ライフサイエンスコーパス: seminiferous

1 the MPW can be used to model and manipulate seminiferous cord development, including induction of fo

2 We conclude that seminiferous cord reformation during the MPW results in

3 nd this is associated with the maturation of seminiferous cords and maturation of PGCs into fetal spe

4 , but result from rupture of normally formed seminiferous cords beyond e20.5.

5 olutely required for the construction of the seminiferous cords of the testis.

6 F-1(-/-) mice resulting in the disruption of seminiferous cords with limited cord structure remaining

7 ggregation, ectopic Sertoli cells, malformed seminiferous cords) is not evident until after the MPW.

8 during the MPW results in reconstitution of seminiferous cords.

9 ee of these are expressed in a region of the seminiferous epithelia (SE) rich in meiotically active c

10 The seminiferous epithelial cycle and spermatogenic wave are

11 od-testis barrier (BTB) at stage VIII of the seminiferous epithelial cycle for further development.

12 Differentiating 12 stages of the mouse seminiferous epithelial cycle is vital towards understan

13 that occur concurrently at stage VIII of the seminiferous epithelial cycle of spermatogenesis are unk

14 (BTB) restructuring at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis to faci

15 ring its cyclic restructuring throughout the seminiferous epithelial cycle of spermatogenesis.

16 extensive restructuring at stage VIII of the seminiferous epithelial cycle to facilitate the transit

17 gical barrier breakdown in all stages of the seminiferous epithelial cycle, except at stage VIII when

18 esponsible for the early onset of the severe seminiferous epithelial degeneration observed in SRC-1(+

19 ted mice lacking all RALDH activities in the seminiferous epithelium (SE).

20 s is compromised, germ cells detach from the seminiferous epithelium and infertility often results.

21 connexin43, which was present throughout the seminiferous epithelium and not restricted to the BTB as

22 and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, resp

23 d to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave.

24 poral order of gene transcription within the seminiferous epithelium are poorly understood.

25 inus, was found to be transported across the seminiferous epithelium at stages VIII-IX of the epithel

26 otic germ cell development take place in the seminiferous epithelium behind the BTB.

27 e same stage in development, stage IV of the seminiferous epithelium cycle, equivalent to mid-pachyne

28 ligand JAGGED-1 (JAG1) at stage VIII of the seminiferous epithelium cycle, therefore mediating germ

29 ogonia located in a niche at the base of the seminiferous epithelium delimited by Sertoli cells and p

30 that reside at the basal compartment of the seminiferous epithelium differentiate into more advanced

31 The localization of Cx43 in the seminiferous epithelium during (i) the normal epithelial

32 posing ends of adjacent Sertoli cells in the seminiferous epithelium during spermatogenesis.

33 uring that occur at the opposite ends of the seminiferous epithelium during spermatogenesis.

34 s cellular events that take place across the seminiferous epithelium during the epithelial cycle of s

35 modeling near the BM at opposite ends of the seminiferous epithelium during the epithelial cycle, kno

36 ce) to coordinate cellular events across the seminiferous epithelium during the epithelial cycle.

37 es to enter the adluminal compartment of the seminiferous epithelium for development into spermatozoa

38 Although the cycle and the wave of the adult seminiferous epithelium have been well characterised, pa

39 ression, shows that PDE8 is expressed in the seminiferous epithelium in a stage-specific manner.

40 AKAP9 robustly expressed across the seminiferous epithelium in adult rat testes, colocalizin

41 nally, expression of Aire was evident in the seminiferous epithelium in an age-dependent manner, as w

42 o critical cellular events that occur across seminiferous epithelium in mammalian testis during sperm

43 tects against late-onset degeneration of the seminiferous epithelium in mice and inhibits Leydig cell

44 Cellular events that occur across the seminiferous epithelium in the mammalian testis during s

45 ets of cellular events take place across the seminiferous epithelium in the testis.

46 of molecules between cells, and separate the seminiferous epithelium into basal and adluminal compart

47 hree MAPKs regulate adhesion function in the seminiferous epithelium is also presented.

48 ion of spermatids and their release from the seminiferous epithelium is AR dependent and maximally se

49 Its expression at the BTB in the seminiferous epithelium is stage specific, being lowest

50 ctions between adjacent Sertoli cells in the seminiferous epithelium near the basement membrane.

51 S) is an actin-rich adherens junction in the seminiferous epithelium of adult mammalian testes.

52 expression was the highest at the ES in the seminiferous epithelium of adult rat testes, most notabl

53 hosphorylation-dependent localization in the seminiferous epithelium of adult rat testes.

