ライフサイエンスコーパス: self-administration

1 ease in drug seeking after cessation of drug self-administration).

2 more than 2 months without altering cocaine self-administration.

3 following prolonged abstinence from cocaine self-administration.

4 of chronic cocaine (n = 8) or water (n = 6) self-administration.

5 nce from noncontingent drug exposure or drug self-administration.

6 luding psychomotor sensitization and cocaine self-administration.

7 tine-induced increases in adolescent cocaine self-administration.

8 sticity is associated with increased alcohol self-administration.

9 ne, such as locomotor sensitization and drug self-administration.

10 nd harmful effects of chronic nicotine vapor self-administration.

11 tum in Npas2 mutant females after dark phase self-administration.

12 ced conditioned place preference and cocaine self-administration.

13 ral changes initially established by cocaine self-administration.

14 ve sites cumulatively across 19 d of cocaine self-administration.

15 or CHD after 12 months of voluntary ethanol self-administration.

16 a maladaptive cognitive response to cocaine self-administration.

17 ation between KOR and stress-induced cocaine self-administration.

18 the acquisition and maintenance of oxycodone self-administration.

19 t, VK4-116 had little effect on oral sucrose self-administration.

20 the lack of animal models of nicotine vapor self-administration.

21 after either intermittent or continuous drug self-administration.

22 or IPN restored a "stop" signal on nicotine self-administration.

23 rats and monkeys, but did not affect cocaine self-administration.

24 ine and the effects of some drugs on cocaine self-administration.

25 and medication event-monitoring devices for self-administration.

26 punishment-induced suppression of aggression self-administration.

27 ntly increased after 6- and 12-month ethanol self-administration.

28 neurons that were active during operant food self-administration.

29 r, as did withdrawal from ShA or LgA cocaine self-administration.

30 e found that PE led to increased amphetamine self-administration.

31 in vivo expedited the acquisition of cocaine self-administration.

32 ergent effects on brain function and cocaine self-administration.

33 lated in the NAcsh of rats following cocaine self-administration.

34 dopamine activity and lower cocaine operant self-administration.

35 mine in the nucleus accumbens nor maintained self-administration.

36 educes AMPH-self administration but not food self-administration.

37 hA) or long (6 hours; LgA) access to cocaine self-administration.

38 eased voluntary alcohol drinking and alcohol self-administration.

39 duces cue-induced drug seeking after cocaine self-administration.

40 es in rats (n = 21) with a history of heroin self-administration.

41 n, and drug-induced reinstatement of cocaine self-administration.

42 not methylphenidate potentiation of cocaine self-administration.

43 occur in vulnerable groups following heroin self-administration.

44 iectomized mutant mice showed no increase in self-administration.

45 lphenidate pretreatments potentiated cocaine self-administration.

46 well as the behavioral economics of cocaine self-administration.

47 efore and after 21 days of cocaine or saline self-administration.

48 -administration (6 days) and then for heroin self-administration (12 days).

49 Male rats underwent intravenous cocaine self-administration (2 h/day) followed by 6 h access to

50 Using cocaine self-administration (3 h/d for 14 d) and extinction proc

51 , we trained male and female rats for social self-administration (6 days) and then for heroin self-ad

52 % received further medical prescriptions for self-administration: 67% corticosteroids, 83% antihistam

53 drug taking, we measured intravenous cocaine self-administration (acquisition, dose-response, progres

54 ed differences in the acquisition of cocaine self-administration across groups.

55 In this study, we found no differences in self-administration across the estrous cycle in the abse

56 we used integrated optical imaging in a rat self-administration and a mouse noncontingent model, to

57 We found that aggression self-administration and aggression seeking induced highe

58 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence

59 cruited for, and control, operant aggression self-administration and aggression seeking on abstinence

60 neurons that is critical for both aggression self-administration and aggression seeking.

61 d2-, expressing neurons decreased aggression self-administration and aggression seeking.

62 1- and Drd2-expressing neurons in aggression self-administration and aggression seeking.

