ライフサイエンスコーパス: serotonergic

1 subtype), noradrenergic alpha1 and alpha2 , serotonergic 5-HT1A and dopaminergic D1/5 receptors usin

2 gic regulation of hemodynamics, we implanted serotonergic (5-HT(+)) neuron-enriched embryonic raphe n

3 As is well recognized, serotonergic (5-HT) fibers distribute widely throughout

4 The serotonergic (5-HT) system has been documented to impact

5 To assess whether serotonergic abnormalities were present, we used [(11)C]

6 olated neurons, and its ability to stimulate serotonergic accumulation in cortical synaptic vesicles.

7 Both dorsal raphe serotonergic activity during aversive reinforcement and

8 these compounds in biofluids based on their serotonergic activity, rather than on their specific str

9 amatergic drive onto these neurons, and that serotonergic afferent activation alters the responses of

10 resting and odorant-evoked responses during serotonergic afferent stimulation.

11 n region that is the principal target of the serotonergic afferents along with the limbic system, and

12 Current-clamp experiments demonstrate that serotonergic afferents are largely excitatory for mitral

13 Serotonergic afferents are predominately inhibitory for

14 Finally, optogenetically stimulating raphe serotonergic afferents in the OB had heterogeneous effec

15 lied, with and without administration of the serotonergic agonist Quipazine, to enable hind limb moto

16 olite with no structural similarity to known serotonergic agonists potentiates an endogenous serotoni

17 increased in frequency following delivery of serotonergic agonists.

18 gic as well as noradrenergic, glutamatergic, serotonergic and adenosine pathways provide insights int

19 n of locomotor circuits including descending serotonergic and corticospinal tract axons and afferents

20 ected and actual outcome), likely reflecting serotonergic and dopaminergic deficits, was associated w

21 sociations between retinal afferents and DRN serotonergic and GABAergic neurons were observed.

22 at ETS-5 functions in a complex network with serotonergic and neuropeptide signaling pathways to cont

23 s out the molecular organization of distinct serotonergic and non-serotonergic subsystems, and will f

24 a significant role in vesicular function in serotonergic and other neuronal cell types, which might

25 after 30 d of hypercapnia; 2) the number of serotonergic and total neurons were reduced within the M

26 We identified cholinergic, serotonergic, and catecholaminergic ciliomotor neurons.

27 s (including the corticospinal, rubrospinal, serotonergic, and dopaminergic pathways), accounts for N

28 intestinal microbiome as well as epithelial, serotonergic, and immune system factors.

29 ecreased sensitivity to the dopaminergic and serotonergic antagonist amisulpride, known to affect sta

30 c drug coverage in Ontario, Canada, in utero serotonergic antidepressant exposure compared with no ex

31 To evaluate the association between serotonergic antidepressant exposure during pregnancy an

32 risk of child autism spectrum disorder with serotonergic antidepressant exposure during pregnancy ma

33 Serotonergic antidepressant exposure was defined as 2 or

34 DRG neurons by which TRPC4 mediates itch to serotonergic antidepressants and demonstrated the antipr

35 stability and enabled a clear delineation of serotonergic areas and melatonin-producing pineal gland

36 eptors as potential mechanisms for mediating serotonergic attenuation of cocaine abuse-related neuroc

37 A network trained with volumes of serotonergic axons in all major brain regions can be gen

38 chronically repaired cord only low levels of serotonergic axons regenerated into the graft, with no e

39 Numerous graft-derived serotonergic axons topographically projected to the caud

40 We assessed the preservation of neurons and serotonergic axons, the levels of inhibitory CSPGs and m

41 s between PhMNs and these sprouting rVRG and serotonergic axons.

42 ll responses, axon sparing, and sprouting of serotonergic axons.

43 Here, we assess the serotonergic background of experience-dependent behavior

44 ke receptors regulate central and peripheral serotonergic biology.

45 pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans.

46 Brainstem serotonergic, catecholaminergic, and inflammatory adapta

47 The serotonergic cells are active when cilia are beating.

48 neurons, developing mouse brain and cultured serotonergic cells indicate that H3K4me3Q5ser nucleosome

49 prostaglandin E2 receptor EP3 selectively on serotonergic cells or selectively in the area of the dor

50 uterocerebral interneurons (CSDns): the only serotonergic cells that innervate the AL [9, 10].

51 inflammatory pain aversion, EP3 receptors on serotonergic cells were dispensable for acute nociceptiv

52 cal organ contains two bilateral clusters of serotonergic cells while GABAergic neurons are localized

53 cular, by investigating the dopaminergic and serotonergic changes both presynaptically and postsynapt

54 Serotonergic changes in brain regions modulating respons

55 INTERPRETATION: Dopaminergic and serotonergic changes progress in a similar fashion in LR

56 , through neuromodulatory projections (e.g., serotonergic, cholinergic, and noradrenergic).

