selectivity to achieve improved in vivo therapeutic outc

276 ht-off temperature of 230 degrees C and 100% selectivity to CO(2).

277 eract with specific RNAs, Rrp6p utilizes its selectivity to discriminate against specific RNAs.

278 However, this compound exhibited moderate selectivity to EP2, a short plasma half-life in rodents

279 Crown ether derivatives exhibit selectivity to Na(+) and K(+) ions within detection rang

280 BM30 exhibits over 100-fold selectivity to NTMT1/2 among a panel of 41 MTs, indicati

281 st to many other proteins that use substrate selectivity to preferentially interact with specific RNA

282 onally, none of these timescales depended on selectivity to task-relevant signals.

283 5) confers very high alpha4beta2/alpha3beta4 selectivity to the alpha4beta2 partial agonism.

284 immature ferrets, cortical neurons developed selectivity to these patterns, indicating an instructive

285 of 468 protein kinases, HS-243 had exquisite selectivity toward both IRAK-1 (IC(50) = 24 nm) and IRAK

286 s RuvC (E71~A87) endows Fpr with an enhanced selectivity toward HJ cleavage but with a target sequenc

287 nderlie the divergent evolution of substrate selectivity toward indole, phenyl, or hydroxyphenyl amin

288 The host T3 showed certain selectivity toward one enantiomer over the other.

289 The sialylation showed selectivity toward the N-glycan compared to another glyc

290 Excellent selectivity towards one- and two-base mismatches (1MM, 2

291 The new receptor displays selectivity towards two out of the seven PIPs, namely PI

292 han pure selectivity even when both forms of selectivity use the same number of spikes.

293 l-scale applications, including lack of mono-selectivity, use of expensive oxidants and limited scope

294 The degree of endothelial selectivity varied inversely with the FUS pressure, with

295 NA-PK catalytic subunit (DNA-PKcs) with good selectivity versus the structurally related PI3 (lipid)

296 Selectivity was demonstrated against 13 other competing

297 The experimentally observed alpha-selectivity was explored in detail, revealing that the l

298 antibody trastuzumab with excellent cysteine-selectivity, we applied our protocol for the site-specif

299 Ts, indicating its potential to achieve high selectivity when targeting the peptide substrate binding

300 Larger cation radii also decreases bonding selectivity, yielding higher dimensional materials.