ライフサイエンスコーパス: sequence variation

1 t of the host effects are reflected in viral sequence variation.

2 st, rapid and cost-efficient way to discover sequence variation.

3 d for genome-scale analysis of core-promoter sequence variation.

4 mblies reveal large parts of the small-scale sequence variation.

5 gene Avr1b that occur in the absence of any sequence variation.

6 le de novo characterization of core promoter sequence variation.

7 based on mechanisms dependent on subtle gene sequence variation.

8 ughput bioinformatics tools for detection of sequence variation.

9 unlikely to be influenced by neighboring DNA sequence variation.

10 g diversity of structural rearrangements and sequence variation.

11 es and can be discriminated based on cryptic sequence variation.

12 lize alternative folds over a broad range of sequence variation.

13 tation is only one of several forces shaping sequence variation.

14 atterns despite significant sample-to-sample sequence variation.

15 of N-linked glycan and tolerance for epitope-sequence variation.

16 cture can predict site-specific evolutionary sequence variation.

17 ethods not yet tuned for naturally occurring sequence variation.

18 dominant FLC haplotypes defined by noncoding sequence variation.

19 h numerous structural properties can predict sequence variation.

20 functional constraints prevent immune-driven sequence variation.

21 slippage and stalling, leading to length and sequence variation.

22 lity to assess the functional impact of rare sequence variation.

23 and miR-140-3p showed the highest number of sequence variations.

24 quence, implying an adaptability of PRDM9 to sequence variations.

25 ic SNPs among regulatory elements and coding sequence variations.

26 th patients and controls to identify unknown sequence variations.

27 ng phenotypes and often do not have VWF gene sequence variations.

28 onsensus sequence, allowing CTCF to adapt to sequence variations.

29 s and interpretation of both known and novel sequencing variations.

30 Unexpectedly, SUP4oc tolerates numerous sequence variations, accommodates slippage in tertiary a

31 nts associated with blood pressure (BP), but sequence variation accounts for a small fraction of the

32 In 2011, the initial analysis of sequence variation across 17 strains found 56.7 M unique

33 Examining sequence variation across phenotypic pools from the cros

34 becoming routine to obtain data sets on DNA sequence variation across several thousands of chromosom

35 ish a detailed map of allelic and paralogous sequence variation across the FCGR2/FCGR3 locus.

36 rthologous genes and demonstrated that 3'UTR sequence variations affect protein production.

37 This analysis elucidates how genome sequence variation affects disease predisposition via ge

38 ecognition spectra through LRR expansion and sequence variation, allowing them to detect multiple sur

39 ntromeric assemblies to assess the extent of sequence variation among 366 individuals from distinct h

40 ed at the molecular level, and the degree of sequence variation among copies of balancer chromosomes

41 ploids is whether and to what extent the DNA sequence variation among homoeologous chromosomes contri

42 Together, these data show how sequence variation among Pcdh isoforms encodes their div

43 in part, by an association between human DNA sequence variation and a disease or trait relevant to th

44 ave moved toward increased representation of sequence variation and allelic differences within S. cer

45 The expression, sequence variation and apparent diversifying selection i

46 at many CpGs across the human genome by DNA sequence variation and by lifetime environmental exposur

47 results provide the first global view of EBV sequence variation and demonstrate an effective method f

48 tion in an analysis of the interplay between sequence variation and DNA methylation is not well under

49 s to investigate relationships between viral sequence variation and EBV-associated diseases.

50 difference in NCCR promoter activity despite sequence variation and emphasized the importance of func

51 by analysing the association between genome sequence variation and exon inclusion across the transcr

52 as ELISA or FACS that are susceptible to the sequence variation and expression level of the protein.

53 strategy for analyzing relationships between sequence variation and function.

54 Thus, relationships between EBV genome sequence variation and health, disease, geography, and e

55 e found to have both low naturally occurring sequence variation and high (>99%) coverage across this

56 methods are highly sensitive to artifactual sequence variation and inadequate to properly recover bi

57 Whole genome sequence variation and morphological trends within this

58 are conserved in PEDV-3CL(pro); however, the sequence variation and positional difference in the loop

59 conducted a comprehensive analysis of viral sequence variation and T-cell receptor (TCR) repertoire

60 Moreover, the relative impacts of DNA sequence variation and temporal changes in lifestyle and

61 ted genes showed that many contain extensive sequence variation and that patterns of single- and mult

62 and constructed networks that integrate DNA sequence variation and variation in gene expression with

63 tiple PLN isoforms, one of which contains 18 sequence variations and a unique luminal extension.