57 ological pathways included genes involved in serotonergic, cholinergic, dopaminergic, GABAergic, and

58 nels are critical regulators of a C. elegans serotonergic circuit and demonstrate a mechanism in whic

59 However, the serotonergic circuit involved in stress vulnerability is

60 s local axonal tiling and global assembly of serotonergic circuitries and results in depression-like

61 s required for axonal tiling and assembly of serotonergic circuitries.

62 ersions will require better understanding of serotonergic circuitry, which has been hampered by our i

63 ember), which encodes a key regulator of the serotonergic circuitry.

64 om disrupted linkage in raphe to hippocampus serotonergic circuitry.

65 ms that integrate metabolic information with serotonergic circuits are poorly characterized.

66 Descending serotonergic circuits from the rostral ventromedial medu

67 l stress and suggest that targeting specific serotonergic circuits may aid the development of therapi

68 614) into the kidney, indicating reconnected serotonergic circuits regulating autonomic activity.

69 life adversity may have a lasting impact on serotonergic circuits underlying executive function that

70 s a prophylactic, we hypothesized that other serotonergic compounds such as serotonin 4 receptor (5-H

71 We further show that this differential serotonergic control in the adult emerges from a non-mod

72 CRF levels in the hypothalamus to DRN-driven serotonergic control of CRF levels in the amygdala may c

73 that a cocaine-induced shift from MRN-driven serotonergic control of CRF levels in the hypothalamus t

74 Thus, differential descending serotonergic control of spinal touch and pain processing

75 es that exploit descending noradrenergic and serotonergic control pathways.

76 iomarker in autopsied infants with SIDS with serotonergic defects.

77 m in individuals with Lewy body disease, and serotonergic degeneration in human ventromedial caudate

78 hypothesis that venlafaxine disrupts central serotonergic development, leading to impaired behavioral

79 Gene-sets comprised serotonergic, dopaminergic, glutamatergic, and neuroendo

80 protein in the axons of a single, identified serotonergic Dorsal Paired Medial (DPM) neuron.

81 Serotonergic DRN neurons respond phasically to swim-indu

82 S disorders potentially treatable with a pro-serotonergic drug.

83 ion antidepressant treatment that included a serotonergic drug.

84 f patients show insufficient SSRI responses, serotonergic dysfunction in heterogeneous OCD patients s

85 Serotonergic dysfunction is implicated in major depressi

86 k inhibition in MDD is linked to hippocampal serotonergic dysfunction which may in turn arise from di

87 release (SR) in mice augmented the brain pro-serotonergic effect of selective serotonin reuptake inhi

88 5-HTP SR's pro-serotonergic effects were stronger in mice with endogeno

89 However, the effect of serotonergic enhancement is poorly characterized, and it

90 , we conducted a study investigating how the serotonergic enhancer 3,4-methylenedioxy-methamphetamine

91 Serotonergic enterochromaffin (EC) cells are proposed to

92 e gill pore papillae, as far as the SCCs and serotonergic fibers extended from the underlying dermis

93 red contralateral-originating rVRG axons and serotonergic fibers.

94 Serotonergic fibres exert background 5-HT3R mediated fac

95 Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activit

96 prevented by the pharmacological blockade of serotonergic function.

97 Exploration of serotonergic gene expression across brain regions implic

98 d, we evaluated the midbrain levels of these serotonergic genes, and also assayed these gene levels i

99 ber of Pet1-lineage neurons, a predominantly serotonergic group distributed throughout DR subdomains.

100 ioassay would lie in the characterization of serotonergic hallucinogens and the screening of these co

101 Classic or serotonergic hallucinogens comprise the third largest nu

102 acterization of these scarcely characterized serotonergic hallucinogens.

103 Our results suggest that serotonergic homoeostatic control of the temporal dynami

104 The serotonergic HSN command neurons initiate the active sta

105 ngs are discussed with respect to a critical serotonergic influence on the amygdala, particularly on

106 nally been attributed to impaired prefrontal serotonergic inhibitory control of emotional reactions t

107 The results of this study revealed serotonergic innervation and cell density differences am

108 Increased serotonergic innervation might contribute to clinical di

109 al raphe serotonergic neurons and changes in serotonergic innervation of rostral brain regions.