54 ith the TJ proteins occludin and ZO-1 in the seminiferous epithelium of adult rats.

55 co-localized to the site of apical ES in the seminiferous epithelium of the rat testis in immunohisto

56 specific adherens junction (AJ) type] in the seminiferous epithelium of the rat testis, we sought to

57 oses a challenge to deliver any drugs to the seminiferous epithelium of the testis, such as a nonhorm

58 iminate expression of a reporter gene in the seminiferous epithelium of transgenic mice, whereas the

59 as an adhesion and maturation factor of the seminiferous epithelium orchestrating spermiogenesis.

60 a show that the cycle and wave of the murine seminiferous epithelium originate at a much earlier stag

61 ) conferred by adjacent Sertoli cells in the seminiferous epithelium segregates post-meiotic germ cel

62 od-testis barrier (BTB) restructuring in the seminiferous epithelium that occur concurrently at stage

63 Sertoli cells are somatic cells in the seminiferous epithelium that orchestrate spermatogenesis

64 y disrupts Sertoli-germ cell adhesion in the seminiferous epithelium to facilitate germ cell migratio

65 tons takes place in Sertoli cells across the seminiferous epithelium to support spermatogenesis.

66 Sepp1 trafficking in the seminiferous epithelium was studied using conventional m

67 d Sertoli cells as the only cell type in the seminiferous epithelium with detectable ApoER2 expressio

68 permiogenesis, age-dependent degeneration of seminiferous epithelium, and disorder of cholesterol hom

69 and sloughing off of spermatogenic cells in seminiferous epithelium, and lack of mature spermatids i

70 sloughing of postmeiotic germ cells from the seminiferous epithelium, and marked reduction in the num

71 ed tracks, and laid perpendicular across the seminiferous epithelium, and prominently expressed at th

72 of germ cells, vacuole formation within the seminiferous epithelium, and reduced sperm production.

73 n the transport of synthetic F5-peptide into seminiferous epithelium, and thus Slc15a1 is a novel tar

74 In the seminiferous epithelium, Eps8 is localized to actin-base

75 involvement in junction restructuring in the seminiferous epithelium, especially at the ectoplasmic s

76 ed Sertoli cells, a somatic component of the seminiferous epithelium, exhibited significantly lower a

77 to survey all laminin chains in cells of the seminiferous epithelium, it was noted that alpha 2, alph

78 triking testicular pathology, with disrupted seminiferous epithelium, multinucleated giant cells, unc

79 In the seminiferous epithelium, Sertoli cells express TNFR1, wh

80 preferentially expressed in stages VII-VIII seminiferous epithelium, the androgen-dependent stages d

81 tact during the transit of spermatids in the seminiferous epithelium, which is associated with extens

82 averse the blood-testis barrier (BTB) in the seminiferous epithelium, which is reminiscent of viral p

83 morphology in postmeiotic germ cells in the seminiferous epithelium, which led to the complete arres

84 totic germ cells by Sertoli cells lining the seminiferous epithelium.

85 with apical ES and BTB restructuring in the seminiferous epithelium.

86 or of cell adhesion and BTB integrity in the seminiferous epithelium.

87 occurs within a highly organized tissue, the seminiferous epithelium.

88 tis in germ cells at the basal aspect of the seminiferous epithelium.

89 ween spermatids and Sertoli cells within the seminiferous epithelium.

90 t by controlling the microenvironment of the seminiferous epithelium.

91 function, leading to germ cell loss from the seminiferous epithelium.

92 ype A spermatogonia in the basal part of the seminiferous epithelium.

93 hich leads to germ cell exfoliation from the seminiferous epithelium.

94 .g., residual bodies, phagosomes) across the seminiferous epithelium.

95 d germ cells at the basal compartment in the seminiferous epithelium.

96 express stage-specifically at the BTB in the seminiferous epithelium.

97 epresenting spermatogenic development in the seminiferous epithelium.

98 ere is a lack of data on Ct infection of the seminiferous epithelium; therefore, we aimed to characte

99 s, in which spermatids are released into the seminiferous lobule lumen (SLL), where they develop into

100 ure separating this species from its closest seminiferous relative, Festuca ovina.

101 normality in which vegetative shoots replace seminiferous (sexual) inflorescences.

102 istinct, periodic, and limited to particular seminiferous stages.

103 KI male homozygotes are infertile because of seminiferous tubular dysmorphogenesis in the testis, sim

104 rain neurons, primitive inner ear cells, and seminiferous tubular epithelium.

105 cele affects Leydig cell function as well as seminiferous tubular function, and is a risk factor for

106 lls migrated to the basement membrane of the seminiferous tubule and were maintained similar to SSCs.

