ライフサイエンスコーパス: serine phosphorylation

1 the addition of a negative charge mimicking serine phosphorylation.

2 enhanced STAT1-mediated gene expression via serine phosphorylation.

3 tivation, which followed the onset of RhoGDI serine phosphorylation.

4 (PKA) activity and increases beta3 integrin serine phosphorylation.

5 cent subunits and regulating factors such as serine phosphorylation.

6 Instead PTP1B was activated by serine phosphorylation.

7 ession, GRK-2 sequestration, and D1 receptor serine phosphorylation.

8 2) membranous translocation, and D1 receptor serine phosphorylation.

9 both direct and indirect regulation of IRS1 serine phosphorylation.

10 d in wild-type, metastatic mammary tumors by serine phosphorylation.

11 h key protein interactions are controlled by serine phosphorylation.

12 cking antibodies and involved beta1 integrin serine phosphorylation.

13 ttle is known about the significance of Spry serine phosphorylation.

14 egulated by EGFR through modulation of STAT3 serine phosphorylation.

15 ine phosphorylation, while stimulating c-Met serine phosphorylation.

16 lipase C (PLC) activity was required for PKD serine phosphorylation.

17 specifically localized to the ER on its own serine phosphorylation.

18 stimulate HBV replication by increasing core serine phosphorylation.

19 ion by ERBB4 is also mediated through STAT5A serine phosphorylation.

20 y through a detailed study of the role of MA serine phosphorylation.

21 ne/threonine kinase responsible for alphaPIX serine phosphorylation.

22 nd NF-kappaB signaling through modulation of serine phosphorylation.

23 ionarily-conserved serine-rich domain with 4-serine phosphorylation.

24 Exposure to E2 significantly decreased STIM1 serine phosphorylation.

25 in in a ternary complex that is regulated by serine phosphorylation.

26 dation, consistent with GRK isoform-specific serine phosphorylation.

27 ivation of Stat5b requires both tyrosine and serine phosphorylation.

28 lysine methylation, lysine acetylation, and serine phosphorylation.

29 tochemistry showed decreases in beta-catenin serine phosphorylation (33/37) and ubiquitinylation in t

30 Increased IRS2 serine phosphorylation, a marker of insulin resistance,

31 interaction is regulated by topoisomerase I serine phosphorylation, a modification that regulates to

32 Analyses of the transport cycle show that serine phosphorylation abolishes the K(+)-dependence of

33 ding domain or mutating two newly discovered serine phosphorylation acceptor sites, Ser106 and Ser110

34 t posttranslational modifications, including serine phosphorylation, acetylation, methylation, and su

35 Conversely, enhancement of serine phosphorylation achieved through either the inhib

36 BDNF stimulated m-calpain but not mu-calpain serine phosphorylation, an effect also blocked by MAPK i

37 horylation as well as an enhancement of KCC2 serine phosphorylation and activity.

38 activates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated

39 Unusually, activation is regulated by serine phosphorylation and consequent inhibition of a ty

40 tion of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ens

41 3-kinase (PI3K)/Akt pathway, which involves serine phosphorylation and degradation of IkappaB alpha.

42 d Ser523 as the first-described site of Jak2 serine phosphorylation and demonstrated that this site i

43 nction-blocking antibodies on beta3 integrin serine phosphorylation and EC-ralpha4LN fragment binding

44 cient mice fail to exhibit LPS-induced Stat3 serine phosphorylation and IL-10 gene expression yet sti

45 because of protein kinase A (PKA)-dependent serine phosphorylation and inactivation of RhoA.

46 nces in hepatic insulin receptor substrate 1 serine phosphorylation and inflammatory marker expressio

47 Serine phosphorylation and inhibition of AMPK activity w

48 der various pathological conditions, through serine phosphorylation and inhibition of insulin recepto

49 vation of p70S6K, which in turn promotes the serine phosphorylation and inhibition of IRS-1.

50 titutively active Src expression resulted in serine phosphorylation and inhibition of WASP-associated

51 a transcription factor that is regulated by serine phosphorylation and is critical for the developme

52 G-CSF induced both serine phosphorylation and membrane translocation of p47

53 ergoes conformational changes in response to serine phosphorylation and proline isomerization.

