ライフサイエンスコーパス: semi-invariant

1 udies focus on type I NKT cells that express semi-invariant aB T cell receptors (TCR) and recognize a

2 vated by CD1d-glycolipid complexes through a semi-invariant alphabeta T cell receptor (NKT TCR).

3 Natural killer T cells express a conserved, semi-invariant alphabeta T cell receptor that has specif

4 Thymocytes expressing the NKT cell semi-invariant alphabeta TCR are thought to undergo agon

5 Their semi-invariant alphabeta TCRs recognize isoglobotrihexos

6 ural killer T cells (NKT cells) expressing a semi-invariant CD1d-reactive T cell receptor (invariant

7 caque spleen-derived Valpha24(+) T cells are semi-invariant double-negative cells with effector memor

8 The semi-invariant MAIT T-cell antigen receptor (TCR) recogn

9 T TCR/MR1 complex structure explains how the semi-invariant MAIT-TCR engages the nonpolymorphic MR1 p

10 MR1 presenting a variety of ligands, how the semi-invariant mouse MAIT TCR binds mouse MR1-ligand rem

11 The semi-invariant natural killer (NK) T-cell receptor (NKTc

12 Semi-invariant natural killer T (iNKT) cells are self-re

13 Semi-invariant natural killer T (NKT) cells are innate-l

14 Utilizing induced expression of the semi-invariant NKT cell TCR on double positive thymocyte

15 Semi-invariant NKT cells are thymus-derived innate-like

16 mammalian phospholipids, demonstrating that semi-invariant NKT TCRs have a capacity for private Ag s

17 and that they recognize; their expression of semi-invariant or diverse T cell receptors; the structur

18 cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire

19 ted invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-

20 ssociated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that detects microb

21 at recognize microbial metabolites through a semi-invariant T cell receptor (TCR).

22 Both the semi-invariant T cell receptor of MAIT cells and the res

23 (MAIT) are innate-like T cells expressing a semi-invariant T cell receptor restricted to the non-cla

24 natural killer T (NKT) cells expressing the semi-invariant T cell receptor V(alpha)14J(alpha)18 requ

25 iated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize micro

26 They express semi-invariant T cell receptors, which recognize glycoli

27 lls comprise a separate T lineage expressing semi-invariant T cell receptors.

28 osal-associated invariant T (MAIT) cells are semi-invariant T cells specifically recognizing riboflav

29 rved alphabeta T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the M

30 ry T cells that comprise type I (express the semi-invariant T-cell receptor [TCR] and can be detected

31 Type I NKT cells use a semi-invariant T-cell receptor and react with alpha-gala

32 itive CD4+CD8+ thymocytes that rearrange the semi-invariant T-cell receptor found on mature NKT cells

33 l-associated invariant T (MAIT) cells have a semi-invariant T-cell receptor that allows recognition o

34 ond to intra-hepatic cytokines, and (via the semi-invariant T-cell receptor) to bacteria translocated

35 population characterized by expression of a semi-invariant T-cell receptor, rapidly produce copious

36 regulatory T cells that recognize CD1d via a semi-invariant TCR (iNKT-TCR).

37 ell-characterized type I NKT cells express a semi-invariant TCR and can recognize both alpha- and bet

38 -associated invariant T (MAIT) cells express semi-invariant TCR and restriction by nonclassical MHC c

39 NKT cells that express the semi-invariant TCR are innate-like lymphocytes whose fun

40 , posing the interesting question of how the semi-invariant TCR can bind to such structurally distinc

41 ulation characterized by the expression of a semi-invariant TCR capable of recognizing bacterial prod

42 ls, or invariant NKT (iNKT) cells, express a semi-invariant TCR characterized by its unique Valpha14-

43 They are an innate-like subset featuring a semi-invariant TCR repertoire that drives their well-rec

44 tudies on NKT cells focused on a subset with semi-invariant TCR termed invariant NKT cells, the major

45 l-associated invariant T (MAIT) cells have a semi-invariant TCR Valpha-chain, and their optimal devel

46 In adults they dominantly express the semi-invariant TCR Valpha7.2, the canonical feature of m

47 Although MAIT cells are identified by a semi-invariant TCR, their phenotypic and functional hete

48 ided into two groups: type I NKT cells use a semi-invariant TCR, whereas type II express a relatively

49 ecognize self-glycolipids by virtue of their semi-invariant TCR, which triggers NKT cell lineage comm

50 KT) cells have at least two subsets: type I, semi-invariant TCRalpha chain-expressing (Valpha14Jalpha

51 How expression of canonical semi-invariant TCRs leads to innate-like effector differ

52 hilin family they interact with, whereas the semi-invariant TCRs of iNKT and mucosal-associated invar

53 Contrastingly, Vdelta2(+) T cells express semi-invariant TCRs, which are present at birth and shar

54 fraction of the autoreactive T cells express semi-invariant TCRs.

55 availability of potent Ags and tetramers for semi-invariant/type I NKT cells allowed this population

56 Semi-invariant/type I NKT cells are a well-characterized

57 Natural killer T (NKT) cells express a semi-invariant Valpha14 T cell receptor (TCR) and recogn

58 Invariant NKT (iNKT) cells expressing a semi-invariant Valpha14 TCR recognize self and foreign l

59 The semi-invariant Valpha14Jalpha18 T cell receptor (TCR) is

60 s that is dependent on their expression of a semi-invariant Valpha7.2(+) TCR.

61 KTgammadelta T cells uses TCRs composed of a semi-invariant Vdelta6.3/6.4-Ddelta2-Jdelta1 chain toget