ライフサイエンスコーパス: sensorimotor gating

1 y over 14 days), lower anxiety, and impaired sensorimotor gating.

2 limbic dopamine transmission, a modulator of sensorimotor gating.

3 flex, suggesting deficits in pre-attentional sensorimotor gating.

4 septum represent a key cell-type involved in sensorimotor gating.

5 DA receptors, specifically in the context of sensorimotor gating.

6 ibit clear apomorphine-induced reductions in sensorimotor gating.

7 ic basis for human population differences in sensorimotor gating.

8 ncluding cognitive inflexibility and reduced sensorimotor gating.

9 ncluding cognitive inflexibility and reduced sensorimotor gating.

10 rning and memory, anxiety-like behaviour and sensorimotor gating.

11 The LC hyperactivity is detrimental for sensorimotor gating.

12 n (PPI), a critical translational measure of sensorimotor gating.

13 behavioral responses, learning, memory, and sensorimotor gating.

14 alysis providing new molecular insights into sensorimotor gating.

15 and altered behaviors, including anxiety and sensorimotor gating.

16 ice exhibited abnormalities in cognition and sensorimotor gating.

17 inhibition (PPI), an operational measure of sensorimotor gating.

18 by subtle deficits in motor coordination and sensorimotor gating.

19 iated with exaggerated startle and deficient sensorimotor gating.

20 alities in prepulse inhibition, a measure of sensorimotor gating.

21 nstrating the importance of these neurons in sensorimotor gating.

22 ver, display changes in rearing behavior and sensorimotor gating.

23 ulatory mechanisms in startle plasticity and sensorimotor gating.

24 receptor in goldfish startle plasticity and sensorimotor gating.

25 nhibition (PPI) is an operational measure of sensorimotor gating.

26 ium channel activity in the mPFC to modulate sensorimotor gating.

27 rations in prepulse inhibition, a measure of sensorimotor gating.

28 ehavioral deficits in social interaction and sensorimotor gating.

29 central nervous system activity and impaired sensorimotor gating.

30 ragile X mental retardation protein regulate sensorimotor gating.

31 impaired cognitive processing, and impaired sensorimotor gating.

32 anxiety-related phenotype but no deficit in sensorimotor gating.

33 inhibition of acoustic startle, a measure of sensorimotor gating.

34 s mediating smooth pursuit eye movements and sensorimotor gating.

35 stimulus, provides an operational measure of sensorimotor gating (a process by which an organism filt

36 Sensorimotor gating abnormalities have been previously c

37 tive studies have led to the hypothesis that sensorimotor gating abnormalities may underlie thought d

38 f this portion of the DGCR is sufficient for sensorimotor gating abnormalities, but not sufficient to

39 s-dependent learning and memory and impaired sensorimotor gating, abnormalities observed in patients

40 and found that these mice have a deficit in sensorimotor gating accompanied by regional neurochemica

41 ramidal neurons, as well as abnormalities in sensorimotor gating, albeit without profound memory defi

42 stomatogastric nervous system, we show that sensorimotor gating also occurs at the level of the proj

43 ncreased compulsive-like behaviors, abnormal sensorimotor gating and altered responsiveness to stimul

44 septum represent a key cell type involved in sensorimotor gating and are relevant to pathologies asso

45 late several behavioral phenomena, including sensorimotor gating and aspects of motor activity.

46 fects on preconscious, automatic measures of sensorimotor gating and auditory sensory processing that

47 ockout (REGgamma-/-) mice exhibit late-onset sensorimotor gating and cognitive deficiencies including

48 macological inhibition of p110delta reversed sensorimotor gating and cognitive deficits.

49 to pathways controlling locomotor activity, sensorimotor gating and cognitive processes.

