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1 pe that was corrected by transformation with serine palmitoyltransferase.
2 hesis of complex sphingolipids downstream of serine palmitoyltransferase.
3 imiting enzyme in sphingolipid biosynthesis, serine palmitoyltransferase.
4  but unlike myriocin FTY720 does not inhibit serine palmitoyltransferase.
5 the activities of both ceramide synthase and serine palmitoyltransferase.
6 we revealed aberrant gene expressions (e.g., serine palmitoyltransferase 1 [SPTLC1] and ceramide synt
7 epsin F (OR = 1.10, p-value = 7.16E-05), and serine palmitoyltransferase 2 (OR = 0.86, p-value = 1.00
8 s and knockdowns affecting either subunit of serine palmitoyltransferase, a key enzyme in ceramide an
9                              Inactivation of serine palmitoyltransferase, a key enzyme in generating
10 ntial substrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme of sphingolipi
11  sphingolipids, apparently via modulation of serine palmitoyltransferase, a rate-limiting enzyme in d
12 were protected from diet-induced increase in serine palmitoyltransferase, acid sphingomyelinase, and
13 tion that associates with increased monocyte serine palmitoyltransferase activity and chemotaxis towa
14 are synthesized from alanine via promiscuous serine palmitoyltransferase activity and correlate with
15    These mutations are dominant and decrease serine palmitoyltransferase activity by 50% when the wil
16  h after ultraviolet B irradiation), whereas serine palmitoyltransferase activity did not change.
17      l-Cycloserine, an inhibitor that blocks serine palmitoyltransferase activity, lowered both sphin
18 LCB1 gene of Saccharomyces cerevisiae reduce serine palmitoyltransferase activity.
19  alpha-oxoamine synthase family required for serine palmitoyltransferase activity.
20  The tsc3 mutant cells have severely reduced serine palmitoyltransferase activity.
21 ation of Tyr(164) to Phe in SPTLC1 increased serine palmitoyltransferase activity.
22 hingomyelin) are reduced secondary to absent serine palmitoyltransferase activity.
23 n, isolation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the fi
24         ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the in
25                                We found that serine palmitoyltransferase and ceramide synthase are lo
26 ion of [(3)H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into
27 ation of [3H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into
28 isin B1, specific inhibitors of key enzymes (serine palmitoyltransferase and dihydroceramide synthase
29 thase activity (over 2-fold, p = 0.01); both serine palmitoyltransferase and glucosylceramide synthas
30 ion are the ORMDL proteins that are bound to serine palmitoyltransferase and mediate feedback inhibit
31 hytosphingosine bypasses the requirement for serine palmitoyltransferase and restores proteolysis.
32 generation through the de novo pathway (e.g. serine palmitoyltransferase) and via the hydrolysis of s
33 hingolipid biosynthetic pathway (mediated by serine palmitoyltransferase), and at least regulated, de
34 is due to impaired homeostatic regulation of serine palmitoyltransferase as responsible for defects i
35                      These results implicate serine palmitoyltransferase as the enzyme controlling de
36 o regulate sphingolipid synthesis by binding serine palmitoyltransferase, but its role in inflammatio
37 n SPTSSA impaired the negative regulation of serine palmitoyltransferase by ORMDLs leading to excessi
38 zymes known as the alpha-oxoamine synthases, serine palmitoyltransferase catalyzes the committed step
39                                              Serine palmitoyltransferase catalyzes the condensation o
40                                              Serine palmitoyltransferase catalyzes the first step of
41                              The enzyme SPT (serine palmitoyltransferase) commences de novo biosynthe
42                                              Serine palmitoyltransferase complex (SPT) mediates the f
43 cycloserine, and 4-HPR transiently activated serine palmitoyltransferase, demonstrating that 4-HPR in
44            Sphingolipids are produced by the serine palmitoyltransferase enzyme, canonically composed
45 is work demonstrates that one subunit of the serine palmitoyltransferase enzyme, SPTLC1, but not subu
46 or angiogenic responses in mice with reduced serine palmitoyltransferase expression.
