ライフサイエンスコーパス: self-renewal

1 ts for Bmi-1 expression (marker of stem cell self-renewal).

2 h its assembly factor CAL1, drives stem cell self-renewal.

3 icient to drive HSC quiescence and long-term self-renewal.

4 stasis by regulating breast cancer stem cell self-renewal.

5 arks including proliferation, apoptosis, and self-renewal.

6 tical role in breast cancer stem cell (BCSC) self-renewal.

7 h multiple target genes related to stem cell self-renewal.

8 ed myeloid progenitor cell proliferation and self-renewal.

9 el and the 3D format were important for HSPC self-renewal.

10 f genes involved in cell differentiation and self-renewal.

11 wth, promoted differentiation, and repressed self-renewal.

12 eased alveolar differentiation and decreased self-renewal.

13 differentiation and an increase in malignant self-renewal.

14 important for macrophage differentiation and self-renewal.

15 topurine yet show impaired proliferation and self-renewal.

16 n, differentiation dynamics, and organ-level self-renewal.

17 NuMA from LGN binding, thereby favoring TIC self-renewal.

18 expression of HOX genes, critical for their self-renewal.

19 or a signaling gradient necessary for tissue self-renewal.

20 aling and greater intestinal stem cell (ISC) self-renewal.

21 k in differentiation and increased malignant self-renewal.

22 ndoderm, and inhibiting ERK supports ES cell self-renewal(1).

23 m while retaining their capacity to re-enter self-renewal(2).

24 reveals a molecular framework that explains self-renewal, aberrant differentiation, and SCC growth i

25 o TAZ protein stability supports cancer cell self-renewal abilities in both in vitro and in vivo sett

26 cancer cells can be selectively deprived of self-renewal ability by interfering with their epigeneti

27 panies are following suit, harnessing iPSCs' self-renewal ability to manufacture cell therapies that

28 racteristics, trophic activity, high invitro self-renewal ability, and can be readily engineered to e

29 induces a loss of HSC quiescence, symmetric self-renewal ability, and renders HSC more vulnerable to

30 reduction of TAZ protein levels and loss of self-renewal ability, which could be reversed by overexp

31 nd rescue of TEAD4 expression restores their self-renewal ability.

32 egative form of RUNX1, resulting in enhanced self-renewal activity in hematopoietic stem/progenitor c

33 Here, we demonstrate that LST-1 self-renewal activity resides within a predicted disorde

34 int mutations of these motifs abrogate LST-1 self-renewal activity.

35 tiproliferative therapies may fail to target self-renewal, allowing for relapse.

36 and stemnness markers, sphere formation and self-renewal, along with growth of tumors and establishe

37 regulators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target.

38 and radiotherapy response by inhibiting BCSC self-renewal and associated pluripotency.

39 (2+) oscillations, recognizing that zG layer self-renewal and cell heterogeneity may complicate this

40 by epidermal stem cells (ESCs) that balance self-renewal and cell-fate decisions to establish a prot

41 ascular niche regulating balance between HSC self-renewal and commitment.

42 Low-dose iAs increased self-renewal and decreased differentiation of human PrSP

43 ological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiat

44 ic stem cell presumed to only be forced into self-renewal and differentiation by injury.

45 y regulatory factors controlling trophoblast self-renewal and differentiation have been poorly elucid

46 The niche controls stem cell self-renewal and differentiation in animal tissues.

47 l-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, a

48 s factor, SOX2, by cytokine stimuli controls self-renewal and differentiation in cells.

49 of the kinetics of progenitor choice between self-renewal and differentiation in vivo is, due to the

50 The balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a healt

51 Precise regulation of the choice between RG self-renewal and differentiation is critical for normal

52 The intricate balance between self-renewal and differentiation is governed by developm

53 Progenitor self-renewal and differentiation is often regulated by s

54 trated that Lrp5 and -6 are required for the self-renewal and differentiation of adult HSCs.