63 ments and procedures for building the social self-administration and choice apparatus.

64 ving and introduces a fully automatic social self-administration and choice procedure to investigate

65 (FosGFP(+)) that were activated during food self-administration and compared these with alterations

66 eadout of acetylated lysines, reduced heroin self-administration and cue-induced drug-seeking behavio

67 Alcohol self-administration and cue-induced reinstatement behavi

68 ocaine seeking after withdrawal from cocaine self-administration and cue-induced reinstatement of coc

69 Both groups equally acquired Meth self-administration and did not differ in total Meth int

70 a behavioral economics approach with cocaine self-administration and ex vivo voltammetric recording o

71 te that neuronal ensembles mediating cocaine self-administration and extinction comingle in vmPFC but

72 nstrate that different ensembles for cocaine self-administration and extinction memories coexist in t

73 tal cortex (vmPFC) encodes both operant drug self-administration and extinction memories.

74 C have recently been shown to play a role in self-administration and extinction of food seeking.

75 statement of drug seeking after operant drug self-administration and extinction of the drug-reinforce

76 t alone reinstates cocaine seeking following self-administration and extinction, but each treatment p

77 Following cocaine self-administration and extinction, female rats were ova

78 Despite comparable self-administration and extinction, females displayed a

79 sociated activity relates to activity during self-administration and extinction.

80 ct of rewarding social interaction on heroin self-administration and incubation of heroin craving and

81 ocyte CB(2)depletion also exacerbated JWH133 self-administration and inhibited antinociception.

82 diates nicotine-induced increases in cocaine self-administration and microglial activation.

83 s HS, accelerated the acquisition of cocaine self-administration and promoted persistent responding d

84 male rats through progressive ratio schedule self-administration and punishment-resistant responding,

85 nd hyperactivity and, thus, decrease cocaine self-administration and reduce cue-induced cocaine-seeki

86 Extinction from sucrose self-administration and reinstated sucrose seeking induc

87 ays, would reduce cocaine seeking in the rat self-administration and reinstatement model of addiction

88 were injected intracranially to reduce drug self-administration and reinstatement.

89 g levels of alcohol had no effect on cocaine self-administration and relapse to cocaine seeking.

90 instated cocaine seeking in a mouse model of self-administration and relapse, and found that either i

91 ur understanding of brain mechanisms of drug self-administration and relapse, but these mechanistic g

92 re we used a novel mouse model of aggression self-administration and relapse, in combination with imm

93 ogeneous profiles of dopamine binding during self-administration and relapse.

94 MCAM selectively reduced opioid self-administration and remained effective with repeated

95 us monkeys with a history of chronic ethanol self-administration and repeated abstinence.

96 FYN activity significantly attenuates heroin self-administration and responding for drug-paired cues

97 g Prosapip1 in mechanisms underlying alcohol self-administration and reward.

98 nsmission in different brain regions in drug self-administration and rodent models of relapse.

99 cebranopadol significantly decreased cocaine self-administration and significantly reduced cue-induce

100 ard (no-screen) or automatic (screen) social self-administration and social choice-induced abstinence

101 p between plasma aldosterone levels, ethanol self-administration and the expression of CYP11B2 and MR

102 receptor agonist exendin-4 reduced oxycodone self-administration and the reinstatement of oxycodone-s

103 nto the accumbens shell attenuated oxycodone self-administration and the reinstatement of oxycodone-s

104 GluR5-dependent LTD in animals after cocaine self-administration and withdrawal.

105 1) extinction or (2) abstinence from cocaine self-administration, and drug seeking behavior was measu

106 ant increases in alcohol preference, operant self-administration, and relapse.

107 enerated in the nucleus accumbens by cocaine self-administration, and subsequently mature after prolo

108 ular system in the PFC contribute to cocaine self-administration, and whether they recover with detox

109 mal models involving traditional cannabinoid self-administration approaches have been notoriously dif

110 the recommended adrenaline auto-injector for self-administration at discharge.

111 rewards and increased intracranial nicotine self-administration at high doses.