110 esent study compared neural cell density and serotonergic innervation of the amygdala among four maca

111 possibly reflecting compensatory changes in serotonergic innervation preceding the motor onset of Pa

112 ur prediction, pigtailed macaques had higher serotonergic innervation than Japanese and moor macaques

113 hesus and Japanese macaques would have lower serotonergic innervation within the amygdala compared to

114 Here, we explored whether a serotonergic input from the dorsal raphe (DR) to ventral

115 Our results indicate that the serotonergic input from the DR to the PBel via 5HT(2a) r

116 Here, we show that serotonergic input has separable suppressive effects on

117 Here, we identified downstream targets of serotonergic input-two types of neurons with opposing ro

118 These results imply a serotonergic mechanism in zebrafish that transmits early

119 Our results imply a conserved serotonergic mechanism that context-dependently modulate

120 ical findings of a role for dopaminergic and serotonergic mechanisms in the processing of natural rew

121 Our results demonstrate that serotonergic modulation at low concentrations targets a

122 ian primary visual cortex (V1), heterogenous serotonergic modulation has been observed in anesthetize

123 s specific cell classes heavily targeted for serotonergic modulation in the olfactory system, and rev

124 The distinct serotonergic modulation of MCs between the MOB and AOB c

125 ntennal lobe, may be required for persistent serotonergic modulation of pheromone responses in the an

126 Here we examined the serotonergic modulation of visual processing in the prim

127 ICANCE STATEMENT All sensory systems receive serotonergic modulatory input.

128 Elucidating how the brain's serotonergic network mediates diverse behavioral actions

129 nally, we show that activation of the entire serotonergic network, as opposed to only activation of t

130 uronal precursors, leading to altered global serotonergic neuroarchitecture and increased spontaneous

131 sing optogenetic tools in vivo, we show that serotonergic neuromodulation prominently inhibits the sp

132 building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effe

133 ine the wiring logic of a broadly projecting serotonergic neuron (the CSDn) that spans several olfact

134 ation of autonomic function, we transplanted serotonergic neuron enriched embryonic raphe nucleus-der

135 scription factors GATA2 and GATA3 operate as serotonergic neuron fate selectors and regulate the diff

136 ine the wiring logic of a broadly projecting serotonergic neuron in the olfactory system of Drosophil

137 esults suggest that intrinsic differences in serotonergic neuron morphology and the resulting circuit

138 We show that the C. elegans serotonergic neuron NSM acts as an enteric sensory neuro

139 cular and anatomical properties, including a serotonergic neuron subtype that preferentially innervat

140 mportance of ZFPM1 for the development of DR serotonergic neuron subtypes involved in mood regulation

141 electors and regulate the differentiation of serotonergic neuron subtypes of DR.

142 d at least 18 distinct neuron subtypes and 5 serotonergic neuron subtypes with distinct molecular and

143 dentify conserved ion channels in an enteric serotonergic neuron that mediate its responses to food i

144 r and physiological properties of an enteric serotonergic neuron, and adaptive feeding behaviors, yie

145 Caenorhabditis elegans implicate an ancient serotonergic neuronal circuit in the link between these

146 to specialized neuronal subtypes within the serotonergic neuronal system, borne out in functional st

147 A pair of serotonergic neurons (the CSDns) innervate the antennal

148 During noxious stimuli, serotonergic neurons activation was due to a suppression

149 al failure of laterally located dorsal raphe serotonergic neurons and changes in serotonergic innerva

150 TN neurons are also activated by inputs from serotonergic neurons and hypothalamic neurons.

151 Furthermore, mutants lacking serotonergic neurons and mutants that cannot synthesize

152 h the diacetyl odor, FLP-34 is released from serotonergic neurons and signals through its evolutionar

153 it is unclear whether and how alterations in serotonergic neurons contribute to SSRI resistance in th

154 le counterparts proliferate and give rise to serotonergic neurons crucial for adult mating behaviour.

155 tocadherin alpha (Pcdhalpha) gene cluster in serotonergic neurons disrupts local axonal tiling and gl

156 NR patient-derived serotonergic neurons exhibited altered neurite growth an

157 hila melanogaster, activation of a subset of serotonergic neurons fragments sleep without major chang

158 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts.

159 ver 800 MDD patients, we generated iPSCs and serotonergic neurons from three extreme SSRI-remitters (

160 The dorsal raphe (DR) serotonergic neurons have long been implicated in the pr

161 t of the DR) was lost, whereas the number of serotonergic neurons in a medial subpopulation (dorsal r

162 the pathophysiological role of dorsal raphe serotonergic neurons in different species and the role o

163 le of efficient and specific transduction of serotonergic neurons in mice and rats for elucidation of

164 Serotonergic neurons in the dorsal raphe (DR) nucleus ar

165 ors, we demonstrate that acute activation of serotonergic neurons in the dorsal raphe nucleus increas

166 d a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN).

167 both short- and long-term activation of DRN serotonergic neurons induce antidepressant-like behavior

168 erm activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust behavioral responses

169 electrophysiology in Drosophila to show that serotonergic neurons innervating the first olfactory rel

170 e effectiveness of transplanting early-stage serotonergic neurons into the spinal cord for cardiovasc

171 olution understanding of the connectivity of serotonergic neurons is currently lacking.