50 tor changes may be involved in disruption of sensorimotor gating and compulsive behavior relevant to

51 on in the hippocampus as well as deficits in sensorimotor gating and contextual memory, putative endo

52 rpose of this study was to examine automatic sensorimotor gating and controlled attentional modulatio

53 rther our understanding of the substrates of sensorimotor gating and could lead to better therapeutic

54 Prepulse inhibition (PPI) is an example of sensorimotor gating and deficits in PPI have been demons

55 n the treatment of subjects with compromised sensorimotor gating and enhanced motor responses to sens

56 ed amphetamine-driven changes in locomotion, sensorimotor gating and hallucination-like perception.

57 for p11 in modulating clozapine's effects on sensorimotor gating and hippocampal connectivity, offeri

58 nhibition (PPI) is an operational measure of sensorimotor gating and is deficient in several neuropsy

59 hat are deleted in patients have deficits in sensorimotor gating and learning and memory.

60 the prefrontal cortical circuitry regulating sensorimotor gating and locomotor behavior, both of whic

61 atal dopamine is implicated in regulation of sensorimotor gating and OCD pathophysiology.

62 ies, including hyperactivity, disturbance in sensorimotor gating and olfactory-associated behavior, a

63 zophrenia, as indexed by alterations both in sensorimotor gating and psychotomimetic-induced locomoto

64 e, LSD, and PCP on two behavioral parameters-sensorimotor gating and repetitive movements-were strong

65 Although sensorimotor gating and sensory gating are not identical

66 nents and in the neural circuits involved in sensorimotor gating and short-term memory.

67 culum, regions involved in the regulation of sensorimotor gating and short-term memory.

68 To address this issue, sensorimotor gating and thought disturbance were measure

69 hizophrenic men were assessed on measures of sensorimotor gating and thought disturbance.

70 Locomotor activity, anxiety-like behaviors, sensorimotor gating, and aggressive behavior also were a

71 nto-striatal pathways resulting in defective sensorimotor gating, and consequently characteristic dif

72 These brain regions are important in sensorimotor gating, and impaired 'gating' may partly ex

73 y on stress sensitivity, cognitive function, sensorimotor gating, and prefrontal cortical transcripti

74 disturbances, such as hyperlocomotion, poor sensorimotor gating, and sensitivity to psychostimulants

75 ce, including cognitive impairment, abnormal sensorimotor gating, and sensitization to methamphetamin

76 al striatal dopamine dysfunction, cognitive, sensorimotor gating, and social behavioral deficits prec

77 e locomotor reactivity to novel environment, sensorimotor gating, anxiety, and cognition.

78 3 m of age, mutant mice displayed increased sensorimotor gating, anxiety, hypoactivity, and decrease

79 amatergic mGluR5 knockout mice are normal in sensorimotor gating, anxiety, motor balance/learning and

80 eactivity to a novel environment but not for sensorimotor gating, anxiety, motor coordination, severa

81 and simulations together indicate that this sensorimotor gating arises from the relative timing of t

82 isorders have been shown to have deficits in sensorimotor gating as assessed by prepulse inhibition o

83 that unmedicated OCD patients have impaired sensorimotor gating as measured by PPI.

84 baseline, DAT (-/-) mice exhibited deficient sensorimotor gating as measured by prepulse inhibition (

85 subjects have been shown to have deficits in sensorimotor gating as measured by prepulse inhibition,

86 ndividuals with fragile X also have impaired sensorimotor gating as measured using the prepulse inhib

87 otor activity, anxiety-related behavior, and sensorimotor gating, as well as handling-induced seizure

88 ormalities of information processing seen in sensorimotor gating associated with stress and stress-re

89 of ectopic dendrites in neurons and enhanced sensorimotor gating behavior in mice.

90 lterations in anxiety-like, stereotypic, and sensorimotor gating behaviors observed in adolescence no

91 These results also indicate that the site of sensorimotor gating can occur at the level of the projec

92 sts, and had similar olfactory, auditory and sensorimotor gating capabilities as wild-type mice.