47 ace of L-serine, the mutant HSAN1-associated serine palmitoyltransferase generates deoxysphingolipids
48    While the putative homologues of giardial serine palmitoyltransferase (gSPT) subunit genes (gspt-1
49  two isoforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the
50 as evolutionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomo
51 A-stimulated RAW264.7 cells (and mutation of serine palmitoyltransferase in CHO-LYB cells); furthermo
52 e for de novo sphingoid base biosynthesis by serine palmitoyltransferase in the transient G0/G1 arres
53 ySLs) are atypical sphingolipids formed when serine palmitoyltransferase incorporates L-alanine inste
54 we1 kinase renders mutant cells sensitive to serine palmitoyltransferase inhibition due to impaired s
55 esis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show st
56                                          The serine palmitoyltransferase inhibitor myriocin reversed
57 lipid synthesis pathway was tested using the serine palmitoyltransferase inhibitor myriocin, the sphi
58 NA knockdown, ORMDL3 overexpression, and the serine palmitoyltransferase inhibitor myriocin.
59          In all eukaryotes analyzed to date, serine palmitoyltransferase is a highly conserved hetero
60 oamine synthases are soluble homodimers, but serine palmitoyltransferase is a membrane-associated enz
61                            We also show that serine palmitoyltransferase is an Lcb1p small middle dot
62                Modeling studies suggest that serine palmitoyltransferase is likely to have a single a
63 ort here that the gene encoding a subunit of serine palmitoyltransferase is located within the HSN1 l
64  This result suggests that the activation of serine palmitoyltransferase is the event responsible for
65 1-100, which harbors a temperature-sensitive serine palmitoyltransferase, lacked increased de novo ge
66 n orthologue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic
67 f ceramide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is req
68  canonically composed of 2 subunits, SPTLC1 (serine palmitoyltransferase long chain base subunit 1) a
69 erase long chain base subunit 1) and SPTLC2 (serine palmitoyltransferase long chain base subunit 2).
70 y a more recently described subunit, SPTLC3 (serine palmitoyltransferase long chain base subunit 3).
71 onstrated that the ER-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1), which
72 olling enzyme of de novo ceramide synthesis, serine palmitoyltransferase long-chain base subunit 1 (S
73 itary neuropathies are dominant mutations in serine palmitoyltransferase, long chain base subunit 1 (
74  the gene was identified as SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1.
75 d an increase in the message and activity of serine palmitoyltransferase (P < 0.05).
76 ysical interaction between Orm1 and Orm2 and serine palmitoyltransferase, responsible for the first c
77 ynthase, and ISP-1, myriocin an inhibitor of serine palmitoyltransferase, significantly attenuated th
78 AHR bound and activated the gene promoter of serine palmitoyltransferase small subunit A (SPTSSA), wh
79                     The relationship between serine palmitoyltransferase (SPT) activity and ORMDL reg
80  precursors and intermediates, and increased serine palmitoyltransferase (SPT) and fatty acid (FA) el
81 member of a family that negatively regulates serine palmitoyltransferase (SPT) and thus biosynthesis
82 disrupt the normal homeostatic regulation of serine palmitoyltransferase (SPT) by ORMDL proteins, res
83                                              Serine palmitoyltransferase (SPT) catalyses the de novo
84                                              Serine palmitoyltransferase (SPT) catalyzes the first co
85                                              Serine palmitoyltransferase (SPT) catalyzes the first st
86                                              Serine palmitoyltransferase (SPT) catalyzes the first st
87                                              Serine palmitoyltransferase (SPT) catalyzes the first st
88                                   The enzyme serine palmitoyltransferase (SPT) catalyzes the formatio
89           Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset,
90                                          The serine palmitoyltransferase (SPT) complex catalyzes the
91 teins function as regulatory subunits of the serine palmitoyltransferase (SPT) complex, which is the
92 ted to a few bacterial phyla that encode the serine palmitoyltransferase (SPT) enzyme, which catalyse
93 a sensory neuropathy due to mutations in the serine palmitoyltransferase (SPT) enzyme.
94 with the SPOTS complex, which is composed of serine palmitoyltransferase (SPT) enzymes and accessory
95                                              Serine palmitoyltransferase (SPT) is a key enzyme in the
96                                              Serine palmitoyltransferase (SPT) is the first and rate-
97                                              Serine palmitoyltransferase (SPT) is the first rate-limi
98                                              Serine palmitoyltransferase (SPT) is the key enzyme in S
99        The LCB chain length is determined by serine palmitoyltransferase (SPT) isoenzymes, which are
100 volved, we utilized two models: heterozygous serine palmitoyltransferase (SPT) subunit 2 (Sptlc2) gen
101 osomucoid-like proteins (ORMs) interact with serine palmitoyltransferase (SPT) to negatively regulate
102 yridoxal-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising t
103 ndensation of alanine with palmitoyl-CoA via serine palmitoyltransferase (SPT), as indicated by incor
104 n SPTLC1 gene, encoding the Lcb1p subunit of serine palmitoyltransferase (SPT), cause hereditary sens
105                                              Serine palmitoyltransferase (SPT), composed of LCB1 and
106                      Indeed, the products of serine palmitoyltransferase (SPT), long-chain bases, loc
107 s with either L-cycloserine, an inhibitor of serine palmitoyltransferase (SPT), or fumonisin B(1), an
108 -chain base 1 (LCB1), one of two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing
109 ere labeled with [14C]serine, a substrate of serine palmitoyltransferase (SPT), the enzyme catalyzing
110  not directly alter the in vitro activity of serine palmitoyltransferase (SPT), the enzyme responsibl
111 apid decrease in LCB levels, indicating that serine palmitoyltransferase (SPT), the first and rate-li
112 nesis, the ehv050 gene predicted to encode a serine palmitoyltransferase (SPT), the first and rate-li
113 ot associated with changes in mRNA levels of serine palmitoyltransferase (SPT), the rate-limiting enz
114                SPTLC1 encodes one subunit of serine palmitoyltransferase (SPT), the rate-limiting enz
115 osynthesis in Leishmania, we have focused on serine palmitoyltransferase (SPT), which catalyses the f
116          We therefore semiquantified mRNA of serine palmitoyltransferase (SPT), which catalyzes the f
117           Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT), which catalyzes the f
118 ipid biosynthesis is initiated by the enzyme serine palmitoyltransferase (SPT), which resides in the
119 cerbate the excess sphingolipid synthesis in serine palmitoyltransferase (SPT)-associated ALS.