64 We associated these with HDV sequence variations and clinical features of patients.

65 The epigenome integrates information from sequence variations and metabolic alterations.

66 evolving, function is undoubtedly driven by sequence variations and post-translational modifications

67 oforms arising from combinatorial amino acid sequence variations and post-translational modifications

68 that are devoid of nonpolymorphic paralogous sequence variations and that define the limits of the ge

69 after long-term storage was similar to inter-sequencing variation and smaller than biological variati

70 ion provides resilience or susceptibility to sequence variations, and how this would contribute to th

71 ess in describing whole-genome, species-wide sequence variation; and then discuss what insights have

72 epigenetic modifications, in contrast to DNA sequence variation, are more likely to be reversible.

73 normal at study entry had a similar rate of sequence variations as the healthy controls (14%).

74 ranscripts and increasingly in recent years, sequence variations, as well as map positions for multip

75 lymorphisms (nsSNPs) are the most common DNA sequence variation associated with disease in humans.

76 t' position in the peptide with tolerance of sequence variation at ancillary positions.

77 Among species, sequence variation at ASIP broadly mirrors the species'

78 Sequence variation at chromosome 9p21.3 accounts for 20%

79 Sequence variation at each gene predicts allorecognition

80 As genetic studies probe sequence variation at greater depth in more diverse popu

81 Sequence variation at neutralizing epitopes does not ful

82 volutionarily distant sequences reveals that sequence variation at sector positions can distinguish h

83 ing enzyme that is relatively insensitive to sequence variation at the first three positions.

84 We show that non-coding sequence variation at the FRO2 locus leads to variation

85 gest that cargo affinity for importin-alpha, sequence variation at the importin-alpha NLS-binding sit

86 Overall, sequence variation at the variant level does not appear

87 It is a complete summary of sequence variation at unlinked sites and more generally,

88 Genetic sequence variations at 101 loci were associated with the

89 Compared to 2013 reference sequences, variations at F protein antigenic sites were

90 Sequence analysis revealed that MG192 sequence variation began at 5 weeks p.i.

91 ries in the human population, or whether DNA sequence variation between individuals influences 3D chr

92 Comparison of the sequence variation between isolates from Malawi and thos

93 hermore, we address considerations regarding sequence variation between strains during probe design.

94 hether these differences arise from the high sequence variation between the different isolates and if

95 in-silico physical mapping of DE genes with sequence variations between fl and WT identified one and

96 divergence within group III occurred through sequence variation both at the ligand-binding pocket and

97 Deep sequencing revealed interpatient gp350 sequence variation but conservation of the CR2-binding s

98 eceptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintai

99 harbour a considerable fraction of total DNA sequence variation, but the functional contribution of t

100 d evidence that DMRs can occur without local sequence variation, but they are less common than in reg

101 studies exploit the mutational landscape of sequence variation by systematically and comprehensively

102 Mitochondrial DNA (mtDNA) sequence variation can influence the penetrance of compl

103 High sequence variation causes BabA functional diversity, but

104 ct, we identify a rich seam of ribosomal DNA sequence variation, characterising 1,068 and 970 polymor

105 ed few off-target effects and a low level of sequence variation, comparable to that accumulated in ro

106 ite preferences for 23 homologs with natural sequence variation compared to CjPglB.

107 MG192 nucleotide sequence variation correlated with estimated recombinati

108 However, the simultaneous display of sequence variation, coverage depth and quality scores ac

109 Sequence variation data of the human proteome can be use

110 phenotype-driven analysis of next-generation sequence-variation data, and translational research, but

111 s musculus Receptor usage and envelope (env) sequence variation define three MLV host range subgroups

112 possible to quantify subtle effects such as sequence variation, demethylation, and de novo methylati

113 and representation of reference genomes and sequence variations derived from population studies and

114 ll pedigrees sustain limited copy number and sequence variation despite extensive serial passaging an

115 ental variables to assess how subtle protein sequence variations drive the molecular transition of th

116 s study, we determined the kinetics of MG192 sequence variation during the course of experimental inf

117 the double mutant, implying that functional sequence variation elsewhere in the protein is necessary

118 use of differences in common or rare genomic sequence variation, environmental factors or their inter

119 Sequence variation existent across fungal taxa provides

120 We find that learning in the presence of sequence variations facilitates rapid relearning after s

121 ding blood lipids has largely focused on DNA sequence variation; few studies have explored epigenetic

122 t this hypothesis, we injected plasmids with sequence variations flanking an I-SceI endonuclease reco

123 Our study identifies population-specific sequence variation for HERV-K proviruses at several loci

124 on landscape features and mitochondrial DNA sequence variation for nine codistributed amphibian spec

125 S) can comprehensively capture low-frequency sequence variation for the cost of a dense genome-wide g

126 ologies have increased the ability to detect sequence variations for complex trait improvement.

