ライフサイエンスコーパス: sequence motif

1 two consecutive repeats of a conserved octad sequence motif.

2 without requiring a cholesterol recognition sequence motif.

3 T sequencing and each recognizes a novel DNA sequence motif.

4 rectly with an evolutionarily conserved Spir sequence motif.

5 teract through the N-terminal small-X3-small sequence motif.

6 ylation and explain why NTMT1 prefers an XPK sequence motif.

7 at cholesterol binding does not require this sequence motif.

8 its specificity for its cognate 5-base-pair sequence motif.

9 han any single regulatory factor or promoter sequence motif.

10 latelet, and plasma glycoproteins via a YTRY sequence motif.

11 uses at GC-rich regions that are marked by a sequence motif.

12 teract directly with ERH-2 using a conserved sequence motif.

13 a Pro at position 2, together with adjacent sequence motifs.

14 Pro) residue and the 5-residue-long adjacent sequence motifs.

15 RNA folding motifs rather than the conserved sequence motifs.

16 er or promoters containing ISRE or NF-kappaB sequence motifs.

17 scription factors (TFs) bind to specific DNA sequence motifs.

18 ed into PP1-dependent categories with unique sequence motifs.

19 ads and reads matching a large dictionary of sequence motifs.

20 n of multiple sequence alignments (MSAs) and sequence motifs.

21 f gene transcription by binding to short DNA sequence motifs.

22 tructures of the 5'UTR, including particular sequence motifs.

23 marks, transcription factor binding, and DNA sequence motifs.

24 al reactivity better than Bw4/Bw6 amino acid sequence motifs.

25 peptides we created that included 3 repeated sequence motifs.

26 but MldC lacks obvious conserved domains or sequence motifs.

27 when the ribosome encounters specific short sequence motifs.

28 stem (ES) cells with over 1000 mammalian TF sequence motifs.

29 in binding, chromatin modifications, and DNA sequence motifs.

30 have a preference for binding phosphorylated sequence motifs.

31 s that are single-stranded and enrich unique sequence motifs.

32 l descriptors, 3D macromolecular shapes, and sequence motifs.

33 n due to the lack of significant bias in the sequence motifs.

34 ion 2, in the presence of distinct adjoining sequence motifs.

35 cessibility patterns and their underlying TF sequence motifs.

36 capable of digesting genomic DNA at defined sequence motifs.

37 of trans-acting factors to cis-localized DNA sequence motifs.

38 class I alleles, corresponding to amino acid sequence motif 77 to 83, produced clustering of HLA mole

39 at least two compartments that differ in TCR sequence motifs, affinity, and coreceptor expression.

40 data mining based on the search for specific sequence motifs allowed the identification of two genes

41 lowing us to predict binders from a specific sequence motif alone.

42 shape features that accompany the preferred sequence motifs also bestow an advantage for weak, seque

43 DNA sequence motif analysis and chromatin immunoprecipitatio

44 Sequence motif analysis identified 8-bp motifs somewhat

45 ent study, we investigated the roles of this sequence motif and glycosylation of the E protein in the

46 the AP2 domain of AP2IX-9 binds a CAGTGT DNA sequence motif and is capable of binding cis-regulatory

47 otein that binds to an AT-rich conserved DNA sequence motif and regulates both the shape and the gene

48 is domain contains a conserved "P[F/P]AAAPP" sequence motif and the well-described amino acid 627, wh

49 Analysis of sequence motifs and 6-mer enrichment patterns show that

50 These processes are governed by multiple sequence motifs and also host genotypes.

51 s1 and Ets2 bind to apparently identical DNA sequence motifs and are thought to regulate overlapping

52 have largely remained conserved in canonical sequence motifs and copy numbers as in E. maclovinus, sh

53 Our analyses show that static sequence motifs and dynamic phosphoproteomics data are c

54 ng amino acid proline, they contain repeated sequence motifs and extensive posttranslational modifica

55 s in the training dataset that share similar sequence motifs and extract effective predictive feature

56 he destination is determined based on KOR1's sequence motifs and folding status.