55 e haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem

56 Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem c

57 5-ITu), a commonly used Haspin inhibitor, on self-renewal and differentiation of mouse embryonic stem

58 naling pathway regulates the balance between self-renewal and differentiation of SCM and CM T cells,

59 turbing the regulatory programs that control self-renewal and differentiation of stem and progenitor

60 de-differentiation on the redistribution of self-renewal and differentiation probabilities also grea

61 emalignant mutations and their impact on HPC self-renewal and differentiation remain poorly understoo

62 s of hematopoietic stem cells (HSCs) balance self-renewal and differentiation to produce the diversit

63 ed rates of bronchiolar club progenitor cell self-renewal and differentiation were reduced, indicativ

64 Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous

65 ng to the indeterminate relationship between self-renewal and differentiation, variation in progenito

66 stem cells and governing the balance between self-renewal and differentiation.

67 ess encompasses the capability of a cell for self-renewal and differentiation.

68 ted distal prostate luminal lineages through self-renewal and differentiation.

69 through a balanced regulation of progenitor self-renewal and differentiation.

70 levels of H3K27me3 in genes regulating HSPC self-renewal and differentiation.

71 s are sought that can enact control over the self-renewal and directed differentiation of human pluri

72 s that maintain redox balance promote T cell self-renewal and enhance anti-tumor immunity.

73 he human intestinal stem cell niche supports self-renewal and epithelial function, but little is know

74 nd LGR5 in organ development, as well as the self-renewal and fitness of adult stem cells.

75 periments showed that MSCs and ECFCs induced self-renewal and genes associated with mesenchymal-epith

76 rough H1.0, Quisinostat inhibits cancer cell self-renewal and halts tumor maintenance without affecti

77 eration, which leads to complete loss of HSC self-renewal and HSC depletion.

78 FTO plays critical roles in cancer stem cell self-renewal and immune evasion and highlights the broad

79 neuronal differentiation, reduced progenitor self-renewal and increased apoptosis.

80 antibody (OMP-131R10/rosmantuzumab) impairs self-renewal and induces differentiation in AML patient-

81 erful approach with which to interrogate HSC self-renewal and lineage commitment and, more broadly, t

82 r dosage, opening perspectives for balancing self-renewal and lineage commitment.

83 o reinforce Notch signaling, instructing ISC self-renewal and lineage decisions.

84 nscriptional regulatory mechanisms to govern self-renewal and lineage-specific differentiation progra

85 d adult stem cells possess the capability of self-renewal and lineage-specific differentiation.

86 y mechanisms that control ESC specification, self-renewal and maintenance during different stages of

87 required in a cell-intrinsic manner for the self-renewal and maintenance of large peritoneal macroph

88 mor growth and metastasis by increasing BCSC self-renewal and may serve as a novel target for chemoth

89 apse-free survival, as well as enhances BCSC self-renewal and metastatic outgrowth.

90 020) provide evidence that APA regulates HSC self-renewal and multi-potency by affecting stem cell ac

91 d that these stem/progenitor-like cells have self-renewal and multilineage differentiation potential.

92 epigenetic systems play minor roles in mESC self-renewal and naive ground state establishment by cor

93 inished progenitor pools, impaired stem cell self-renewal and nearly complete loss of competitive rep

94 oRNAs (miRNAs) are dispensable for stem-cell self-renewal and neuron production but essential for tim

95 Abeta42 peptides, but to impairments in the self-renewal and neuronal differentiation of AHNPCs that

96 eural progenitor cells (NPCs), Ybx1 controls self-renewal and neuronal differentiation.

97 pports a model whereby alpha-cells expand by self-renewal and not via specialized progenitors.

98 The niche controls stem cell self-renewal and progenitor differentiation for maintain

99 t the single-cell level and demonstrate that self-renewal and proliferation are distinct in AML.

100 rate that the transcriptional foundations of self-renewal and proliferation are distinct in LSCs as t

101 Self-renewal and proliferation are separate functions in

102 sion in the crypt Osx+ cells is critical for self-renewal and proliferation.

103 AMPK activates KLF4 in progenitors to reduce self-renewal and promote PC fate, whereas AMPK-PGC1alpha

104 ASPN loss impaired MSC self-renewal and promoted terminal cell differentiation.

105 ncluding Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell l

106 ling on monocyte/macrophage differentiation, self-renewal and repairing ability, as evidenced by the

107 ally attenuate leukemia stem/initiating cell self-renewal and reprogram immune response by suppressin

108 Cancer stem cells possess the capacity for self-renewal and resistance to chemotherapy.

109 ation mouse and human embryos by controlling self-renewal and stemness of trophoblast progenitors wit

110 have been demonstrated to regulate mouse HSC self-renewal and stemness, we screened small molecules t

111 he is compartmentalized to control stem cell self-renewal and stepwise progeny differentiation.