127 ides an opportunity to make increased use of sequence variations for phenotype prediction.

128 Results indicate that folding is robust to sequence variations for proteins with some nonlocal fold

129 papillomavirus (HPV) 16 displays substantial sequence variation; four HPV16 lineages (A, B, C, and D)

130 populations, we had to carefully distinguish sequence variation from errors due to experimental proto

131 y, we examined these hypotheses by employing sequence variation from multiple nuclear and chloroplast

132 Using full-genome sequence variation from the 1000 Genomes Project, we fir

133 identical latent membrane protein 1 (LMP-1) sequence variations from the reference EBV strain, makin

134 uccess in identifying disease-associated DNA sequence variation has followed from new genomic technol

135 Understanding the effects that sequence variation has on a molecule's interactions is a

136 a system to encompass the full complexity of sequence variations (i.e., isomiRs) in the analysis of s

137 A sequence variation (I148M) in patatin-like phospholipase

138 Twelve sequence variations identified by exome sequencing were

139 In addition, sequence variations identified from FFPE RNA show 99.67%

140 ely via the VWF A1 domain, and that specific sequence variations identified through VWF patient sampl

141 e advancing our understanding of how protein sequence variation impacts molecular protein function.

142 Second, to analyze the effect of minor sequence variation in a clinical setting, we screened tu

143 nt study, we characterized Tp0750 and Tp0751 sequence variation in a diversity of pathogenic and nonp

144 MD-MX associations as they may relate to DNA sequence variation in AMD- and lipoprotein-related genes

145 ome-wide association study (GWAS) results is sequence variation in cis-regulatory elements (CREs) mod

146 These results suggest that alongside sequence variation in coding immunological genes, variat

147 To examine the role of recurrent coding sequence variation in CRC aetiology, we genotyped 12,638

148 onclusion, we reported a genome-wide view of sequence variation in EBV isolated from primary NPC biop

149 t-generation sequencing datasets to identify sequence variation in genes and enhancer elements in con

150 ID), the enzyme responsible for induction of sequence variation in immunoglobulins (Igs) during the p

151 o the variable expression of OsMOT1;1 due to sequence variation in its promoter.

152 urotropic JCPyV, little is known about viral sequence variation in JCPyVAN owing to the rarity of thi

153 In summary, we found a high degree of sequence variation in LCR22A and LCR22D and a potential

154 0 eukaryotic RR sequences to examine natural sequence variation in loop 2.

155 that variation in microRNA expression and/or sequence variation in microRNA binding sites in target g

156 Therefore we contrast sequence variation in miRNAs and their targets within A.

157 ng by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighti

158 We hypothesized that geographically-biased sequence variation in mpb70 and mpb83, or in the genes t

159 Thus, sequence variation in mpb70, mpb83, sigK, and rskA does

160 Despite similar degrees of sequence variation in naturally occurring IN and CA sequ

161 e aims of this study were to determine MG192 sequence variation in patients with chronic M. genitaliu

162 work yields functional insights into the SD sequence variation in prokaryotic genomes, identifies a

163 Sequence variation in regulatory DNA alters gene express

164 Here, we show that sequence variation in regulatory domains of the fruit-ti

165 Here we describe the detailed sequence variation in the complete IGS of A. thaliana WT

166 Despite substantial overall sequence variation in the CTT, specific arginines are hi

167 These isolates exhibited extensive sequence variation in the form of single-nucleotide poly

168 Here we explore natural sequence variation in the FRI locus in more than 1000 Ar

169 lymorphisms (SNPs) are the most abundant DNA sequence variation in the genomes which can be used to a

170 Also, sequence variation in the HA gene was greater at the beg

171 Subtle sequence variation in the modular synthetic ligand dicta

172 DNA sequence variation in the NRAT1 coding and regulatory re

173 es followed, to determine a loss of function sequence variation in the phospholipase A2-activating pr

174 as established to estimate independently the sequence variation in the probe binding regions from the

175 ular simulation based functional analysis of sequence variation in the protein targets of small molec

176 lls) appears to have had a greater impact on sequence variation in the TDH3 promoter than selection o

177 Finally, we used sequence variation in the transcriptome data to determin

178 ovide insights into functional correlates of sequence variation in the VacA midregion (m region).