57 ched over 3' untranslated regions at defined sequence motifs and marks unstable transcripts, includin

58 d regions and intronic regions, share common sequence motifs and overlap with binding sites for RNA-b

59 Here, we quantitatively define UbiB-specific sequence motifs and reveal their positions within the cr

60 remodeling complex collaborates with two DNA sequence motifs and sequence-specific general regulatory

61 acterized by conserved C-terminal amino acid sequence motifs and their cognate receptors were examine

62 grons include, to varying extents, adjoining sequence motifs, and also internal lysine residues that

63 SVR) to provide comprehensive models for the sequence motifs, and found that the SVR-based approach i

64 e also uncover a collection of protein-bound sequence motifs, and identify their structural contexts,

65 o two-fold symmetric fold, several canonical sequence motifs, and similar splicing mechanisms.

66 good performance on challenging cases where sequence motifs are absent but a function is known to ex

67 Thus, diverse sequence motifs are capable of forming amyloidal signali

68 The problematic sequence motifs are confined to the nascent peptide resi

69 iliar cell-binding domains, but the proposed sequence motifs are not highly conserved across species.

70 s applied to each cluster to determine which sequence motifs are overrepresented in each geometry.

71 GQ sequence motifs are overrepresented in promoters, origin

72 Whereas these sequence motifs are quite accurate descriptions of DNA b

73 Sequence motifs are short, recurring patterns in DNA tha

74 We used a DOPA-containing sequence motif as the starting point for generation of a

75 ster hierarchical representation learning of sequence motifs-assembling partial features into whole f

76 We identified a sequence motif associated with promoter-proximal pausing

77 We identify sequence motifs associated with carbon source-specific T

78 The sequence motifs associated with each peak represent diff

79 We identify, de novo, DNA sequence motifs associated with individual components th

80 e were able to identify a number of promoter sequence motifs associated with leaf senescence.

81 tural properties are shown to correlate with sequence motifs associated with replication origins and

82 es and characterization of known and de novo sequence motifs associated with variation in chromatin a

83 g methods have revealed the prevalence of G4 sequence motifs at gene regulatory regions in various ge

84 ng either the Bw4 or Bw6 epitope (defined by sequence motifs at positions 77 to 83) were generated us

85 d we identified significant enrichment in G4 sequence motifs at the transcription start site and 5' e

86 l functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold.

87 We find that DpnI cuts other sequence motifs besides the canonical GATC restriction s

88 TIFA incorporated the observed genome and sequence motif bias of the miniHimar transposon.

89 stants and that variants lacking the minimal sequence motif bind competitively with consensus RNA.

90 NA binding proteins (RBPs) bind specific RNA sequence motifs, but only a small fraction ( approximate

91 Conventional programs identified some sequence motifs, but these are found in less than 5-10%

92 o NRPs through a carboxy (C)-terminal, basic sequence motif (C-end Rule or CendR motif).

93 Our results demonstrate that simple sequence motifs can rigidify elementary membrane protein

94 ng locations for each TF assayed, from which sequence motifs can then be derived.

95 Short aggregation prone sequence motifs can trigger aggregation in peptide and p

96 NAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends, representing the si

97 n-beta family proteins, binds to a PY-NLS(2) sequence motif close to the amino terminus of matrix pro

98 vivo and in vitro confirmed that residues in sequence motifs conserved across bacterial and eukaryoti

99 Dozens of consensus sequence motifs containing predicted transcription facto

100 iscuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, at

101 al feature conserved across all groups was a sequence motif critical for cell-killing that is general

102 Whereas TCR sequence motifs define CD1d-reactive NKT cells, the avai

103 A sequence motif defining these families, the X position i

104 , virus biology, host-pathogen interactions, sequence motif discovery and pattern recognition, molecu

105 espective coat protein core partners, and in sequence motifs displayed on the capsid surfaces.

106 ice, which enables the identification of DNA sequence motifs driving epigenetic features.