112 ALL, which is characterized by the aberrant self-renewal and subsequent oncogenic transformation of

113 C homeostasis in vitro, leading to increased self-renewal and suppressed differentiation.

114 al properties of adult tissue stem cells are self-renewal and the ability to generate diverse residen

115 quirement for Ldb1 in Lmo2-induced thymocyte self-renewal and thymocyte radiation resistance and for

116 epithelial cells (TECs) use LXRalphabeta for self-renewal and thymocytes for negative selection.

117 n embryos to transition away from heightened self-renewal and toward competency for lineage specifica

118 tively active isoform of MBNL1 inhibited GSC self-renewal and tumor initiation in orthotopic transpla

119 Lck-I, results in significant inhibition of self-renewal and tumor-sphere formation.

120 not abrogate their stem-ness, as measured by self-renewal and tumorigencity.

121 oacylglycerol lipase (MAGL), to regulate the self-renewal and tumorigenicity of GSCs through producti

122 ed that only CD69(High) LSCs were capable of self-renewal and were poorly proliferative.

123 , reduced reconstitution potential, impaired self-renewal, and a proinflammatory phenotype.

124 trol of cell proliferation, differentiation, self-renewal, and epithelial-mesenchymal transition.

125 g those that regulate the cycle, metabolism, self-renewal, and immune cell signaling.

126 resulted in de-repression of IHH, decreased self-renewal, and increased sensitivity to chemotherapy

127 Skin undergoes constant self-renewal, and its functional decline is a visible co

128 ne deacetylase, in driving RMS tumor growth, self-renewal, and migration/invasion.

129 ibutes to impaired differentiation, enhanced self-renewal, and proliferation of immature myeloid cell

130 ity control might be implicated in HSC fate, self-renewal, and regenerative potential.

131 derived stem cells requires Wnt proteins for self-renewal, and this subset specifically relies on Wnt

132 acetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of dis

133 RSF3 expression promoted cell proliferation, self-renewal, and tumorigenesis.

134 ckade decreases lineage bias, proliferation, self-renewal, and tumorigenicity.

135 We investigated whether proliferation and self-renewal are separate functions in LSCs as they ofte

136 DOT1L is dispensable for ESC self-renewal but is required for establishing the proper

137 l) as a novel regulator for SSC survival and self-renewal, but how these functions are controlled by

138 shown that Wnt plays a priming role for ISC self-renewal by inducing RSPO receptor LGR5 expression.

139 l checkpoint that governs HSC quiescence and self-renewal by Rheb-mediated restriction of mTOR activi

140 We found that this self-renewal can be reversed by oral administration of a

141 ulation of archetypal hPSC enriched for high self-renewal capacity (ESR) has distinct properties rela

142 dormant state, with the potential to recover self-renewal capacity and contribute to disease recurren

143 Targeting MUC1-C decreases PC self-renewal capacity and tumorigenicity, suggesting a p

144 nhances adult prostate stem/progenitor cells self-renewal capacity in both organoid and allograft ass

145 Full differentiation potential along with self-renewal capacity is a major property of pluripotent

146 vity in basal cells as shown by the impaired self-renewal capacity of Bmp5-deficient stem/progenitor

147 DDX3 and PAF1 to the Nanog promoter, and the self-renewal capacity of CSCs, were decreased in cells i

148 reater potency to inhibit cell viability and self-renewal capacity of FGbeta(3) cells.

149 Forced expression of miR-486-5p enhanced the self-renewal capacity of GBM neurospheres, and inhibitio

150 t there is considerable heterogeneity in the self-renewal capacity of HSCs ex vivo.

151 The self-renewal capacity of multipotent haematopoietic stem

152 ammosphere formation, indicating compromised self-renewal capacity.

153 ibit a stable phenotype and nearly limitless self-renewal capacity.

154 y irreversibly dampening satellite cell (SC) self-renewal capacity.

155 lly exhausted phenotype, marked by a loss of self-renewal capacity.

156 by leukemia stem cells (LSC), the cells with self-renewal capacity.