112 We demonstrate that prior cocaine self-administration attenuates attention and attention-r

113 task predicted greater escalation of cocaine self-administration behavior and greater motivation for

114 rna3 transcripts markedly increased nicotine self-administration behavior in rats (0.01-0.18 mg kg(-1

115 mum) into the IPn in rats increased nicotine self-administration behavior.

116 ns as modulating highly compulsive-like food self-administration behaviors that result from intermitt

117 However, Intermittent Access (IntA) cocaine self-administration better reflects human patterns of us

118 nt of rats with 6 mg/kg 6c s.c. reduces AMPH-self administration but not food self-administration.

119 stinct pathways after acquisition of ethanol self-administration but before extinction and reinstatem

120 on responding and reacquisition of oxycodone self-administration but had a weaker (nonsignificant) ef

121 the control, significantly decreased cocaine self-administration by 67% relative to baseline at great

122 rlies the behavioral potentiation of cocaine self-administration by sigma1R agonists in animal models

123 old-chain independence and the potential for self-administration can expand influenza vaccination cov

124 rocedure by introducing a screen between the self-administration chamber and the social-peer chamber;

125 Next, rats were removed from the self-administration chambers and were subjected to a 14

126 etreatment with CTDP-32476 inhibited cocaine self-administration, cocaine-associated cue-induced rela

127 rically, dose-dependently attenuated cocaine self-administration, cocaine-conditioned place preferenc

128 ut not AD1 following extended-access cocaine self-administration compared to saline controls.

129 This preclinical paradigm of drug self-administration concurrent with socio-sexual behavio

130 On day 14, rats were returned to the self-administration context for a 3 h heroin-seeking tes

131 iction, we have yet to ascertain how cocaine self-administration disrupts neural signals in anterior

132 ucing adverse consequences of continued drug self-administration (e.g., punishment or electric barrie

133 Cocaine self-administration elevated BNST PACAP, and BNST PACAP

134 Selective Daun02 lesioning of the self-administration ensemble (no-extinction) decreased c

135 Fos colabeling in vmPFC indicated that vmPFC self-administration ensembles project to NAc core while

136 these regions in regulation of punished EtOH self-administration (EtOH-SA).

137 During a progressive-ratio alcohol self-administration experiment, participants could press

138 active) phase with Npas2 mutation increasing self-administration, extinction responding, and reinstat

139 lcohol pre-exposure had no effect on cocaine self-administration, extinction responding, and reinstat

140 o identify mesolimbic dopamine signatures of self-administration, extinction, and relapse.

141 Rats underwent cocaine self-administration, followed by extinction training.

142 ousing during forced abstinence from cocaine self-administration for either 1 or 21 days.

143 eated MCAM administration decreased fentanyl self-administration for more than 2 months without alter

144 ion group, 74.0% (CI, 68.9% to 78.6%) in the self-administration group, and 76.4% (CI, 71.3% to 80.8%

145 Ethanol self-administration had no effect on AGM lung CYP2A prot

146 We examined the impact that prior cocaine self-administration had on firing in dorsal lateral stri

147 ly determine the acquisition rate of alcohol self-administration, highlighting this process as a key

148 explore reward deficits we used intracranial self-administration (ICSA) by directly injecting nicotin

149 f forced abstinence from intravenous cocaine self-administration in 10-week-old Sprague Dawley rats a

150 It also failed to maintain self-administration in a drug substitution test, suggest

151 cues has furthered our understanding of drug self-administration in animals and addiction in humans.

152 in context A, and reacquisition of oxycodone self-administration in context A.

153 s regulation in the development of voluntary self-administration in Drosophila SIGNIFICANCE STATEMENT

154 r site) reversed the escalation of oxycodone self-administration in HA rats but not in LA rats.

155 c tissue collected following cocaine or food self-administration in male mice.

156 e GluA1 increases induced by chronic cocaine self-administration in male rats.

157 Acute sleep deprivation increased sucrose self-administration in mice and altered the BLAp-NAc tra

158 anscription sites following extended cocaine self-administration in mice.