93 t in prepulse inhibition (PPI), a measure of sensorimotor gating commonly deficient in individuals wi

94 Sensorimotor gating commonly occurs at sensory neuron sy

95 e first to demonstrate that BN have impaired sensorimotor gating compared with WKY, without impaired

96 udy was to examine the relationships between sensorimotor gating, compulsive behavior, and striatal d

97 ette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of c

98 me degradation pathway may contribute to the sensorimotor gating deficiency and cognitive disorders i

99 ates prepulse inhibition (PPI), a measure of sensorimotor gating deficient in several illnesses inclu

100 ut not PND 35, suggesting the emergence of a sensorimotor gating deficit in early adulthood.

101 Finally, mice lacking IgSF21 show a sensorimotor gating deficit.

102 SA-born WT mice exhibited sensorimotor gating deficits (males), increased reward p

103 anisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in proce

104 Sensorimotor gating deficits and rearing are attenuated

105 phenotypic differences in an animal model of sensorimotor gating deficits in human neuropsychiatric d

106 o) proteins, alteration of which could cause sensorimotor gating deficits in schizophrenia.

107 eases tic-like responses and elicits TS-like sensorimotor gating deficits in the D1CT-7 mouse, one of

108 The finding of sensorimotor gating deficits is particularly significant

109 In addition, sensorimotor gating deficits previously noted in Bdr mut

110 te maps associated anxiety-like, social, and sensorimotor gating deficits with volume of the dorsal a

111 Sensorimotor gating deficits, as measured by acoustic pr

112 s to have important roles in the reversal of sensorimotor gating deficits, as measured by prepulse in

113 itive effects on locomotor hyperactivity and sensorimotor gating deficits, but further produces syner

114 that the Pvalb/Gad1 Tg mice have pronounced sensorimotor gating deficits, increased novelty-seeking

115 .2(dp/+) mice did not exhibit the SZ-related sensorimotor gating deficits, psychostimulant-induced hy

116 a genetically transmitted susceptibility to sensorimotor gating deficits.

117 elevant to schizophrenia, including impaired sensorimotor gating, discrimination memory, and social b

118 ein levels; and a greater sensitivity to the sensorimotor gating-disruptive effect of amphetamine, co

119 These measures of sensory and sensorimotor gating have both been proposed as models fo

120 tle reflex amplitude, as well as significant sensorimotor gating impairments, as assessed by the prep

121 LSD altered sensorimotor gating in a human model of psychosis, suppo

122 failed to induce deficits in sociability or sensorimotor gating in adult KO mice.

123 sent results from a study examining abnormal sensorimotor gating in Fmr1KO mice.

124 Thus, we compared brain anatomy and sensorimotor gating in healthy people with Asperger's sy

125 , our results provide the first evidence for sensorimotor gating in larval zebrafish and report on th

126 amphetamine (AMPH)-induced sensitization and sensorimotor gating in rats, two preclinical procedures

127 the first data that demonstrate a deficit in sensorimotor gating in rodents caused by an inadequate a

128 We found a trend for disruption of sensorimotor gating in Sapap3-KOs using the translationa

129 ffer a useful animal model to study impaired sensorimotor gating in schizophrenia.

130 t studies carefully assessed drug effects on sensorimotor gating in SD versus W strains, across rat s

131 nstrated hypoactivity, anxiety, and impaired sensorimotor gating in the L825V/+ strain, particularly

132 ceptor antagonist can affect the deficits in sensorimotor gating in the NR1(neo/neo) mice.

133 has a significant, dose-dependent effect on sensorimotor gating in which lower doses (0.25-1.0 micro

134 transmitted deficit in prepulse inhibition (sensorimotor gating) in patients with schizophrenia spec

135 in Htr2B(-/-) mice, as shown by deficits in sensorimotor gating, in selective attention, in social i

136 Sensorimotor gating is a neural filtering process that a

137 Sensorimotor gating is often studied in humans and roden

138 titative and clinically important measure of sensorimotor gating is prepulse inhibition (PPI) of the

139 inhibition (PPI), an operational measure of sensorimotor gating, is deficient in schizophrenia patie

140 f the acoustic startle response-a measure of sensorimotor gating-is highly sensitive for manipulation