107 ted toward involvement of a highly conserved sequence motif, E1XXE2RFXYY (from here on referred to as

108 on to poly(A) tails, Nab2 can also recognize sequence motifs elsewhere in transcripts in which adenos

109 ion ribozymes, we identified a 17-nucleotide sequence motif embedded in a 44-nucleotide pseudoknot st

110 sgRNA efficiency is associated with specific sequence motifs, enabling the prediction of more effecti

111 Two of the cis sequence motifs enriched in the PREs are cognate binding

112 Furthermore, we identified sequence motifs enriched in the promoters of similarly p

113 alpha4, via direct interactions with the DNA sequence motif ER-2.

114 disease virus that the TURBS contains three sequence motifs essential for reinitiation.

115 al and are highly enriched for complementary sequence motifs, even those supported by only a few read

116 that consider a single type of data, such as sequence motifs, evolutionary conservation, or the bindi

117 le kernel learning approach to integrate DNA sequence motifs, evolutionary patterns, and diverse func

118 e interconnected loops, one of which carries sequence motifs expected of an EPRV (including the gag a

119 We found a highly conserved peptide sequence motif for HLA-C*05:01-restricted activation of

120 ition and substrate recognition and define a sequence motif for metal binding within this family of r

121 ns and to derive a statistically significant sequence motif for phospho-Ser autophosphorylation.

122 There is no well-defined sequence motif for TPST sulfation, and the underlying de

123 ed routine generation of RNA target sets and sequence motifs for RNA-binding proteins (RBPs).

124 firm and expand the current catalogue of DNA sequence motifs for transcription factors, and describe

125 ins, which contain multiple repeats of short sequence motifs, form a large but seldom-studied group o

126 ain even in highly repetitive RGG amino acid sequence motifs found in numerous proteins within intrin

127 In addition, the sequence motifs found in the potential branch-point regi

128 ional approaches based on kinase recognition sequence (motifs) from known substrates, protein structu

129 binding of zinc finger protein ZNF768 to the sequence motif GCTGTGTG (N20) CCTCTCTG in the core regio

130 Although the consensus sequence motif has been identified and used to explain s

131 pe led to the identification of a C-terminal sequence motif important for substrate tolerance and spe

132 upy promoters harboring the newly identified sequence motif in cell in a methyl-dependent manner and,

133 identified a new and functionally important sequence motif in EL5 containing a conserved tyrosine re

134 Finally, we identify a short sequence motif in HtsRC that is necessary for Kelch bind

135 We report a novel DNA sequence motif in human and mouse genomes.

136 TGTG)-3', corresponding to the most abundant sequence motif in irregular telomeric DNA from Saccharom

137 ith Microprocessor and binding to a specific sequence motif in pri-miRNAs.

138 In addition to transcriptional regulation, a sequence motif in the 3' UTR (D3U-box) mediates transcri

139 miR-155 targeted a conserved sequence motif in the 3'UTR of TRF1, resulting in its tr

140 autorepressed conformation and define a key sequence motif in the Atro box that is essential for TLX

141 RRM to miRNA precursors containing the same sequence motif in their terminal loops, including miR-20

142 ly target cytosine within distinct preferred sequence motifs in DNA, with specificity largely conferr

143 The existence of over- and under-represented sequence motifs in genomes provides evidence of selectiv

144 We identified 2 short-sequence motifs in human NTCP that were required for spe

145 tegrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA.

146 We identified short sequence motifs in rice promoters that are shared across

147 igin establishment requires well-defined DNA sequence motifs in Saccharomyces cerevisiae and some oth

148 erved receptor domains to recognize specific sequence motifs in substrates, such as D and KEN boxes.

149 Importantly, the sequence motifs in the transmembrane domain that are ass

150 pression by recognizing short and degenerate sequence motifs in their target transcripts, but precise

151 ture plays an essential role, in addition to sequence motifs, in determining the specificity of RBP b

152 -residue globular prodomain with a conserved sequence motif including a cysteine engaged in "cysteine

153 ired for fusogenic activity, and we identify sequence motifs, including two hydrophobic segments, tha

154 1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential.