54 e isomerisation can be inhibited by adjacent serine phosphorylation and requires a prolyl isomerise,

55 cer and activator of transcription 1 (Stat1) serine phosphorylation and Stat1 nuclear translocation t

56 (-/-) animals, OPN was necessary for PDLIM2 serine phosphorylation and STAT1 ubiquitination in bone

57 induces Egr-1 nuclear accumulation and CREB serine phosphorylation and that both are markedly attenu

58 glucose induces a decrease in overall PDX-1 serine phosphorylation and that overexpression of WT PAS

59 e we show that Ins(1,3,4,5,6)P5 inhibits the serine phosphorylation and the kinase activity of Akt/PK

60 Moreover, loss of serine phosphorylation and the resulting enhanced degrad

61 The relative levels of serine phosphorylation and tyrosine phosphorylation are

62 etagamma subunits were required for both PKD serine phosphorylation and tyrosine phosphorylation, int

63 anslocation and subsequent D1 receptor hyper-serine phosphorylation and uncoupling.

64 lated Akt phosphorylation and higher Irs-1/2 serine phosphorylation, and all of these events were dep

65 alpha, PKA, PKG, and CaMKII, which catalyzed serine phosphorylation, and ERK1, JNK, and p38, which ca

66 d partial inhibition of IkappaB and RelA/p65 serine phosphorylation, and p50 and p65 nuclear transloc

67 r export, is associated with increased HDAC7 serine phosphorylation, and requires conserved serines i

68 we demonstrated that both Stat3 tyrosine and serine phosphorylations are required for optimal binding

69 mplex phosphosignaling network with kindlin2 serine phosphorylation as a key regulatory element.

70 ythrocytes undergoes increased PKA-dependent serine phosphorylation as a result of activation.

71 aling promotes AQP4 expression by decreasing serine phosphorylation associated with the water channel

72 Activation of up-regulated AKT2 by serine phosphorylation associates with high-grade tumors

73 e findings suggested that the requirement of serine phosphorylation at residue 536 and the distance b

74 nscriptional activity by a process involving serine phosphorylation at serine (Ser) residue 276.

75 utational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions

76 In addition, serine phosphorylation at various sites of the p65 subun

77 coexpressed with ERBB4, we identified STAT5A serine phosphorylations at the previously described Ser-

78 ivities of GSK-3 are regulated negatively by serine phosphorylation but positively by tyrosine phosph

79 whose activities are negatively regulated by serine phosphorylation but positively controlled by tyro

80 rotein, reduction in efflux, and increase in serine phosphorylation by 12S-hydroxyeicosatetranoic aci

81 singly, full Paxillin activity also requires serine phosphorylation by a kinase downstream of MOS and

82 ite motifs, which is mutually exclusive with serine phosphorylation by Akt.

83 nding motif, dramatically increased endoglin serine phosphorylation by all three receptors, suggestin

84 uman PDC is subject to inactivation at E1 by serine phosphorylation by four kinases, an inactivation

85 Activity of TFEB is inhibited upon its serine phosphorylation by mTOR The overall mechanisms by

86 sits to the Golgi complex where it undergoes serine phosphorylation by PKD.

87 We found that laminar flow induced SP1 serine phosphorylation by protein kinase CK2 and thereby

88 ple tyrosine phosphorylation events and also serine phosphorylation by protein kinase D.

89 mechanisms, including regulation of cofilin serine phosphorylation by Rho GTPases.

90 C-terminal serine phosphorylation by TGF-beta and BMP membrane rece

91 Serine phosphorylation, calcium, and calmodulin binding

92 and that coincident AKT2 activation through serine phosphorylation correlates with malignancy.

93 Thus, ARF is a serine phosphorylation-dependent coregulator of topoisom

94 including the ligand-stimulated and specific serine phosphorylation-dependent degradation of the IFNA

95 A mutant of hSpry2 that is deficient in serine phosphorylation displays enhanced tyrosine phosph

96 importance of threonine phosphorylation than serine phosphorylation due to larger induced structural

97 Concurrently, a serine phosphorylation event in the transcription activa

98 appeared to be a likely site for regulatory serine phosphorylation events.

99 ike that of H358 cells, is largely devoid of serine phosphorylation, has low activity, and complexes

100 tion was associated with enhanced N-terminal serine phosphorylation in both GSK-3 isoforms.

101 mandatory requirement for constitutive STAT3 serine phosphorylation in gastric cancer.

102 t analyses indicated that BDNF increases SK2 serine phosphorylation in hippocampal slices.

