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1 ted following phosphorylation at a conserved serine residue.
2 tly phosphorylates SRF on a highly conserved serine residue.
3 e and perturbs the position of the catalytic serine residue.
4 ch is controlled by an N-terminal regulatory serine residue.
5 s a G-to-S change at the predicted catalytic serine residue.
6 is primed by the phosphorylation of a single serine residue.
7 , Cdc8, is regulated by phosphorylation of a serine residue.
8 s partially rescued by removing the adjacent serine residue.
9 ced the highly conserved cysteine 107 with a serine residue.
10 n responded to modification of even a single serine residue.
11 oteins, and (iii) phosphorylation of various serine residues.
12 ciated with dephosphorylation of the Ntcp on serine residues.
13 of three hydrophobic amino acids flanked by serine residues.
14 mapping and mutating the key O-GlcNAcylated serine residues.
15 ons, including modification of glutamine and serine residues.
16 -acetylglucosamine (O-GlcNAc) also occurs on serine residues.
17 cted kinase that phosphorylates cyclin L2 at serine residues.
18 inase 1 (Clk1) phosphorylates SPF45 on eight serine residues.
19 ymes through nonenzymatic acetylation of key serine residues.
20 rane binding and phosphorylation at specific serine residues.
21 step formal cycloaddition between two distal serine residues.
22 elium SCAR is basally phosphorylated at four serine residues.
23 effects based on phosphorylation at specific serine residues.
24 CaMKK2 by phosphorylation of three conserved serine residues.
25 hosphorylation switch of adjacent lysine and serine residues.
26 ic peptide containing N-terminal alanine and serine residues.
27 tion has to precede phosphorylation of other serine residues.
28 that it is phosphorylated mainly on multiple serine residues.
29 directly interacting with its two canonical serine residues.
30 the change of phosphorylation state of other serine residues.
31 function of each of these two phosphorylated serine residues.
33 ion of the Na-K-2Cl cotransporter (NKCC2) at serine residue 126 (pS126 NKCC2) and of the Na-Cl cotran
35 that constitutively active IKKbeta in which serine residues 177/181 were mutated into negatively cha
36 We discovered that dual serine (traditional serine residues 177/181) and tyrosine (188/199) phosphor
37 PKC-dependent NMDAR insertion, and identify serine residue-187 as the molecular target of PKC phosph
38 ndividually contained one of six cysteine-to-serine (residues 193, 197, 209, 211, 214, and 218) subst
41 o 2.8-fold increased phosphorylation of Cx43 serine residues 255, 262, 279/282, and 368, and appeared
42 ion with MEF2s in nuclear speckles requiring serine residues 259 and 498, whose phosphorylations cont
43 RK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is requ
44 somal neural-derived IRS-1 phosphorylated at serine residue 307 (corresponding to serine residue 312
45 ated at serine residue 307 (corresponding to serine residue 312 in humans) negatively correlated with
46 sulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in th
47 ceptor substrate 1 (IRS-1) phosphorylated at serine residue 312 was more apparent in inclusion bearin
50 ABAARs is potentiated via phosphorylation of serine residues 408 and 409 (S408/9) in the beta3 subuni
51 tion, the beta3 subunit is phosphorylated on serine residues 408/409 by PKC activity, whereas the del
53 site-directed mutagenesis, which identified serine residues 421 and 423 as critical for its nuclear
61 ational modification occurs predominantly on serine residues(6-8) and requires HPF1, an accessory fac
62 d decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational
63 on cascade that modulates phosphorylation of serine residue 863 (S863) in the GluA1 AMPAR subunit and
64 Allodynia suppression was a consequence of serine residue 896/897 phosphorylation of NMDA receptor
65 els purified from brain is phosphorylated on serine residues 9 and 31, and that cyclin-dependent kina
66 intracellular inhibitor of PP2A (I2PP2A) on serine residues 9 and 93, resulting in enhanced binding
68 er, our data suggest that phosphorylation of serine residues adjacent to the PIAS1 SUMO-interacting m
71 tly phosphorylated mTOR and RAPTOR on unique serine residues, an effect that was independent of insul
72 ate that Scute is phosphorylated by Sgg on a serine residue and that mutation of this residue results
74 diversity, consisting mostly of tyrosine and serine residues and a small but significant contribution
75 ion, we induced a mutation in the C-terminal serine residues and examined their effects on the intera
77 sues, is phosphorylated on more than a dozen serine residues and interacts with a variety of protein
78 horylation of NRF1 can occur at two distinct serine residues and negatively regulates NRF1 DNA bindin
79 (AICAR) resulted in STIM1 phosphorylation on serine residues and prevented protease-activated recepto