157 pment, relapse and metastasis; the intrinsic self-renewal characteristics and tumorigenic properties

158 The HSC self-renewal defect is rescued after cell transplantatio

159 CMT confirmed its role in regulating TAZ and self-renewal, demonstrating the potential utility of tar

160 are a class of cancer cells characterized by self-renewal, differentiation and tumorigenic potential.

161 ls and requires a controlled balance between self-renewal, differentiation, and quiescence.

162 erstanding of PSC metabolism and its role in self-renewal, differentiation, and somatic cell reprogra

163 m balancing forebrain-hindbrain lineages and self-renewal-differentiation choices in NPCs.

164 elopment, suggesting a common rule governing self-renewal/differentiation behaviors in mouse cortical

165 a biomolecule shown to control SC symmetric self-renewal divisions via the noncanonical WNT/planar c

166 t does not affect the mode or the outcome of self-renewal divisions.

167 ts associated with planar-oriented symmetric self-renewal divisions.

168 that hepatocytes are primarily maintained by self-renewal during normal liver homeostasis, as well as

169 sms underlying the spatiotemporal control of self-renewal during skeletal muscle repair.

170 cross 9 time points over 5 broad conditions: self-renewal, early neuronal differentiation, neural pre

171 Self-renewal epidermoid epithelia are continuously expos

172 emain largely undifferentiated and locked in self-renewal, even in the presence of differentiation st

173 (CD34(+), CD133(+), and ALDH(hi) cells) HSC self-renewal ex vivo.

174 Thus, MYC maintains self-renewal exclusively in CSCs by selectively binding

175 capable of stem cell-like behavior including self-renewal, expansion, and multipotency, resulting in

176 umor-reactive stem-like TILs were capable of self-renewal, expansion, persistence, and superior antit

177 estrates gene expression programs to control self-renewal for the maintenance of mESC state.

178 n cell-cycle gene expression and increase in self-renewal gene expression are coregulated by SOX2 and

179 SCs demonstrate that IKZF2 regulates a HOXA9 self-renewal gene expression program and inhibits a C/EB

180 e Yap/Tead complex as a key regulator of the self-renewal gene network in organ of Corti progenitor c

181 findings define and functionally validate a self-renewal gene profile of leukemia stem cells at the

182 ignaling pathway, RSPO-LGR4, upregulates key self-renewal genes and is essential for LSC self-renewal

183 transcriptional regulation of cell-cycle and self-renewal genes is orchestrated during these conversi

184 r RNA Polymerase II binding to proliferation/self-renewal genes such as MYC, CYR61, FGFBP1, EGFR, and

185 embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive.

186 necroptotic cell death, which underlies the self-renewal impairment after inhibiting BMI1.

187 proliferative features in vivo and enhanced self-renewal in a manner not observed with either mutati

188 self-renewal genes and is essential for LSC self-renewal in a subset of AML.

189 (p210)-induced CML by impairing survival and self-renewal in BCR-ABL1+ CD150+ lineage-negative Sca-1+

190 complexes which normally function to enforce self-renewal in bone marrow hematopoietic progenitors.

191 gnalling system that regulates cell fate and self-renewal in development and tissue homeostasis.

192 suppressive factor that inhibits cancer cell self-renewal in many cancer types, can be broadly induce

193 preserving LSC quiescence, and promoting LSC self-renewal in MLL-rearranged AML.

194 eness to undergo differentiation and loss of self-renewal in response to inflammation.

195 t loss of TEAD4 is associated with defective self-renewal in RPL-TSCs and rescue of TEAD4 expression

196 in which IGF1 together with Activin maintain self-renewal in the absence of fibroblast growth factor

197 tion of Gli1-targeted NSCs showing long-term self-renewal in the adult hippocampus.

198 ential drivers of hematopoietic survival and self-renewal in the bone marrow niche; how to apply this

199 Signals driving aberrant self-renewal in the heterogeneous leukemia stem cell (LS

200 s suggests that DRD2 is capable of promoting self-renewal in these cell lines, but that it is not act

201 ke cells derived from EpiSCs exhibit limited self-renewal in vitro and a gene expression signature li

202 ew presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses importan

203 sion of Bmi-1 (master regulator of stem cell self-renewal) in dental pulp stem cells.