103 To directly assess the role of serine phosphorylation in mediating fat-induced insulin

104 inhibitor, resulted in an opposite effect on serine phosphorylation in N2A cells and primary hippocam

105 r, these results highlight the importance of serine phosphorylation in regulating type II hemidesmoso

106 eins have been shown to undergo tyrosine and serine phosphorylation in response to growth factor stim

107 s expressed ubiquitously and is activated by serine phosphorylation in response to viral infection or

108 f binding to EloC is negatively regulated by serine phosphorylation in the BC-box motif of the SOCS-b

109 Here we investigate the effect of serine phosphorylation in the interior of an alpha-helix

110 N2A neuroblastoma cell line along with p35, serine phosphorylation in their Cdk5 motifs was found to

111 ted erbB2/4 tryosine phosphorylation and Akt serine phosphorylation in ventricular myocytes, whereas

112 activation and insulin receptor substrate 1 serine phosphorylation in vitro and in vivo.

113 Glycogen synthase kinase 3 (GSK-3beta) serine phosphorylation (inactivation) was blunted in PEC

114 ersed inflammatory cytokine-stimulated IRS-1 serine phosphorylation, increased insulin signaling to A

115 Rapamycin inhibits S6K1-dependent IRS-1 serine phosphorylation, increases IRS-1 protein levels,

116 hypothesis that PKA regulates beta3 integrin serine phosphorylation indirectly through phosphorylatio

117 at antagonism between lysine methylation and serine phosphorylation is a fundamental mechanism for co

118 Inhibitory serine phosphorylation is a potential molecular mechanis

119 nolytic vascular surveillance by blockade of serine phosphorylation is A2-dependent.

120 This serine phosphorylation is essential for the maximal tran

121 This serine phosphorylation is necessary for SRF activity and

122 The amount of serine phosphorylation is regulated by agents that affec

123 ortance of sequential modification of FAK-by serine phosphorylation, isomerization, and tyrosine deph

124 phosphorylation, resulting in blocking Stat1 serine phosphorylation, its subsequent nuclear transloca

125 e 3 (GSK-3beta) association and beta-catenin serine phosphorylation levels were increased and beta-ca

126 insulin/glucose-dependent Ser/Thr-Pro motif serine phosphorylation mediated by the mTOR pathway.

127 inhibited IL-2-induced Stat5a/b tyrosine and serine phosphorylation, nuclear translocation, and DNA b

128 ore serine mutants demonstrate that multiple serine phosphorylations occur on the same core protein.

129 Our previous studies indicated that serine phosphorylation of a single tryptic peptide inhib

130 Treatment of myeloma cells with IL-6 induced serine phosphorylation of A1 and increased its binding t

131 y, to reduce protein levels, and to increase serine phosphorylation of ABCA1.

132 rated that 12/15LO enhances the turnover and serine phosphorylation of ABCG1.

133 ne phosphorylation transiently, and enhanced serine phosphorylation of Akt and ERK.

134 actions, including erbB2/4 phosphorylation, serine phosphorylation of Akt, and negative inotropy.

135 Serine phosphorylation of AMPA receptor (AMPAR) subunits

136 to alanine abolished the insulin-stimulated serine phosphorylation of APS and prevented the localiza

137 The insulin-stimulated serine phosphorylation of APS was inhibited by a PI3-kin

138 oocyte permeability assays, we conclude that serine phosphorylation of AQP0 does not inhibit CaM bind

139 nged PTEN expression results in the enhanced serine phosphorylation of Bdp1.

140 ity of GSK-3beta, which in turn affected the serine phosphorylation of beta-catenin and its proteosom

141 assic isoforms of protein kinase C mediating serine phosphorylation of beta-catenin and Src-tyrosine

142 ERK activation-induced serine phosphorylation of both STAT1 and p65 mediated th

143 We recently revealed that p38 MAPK-mediated serine phosphorylation of both Stat1 and Stat3 is requir

144 hat PTEN initially induces a decrease in the serine phosphorylation of Brf1, leading to a selective r

145 is accompanied by PKC-dependent increase in serine phosphorylation of c-Cbl in cells expressing elev

146 ibitors of protein kinase C activity reduced serine phosphorylation of caveolin-1 and increased stero

147 MIF binding was associated with the serine phosphorylation of CD74 and CD44.

148 inase assays show that EGFRvIII induction of serine phosphorylation of Dock180 is PKA-dependent.