155 This novel AR-binding sequence motif is found in regions predicted to be unstr

156 ptamer, which does not contain the conserved sequence motif, is specific for the rRNA binding site of

157 ions is mediated primarily by two amino acid sequence motifs, ITAMs (immunoreceptor tyrosine-based ac

158 in parallel with evolution of consensus RNA sequence motifs known to be associated with the enzymati

159 alization, was affected by mutating adjacent sequence motifs known to be involved in kindlin binding.

160 ites lie in canonical polo-box motifs (PBM), sequence motifs known to direct recruitment of PLKs to c

161 Moreover, at least two sequence motifs known to interact with the Sp1 transcrip

162 twork layers reveals that APARENT recognizes sequence motifs known to recruit APA regulators, discove

163 nd found collisions were enriched on diverse sequence motifs known to slow translation.

164 f 18 residues of WelO5 within the identified sequence motif led to a functional mutant with an expand

165 These differences impact small sequence motifs like transcription factor binding sites

166 We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may

167 romatin in one cell type to many TFs through sequence motif mapping.

168 sults show that the vast majority of hexamer sequence motifs measurably influence splice site selecti

169 ding proteins (e.g., SRSF1/RBM42) with 5'UTR sequence motifs mediate many of these changes.

170 tide, Ac-c[CVDINNNC]-NH2, containing the key sequence motif mediating the SPSB2-iNOS interaction, whi

171 ocess, characterized by recombination signal sequence motifs near breakpoints, incorporation of non-t

172 increasing intramolecular contacts to basic sequence motifs near the N and C termini.

173 class light chains through a five-amino-acid sequence motif necessary for VRC01 light chain recogniti

174 Recently, the sequence motif of almost 400 human TFs have been identif

175 We also identified 5'-ACG-3' as a common sequence motif of C > T transition.

176 preferential recognition of the four-residue sequence motif of furin.

177 ends on tyrosine 7, located in a cytoplasmic sequence motif of NKp65 resembling a hemi-immunoreceptor

178 of A3H displayed a strong preference for the sequence motif of T-mCpG-C/G, which may suggest a potent

179 can be rewired through the programming of a sequence motif of the general form G-G/F-XXX-G found in

180 these glycans is located within a conserved sequence motif of the receptor-binding region, suggestin

181 The location and surrounding sequence motifs of a PAS appear to differentiate its reg

182 performed a systematic investigation of the sequence motifs of B-class and C-class phosphodiester OD

183 Hotspots were enriched for sequence motifs of key TFs in that cell type and more th

184 A highly conserved sequence motif on helix I contributes to positioning the

185 A neurotoxin-like sequence motif on the receptor-binding domain also exhib

186 We apply MIAA to measure the effects of sequence motifs on cell type-specific accessibility betw

187 Finally, introduction of preferred sequence motifs only at specific codon positions improve

188 erous partners need not converge on a single sequence motif or be increasingly constrained in more co

189 ficity is based on recognition of either RNA sequence motifs or other sequence properties, no such un

190 The APC/C recognizes short linear sequence motifs, or degrons, on its substrates.

191 rovides binding sites for specific substrate sequence motifs, or degrons.

192 Despite prior findings of linear sequence motifs, our measurements revealed widespread re

193 vely spliced exons and a family of conserved sequence motifs overlapping branchpoints we term B-boxes

194 least the first six residues of theMRKTKLAPT sequence motif play a vital role in the maintenance of f

195 matic analysis of these RNAs revealed common sequence motifs potentially recognized by PfSR1.

196 nct epigenetic signatures and cis-regulatory sequence motifs predicted to bind putative co-regulatory

197 Finally, sequence motif predictions identified associations with

198 sic DNA features, such as complexed repeated sequence motifs, predispose the human genome to chromoso

199 We have identified a common short sequence motif present in miRNAs that are selectively lo

200 Plant HSFs of subgroup B lack a conserved sequence motif present in the transcriptional activation

201 cient to explain the CDTS, and that flanking sequence motifs provide individual context that is an eq

202 e range of result types, including BLAST and sequence motif queries.

203 tions were the position of RNA structure and sequence motifs, RBP co-binding and gene region type.

204 modification of selected targets by primary sequence motif recognition.