107 Treatment of mice with JQ1 reduced seminiferous tubule area, testis size, and spermatozoa n

108 Focal seminiferous tubule atrophy accompanied by Leydig cell h

109 Seminiferous tubule basement membrane (STBM) plays an im

110 , we observed a lower mutation frequency for seminiferous tubule cell preparations, which contain all

111 tion studies, non-selected, freshly isolated seminiferous tubule cells were transferred to the testis

112 optosis of germ cells, spermatogenic arrest, seminiferous tubule degeneration, and infertility.

113 ce have excessive spermatocyte apoptosis and seminiferous tubule degeneration.

114 tion, there was some impairment of renal and seminiferous tubule development.

115 ndrogen effects, such as testicular atrophy, seminiferous tubule diameter reduction and hyperplasia o

116 ter testicular atrophy and decreased average seminiferous tubule diameter when compared with K48R-age

117 ls and hyperplastic Leydig cells, leading to seminiferous tubule dilation and degeneration of germ ce

118 animals produces sexual hormone dysfunction, seminiferous tubule dystrophy and spermatogenesis blocka

119 rum of phenotypes, including thinning of the seminiferous tubule epithelia, dilation of the rete test

120 ired in PTM-ARKO males, indicated by reduced seminiferous tubule fluid production and reduced express

121 ermatids, and the bicarbonate present in the seminiferous tubule may be a signal that regulates cAMP

122 m cells caused their premature exit from the seminiferous tubule niche, resulting in germ cell deplet

123 s while OSKM cells that remained outside the seminiferous tubule proliferated extensively and formed

124 The CSS pipeline comprises four parts: (i) A seminiferous tubule segmentation model is developed to e

125 Seminiferous tubule staging shows that stages X to XII,

126 integrate local and global information of a seminiferous tubule to distinguish Stages I-V from Stage

127 l stem cells from other species to the mouse seminiferous tubule to generate spermatogenesis.

128 testis and was localized to a region of the seminiferous tubule where secondary spermatocytes and ea

129 eir radial migration to the periphery of the seminiferous tubule where the spermatogenic niche will f

130 not DeltaNp73KO mice, display a "near-empty seminiferous tubule" phenotype due to massive premature

131 zed that Ct may infect the epithelium of the seminiferous tubule, formed by Sertoli cells, thus leadi

132 expressed in both the podocyte and the basal seminiferous tubule, suggesting that the loss of CD2AP i

133 roliferate and migrate within the developing seminiferous tubule, with proper niche interaction and m

134 yma to be mostly replaced by bone tissue and seminiferous tubule-like structures.

135 is in the fluctuating environment within the seminiferous tubule.

136 re elongate spermatids into the lumen of the seminiferous tubule.

137 als, including human, can replicate in mouse seminiferous tubules after transplantation, the growth f

138 rm counts and a high frequency of degenerate seminiferous tubules and abnormal sperm.

139 Testes from PTU-treated male tadpoles had seminiferous tubules and advanced stage male germ cells,

140 the establishment of the avascular nature of seminiferous tubules and after puberty androgens may fur

141 stem cells reside in specific niches within seminiferous tubules and continuously generate different

142 zation success and caused disorganization of seminiferous tubules and dysregulated spermatogenic gene

143 were evident in light micrographs of testis' seminiferous tubules and epithelial cells lining the epi

144 e when administered intratesticularly enters seminiferous tubules and exerts effects beyond BTB is cu

145 PAC1R(3a) mRNA is preferentially detected in seminiferous tubules and is expressed at the highest lev

146 ar space, creating a microenvironment within seminiferous tubules and providing immune privilege to m

147 fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts.

148 the testes of adult males showed dilation of seminiferous tubules and reduction in their density when

149 nockout resulted in disruption of developing seminiferous tubules and subsequent progressive loss of

150 , almost all Sertoli cells are lost from the seminiferous tubules and the Leydig cell population is r

151 scent protein (GFP) transgenic mice into the seminiferous tubules and the testicular interstitium of

152 ules were approximated by a cross-section of seminiferous tubules arranged in a hexagonal pattern, wi

153 ZIKV antigens were only detected in seminiferous tubules at 14 DPI.

154 Rat seminiferous tubules at stages I, II-III, IV-V, VI, VIIa

155 ically significant decrease in the number of seminiferous tubules containing germ cells.

156 In isolated 7 days postpartum seminiferous tubules containing mostly germ line stem ce

157 c expression of I-CREBs in germ cells of the seminiferous tubules correlates with the cyclical down-r

158 ertile by 3 mo of age and eventually exhibit seminiferous tubules devoid of germ cells.