149 We demonstrate that EGFRvIII induces serine phosphorylation of Dock180, stimulates Rac1 activ

150 SK1 phosphorylation at Serine-966, decreased serine phosphorylation of FAK, and decreased association

151 on of 18 kDa subunit of complex I, decreased serine phosphorylation of FeS protein in complex III, in

152 GRP blockade diminished serine phosphorylation of GRPR with ozone or OVA.

153 d treatment with lithium and VPA potentiated serine phosphorylation of GSK-3 alpha and beta isoforms

154 otein kinase IV (CaMKIV), through inhibitory serine phosphorylation of GSK-3beta and inhibition of FB

155 Increased serine phosphorylation of hepatic IRS-1 may contribute t

156 Similarly, whereas CaMKIV(+/+) Mphi showed serine phosphorylation of HMGB1 in response to LPS, this

157 Although serine phosphorylation of HMGB1 is necessary for nucleoc

158 Additionally, LPS induced serine phosphorylation of HMGB1, which correlated with a

159 ess may be mediated through CaMKIV-dependent serine phosphorylation of HMGB1.

160 Our results imply that Mnk1-mediated serine phosphorylation of hSpry2 constitutes a regulator

161 tutive activation of NF-kappaB signalling by serine phosphorylation of IkappaBalpha and constitutive

162 In this study, we examine the role of serine phosphorylation of insulin receptor substrate (IR

163 Furthermore, resistin increased serine phosphorylation of insulin receptor substrate (IR

164 nied by increased phosphorylation of JNK and serine phosphorylation of insulin receptor substrate 1 (

165 Consistent with these changes, serine phosphorylation of insulin receptor substrate 1 w

166 kt and insulin receptor was reduced, whereas serine phosphorylation of insulin receptor substrate 1 w

167 Serine phosphorylation of insulin receptor substrate-1 (

168 Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 a

169 togen-activated protein kinase, enhances the serine phosphorylation of insulin receptor substrate-1,

170 ns-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1.

171 TLR4 signaling also led to increased serine phosphorylation of intestinal focal adhesion kina

172 osine kinase (IRK) activity and a kinase for serine phosphorylation of IR substrate 1 (IRS-1).

173 First, it became apparent that serine phosphorylation of IRS proteins can reduce their

174 Here, we show that serine phosphorylation of IRS-1 (IRS-1pSer) is common to

175 Concurrently, serine phosphorylation of IRS-1 at serine 632/635, which

176 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, o

177 creased expression of p85alpha and increased serine phosphorylation of IRS-1 is needed to induce clin

178 These data demonstrate that serine phosphorylation of IRS-1 plays an important role

179 n of the PI3K/Akt pathway via the inhibitory serine phosphorylation of IRS-1, notably on serine 1101

180 d insulin signaling as well as a decrease in serine phosphorylation of IRS-1.

181 tivation of protein kinase p70S6K and to the serine phosphorylation of IRS-1.

182 tion of several serine kinases, leading to a serine phosphorylation of IRS-1.

183 ity after IL-4 stimulation is dependent upon serine phosphorylation of IRS-2.

184 ylation of IRS1/2, while slightly increasing serine phosphorylation of IRS.

185 lin-induced akt phosphorylation by increased serine phosphorylation of IRS1 and increased expression

186 uced (siRNA or a pharmacological inhibitor), serine phosphorylation of IRS1 is reduced, and insulin-i

187 cells resulted in a significant induction of serine phosphorylation of JAK3 and STAT5, and serine/thr

188 that Fsk-treated cells resulted in elevated serine phosphorylation of Jak3 but not Stat5, suggesting

189 IL-6 also induced serine phosphorylation of K8.

190 0 null junctions supported this pathway, and serine phosphorylation of KENESKA was critical.

191 Specifically, AMPA stimulation triggered serine phosphorylation of KLC2 and, subsequently, the di

192 s attain additional negative charges through serine phosphorylation of Lys-Ser-Pro (KSP) repeat motif

193 Further, AT1002 increased serine phosphorylation of myosin 1C and, at the same tim

194 ng [(3)H]tetraphenylphosphonium), as well as serine phosphorylation of NOS-3 (by Western blotting and

195 This disruption was the result of serine phosphorylation of Notch.

196 We have shown that serine phosphorylation of P450c17 and the allosteric act

197 neutrophil NADPH oxidase involves extensive serine phosphorylation of p47(phox), the role of tyrosin

198 In addition, Ron inhibits serine phosphorylation of p65 and NF-kappaB transcriptio

199 Importantly, Erk-mediated serine phosphorylation of paxillin is also required for

200 resent study, we show that palmitate-induced serine phosphorylation of phosphoinositide-dependent pro

201 -linking of VCAM-1 stimulated an increase in serine phosphorylation of PTP1B, the active form of PTP1

202 in oxidative activation of PKCalpha and then serine phosphorylation of PTP1B.