179 We find reduced sequence variation in this gene region for SA wintering

180 prevalence and evolutionary significance of sequence variation in this ubiquitous genomic region are

181 Therefore, we analysed the allelic sequence variation in three Sub1 genes in a panel of 179

182 Significant sequence variation in TLR5 exists between animal species

183 Sequence variation in tRNA genes influences the structur

184 ic experiments covering 69% of the available sequence variation in two distinct sites, we show that v

185 We also compared replication and sequence variation in wild-type mice expressing N-glycol

186 resistance to orthosomycins and revealed the sequence variations in 23S rRNA nucleotides alongside th

187 omosome, mitochondrial DNA, and whole-genome sequence variations in a large number of 595 rams repres

188 Large sequence variations in CCP domains explain the diverse C

189 We identified amino acid sequence variations in GRMZM2G075262 that segregate with

190 s contribution to binding affinity, and that sequence variations in H2 that do not change the level o

191 this, human genomic studies are identifying sequence variations in patients, resulting in numerous c

192 ificity, and interprets the action of coding sequence variations in proteins, people and populations.

193 is information can be used to determine when sequence variations in seasonal influenza virus strains

194 Monitoring copy number and sequence variations in the CFHR gene cluster in C3G-DDD

195 ver, analysis of DNA from 79 subjects showed sequence variations in the latent protein, LMP1, which a

196 Sequence variations in the myocilin (MYOC) gene account

197 GI NoVs, similar to GII, exhibit significant sequence variations in the P domain; it is unclear how t

198 becomes more economical, we are identifying sequence variations in the population faster than ever.

199 itivity to the toxin is conferred by natural sequence variations in the S1-S2 loop of domain II.

200 d beta barrel, an elegant structure allowing sequence variations in the strand-connecting loops while

201 AC blockade and what effects might be due to sequence variations in these tail peptides or to tubulin

202 Sequence variations in this region that result in differ

203 m to reveal the functional impact of natural sequence variations in trans recognition.

204 n 4 was associated with select VWF A1 domain sequence variations in type 1 and type 2M VWD.

205 To understand the sequence variations in zfPLN, chimeras were created by t

206 Arabidopsis accessions were cis-regulated by sequence variation, including those in core splice site

207 increasingly used for the quantification of sequence variations, including single nucleotide polymor

208 Analysis of gene expression and DNA sequence variation indicates that isoform expression dif

209 tion to host HLA, where HIV subtype-specific sequence variation influences both epitope-HLA binding a

210 How DNA sequence variation influences gene expression remains po

211 Moreover, we find that DNA sequence variation influences several features of 3D chr

212 rks enriched for genes intolerant to protein sequence variation, informing novel polygenic contributi

213 Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine

214 Accurate interpretation of DNA sequence variation is a prerequisite for implementing pe

215 ificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity.

216 ethylation differences are maximized and DNA sequence variation is minimized.

217 Comprehensive enumeration of sequence variation is necessary to identify functional a

218 enome bins and show that substantial genomic sequence variation is present in a real metagenome.

219 Understanding how DNA sequence variation is translated into variation for comp

220 atforms, miRNA mapping associated with miRNA sequence variation (isomiR) and RNA editing, and the ori

221 and uncovered three mechanisms by which GBSS sequence variation led to different amylose contents: (1

222 ecent studies have shown how the analysis of sequence variation leverages the available protein-struc

223 One mechanism by which sequence variation may reduce propensity to form amyloid

224 amino acid positions 112 and 158, and these sequence variations may confer conformational difference

225 we explored whether 'laboratory', synthetic sequence variation might also yield 3D structures.

226 stand the molecular mechanisms by which this sequence variation modifies platelet function, we produc

227 The sequence variations observed at drug-resistance loci ref

228 In addition, we provided evidence that MG192 sequence variation occurred during the process of M. gen

229 The majority of sequence variation occurred in the HA gene, and some mut

230 Here, we show that sequence variation occurring early in the evolution of k

231 Here we report the sequence variation of 16 different isolates of parainflu

232 The distinct structure and sequence variation of clade B gp120 differentially impac

233 mparisons suggest that this reflects limited sequence variation of macaque IgGs as a result of their

234 Sequence variation of the glycoprotein (G) gene alone wa

235 nd in Williams syndrome were associated with sequence variation of the LIMK1 gene.

236 Genome organization and sequence variation of tRNA genes are also discussed in l

237 However, it has not been elucidated which sequence variations of the canonical CHR are functional

238 sive-disease potentials revealed intraclonal sequence variations of the virulence-associated proteins

239 We demonstrate that M-Probes can tolerate sequence variations of up to 7 nt at prescribed position

240 ng findings regarding the role of non-coding sequence variation offer opportunities for understanding

241 nt inability to predict the effect of genome sequence variation on DNA methylation precludes a compre

242 To further investigate the influence of sequence variation on N-glycosylation efficiency in the

243 demonstration of the strong effect of minor sequence variation on pMHC-based personalized immunomoni

244 ortant context when predicting the impact of sequence variation on protein function.