141 number of abnormal traits including reduced sensorimotor gating, lower density of dendritic spines i

142 These findings suggest that robust sensorimotor gating may represent a resiliency factor fo

143 his polymorphism is associated with impaired sensorimotor gating measured by prepulse inhibition--an

144 psychotic disorders (CPD) exhibit deficient sensorimotor gating (measured by prepulse inhibition (PP

145 Sensorimotor gating, measured by prepulse inhibition (PP

146 dorsal thalamus relay cells and (2) impaired sensorimotor gating, measured via paired-pulse inhibitio

147 PPI reflects a nonlearned sensorimotor gating mechanism and also shows a robust ge

148 dence for within-gender differences in basic sensorimotor gating mechanisms and implicate the known n

149 eficit in social engagement, working memory, sensorimotor gating, native locomotor activity, and dopa

150 -like behaviors, motor function and balance, sensorimotor gating, novel object recognition, and spati

151 Prepulse inhibition (PPI), a form of sensorimotor gating, occurs when an auditory startle res

152 regions in their neurochemical modulation of sensorimotor gating of acoustic startle in the rat.

153 e has been used as an operational measure of sensorimotor gating or inhibition, and is reduced in sch

154 This study tested the hypothesis that sensorimotor gating performance is associated with risk/

155 ictive validity of animal PPI to model human sensorimotor gating phenomena but only limited studies h

156 ystems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibit

157 ry-adrenal axis stress response and impaired sensorimotor gating, phenotypic effects that were associ

158 exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the s

159 tal cortex 5-HT(2A)R expression and improved sensorimotor gating processes via 5-HT(2A)R.

160 frontal cortex dendritic spine structure and sensorimotor gating processes.

161 R) have been used as measures of sensory and sensorimotor gating, respectively.

162 ll as anxiety-related locomotor behavior and sensorimotor gating, revealing potential therapeutic app

163 s considerable interest in the regulation of sensorimotor gating, since deficits in this process coul

164 f picrotoxin caused locomotor hyperactivity; sensorimotor gating (startle prepulse inhibition) was un

165 ant to pathologies associated with disrupted sensorimotor gating such as schizophrenia.SIGNIFICANCE S

166 g that pathologies associated with disrupted sensorimotor gating, such as with schizophrenia, could b

167 ehavioral deficits in social interaction and sensorimotor gating tasks.

168 story of tics may have greater impairment in sensorimotor gating than the general OCD population.

169 on (PPI), which is an operational measure of sensorimotor gating that is deficient in schizophrenia p

170 Prepulse inhibition is a type of sensorimotor gating that is disrupted in some neuropsych

171 (PPI) of the startle reflex is a measure of sensorimotor gating that is reduced in humans with certa

172 of the startle response, a manifestation of sensorimotor gating that is reduced in humans with schiz

173 nhibition (PPI) is an operational measure of sensorimotor gating that is thought to probe preattentio

174 t brought the investigation of H1 effects on sensorimotor gating to human studies.

175 ed brain anatomy using quantitative MRI, and sensorimotor gating using prepulse inhibition of startle

176 Sensorimotor gating was abnormal, as measured by deficit

177 Sensorimotor gating was examined operationally via the u

178 creased, and acoustic, but not non-acoustic, sensorimotor gating was impaired in Tbx1 heterozygous mi

179 Sensorimotor gating was measured by prepulse inhibition

180 Moreover, sensorimotor gating was significantly impaired in Asperg

181 rs across working memory, fear processes and sensorimotor gating, we examined these functions between

182 impairments in social approach behavior and sensorimotor gating, whereas MIA offspring with a low in

183 PPI is an operational measure of sensorimotor gating which is strongly regulated by mesol

184 response (PPI) is a cross-species measure of sensorimotor gating, which is severely disrupted in pati

185 order (OCD) is associated with disruption of sensorimotor gating, which may contribute to difficultie

186 lse inhibition (PPI) is used as a measure of sensorimotor gating, with smaller PPI indicating less fi