159 leep parameters disrupted by methamphetamine self-administration in non-human primates.

160 Treatment with Ro 61-8048 decreased nicotine self-administration in rats and monkeys, but did not aff

161 tle choice chronic ethanol intake or operant self-administration in rats before or after dependence.

162 ine potentiated the dose response of cocaine self-administration in rats, consistent with the effects

163 Using cocaine self-administration in rats, we link tolerance to cocain

164 accination also reduced fentanyl intravenous self-administration in rats.

165 a long duration of action, attenuates heroin self-administration in rhesus monkeys, suggesting it cou

166 is assessed after cessation of operant drug self-administration in rodents and monkeys.

167 idate a novel animal model of nicotine vapor self-administration in rodents with relevance to electro

168 e, but not modafinil, maintained intravenous self-administration in Sprague-Dawley rats similar to co

169 motivation for cocaine, heroin, and alcohol self-administration in the absence of N/OFQ function.

170 drug taking, we measured intravenous cocaine self-administration in wild-type (WT) and Npas2 mutant m

171 Both drugs attenuated alcohol self-administration in Wt rats but not in NOP (-/-) rats

172 In experiment 1, cocaine self-administration increased BNST PACAP transcript leve

173 Cocaine self-administration increases expression of GluA1 subuni

174 se in heroin seeking after cessation of drug self-administration (incubation of craving) was lower af

175 oxycodone seeking after cessation of opioid self-administration (incubation of opioid craving) was s

176 n model-based behavior, indicating that drug self-administration independently altered both reinforce

177 can be modeled in rodent studies where drug self-administration is followed by a period of abstinenc

178 ts were given extended access to intravenous self-administration (IVSA) of saline or nicotine.

179 Intravenous self-administration (IVSA) of various doses of nicotine

180 lly housed and underwent limited-access Meth self-administration (maximum 1 mg/kg/session).

181 ollectively support the utility of the vapor self-administration model for the preclinical assessment

182 emonstrate that the operant sufentanil vapor self-administration model has both face and construct va

183 so introduce a fully automatic social reward self-administration model that eliminates the intense wo

184 A rat heroin self-administration model was used to obtain translation

185 elapse vulnerability as assessed in a rodent self-administration model, indicating its therapeutic pr

186 ions and relapse-like behaviors in a cocaine self-administration model.

187 Drug self-administration models of addiction typically requir

188 Traditional self-administration models often include light or tone c

189 We show that rat morphine self-administration (MSA), a paradigm that effectively m

190 We show that heroin self-administration negatively regulates the actin-bindi

191 rhesus macaque model of FASD, involving oral self-administration of 1.5 g/kg ethanol per day beginnin

192 ADX71441 dose-dependently decreased alcohol self-administration of both dependent and non-dependent

193 neurobiology underlying relapse involve the self-administration of cocaine alone, whereas many, if n

194 We previously found that self-administration of cocaine increases AMPA glutamate

195 We found that self-administration of cocaine, but not of saline, disru

196 gressively intensifies after withdrawal from self-administration of cocaine, methamphetamine, and oth

197 commonly identified with habitual nonmedical self-administration of drugs.

198 her handling nor pDNA-IL-10 treatment alters self-administration of food or sucrose rewards.

199 e and model-based processes before and after self-administration of methamphetamine or saline.

200 We examined potential routes for self-administration of molecular imaging agents in the f

201 bserved strong motivation to acquire operant self-administration of opportunities to aggress and rela

202 opamine (NAcc DA) response to amphetamine or self-administration of the drug using a lever press oper

203 of acute and repeated MCAM administration on self-administration of the high-efficacy mu opioid recep

204 ontaneous neuropathic pain through on-demand self-administration of the selective CB(2) agonist JWH13

205 acted abstinence following long-term ethanol self-administration on the central nucleus of the amygda

206 tion, MCAM and naltrexone decreased fentanyl self-administration on the day of treatment, with attenu

207 In contrast, BCP failed to alter food self-administration or cocaine-induced hyperactivity.

208 We also found no sex differences in heroin self-administration or the strong preference for the pal

209 Additionally, we showed that our self-administration paradigm in mice recapitulated the s

210 We developed a voluntary, gelatin oral self-administration paradigm that allowed male and femal

211 ion in an intra-VTA (ventral tegmental area) self-administration paradigm.