159 from the basal to apical compartments of the seminiferous tubules for further development and maturat

160 h spermatozoa formation in 13% to 17% of the seminiferous tubules formed in the grafts.

161 ed by GFP fluorescence in squashes of living seminiferous tubules from adult testes, and the presence

162 hese pathological responses are conserved in seminiferous tubules from Gravin(-/-) mice where an over

163 males are infertile and the analysis of the seminiferous tubules identified disrupted acrosomal deve

164 n of germ cells in a substantial fraction of seminiferous tubules in aged mice.

165 e adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells.

166 tis barrier showed increased permeability of seminiferous tubules in the Arid4a(-/-)Arid4b(+/-) teste

167 ial for the maintenance of Sertoli cells and seminiferous tubules in the developing testes.

168 d mild interstitial edema and closely packed seminiferous tubules in the left testes, indicating reve

169 Histological analysis of seminiferous tubules in the testes, caput and corpus epi

170 tive dysfunction associated with hypoplastic seminiferous tubules in the testis and perturbed corpus

171 Here we show that cells from adult seminiferous tubules interact with mammary epithelial ce

172 d in a second-level tubule CNN, which places seminiferous tubules into one of 12 distinct tubule stag

173 ural networks (CNNs) to classify nuclei from seminiferous tubules into seven distinct cell types with

174 e Sertoli cells of the adult mouse and human seminiferous tubules into testicular interstitial fluid

175 expression of RAR-dependent genes along the seminiferous tubules is disrupted.

176 showed hypoplastic and dysgenic testes, with seminiferous tubules lacking spermatogonia.

177 In the seminiferous tubules of busulfan-treated mice, GFP-posit

178 Consistent with enhanced apoptosis in seminiferous tubules of C/C testes, we recorded a drasti

179 of undifferentiated iPSCs directly into the seminiferous tubules of germ cell-depleted immunodeficie

180 When rat PGCLCs are transplanted into the seminiferous tubules of germline-less rats, functional s

181 spermatogenesis was totally compromised, as seminiferous tubules of homozygous mutant animals were d

182 , identifiable mutations directly within the seminiferous tubules of human testes.

183 at clump-forming rabbit germ cells colonized seminiferous tubules of immunodeficient mice, proliferat

184 a rare population of macrophages within the seminiferous tubules of Mlh3(-/-) and Hormad1(-/-) mice,

185 8(Ink4c) and p19(Ink4d) are expressed in the seminiferous tubules of postnatal wild-type mice, being

186 We detected MPXV in interstitial cells and seminiferous tubules of testes as well as epididymal lum

187 hest level of expression was detected in the seminiferous tubules of testis.

188 nor cells established spermatogenesis in the seminiferous tubules of the host, and normal spermatozoa

189 genesis takes place in the epithelium of the seminiferous tubules of the testes, producing millions o

190 on becomes XY-specific and restricted to the seminiferous tubules of the testis as gonadogenesis proc

191 l arrest at the round spermatid stage in the seminiferous tubules of the testis in ZFP628-deficient m

192 ransdifferentiation to structures resembling seminiferous tubules of the testis, including Sertoli-li

193 larin family, is expressed at high levels in seminiferous tubules of the testis, specifically in Sert

194 ed mainly by spermatocytes and spermatids in seminiferous tubules of the testis.

195 d that both mRNAs were strongly expressed in seminiferous tubules of the testis.

196 on spermatogenesis, which takes place in the seminiferous tubules of the testis.

197 However, this was not found in the seminiferous tubules of W/W(v) mice.

198 tis and mechanisms by which the virus enters seminiferous tubules remain unclear.

199 yclic peptide exposure of cultures from mice seminiferous tubules resulted in significant inhibition

200 More detailed analysis of specific cells in seminiferous tubules shows localization of Atr to the nu

201 UB1 is involved in cellular functions in the seminiferous tubules such as spermatogenesis.

202 meiotic spermatids are the only cells of the seminiferous tubules that express HIP1.

203 ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SS

204 disruptive distribution of AKAP9 across the seminiferous tubules was also noted during adjudin-induc

205 Focal vacuolization in some of the seminiferous tubules was observed in 4-week-old mutant t

206 The seminiferous tubules were divided into concentric layers

207 uptake into the testis as a whole and to the seminiferous tubules where the germ cells are located.

208 t cells (MGC) were found lining the lumen of seminiferous tubules with many of them undergoing apopto

209 n Leydig cells (somatic cells outside of the seminiferous tubules).