80 structural changes due to phosphorylation of serine residues and shown a correlation between the CTD
81 erichia coli was phosphorylated by CKII on a serine residue, and its phosphorylation was dependent on
82 -unsaturated fatty acyl group at a conserved serine residue, and this modification is required for Wn
83 y, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr i
85 otably, these two clusters of closely spaced serine residues are located in disordered domains flanki
89 signature depends on phosphorylation of the serine residue at position 273 of PPARgamma, in striking
90 tudies have shown that cannabinoids target a serine residue at position 296 in the third transmembran
91 smic tail of rat ADAM17 contains a conserved serine residue at position 811, which resides in a canon
93 ed that the phosphate moiety attached to the serine residue at position P5 of pMART-1 is available fo
94 f-function" mutation [a leucine mutated to a serine residue at the 9' position (Leu9'Ser)] in VTA GAB
95 or tryptophan residue in Env with a natural serine residue at this position (S375H/W) increased the
97 ur findings show enhanced phosphorylation of serine residues at amino acid positions 15 and 46 in the
98 quent mutagenesis analysis demonstrated that serine residues at amino acids 225 and 232 in NS5A (geno
99 ion in cells leads to phosphorylation of two serine residues at analogous sites on both SH2 domains o
101 o restrict MLV/GaLV Env, but mutation of the serine residues at positions 52 and 56 completely allevi
102 pha-helices have an L-shape, with proline or serine residues at the kinks, which functions as a lever
106 a at serine residue 235 and Dok-7 at several serine residues but does not phosphorylate Rapsyn or Rac
108 defined, conserved N-terminal threonine and serine residues, but the kinase pathways that mediate th
110 vation, we mutated cysteine 203 of CypD to a serine residue (C203S) and determined its effect on mPTP
111 n article, we show that five, and only five, serine residues can be phosphorylated both in vitro and
112 sidue plays a role in activating an adjacent serine residue carrying out nucleophilic attack, opening
113 y ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allow
114 assays showed that Cdc5 phosphorylates nine serine residues clustered within the N-terminus of Cse4.
115 osophospecific antibody, and substitution of serine residues demonstrate phosphorylation of candidate
117 the observation that mutation of Cys475 to a serine residue eliminates the formation of the protein a
118 cytosolic S4-S5 linker of both proteins by a serine residue forces the channels into an open conforma
119 -R353A, but not FXII lacking the active site serine residue (FXII-S544A), shortened the clotting time
120 Conversely, the replacement of His 375 by a serine residue (H375S) within HIV-1 CRF01_AE decreased t
123 ough its serine-rich domain in which most of serine residues have the propensity to be phosphorylated
124 duced by phosphorylation of highly conserved serine residues (human S183/S185, mouse S180) in the DNA
125 lation analysis of Pah1, we identified eight serine residues (i.e. Ser-114, Ser-475, Ser-511, Ser-602
128 n I; group B, comprising mutations affecting serine residues important for hyperphosphorylation and a
130 sporter EAAT2, and we identified a conserved serine residue in Flot1 that is essential for transporte
132 In addition, a modification to an adjacent serine residue in Rab1 was discovered, which was indepen
136 (APC/C); while phosphorylation of a specific serine residue in the APC/C coactivator Cdc20 prevents d
138 nthesis by transfer of its acetyl group to a serine residue in the cyclooxygenase (COX) active site.
141 d the consequences of changing the conserved serine residue in the P-loop to asparagine, within a chi
142 mline mutation (S631G) at a highly conserved serine residue in the uncharacterized gene VSIG10L that
143 he enzyme is regulated by phosphorylation of serine residues in a regulatory domain and by binding of
144 s inhibited by phosphorylation of up to four serine residues in a repeating sequence in the C-termina
145 ly at Ser12, indicating that the pore-facing serine residues in BM2 mediate proton relay to the proto
146 equires phosphorylation at three clusters of Serine residues in Drosophila Hedgehog (Hh) signaling.
147 nM, can covalently transacylate arginine and serine residues in GSTP and cross-link them to adjacent
148 ened interactions between formoterol and two serine residues in H5 at the orthosteric binding site of
149 a signature 25-residue insert of glycine and serine residues in loop L11 of its motor domain, and thi
151 oselective, and modular functionalization of serine residues in native polypeptides, which uses a rea
152 t AvrPtoB phosphorylation occurs at multiple serine residues in planta, with S258 phosphorylation sig
153 entially phosphorylated at three clusters of serine residues in response to levels of Hh activity.