205 ite many advances in the characterization of sequence motifs recognized by TFs, our ability to quanti

206 implemented filters based on alignment data, sequence motifs, regional coverage and base quality.

207 ites, shorter flanking introns, and distinct sequence motifs relative to "slow-excluded" and "fast-in

208 osylation and the potential role of specific sequence motifs remain largely unknown.

209 358 that defines APOE4 is located in a short sequence motif repeated several times within exon 4 of a

210 and max-pooling, influences the extent that sequence motif representations are learned by first laye

211 to limit the ability to hierarchically build sequence motif representations in deeper layers tend to

212 of P1, suggesting that P2 contains intrinsic sequence motifs required for activation.

213 Sequence motifs required for lysogeny are detectable in

214 We further show that the CNNC primary sequence motif selectively enhances the processing of op

215 We further demonstrate that the sequence motif sensed by TLR8 is clearly distinct from t

216 re promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding transcrip

217 specified for dosage compensation, since DNA sequence motifs shown to be important for dosage compens

218 A-2 binding sites in these cell genes have a sequence motif similar to the sequence known to mediate

219 ng is determined by the presence of specific sequence motifs (SM) and chromatin accessibility, where

220 res learnt by DeepCirCode are represented as sequence motifs, some of which match human known motifs

221 In addition, a preferred sequence motif spanning most SMG6 cleavage sites has bee

222 ily expansions are facilitated by repeats of sequence motifs such as C2H2 zinc fingers.

223 family members bind to similar or identical sequence motifs, such as G-boxes (CACGTG), so it is diff

224 s promote replication errors in specific DNA sequence motifs suggesting increased misinsertion and in

225 s were most enriched for NF-E2, FLI and RUNX sequence motifs, suggesting that this TF triad controls

226 t contains in its helical domain a conserved sequence motif termed COS-box that has been speculated t

227 or in eukaryotes that binds to conserved DNA sequence motifs, termed metal response elements.

228 ch revealed that, even in the absence of the sequence motif, TFs have propensity to bind to DNA molec

229 proposed to specify FMRP binding, the short sequence motifs TGGA and GAC were corroborated, and a no

230 gene of each TU tend to have more conserved sequence motifs than those of the other genes inside the

231 hlight the importance of a master-controller sequence motif that controls both alphaSyn aggregation a

232 chemical, and cellular studies reveal that a sequence motif that defines these ligands binds to a hig

233 lu134 residue of the rhodopsin-conserved ERY sequence motif that helps break the cytoplasmic "ionic l

234 elices, we identified a highly amyloidogenic sequence motif that instigates aggregation and forms the

235 rn of Nuclear Export Signal (NES) is a short sequence motif that is commonly identified in protein se

236 complex recognizes a conserved 21-bp GA-rich sequence motif that is enriched on the X chromosome, and

237 d experimentally validate a promoter element sequence motif that is enriched upstream of the transcri

238 tro, and we biochemically define a bipartite sequence motif that is necessary and sufficient to confe

239 ion of the UPR, some of which share a common sequence motif that may direct cleavage of these mRNAs.

240 Gbeta(2) interacted with a sequence motif that was present in several transcription

241 genesis, and concentrated in specific 5-base sequence motifs that are CA- and CT-rich but depleted of

242 enes through binding to genomic regions with sequence motifs that are conserved among mammals and tha

243 ed among teleost species and that they share sequence motifs that are critical for RGB cone-specific

244 osed protein surfaces and is associated with sequence motifs that are distinct from those for other t

245 nsic biochemical ability to scan partial DNA sequence motifs that are exposed on the surface of a nuc

246 integral membrane proteins contain conserved sequence motifs that are known to be important in helix

247 ions, (iii) in surfaces charges, and (iv) in sequence motifs that are potential ligand-binding sites.