210 IKV to establish persistent infection in the seminiferous tubules, an immune-privileged site in the t

211 ased apoptotic cells within the walls of the seminiferous tubules, and a decrease in the number, moti

212 progenitor cells, macrophage penetration of seminiferous tubules, and increased tumor necrosis facto

213 Rfx2-null round spermatids detached from the seminiferous tubules, forming large multinucleated giant

214 tis displayed typical signs of aging (patchy seminiferous tubules, germ cell depletion, and vacuoliza

215 When transplanted into the seminiferous tubules, hGaSCs formed embryo-like structur

216 ced testis size and numbers of germ cells in seminiferous tubules, increased germ cell apoptosis, and

217 Sperm develop from puberty in the seminiferous tubules, inside the blood-testis barrier to

218 lls, which are an important component of the seminiferous tubules, is robust and induces a strong ant

219 decreased number of germ cells, degenerating seminiferous tubules, maturation arrest and apoptosis, i

220 s of cells: (i) epithelial germ cells of the seminiferous tubules, primarily spermatids and spermatoc

221 e Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche throu

222 how impaired testis development, degenerated seminiferous tubules, reduced sperm count and low fertil

223 are small, compared with the diameter of the seminiferous tubules, resulting in high energy depositio

224 was small, compared with the diameter of the seminiferous tubules, resulting in high energy depositio

225 sues only in the developing spermatocytes of seminiferous tubules, suggesting that mSgy is a spermato

226 n the Sertoli-Sertoli tight junctions in the seminiferous tubules, the approximately 32 kDa murine JA

227 iremia, ZIKV must establish infection in the seminiferous tubules, the site of spermatozoon developme

228 Adult testicular cells, isolated from seminiferous tubules, were mixed with limiting dilutions

229 ed that the testes were composed of atrophic seminiferous tubules, whereas germ cells were found in 1

230 The testis cords give rise to the adult seminiferous tubules, whereas steroidogenic Leydig cells

231 n culminates in complete degeneration of the seminiferous tubules, which become acellular, empty spac

232 unostaining for Mamu-AG5 in cells within the seminiferous tubules, which was corroborated by localiza

233 is normally provided by Sertoli cells of the seminiferous tubules, whose function depends on testoste

234 ozoa, which takes place in the epithelium of seminiferous tubules.

235 genesis in juvenile mice results in agametic seminiferous tubules.

236 icle-stimulating hormone receptor within the seminiferous tubules.

237 ce of active spermatogenesis in 24 +/- 7% of seminiferous tubules.

238 the proportion of abnormal sperm and clogged seminiferous tubules.

239 oimaging, and in situ confocal microscopy of seminiferous tubules.

240 n of germ cells localized at the base of the seminiferous tubules.

241 ressed primarily in Sertoli cells within the seminiferous tubules.

242 Both radionuclides gained access to the seminiferous tubules.

243 testicular size and no spermatozoa in their seminiferous tubules.

244 reduced sperm counts, and disruption of the seminiferous tubules.

245 within the thin vascular layer overlying the seminiferous tubules.

246 storage vesicles within Sertoli cells of the seminiferous tubules.

247 stmeiotic round spermatid compartment of the seminiferous tubules.

248 questered behind the Sertoli cell barrier in seminiferous tubules.

249 permatocytes in the basal compartment of the seminiferous tubules.

250 rized by calcifications within the lumina of seminiferous tubules.

251 in the kidney collecting tubules and testis seminiferous tubules.

252 g, oviduct, epididymis, ductus deferens, and seminiferous tubules.

253 erstitial tissue that normally surrounds the seminiferous tubules.

254 aled that UT3 is located in Sertoli cells of seminiferous tubules.

255 ble to generate spermatogenesis in recipient seminiferous tubules.

256 study mechanisms of virus persistence in the seminiferous tubules.

257 facilitate seminoma disseminating beyond the seminiferous tubules.

258 orescent staining showed fewer germ cells in seminiferous tubules.

259 nted mouse spermatogonial stem cells in host seminiferous tubules.

260 oordinated spatiotemporally across and along seminiferous tubules.

261 sulting in cell death and destruction of the seminiferous tubules.

262 creased mitotic index and disorganization of seminiferous tubules.

263 ring formation of structures resembling male seminiferous tubules.

264 , which are however found in the wall of the seminiferous tubules.

265 a PEDF, may prevent vascularization of human seminiferous tubules.

266 d18 foci were increased in the lumina of the seminiferous tubules.

267 r for the identification of Sertoli cells in seminiferous tubules.

268 ecifically in the nuclei of Sertoli cells in seminiferous tubules.

269 es, which in turn are composed of convoluted seminiferous tubules.