212 iming drink of alcohol followed by 3 1-hour, self-administration periods during which they had ad-lib

213 ocaine self-administration procedure [puzzle self-administration procedure (PSAP)] that required rats

214 addicts, we first developed a novel cocaine self-administration procedure [puzzle self-administratio

215 ent 2, we developed a fully automatic social self-administration procedure by introducing a screen be

216 alcohol using a two-bottle choice or operant self-administration procedure.

217 udies using conditioned place preference and self-administration procedures followed by a period of a

218 ical studies using Long Access (LgA) cocaine self-administration procedures suggest D-amphetamine may

219 y utilized the two-bottle choice and operant self-administration procedures to investigate neuroanato

220 n and palatable food was enhanced in operant self-administration procedures.

221 by the conditioned place preference and drug self-administration procedures.

222 eover, 3 weeks of daily (1 h) nicotine vapor self-administration produced addiction-like behaviors, i

223 nally, 3 weeks of daily (1 h) nicotine vapor self-administration produced cardiopulmonary abnormaliti

224 IntA cocaine self-administration produced psychomotor (locomotor) sen

225 me mouse, we used a dual cocaine and sucrose self-administration protocol allowing reward-specific se

226 Transgenic rats were trained on a heroin self-administration protocol in which a light/tone cue w

227 is needed for DHE delivery enabling painless self-administration, quick onset of action, and high bio

228 In a substitution test, cocaine self-administration rats displayed a progressive reducti

229 rug use predicted subsequent methamphetamine self-administration; rats with lower model-free behavior

230 y under LgA conditions and, like LgA cocaine self-administration, reduced CRF immunodensity in the ce

231 Operant self-administration reflected drug-taking to alleviate s

232 In the light (inactive) phase, cocaine self-administration, reinforcement, motivation and extin

233 onkeys, focusing on whether they reduce drug self-administration, reinstatement of drug seeking, and

234 Here, we used a modified self-administration/reinstatement procedure combined wit

235 rewarding social interaction suppresses drug self-administration, relapse to drug seeking, and brain

236 that pioglitazone reduces alcohol and opioid self-administration, relapse to drug seeking, and plays

237 teral VTA TH neuron activity profiles during self-administration, renewal, and reacquisition.

238 d-type TrkB expression after chronic cocaine self-administration reverses the sustained increase in d

239 of the Ras-ERK signaling cascade, on cocaine self-administration (SA) in male mice.

240 r of the transcriptional response to cocaine self-administration (SA) in PFC.

241 However, these self-administration (SA) models do not include adverse c

242 tations in reward circuits following cocaine self-administration (SA) underlie reinstatement of drug-

243 ve ingredient in marijuana, as assessed with self-administration (SA), has only been established in N

244 lop a rodent model of adolescent cannabinoid self-administration (SA), using the synthetic cannabinoi

245 ts previously exposed to intravenous cocaine self-administration (SA).

246 conditioned place preference and aggression self-administration, seeking, and relapse, highlighting

247 Cocaine self-administration selectively and persistently up-regu

248 the unit fentanyl dose available during the self-administration session 10-fold empirically determin

249 discrete motivational states during a single self-administration session.

