ライフサイエンスコーパス: sense strand

1 reverse transcriptase which cleaves the anti-sense strand.

2 the morpholino GalNAc moieties at the siRNA sense strand.

3 to cells while retaining the potency of the sense strand.

4 g complex as siRNAs with a GalNAc-conjugated sense strand.

5 anscripts carrying seed matches to the shRNA sense strand.

6 ond makes a base-specific contact to the DNA sense strand.

7 cripts is suppressed by transcription of the sense strand.

8 nome encoding 3'-untranslated regions on the sense strand.

9 ted with reduced off-target silencing by the sense strand.

10 mediated by siRNA knockdown of TNFR1 via its sense strand.

11 blocked by a cDNA expressing the E2F4 3'-UTR sense strand.

12 smembrane proteins, are transcribed from the sense strand.

13 ated more than 250-fold upon addition of the sense strand.

14 ding protein which binds the pyrimidine-rich sense strand.

15 ly bound nuclear proteins on its purine-rich sense strand.

16 gh proportion of human protein-coding region sense strands.

17 ere well tolerated in both the antisense and sense strands.

18 a bias towards low internal stability at the sense strand 3'-terminus, lack of inverted repeats, and

19 ent siRNA and identified that connecting two sense strands 3' and 5' through an intra-strand linker e

20 standard were hybridized to a set of 21,807-sense strand 60-mer oligonucleotides on each slide repre

21 pair mismatches in the central region of the sense strand (9-12 nt), significantly improve the potenc

22 s concern with a novel strategy that reduces sense strand activity of vector-encoded shRNAs via codel

23 However, in principle, the sense strand also possesses silencing capacity that may

24 a bifunctional TuD against an anti-HCV shRNA sense strand and an HCV-related cellular miRNA.

25 ut any phosphorothioate stabilization in the sense strand and clearly improved the duration of action

26 lex unwinding and degradation of the unwound sense strand and RNA-induced silencing complex formation

27 Four consecutive T residues in the sense strand are sufficient to terminate transcription b

28 e) that were endogenously generated from the sense strand at Map2b, antisense strand at Nefl, and bot

29 d 3'-terminus, lack of inverted repeats, and sense strand base preferences (positions 3, 10, 13 and 1

30 spliced genomic transcripts and are strongly sense-strand biased.

31 at 2'-5' linkages were well tolerated in the sense strand, but only at a few positions in the antisen

32 When inverted into the sense strand by a site-specific recombinase, the COIN mo

33 excised intron RNA, which cleaves the DNA's sense strand by partial reverse splicing; and the intron

34 Oprm1 circRNAs were sense-stranded circRNAs resistant to RNase R digestion.

35 process was found to be facilitated through sense strand cleavage, there is evidence for an alternat

36 For aI2, sense-strand cleavage occurs mainly by a partial reverse

37 by the intron-encoded endonuclease, with the sense strand cleaved by partial or complete reverse spli

38 AS ODNs containing eight mismatches, or the sense strand controls (P < 0.0001).

39 betaMyHC distal negative regulatory element-sense strand (dbetaNRE-S) element is markedly increased

40 specific to the distal region of the betaNRE sense strand (dbetaNRE-S; -332 to -311).

41 nzymatic ligation reaction (leaving the anti-sense strand dissociable).

42 we extend this model, showing that positive-sense strands do accumulate in LuDelta2 infections as pa

43 y which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the

44 Expanded (GAA)n repeats in the sense strand for transcription caused a significant decr

45 al- and carrier-size (TTC)n repeats into the sense strand for transcription led to the appearance of

46 nt only when the (CTG)(n) tracts were in the sense strand for transcription.

47 To synthesize sciRNAs, a sense strand functionalized with the trivalent N-acetylg

48 the cells harboring the target RNA, whereas sense strand gets degraded.

49 y which antisense RNA might give rise to new sense-strand globin mRNA.

50 n of TuDs can sequester and inactivate shRNA sense strands in human cells selectively without affecti

51 Whereas both DNA strands are sense strands in the Drosophila gene, the coding region

52 ased linker within the central region of the sense strand, in conjunction with an affinity-enhancing

53 litates insertion of the 3' end of the minus-sense strand into the template channel.

54 The sense strand is nicked at variable distances from the TT

55 s biphasic, so that accumulation of positive-sense strands is ultimately suppressed, probably because

56 ied two p40 binding sites on the full-length sense strand L1Hs RNA.

57 ive chromatin to further regulate or enhance sense-strand mRNA expression.

58 overlap and higher complementarity with the sense-strand mRNAs compared to other NATs.

59 mical modification and mismatches within the sense strand of 736 also inhibited silencing activity.

60 pholino GalNAc scaffolds were coupled to the sense strand of a transthyretin-targeting siRNA and test

61 rming helix-destabilizing complexes with the sense strand of an asymmetric polypurine-polypyrimidine

62 Expressed signatures were derived from the sense strand of at least 19,088 of 29,084 annotated gene

63 Okazaki fragments were incorporated into the sense strand of exon 4, replacing the normal sequence.

64 ssing SH-SY5Y cells, we demonstrate that the sense strand of PPy/u interacts with a major nuclear pro

65 ies of related factors with affinity for the sense strand of PRR.