248 hexasome containing genes identified two DNA sequence motifs that correlate with hexasome orientation

249 domly associated with a number of structural/sequence motifs that correlate with paused DNA replicati

250 N terminus of eRF1 contains highly conserved sequence motifs that couple stop codon recognition at th

251 Analyses of enriched DNA sequence motifs that may act as cis-regulatory elements

252 gorithms find statistically over-represented sequence motifs that may function as transcription facto

253 Bcl-2 homology 3 (BH3) domains are short sequence motifs that mediate nearly all protein-protein

254 Nef sequence motifs that modulate these functions have been

255 Furthermore, we identify specific sequence motifs that predict consistent, localized meiot

256 t CDC6 and Cyclin F interact through defined sequence motifs that promote CDC6 ubiquitylation and deg

257 regulatory modules that are enriched for DNA sequence motifs that resemble sequences known to be boun

258 ARP homology domain missing a PARP consensus sequence motif; the domain has enigmatic functions and a

259 e particular clades of enzymes sharing these sequence motifs; the phylogeny was instead dominated by

260 These peptides contained repeat sequence motifs; their interaction with hmAb 1002-1E03 w

261 single PIF-binding sites, containing single sequence motifs, through multiple PIF-binding sites, eac

262 cognition mechanism and nucleus localization sequence motif to design a phosphorylation switch that s

263 matin immunoprecipitation (ChIP) data and TF sequence motifs to computationally classify cell type-sp

264 stinct ways through the enrichment of unique sequence motifs to generate new families of pseudokinase

265 characteristic germline genes and convergent sequence motifs to recognize overlapping epitopes in the

266 transcription factors recognize specific DNA sequence motifs to regulate transcription.

267 ins, containing a conserved W-x-G amino acid sequence motif, to the growth medium.

268 is tool to identify six position-independent sequence motifs together with their cognate transcriptio

269 able to quantify the contribution of various sequence motifs towards the resulting DNA methylation st

270 Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2.

271 The binding epitope on S harbors a sequence motif unique to SARS-CoV-2 (not present in othe

272 The enrichment of G4 sequence motifs upstream of TSS of non-poised active gen

273 ias when accurately identifying enriched DNA sequence motifs using score-based MEA.

274 t detected but can be induced-at a conserved sequence motif-via the ectopic overexpression of eukaryo

275 One sequence motif, VNDT, containing an N-linked glycosylati

276 A Smy1-like sequence motif was also identified in a different Bnr1 r

277 his defect was most severe when the upstream sequence motif was altered.

278 Moreover, a 'TCCCC' sequence motif was specifically enriched in bivalent pro

279 Based on DNA sequence motifs, we propose two distinct mechanisms for

280 A few sequence motifs were found enriched close to the fusion

281 rains 26695 and J99-R3, 17 and 22 methylated sequence motifs were identified, respectively.

282 n this work, synthetic peptides with various sequence motifs were used as trypsin substrates.

283 ill allow researchers to accurately identify sequence motifs which will lead to a better understandin

284 -packaged protein(2,4) that contains a DFDxD sequence motif, which forms the catalytic site in cellul

285 e Yfh1 interaction with Isu involves the PVK sequence motif, which is also the site key for the inter

286 l associations that closely match a hendecad sequence motif, which strengthens the conclusion that th

287 We identified sequence motifs, which enhance or reduce the ability of

288 wo-thirds of Dorsal target genes contain DPE sequence motifs, which is significantly higher than the

289 reactivity are controlled by particular CDR3 sequence motifs, which would allow thymic selection to c

290 By integrating promoter sequence motifs with companion ENCODE epigenomic profile

291 Also, the sequence motifs with successive lysine and/or arginine r

292 interactions between highly diverse receptor sequence motifs with their interacting proteins, such as

293 ted with the presence of a bacterial pausing sequence motif, with reduced SNP density, and with a DNa

294 Primary sequence motifs, with millimolar affinities for binding

295 A di-Arg motif and a long sequence motif within the transmembrane domains were fou

296 This study identifies sequence motifs within ICP0 that are involved in targeti

297 quired for MYC function has been to focus on sequence motifs within MYC that are conserved throughout

298 Conserved sequence motifs within the TMD were replaced with those

299 ENaC channels contain regulatory domains and sequence motifs within their cytosolic domains.

300 identified features, including three primary-sequence motifs, yielded a unifying model defining mamma