155 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubi
156 vered a new form of ADPr that is attached to serine residues in target proteins (Ser-ADPr) and showed
157 sphorylation of PKD1 at two highly conserved serine residues in the activation loop; this modificatio
159 dy revealed extensive phosphorylation of two serine residues in the C terminus of both MKP-1 and MKP-
160 s spectrometry analysis, we identified three serine residues in the CCE domain of CRY2 (S588, S599, a
162 ed a mutational analysis of highly conserved serine residues in the linker region between domains I a
163 Many prior papers have pinpointed several serine residues in the low complexity sequence I region
164 fy HDAC1 and the phosphorylation of specific serine residues in the molecule as potential targets for
167 thway responsible for the phosphorylation of serine residues in the Ser-x-Glu/pSer motifs in several
170 s can form hydrogen bonds with two conserved serine residues in transmembrane helix 5 (Ser(5.42) and
171 function mutations at either of two adjacent serine residues in TSC2 (S1365 and S1366 in mice; S1364
174 hway, which phosphorylates Runx2 on multiple serine residues including S301 and S319 (equivalent to S
175 vates PDC by phosphorylating PDH at specific serine residues, including Ser-293, whereas dephosphoryl
176 t study of phosphorylated and phosphomimetic serine residues indicating lowered single motor stalling
177 and also SrtB from Staphylococcus aureus The serine residue indispensable for SrtB activity may be in
178 f Dazl by MK2 on an evolutionarily conserved serine residue inhibits its interaction with poly(A)-bin
179 LGST motif from bacteria to humans, only the serine residue is absolutely required for Psd1p autocata
181 osphorylation of kinesin motor domain at the serine residue is implicated in Huntington's disease, wi
182 the nitrogen atom of an internal cysteine or serine residue is usually cleaved by the side chain -SH
183 thermore, the presence of the phosphorylated serine residues is demonstrated to have a shielding effe
184 ation of cMyBP-C's N terminus on 3 conserved serine residues is hierarchical and antagonizes phosphor
185 n of the viral nonstructural protein NS5A at serine residues is important for the efficient assembly
186 occurs when Cdr1 phosphorylates a cluster of serine residues linking alpha-helices G and H of the Wee
187 ing PKCbeta phosphorylation of TFEB on three serine residues located in its last 15 amino acids.
188 d ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signatur
189 initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR
190 e report the first evidence that a conserved serine residue near the active site participates in the
192 osphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser-883 in Xe
194 kt, the enzyme multi-phosphorylated a single serine residue of a diserine DCF substrate in a time-dep
195 established that transesterification of the serine residue of desmethylsalinamide E with acylated gl
196 A, that catalyzes the conjugation of Ub to a serine residue of target proteins via a phosphoribosyl l
197 We show that replacing catalytic cysteine or serine residues of enzymes with DAP permits their first-
198 l activation requires phosphorylation of two serine residues of INCENP that are conserved through evo
202 rthermore, we show that SRPK1 phosphorylates serine residues of SR/RS dipeptides in the hinge region
203 ets RNA polymerase II but also the conserved serine residues of the polylinker region in Smad3, sugge
204 the N-terminal structure suggested that the serine residue (of CSQCH) would be anchored where the fi
208 sphorylation by protein kinase A of specific serine residues on Rad decreases its affinity for beta s
209 s studies have shown that phosphorylation of serine residues on synaptic proteins is a major regulato
210 by GCK-3 kinase-mediated phosphorylation of serine residues on the cytoplasmic C-terminus linker con
211 l six cysteines were individually altered to serine residues, only C145S and C195S derivatives lost t
212 th this prediction, phosphorylation at these serine residues or mutation to aspartate inhibits bindin
213 )KVTF(901), and can dephosphorylate multiple serine residues phosphorylated by checkpoint kinases.
215 pathway in human cells; additionally, as the serine residue promoting thermal lability is conserved a
216 erential phosphorylation of SPL tyrosine and serine residues provides a key to understanding both.
217 ations of cysteine, tyrosine, histidine, and serine residues react with octafluorocyclopentene (OFCP)
218 ing with the dockerin's critically conserved serine residues reduced the observed rupture forces.