245 d uses this network to predict the impact of sequence variation on proximal CpG site DNA methylation.

246 lines (LCLs) and analyzed the effect of DNA sequence variation on RNA half-life differences.

247 nature of most RNA structures or effects of sequence variation on structure are not known.

248 interactions and the impact of heterozygous sequence variation on the expression of neighboring gene

249 enables systematic analysis of the impact of sequence variation on transcription factor occupancy in

250 To comprehensively define the effects of sequence variation on tRNA function, we developed a high

251 Mapping of sequence variations on a CPB structure modeled using rel

252 , basecaller software frequently missed gene sequence variations or could not identify variant bases

253 e selection and undergo patterned changes in sequence variation over time, the relationships between

254 al Gag protein exhibits extensive amino acid sequence variation overall; however, one region of Gag,

255 The sequence variation p.[P33S(;)P168S] is the most prevalen

256 g rheology and spectroscopy, we describe how sequence variations, pH, and peptide concentration alter

257 isolates 'glycan holes' occur due to natural sequence variation, potentially revealing the underlying

258 e sensitivity of binding properties to minor sequence variation represent a substantial challenge to

259 show for the first time that unresolved rDNA sequence variation resulting from imperfect concerted ev

260 However, the wide sequence variation, sources and modalities of group memb

261 mographic history imparts on patterns of DNA sequence variation, statistical methods that have been d

262 In addition, infants expressing the sequence variation tended to have significantly lower BW

263 hanges in gene expression independent of DNA sequence variation that are inherited through cell divis

264 s some were attributable to subtype-specific sequence variation that influenced epitope-HLA binding,

265 strain of protein-coding genes that acquired sequence variations that cause premature STOP codons, lo

266 Our comparisons of IEE sequences showed sequence variations that could be divided into at least

267 , yet it has been difficult to identify gene sequence variations that underlie this heritability.

268 rom patients with persistent reinfection had sequence variations that were not recognized by the pre-

269 Two sequence variations that were significantly (P < 0.0001)

270 ment of the ITS amplicons showed very little sequence variation, there was preliminary single nucleot

271 In the absence of sequence variations, these correlations grow, due to the

272 on may lie on the regulatory pathway linking sequence variation to blood pressure.

273 ensively explores the contribution of coding sequence variation to CRC risk, identifying associations

274 n have emerged as a key tool for linking DNA sequence variation to phenotypes.

275 in our knowledge of the contribution of DNA sequence variations to cardiovascular disease and stroke

276 ser to specify a reference panel of expected sequence variations to improve the model accuracy.

277 such as heteroplasmy (i.e. intra-individual sequence variation) to a higher level of detail.

278 Naturally occurring JCV sequence variation, together with drug treatment-induced

279 Remarkably narrow sequence variation was found within the HvCslF6 promoter

280 erization of local centromeric tandem repeat sequence variation we have designed Alpha-CENTAURI (ALPH

281 lationships of Hsp21 and understanding these sequence variations, we developed a structural model of

282 In contrast, in patients displaying sequence variations, we were able to induce HCV-specific

283 Higher levels of sequence variations were also observed for genes involve

284 VWF sequence variations were most frequent in subjects with

285 agent of typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationa

286 le genome, that is, population-level natural sequence variation within a species that is not present

287 enomes Consortium, we characterize rRNA gene sequence variation within and among accessions.

288 Sequence variation within enhancers plays a major role i

289 latory sequences in neurobiology and linking sequence variation within enhancers to genetic risk for

290 reference databases for studying patterns of sequence variation within human populations.

291 DNA (rDNA) internal transcribed spacer (ITS) sequence variation within the Chrysanthemum indicum comp

292 nal tolerance and a strong correspondence to sequence variation within the enzyme family, but also re

293 We demonstrate that sequence variation within the mitochondrial DNA (mtDNA)

294 There is considerable sequence variation within the TZF domains from different

295 These data directly link sequence variation within the XDP-specific SVA sequence

296 The data demonstrate that small sequence variations within an activator family significa

297 ting viral escape from KIR+ NK cells through sequence variations within HLA class I-presented epitope

298 I function in vivo and capitalize on natural sequence variations within it to facilitate structural a

299 Sequence variations within the hypervariable region of R

300 sequencing analysis indicated large peptide sequence variation without specific clone expression dur