204 gest that therapeutic strategies that target self-renewal, in addition to proliferation, are critical

205 of transcriptional regulators promoting hPSC self-renewal including ZNF398, a human-specific mediator

206 ays related to stem cell differentiation and self-renewal, including Notch, ERK/MAPK and Wnt/beta-cat

207 et programs shifts leukemia cell fate out of self-renewal into differentiation.

208 f-of-concept that targeting BMI1-related CSC self-renewal is a clinically relevant anti-cancer therap

209 nce that oncogene-induced loss of progenitor self-renewal is driven by eIF2B5-mediated translation of

210 panies differentiation, however, its role in self-renewal is less well understood.

211 p aberration in mice abnormally promotes HSC self-renewal leading to AML-like disease by altering the

212 n postimplantation mouse TSPCs impairs their self-renewal, leading to embryonic lethality before embr

213 y signaling pathways are known to control SC self-renewal, less is known about the mechanisms underly

214 transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhau

215 ppears to regulate tumor growth through cell self-renewal maintenance, and BPTF knockdown leads these

216 ions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic p

217 itigating HSPC differentiation and promoting self-renewal might result from an inhibition of excessiv

218 rategies: while under asymptotic conditions, self-renewal models of the same universality class canno

219 orchestrates muscle stem cell proliferation, self-renewal, myoblast differentiation, and ultimately f

220 Cs depleted of PAF1 downregulated markers of self-renewal (NANOG, SOX9, and beta-CATENIN), of CSCs (C

221 re/time course of transcriptional responses, self-renewal of APhi, and the contribution from bone mar

222 ion of HDAC11 not only significantly reduces self-renewal of cancer stem cells (CSCs) from NSCLC but

223 XEN445 inhibited the self-renewal of cancer stem cells (CSCs) in vitro and TN

224 factors (e.g., interleukin-6 [IL-6]) promote self-renewal of dental pulp stem cells cultured in low-a

225 t endothelial cell-derived IL-6 enhances the self-renewal of dental pulp stem cells via STAT3 signali

226 initiated signaling is necessary to maintain self-renewal of dental pulp stem cells.

227 n graft, without perturbing repopulation and self-renewal of edited HSCs.

228 actor that is essential for pluripotency and self-renewal of embryonic stem cells(3).

229 e mechanisms of Hydra aging, we compared the self-renewal of epithelial stem cells in these two strai

230 Persistent self-renewal of ESCs was supported both in Atp2b1(-/-)Tc

231 regeneration of beta cells provides hope for self-renewal of functional insulin-secreting cells follo

232 TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells.

233 let-7 miRNAs are essential for limiting the self-renewal of HC progenitor cells.

234 uired for normal differentiation, but limits self-renewal of hematopoietic stem cells (HSCs) during a

235 MPN risk is associated with the function and self-renewal of HSCs.

236 However, the potential for long-term self-renewal of individual NSCs within the adult brain r

237 Self-renewal of intestinal stem cells is controlled by W

238 reported, and only LGR4 is essential for the self-renewal of intestinal stem cells.

239 r the development and maintenance of AML and self-renewal of leukemia stem/initiating cells (LSCs/LIC

240 kade of Gsk3alpha/beta and Mek1/2 to sustain self-renewal of mESCs in combination with leukaemia inhi

241 xm1 is required for survival, quiescence and self-renewal of MLL-AF9 (MA9)-transformed leukemia stem

242 fic Cic deletion increases proliferation and self-renewal of neural stem cells.

243 FTO inhibited the self-renewal of ovarian CSC and suppressed tumorigenesis

244 nizes the effects of hypoxia on preferential self-renewal of SMSCs through dephosphorylation or activ

245 3A and TET2 confer an advantage by enhancing self-renewal of stem and progenitor cells and inhibiting

246 1 (Msi1), which mediates the maintenance and self-renewal of stem cells and acts as a translational r

247 and SH2B3) encode proteins that regulate the self-renewal of stem cells(14-16).

248 tically, NRP1 cell-intrinsically limited the self-renewal of the CD44(+)PD1(+)TCF1(+)TIM3(-) progenit

249 ly optimized to promote long-term health and self-renewal of the crypts which were assayed in situ by

250 r and immunological processes regulating the self-renewal of the local pool of ILC2s in the context o

251 nt-responsive stem cells that contributed to self-renewal of the tissue.