203 respectively, leading to enhanced inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) a

204 anding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) b

205 nvestigated the role of direct AMPK-mediated serine phosphorylation of RAPTOR in a new Raptor (AA) mo

206 otensin II or 1 microm serotonin resulted in serine phosphorylation of Rb that was equal in magnitude

207 r 15 min of ligand stimulation, but only the serine phosphorylation of signal transducer and activato

208 tide agonist suppressed the TGF-beta-induced serine phosphorylation of Smad2, a critical mediator of

209 s remain relatively constant while levels of serine phosphorylation of Smad6 increase.

210 LC-MS/MS analysis further revealed that serine phosphorylation of Sort1 protein was required for

211 r, Ly294002 and H7 blocked IFN-gamma-induced serine phosphorylation of STAT1alpha.

212 n of MAPK activity blocked IFN-gamma-induced serine phosphorylation of STAT1alpha; but its tyrosine p

213 As well, OSM and IL-6/R induce tyrosine and serine phosphorylation of STAT3 in primary cortical neur

214 es such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activati

215 e kinase responsible for LMP1-CTAR1-mediated serine phosphorylation of STAT3 was identified to be PKC

216 ion of STAT3((Tyr705)), while increasing the serine phosphorylation of STAT3((Ser727)).

217 gulated kinases, which caused an increase in serine phosphorylation of STAT3(Ser727).

218 a serum-independent manner with constitutive serine phosphorylation of STAT3.

219 m DARPP-32-depleted mice, basal tyrosine and serine phosphorylation of striatal NMDA receptor subunit

220 nase- (ERK) dependent pathways and increases serine phosphorylation of the alpha(1)-subunit.

221 one (PTH) inhibits Na+-K+-ATPase activity by serine phosphorylation of the alpha1 subunit through pro

222 d adhesion via a protein kinase A-dependent, serine phosphorylation of the alpha4 cytoplasmic domain.

223 ome disassembly by a mechanism that involves serine phosphorylation of the beta 4 integrin subunit.

224 Concomitantly, there is an increase in serine phosphorylation of the beta3 integrin cytoplasmic

225 ide additional support for the idea that the serine phosphorylation of the C-terminal domain (CTD) se

226 Although serine phosphorylation of the hinge of SF-1 (NR5A1), the

227 a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at th

228 ds to a significant decrease in the level of serine phosphorylation of the insulin receptor substrate

229 ha inhibitory peptide blocked PTH-stimulated serine phosphorylation of the Na+-K+-ATPase alpha1 subun

230 sphoinositide 3-kinase and PKB/Akt-dependent serine phosphorylation of the precursor SREBP-1c protein

231 of gene expression by Sall1 is modulated by serine phosphorylation of the Sall1 repression motif.

232 2A and NR2B was drastically reduced, whereas serine phosphorylation of these NMDA subunits was unchan

233 orrelated with the ability of IL-6 to induce serine phosphorylation of this domain.

234 Lipopolysaccharide (LPS) treatment induced serine phosphorylation of USP14 as well as further reduc

235 Serine phosphorylation of WASP enhanced the ability of W

236 Src diminished the SGK1-mediated increase in serine phosphorylation of WNK4, suggesting that c-Src en

237 tegrin alpha5beta1 induced tyrosine, but not serine, phosphorylation of YAP in ECs.

238 LPS caused serine-phosphorylation of ANXA1 (ANXA1-S27-PO4) and tran

239 us of FX mice displayed decreased inhibitory serine-phosphorylation of GSK3beta compared with wild-ty

240 To investigate the effects of serine phosphorylation on CaM-mediated Ca(2+) regulation

241 orylation on residue Y705 but have increased serine phosphorylation on residue S727, consistent with

242 l peptides were synthesized with and without serine phosphorylation on S231 and S235, and the ability

243 ased STAT1 tyrosine phosphorylation, whereas serine phosphorylation on the protein was unchanged.

244 SIN-1, which also blocked tyrosine, but not serine phosphorylation, on STAT1.

245 p50 but did not affect basal levels of STAT3 serine phosphorylation or induce EGFR expression.

246 ynamic remodeling of the CTD, especially its serine phosphorylation pattern, conveys informational cu

247 three Galphai isoforms exhibited a selective serine phosphorylation patterns for each AIS endophenoty

248 hat PKD plays a key role in copper-dependent serine phosphorylation, permitting high levels of ATP7B

249 These results suggest that serine phosphorylation plays an important role in at lea

250 oprecipitate with IGF-1R and increase IGF-1R serine phosphorylation, promoting beta-arrestin1 associa

251 On the other hand, serine phosphorylation protected WT ATP7B from degradati

252 ) and phosphorylation of Akt while enhancing serine phosphorylation (pS(307)) of IRS1.