219 Replacement of the Asp f3 cysteines with serine residues retained its dimeric structure, but dimi
221 in activation, we demonstrated a key role of serine residue S1163 of the alphaE chain intracellular d
222 his study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A v
223 ere we show that phosphorylation of a single serine residue (S2844) in the sarcoplasmic reticulum (SR
226 hypophosphorylation of Cx43 at a triplet of serine residues (S325/S328/S330) in the regulatory C-ter
229 wever, RelA phosphorylation, particularly at serine residues S536 and S276, is critical for RelA func
230 lysine substrate, also involving two nearby serine residues - S566 and S527- that possess a proton r
231 ing that phosphorylation of GluA1 C-terminal serine residues S831 and S845 is not required for CaN in
232 n addition, APE2 associates with Chk1, and a serine residue (S86) in the Chk1-binding motif of APE2 i
233 tor domain by the kinase JNK3 at a conserved serine residue (Ser-175 in the B isoform and Ser-176 in
234 ntaining an aspartic acid substitution for a serine residue (Ser-189) that in GRASP65 is phosphorylat
235 NAD(+) (the oxidized form of NADH), on three serine residues (Ser(44), Ser(46), and Ser(48)) within a
236 ction, MAPK phosphorylation of the preceding serine residues (Ser(P)(279)and Ser(P)(282)) increases t
237 rylation, the phosphorylation of a conserved serine residue, Ser(779), can quantitatively control Ras
239 terized several mutants of the corresponding serine residue, Ser-364, of human glutamate transporter
244 imuli promote Hsp27 phosphorylation on three serine residues--Ser(15), Ser(78), and Ser(82)-by a numb
246 s containing HSP27 mutated at three critical serine residues (Ser15, Ser78, and Ser82) to either alan
247 we investigated the roles of three conserved serine residues [Ser198(5.42), Ser199(5.43), and Ser202(
248 s from the hearts of mice in which the three serine residues (Ser273, Ser282, and Ser302) that are ph
249 The amino terminus of H3.3 contains a unique serine residue (Ser31) that is absent in 'canonical' H3.
250 implicate the phosphorylation of a specific serine residue (Ser322) on the synaptic protein UNC-18 a
251 bits increased phosphorylation of a critical serine residue (Ser354) and higher protein expression as
252 CD4 (programmed cell death protein 4) on two serine residues (Ser76 and Ser457) that regulate its sub
253 ependent phosphorylation of Hof1 at a single serine residue (serine 313) in this region diminishes th
256 as been measured biochemically at C-terminal serine residues, suggesting that these residues are crit
257 tamine followed by a stretch of threonine or serine residues, suggesting the presence of structural r
258 that a stretch of consecutive threonine and serine residues, T(21) T(22) S(23) S(24,) is necessary f
259 t inhibition of p65 phosphorylation on these serine residues targets NF-kappaB activity to distinctiv
260 contains the C-terminal ITIM tyrosine and a serine residue that undergo activation-dependent phospho
262 egion on which lie two functionally critical serine residues that are phosphorylated during infection
264 issociation is prevented by mutation of four serine residues that are potential sites of phosphorylat
265 on of the B55alpha subunit itself on several serine residues that drastically increases the affinity
267 ter mutation of the putative phosphoacceptor serine residues, the localization of the E2 protein was
268 nes through phosphorylation of different p65 serine residues, thus shedding light on novel mechanisms
269 of RdmB and show that insertion of a single serine residue to DnrK is sufficient for introduction of
270 sphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress respo
271 he transcription factor Gata6 on a conserved serine residue to promote neural crest migration and pro
272 ally phosphorylated on specific tyrosine and serine residues to acquire full transcriptional activity
273 rom homology modeling, mutation of three TM5 serine residues to alanine (S5.42A, S5.43A, S5.46A) had
275 ggest new strategies to target distinct AQP2 serine residues to induce membrane expression of this wa
276 ctivation, acting through N-terminal phospho-serine residues to regulate GR recruitment to its target
277 in HP1alpha molecules and show that specific serine residues uniquely contribute to gel formation.
279 sphate precipitate core of LCP, two phosphor-serine residues were added to the N-terminal of the pept
280 enotype 1b Con1 NS5A, we found that specific serine residues were important for efficient hyperphosph
282 re, E4orf4 reduces PARP-1 phosphorylation on serine residues, which likely contributes to PARP-1 inhi
283 s known to phosphorylate PDX-1 on C-terminal serine residues, which triggers PDX-1 proteasomal degrad
284 C-terminal domain of p53 through two unique serine residues, which were acquired during recent verte
285 e specifically phosphorylates the C-terminal serine residue while ignoring those located elsewhere.
288 a PXXYHXXHXP motif, and a uniquely conserved serine residue within a GS(S/T) motif, suggesting that P
289 , by phosphorylating a specific threonine or serine residue within the activation loop which is criti
291 region (S4-S6) of TRPC4 predicts a conserved serine residue within the C-terminal sequence of the pre
292 nase A-dependent phosphorylation of a single serine residue within the core of the polybasic domain,
294 MA promotes PKC-dependent phosphorylation of serine residues within CXCR4 C-tail that are required fo
296 In both cases, in vitro phosphorylation of serine residues within the acidic tail stabilizes the as
298 forming a complex that dephosphorylates two serine residues within the catalytic domains of IkappaB
299 cultured cells, phosphorylation of specific serine residues within the cluster is also required for