120 ed a variant in SPTLC1 encoding a subunit of serine palmitoyltransferase (SPT).
121 ntally observed repressive effect of ORMs on serine palmitoyltransferase (SPT).
122 proteins are claimed to be inhibitors of the serine palmitoyltransferase (SPT).
123 sphingolipids are 2-amino, 1,3-diols made by serine palmitoyltransferase (SPT).
124 ep in sphingolipid synthesis is catalyzed by serine palmitoyltransferase (SPT).
125 s encoding 2 of the 3 subunits of the enzyme serine palmitoyltransferase (SPT).
126 esults from mutations in the LCB1 subunit of serine palmitoyltransferase (SPT).
127 yl-CoA catalyzed by the PLP-dependent enzyme serine palmitoyltransferase (SPT).
128 novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT).
129 re produced by the activity of virus-encoded serine palmitoyltransferase (SPT).
130 and committed biosynthetic step catalyzed by serine palmitoyltransferase (SPT, EC 2.3.1.50).
131 ion is catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which is
132  of the Lcb1p subunit of yeast and mammalian serine palmitoyltransferases (SPT) were investigated.
133  encodes the second catalytic subunit of the serine-palmitoyltransferase (SPT) complex.
134 dependent reaction is mediated by the enzyme serine-palmitoyltransferase (SPT).
135 rotoxic sphingolipids that are formed by the serine-palmitoyltransferase (SPT).
136 pressed the expression of SPTLC1 and SPTLC2 (serine palmitoyltransferase [SPT] long-chain base subuni
137  trypanosomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2-) and SLs grow well, a
138 he same prototypical fold found in bacterial serine palmitoyltransferases (Spts), enveloping the PLP
139 etion of the key de novo biosynthetic enzyme serine palmitoyltransferase subunit 2 (SPT2).
140 e report that HSAN-I-associated mutations in serine palmitoyltransferase subunit SPTLC2 dampened huma
141 t A (SPTSSA), which encodes a subunit of the serine palmitoyltransferase that catalyzes the first and
142 th myriocin (50 nm), a specific inhibitor of serine palmitoyltransferase (the first step in de novo s
143 n of Sptlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enzyme responsible for
144                                              Serine palmitoyltransferase, the enzyme that catalyses t
145 synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting
146 is, increase the activity and mRNA levels of serine palmitoyltransferase, the first committed step in
147 rtially reduced by myriocin, an inhibitor of serine palmitoyltransferase, the first committed step in
148                     We therefore inactivated serine palmitoyltransferase, the first enzyme in the sph
149 ngolipids since it is the main substrate for serine palmitoyltransferase, the initial and rate-limiti
150  investigation using a labeled substrate for serine palmitoyltransferase, the rate-limiting enzyme in
151 treated with myriocin, a potent inhibitor of serine palmitoyltransferase, the rate-limiting enzyme in
152                              Nogo-B inhibits serine palmitoyltransferase, the rate-limiting enzyme of
153  synthase, but not by ISP-1, an inhibitor of serine palmitoyltransferase, the rate-limiting step in t
154 xysphingolipids are produced when the enzyme serine palmitoyltransferase uses l-alanine instead of l-
155 lytic activity and homeostatic regulation of serine palmitoyltransferase was investigated in human em
156 cted a deletion mutant of BF2461, a putative serine palmitoyltransferase whose yeast homolog catalyze
157                       AT2 receptor activated serine palmitoyltransferase with a maximum time of 24 h
158 t lack Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates end

 
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