253 By contrast, serine phosphorylation (pS) of STAT3 can augment its nuc

254 uced rapid, sustained, and site-specific k-8 serine phosphorylation (pSer73) dependent on signaling b

255 These studies suggest that, through serine phosphorylation, Raptor-mTOR and S6K1 cell autono

256 b have been extensively studied, the role of serine phosphorylation remains to be fully elucidated.

257 ct tyrosine kinase activity to regulate GAT1 serine phosphorylation requires a change in its tyrosine

258 etween tyrosine phosphorylation (Tyr(P)) and serine phosphorylation (Ser(P)) of IRS-2 after IL-4 stim

259 ity in a human disease by revealing specific serine phosphorylation signatures of Galphai isoforms th

260 To investigate these issues, we mutated a serine phosphorylation site (S408) in the cytoplasmic ta

261 analysis, Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not l

262 to acquire full transcriptional activity, no serine phosphorylation site in STAT2 has been reported.

263 ence of c-Src, and by mutation of a putative serine phosphorylation site in the actin-binding domain

264 hysiological substrate for PKB and the first serine phosphorylation site on APS.

265 Previously identified potential serine phosphorylation sites at Ser-10, Ser-77, and Ser-

266 ectrometry analyses of DP revealed six novel serine phosphorylation sites dependent on GSK3 signaling

267 f 14-3-3 required 2 previously unappreciated serine phosphorylation sites in LNK, and we found that t

268 binding focal adhesion protein with several serine phosphorylation sites in the amino terminus that

269 Serine phosphorylation sites mutant, cortactin(S405A/S41

270 dentified serines 1248 and 1291 as the major serine phosphorylation sites of the IGF-1R, and subseque

271 Mutagenesis of potential serine phosphorylation sites on Sox9 was used to demonst

272 the alpha-parvin N-terminal proline-directed serine phosphorylation sites reduced its complex formati

273 YK phoshorylates Ikaros at unique C-terminal serine phosphorylation sites S358 and S361, thereby augm

274 Multiple serine phosphorylation sites were identified in the secr

275 We have identified more than six novel serine phosphorylation sites within Htt, one of which li

276 arkedly increased upon mutation of two GSK-3 serine phosphorylation sites within the carboxyl-termina

277 To determine whether specific serine phosphorylation sites within the Na(+),K(+)-ATPas

278 reen of human TRPC6 identified several novel serine phosphorylation sites.

279 post-translationally regulated by these five serine phosphorylation sites.

280 orylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an

281 1 and 2A and activation of PKC increased the serine phosphorylation state of the HCN1 protein.

282 ted threonine phosphorylation required prior serine phosphorylation, suggesting a sequential mechanis

283 ot all, MAPK agonists induced the regulatory serine phosphorylation, suggesting an involvement of dif

284 Tyr(641) was dispensable for IL4-mediated serine phosphorylation, suggesting that dimerization is

285 duced ABCA1 protein levels and increased its serine phosphorylation, suggesting that PLD2-generated d

286 , we investigate an evolutionarily conserved serine phosphorylation that occurs at the site of commun

287 l growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmi

288 LPS induces cortactin serine phosphorylation, ubiquitination, and degradation

289 An additive increase in GSK-3 serine phosphorylation was also observed in mice chronic

290 IL-2-stimulated serine phosphorylation was corroborated in Kit 225 T cel

291 We found that the serine phosphorylation was crucial for TLR-induced inter

292 Stat3 tyrosine and serine phosphorylation was still detected in these mice

293 axillin and significantly increased paxillin serine phosphorylation, whereas Nek3 siRNA-transfected c

294 is also inhibited, thereby preventing Stats serine phosphorylation, which is essential for downstrea

295 ced adhesion turnover downstream of paxillin serine phosphorylation, which is rescued by addition of

296 However, the transcriptional role of STAT3 serine phosphorylation, which promotes STAT3-driven mito

297 Moreover, TNFalpha enhanced FLIP(L) serine phosphorylation, which was increased by activated

298 We propose that serine phosphorylation within LCS I may regulate the ass

299 We conclude that serine phosphorylation within the ICAP1 N-terminal regio

300 owed that Grb10 underwent insulin-stimulated serine phosphorylation, yet the kinase(s) responsible fo