66 ause of the common cold, contains a positive-sense strand of RNA which is translated into a large pol

67 residues, e.g., 2'-O-Me and 2'-O-MOE, in the sense strand of siRNA did not show a strong positional p

68 ctive for RNAi we modified the 3' end of the sense strand of siRNA with a nuclease-resistant DNA hair

69 gene, and the Y box protein MSY-1 bound the sense strand of the -83- to -69-bp region.

70 mbly of the dimeric Purbeta repressor on the sense strand of the ACTA2 enhancer is dictated by the as

71 clear protein that binds specifically to the sense strand of the C-rich sequence overlapping the Sp1

72 more sensitive to mismatch insertions on the sense strand of the DNA binding site, especially within

73 cells with a VSV recombinant expressing the sense strand of the enhanced green fluorescent protein g

74 -R cDNA, which is fully complementary to the sense strand of the EPO-R gene from 2.5kb 3' to the sens

75 leting transcription start sites on the anti-sense strand of the Gpr27 coding exon.

76 The sense strand of the hybridized duplex DNA could be coval

77 in which the excised intron RNA cleaves the sense strand of the recipient DNA by reverse splicing, w

78 outlined the coding capacity of the positive-sense strand of the SARS-CoV-2 genome, which can be used

79 alNAc moiety of the ligand conjugated to the sense strand of the siRNA.

80 ndergo unidirectional transcription from the sense strand of the viral genome.

81 c-length virus- and virus-complementary (vc)-sense strands of all WMoV genomic RNAs accumulated asymm

82 t much higher frequency than expected in the sense strands of introns >20 kb, but they are found only

83 )]-nucleoside residues) in the antisense and sense strands of short interference RNA (siRNA) was perf

84 The conjugation of the sense strands of small interfering RNA (siRNA) to tri-N-

85 in rat testis that binds specifically to the sense strands of the PhGPx and GPx 3' UTRs.

86 The message (sense) strand of the IRP1 operator (5'-TTAGGTTAGCCAAACCT

87 The message (sense) strand of the IRP3 operator (5'-TTAGGTGAGACGCACCC

88 Also, the intron RNA cleaves the sense-strand of the recipient DNA by a reverse splicing

89 tion upon annealing with a 20-nucleotide DNA sense strand oligo, representing the greatest activation

90 mation, which is activated upon binding of a sense strand oligonucleotide to the antisense module.

91 l samples by hybridization with biotinylated sense-strand oligonucleotides coupled to streptavidin ma

92 liced genomic transcripts are processed into sense-strand PIWI-interacting RNAs (piRNAs), which may p

93 A fluorescent sense strand PNA probe binding to RNAi duplex guide stra

94 actions (aPCR), using an excess of one short sense-strand primer to be extended and a limiting amount

95 bone indicate that enzymatic cleavage of the sense strand prior to strand dissociation is not require

96 gatively correlated with that of overlapping sense-strand protein-coding genes.

97 ASOs targeting sense strand repeat-containing RNAs do not correct this

98 I and LuDelta2) packaged 47 and <8% positive-sense strands, respectively.

99 A transgene encoding a translatable sense-strand RNA from the 5' end of iaaM silenced the ia

100 d of the siRNAs bind directly to DNA or to a sense-stranded RNA transcript corresponding to the known

101 Retroviral genomes are assembled from two sense-strand RNAs by noncovalent interactions at their 5

102 oviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5' ends by noncovalent

103 Retroviral genomes contain two sense-strand RNAs that are noncovalently linked at their

104 Within nuclei, sense-strand RNAs were preferentially localized within n

105 plex internal stability and siRNA sense/anti-sense strand secondary structure.

106 ty, when used as a double 3'-overhang at the sense strand sequence.

107 ocked by attaching a partially complementary sense strand (sODN) via a heterobifunctional photocleava

108 inker (PL) to partially complementary 20-mer sense strands (sODNs).

109 ene bodies, MPRA strand asymmetry favors the sense strand, suggesting that function related to endoge

110 gion alter the distribution of RNAPII on the sense strand, suggesting that the barrier observed after

111 t alter ratios of positive-sense to negative-sense strands, suggesting that entry rather than replica

112 GGCCCC) direction, which are not affected by sense strand-targeting ASOs.

113 d specific nucleotide positions in the siRNA sense strand that could be modified with a corresponding

114 taining cholesteryl modifications within the sense strand that were used for in vivo studies.

115 the antisense strand and position 11 of the sense strand, the TNA modification did not inhibit the a

116 thyl-CODEC links an enzymatically deaminated sense strand to the reverse complement of the antisense

117 eparate from its complementary passenger (or sense) strand to generate the active RISC complex.

118 h was confirmed by in vitro translation of a sense-strand transcript, producing a protein of approx.

119 led with sequence analyses revealed that the sense-strand transcription of the retrocopies often lead

120 espread genomic changes, including increased sense-strand transcription upstream and downstream of ge

121 HeT-A produces only sense-strand transcripts of the full-length element, whe

122 In these analogs, we left the active sense strand untouched so that its biological activity r

123 observed improved metabolic stability of the sense strand upon circularization and off-target effects

124 binding at the distal region of the betaNRE sense strand was antigenically distinct from cellular nu

125 tion, and complementary PNAs targeted to the sense strand were also inactive.

126 Multiple ANA modifications within the sense strand were also well tolerated.

127 the methylation-susceptible cytosines in the sense strand were replaced by thymine displayed marked l