250 PET scans and performed two types of cocaine self-administration sessions in the laboratory as follow

251 ine infusions increased across trials during self-administration sessions using a fixed-ratio reinfor

252 le food was then restricted to daily operant self-administration sessions using fixed ratio 1, 3, and

253 h 24-h energy intake and fixed-ratio operant self-administration sessions, and withdrawal-like irrita

254 Recently, studies using intermittent-access self-administration showed increased motivation to self-

255 ale and female rats with a history of heroin self-administration showed incubation of heroin craving

256 Studies using continuous-access drug self-administration showed that cocaine seeking increase

257 and behavioral alterations following cocaine self-administration.SIGNIFICANCE STATEMENT Drug-induced

258 e have previously shown that methamphetamine self-administration significantly disrupts activity-base

259 tant NMDA receptor (NMDAR) activation during self-administration, similar to cocaine-induced long-ter

260 mice with low striatal D2Rs acquired cocaine self-administration similarly to littermate controls and

261 There were no differences in social self-administration, social choice-induced abstinence, a

262 These results suggest that cocaine self-administration strengthens action-outcome encoding

263 tinic receptors (nAChRs) can reduce nicotine self-administration, suggesting that a positive alloster

264 failed to alter BCP's action against cocaine self-administration, suggesting the involvement of non-C

265 a) reversed BCP-induced reduction in cocaine self-administration, suggesting the involvement of PPARa

266 orcing effect of cocaine in an operant-based self-administration task.

267 for and intake of cocaine in an intravenous self-administration test.

268 ed rats following intermittent-access heroin self-administration that identifies subgroups as addicti

269 roin (20 mug/infusion) and ethanol (10% v/v) self-administration, they showed significantly lower dru

270 ses of relapse after extinction from cocaine self-administration to assess how cocaine use affects t-

271 rat model of sequential cocaine and alcohol self-administration to test the hypothesis that this com

272 abstinence from intravenous methamphetamine self-administration, to demonstrate that the activation

273 given for five consecutive days during which self-administration took place in the morning.

274 o lowered the break-point (BP) for oxycodone self-administration under a progressive-ratio schedule o

275 s toxoid conjugate vaccine to alter fentanyl self-administration using a fentanyl-vs.

276 we have developed a novel method of cannabis self-administration using response-contingent delivery o

277 We have developed a novel model of cannabis self-administration using response-contingent delivery o

278 s shell to play dissociable roles in cocaine self-administration versus extinction, respectively.

279 ide exchange factor RasGRF2 mediates cocaine self-administration via an ERK-dependent mechanism, wher

280 The impact of ethanol self-administration was also investigated, with and with

281 ined to self-administer cocaine, after which self-administration was extinguished and then reinstated

282 between [(11)C]GR103545 binding and cocaine self-administration was seen: greater KOR availability w

283 Subsequent nicotine self-administration was significantly higher among non-s

284 vailability and phosphorylation, and cocaine self-administration, we tested the effects of chemogenet

285 to elucidate how VU0364572 modulates cocaine self-administration, we then examined its long-term effe

286 ce preference (CPP) and saccharin (0.2% w/v) self-administration were also investigated.

287 Sex differences in intravenous (IV) fentanyl self-administration were examined under a fixed-ratio (F

288 A neurons inhibited cocaine, but not heroin, self-administration, whereas activation of SNr GABA neur

289 of VTA DA neurons reduced intravenous heroin self-administration, whereas activation of these neurons

290 rsion and inhibited cocaine, but not heroin, self-administration, whereas optogenetic activation of S

291 this bias was further exacerbated by cocaine self-administration, whereas the choice pattern of optim

292 re reduced in rats following methamphetamine self-administration, which was due to a decrement in the

293 in D1-MSNs blocks drug seeking after cocaine self-administration, while enhancing the fission promoti

294 played a progressive reduction in CTDP-32476 self-administration with an extinction pattern of drug-t

295 A neurons caused a robust increase in heroin self-administration with an extinction pattern, suggesti

296 try, pharmacology, biochemistry, and cocaine self-administration with economic demand analysis to dem

297 group, and 76.4% (CI, 71.3% to 80.8%) in the self-administration-with-reminders group.

298 of the drug-reinforced action during cocaine self-administration, without affecting cue-induced reins

299 of psychostimulant abuse, including cocaine self-administration, without the side effects characteri

300 We examined whether intermittent cocaine self-administration would potentiate incubation of cravi