252 conserved molecular mechanisms that regulate self-renewal of trophoblast progenitors and their associ

253 matical model to estimate the probability of self-renewal or differentiation of cortical progenitor b

254 ; their progeny either remain as stem cells (self-renewal) or proliferate and differentiate to enter

255 ed three novel oncogenic pathways to promote self-renewal, p53 loss, and Nanog transcription in TICs.

256 on polysomes and enhancing proliferative and self-renewal pathways.

257 Our results showed that DON decreased the self-renewal potential and metastatic ability of tumor c

258 ophage progenitors (GMPs) and acquisition of self-renewal potential in a non-self-renewing progenitor

259 esis is sustained by mitotic germ cells with self-renewal potential known as undifferentiated spermat

260 ain in quiescence to sustain their long-term self-renewal potential.

261 oth physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that p

262 e hematopoietic precursors and promote their self-renewal, proliferation, and differentiation.

263 egulation of stem cell quiescence, survival, self-renewal, proliferation, senescence, and differentia

264 ossess stem cell-like properties of enhanced self-renewal/proliferation, and proliferation of latentl

265 ESC cytonemes select self-renewal-promoting Wnts via crosstalk between Wnt re

266 nal centre B cells with enhanced fitness and self-renewal properties, ultimately leading to aggressiv

267 HP1gamma-deleted ESCs have a slower self-renewal rate and an impaired ability to differentia

268 ided stem cells having the largest effective self-renewal rate.

269 teracted EZH2 and SOX2 during cell-cycle and self-renewal regulation to restrain tumorigenesis.

270 ation patterns are maintained during lineage self-renewal remain unclear.

271 etitive antigenic stimulation impairs T cell self-renewal remains poorly defined.

272 pdSCs are serine auxotrophs whose growth and self-renewal require abundant exogenous serine.

273 Here, we tested the hypothesis that PCFU self-renewal requires GLIS family zinc finger 3 (GLIS3),

274 To identify strategies of stem cell self-renewal requires that different models of stem cell

275 chondroprogenitors acquire the capacity for self-renewal, resulting in the formation of large, stabl

276 onal networks associated with cell cycle and self-renewal.See related commentary by Pardini and Drago

277 nance is regulated by a balance between BMP5 self-renewal signal and GATA3 dampening activity.

278 that suppression of ICMT results in reduced self-renewal/stemness in KRAS-driven pancreatic and brea

279 canonical asymmetric vs. symmetric stem cell self-renewal strategies and are distinguished by a conse

280 nges and opportunities to identify stem cell self-renewal strategies: while under asymptotic conditio

281 Second, MDM2 promoted CSC self-renewal, the expression of stem cell factors, and C

282 esses multiple extrinsic pathways that favor self-renewal, thereby ensuring robustness of neuronal fa

283 Although the SEPs are capable of self-renewal, they are erythroid restricted.

284 tes aged muscle regeneration by enhancing SC self-renewal through active repression of p16(Ink4a) tra

285 role for HNRNPK in maintaining adult tissue self-renewal through both transcriptional and post-trans

286 Targeting of uncontrolled self-renewal through inhibition of stem cell-related sig

287 During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of

288 etic stem cells (HSCs) have the capacity for self-renewal to maintain the HSCs' pool and the ability

289 d hyperproliferation with loss of progenitor self-renewal to restrain aberrant growth and tumorigenes

290 isoform switch to regulate glioma stem cell self-renewal, tumorigenicity, and progression.

291 a subpopulation of cancer cells endowed with self-renewal, tumorigenicity, pluripotency, chemoresista

292 L as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC(tg

293 e associated with inhibition of survival and self-renewal via depletion of c-Myc protein and p53 acti

294 Alveolar Type II progenitor cell density and self-renewal were maintained per unit tissue area with a

295 ow CMA activity promotes embryonic stem cell self-renewal, whereas its up-regulation enhances differe

296 wed that H3.3 K27M enhanced neural stem cell self-renewal while preserving regional identity.

297 anisms that coordinate the rate of stem cell self-renewal with differentiation at a population level

298 ured H2-K1 cells eventually develop impaired self-renewal with features of senescence, limiting compl

299 niche to maintain stemness but must balance self-renewal with the production of daughters that leave

300 We show that microglia were replenished via self-renewal, with no contribution from nonmicroglial li