172 g of the synaptic connectivity of individual serotonergic neurons is lacking.

173 We propose that DR serotonergic neurons preempt reward delays at the decisi

174 Serotonergic neurons project their axons pervasively thr

175 Serotonergic neurons project widely throughout the brain

176 Here we show that network-spanning serotonergic neurons segregate information about stimulu

177 In Drosophila, a small group of serotonergic neurons selectively modulates the escalatio

178 These SONs activate serotonergic neurons to inhibit nociceptor-to-SON transm

179 of GATA cofactor ZFPM1 in the development of serotonergic neurons using Zfpm1 conditional mouse mutan

180 an hydroxylase 2 gene efficiently transduced serotonergic neurons with a specificity of approximately

181 In this study, we use a pair of identified serotonergic neurons within the Drosophila olfactory sys

182 ngle-cell level, the complex connectivity of serotonergic neurons within their target networks, ident

183 and two neuronal subtypes (dopaminergic and serotonergic neurons).

184 c excision of KOR from dopaminergic, but not serotonergic neurons, also blocked KOR-mediated disrupti

185 was used to quantify total enteric neurons, serotonergic neurons, and 5-HT-dependent subsets of neur

186 Genome-wide analyses of human serotonergic neurons, developing mouse brain and culture

187 the larva forms an anterior concentration of serotonergic neurons, or apical organ.

188 In this study we show that the output of serotonergic neurons, possibly through points of synapti

189 raphe nucleus (RN), the major source of most serotonergic neurons, was altered in OCD patients and co

190 ur study reveals the complex connectivity of serotonergic neurons, which combine the integration of l

191 lls also activate dorsal raphe nucleus (DRN) serotonergic neurons, which project to the vicinity of t

192 Pet1 neurons may act downstream of Egr2-Pet1 serotonergic neurons, which were previously established

193 ntly augmented or reduced the activity of DR serotonergic neurons, while mice decided between differe

194 raphe, which contains different subtypes of serotonergic neurons.

195 of optogenetic tools for precise control of serotonergic neurons.

196 uded expansive proliferative populations and serotonergic neurons.

197 h is the only Pcdhalpha isoform expressed in serotonergic neurons.

198 crossed with Tph2-Cre mice expressing Cre in serotonergic neurons.

199 ned place aversion to pain via inhibition of serotonergic neurons.

200 a branch specific for the differentiation of serotonergic neurons.

201 The 5-HT(3) receptor mediates fast serotonergic neurotransmission by undergoing a series of

202 Disrupted serotonergic neurotransmission has long been implicated

203 Exposure to social stress and dysregulated serotonergic neurotransmission have both been implicated

204 We studied serotonergic neurotransmission in patient forebrain neur

205 decreasing circulating BCAAs levels to favor serotonergic neurotransmission in the hippocampus and pr

206 smission, but it remains unclear how altered serotonergic neurotransmission may contribute to the SSR

207 Moreover, metformin increased hippocampal serotonergic neurotransmission while promoting anxiolyti

208 They regulate serotonergic neurotransmission, but it remains unclear h

209 cortical tissues, and links to GABAergic and serotonergic neurotransmission.

210 ctional utility of i5HT neurons for studying serotonergic neurotransmission.

211 NCA mutation might show abnormalities in the serotonergic neurotransmitter system before the diagnosi

212 The serotonergic neurotransmitter system has been widely imp

213 loid 1 (TRPV1) and TRPN-like channels in the serotonergic or dopaminergic neurons, respectively, and

214 Four of these compounds regulated either serotonergic or dopaminergic signaling, and subsequent e

215 ical modification of cholinergic, GABAergic, serotonergic or dopaminergic systems, or reduction of co

216 ed and provided evidence for the key role of serotonergic pathology in patients with Parkinson's dise

217 The presence of serotonergic pathology in premotor A53T SNCA carriers pr

218 en, highlighting the potential early role of serotonergic pathology in the progression of Parkinson's

219 eficits were coupled with impairments in the serotonergic pathway in the brain, decreased hippocampal

220 l, and enhanced the plasticity of descending serotonergic pathways and corticospinal tract axonal reg

221 roplasticity of the spared corticospinal and serotonergic pathways.

222 duces resilience, and suppresses the gain of serotonergic phenotype in the DRv that is characteristic

223 racranial self-stimulation, while changes in serotonergic phenotype were investigated using immunohis

224 Our findings reveal a significant serotonergic plasticity arising in the DAT Val559 model

225 t essential for the early differentiation of serotonergic precursors in the embryonic rhombomere 1.

226 ersely, we identified a subset of inhibitory serotonergic projection neurons in the dorsal raphe that

227 Our results highlight a differential role of serotonergic projections arising from the MRN and DRN in

228 nucleus (MRN) and dorsal raphe nucleus (DRN) serotonergic projections differentially mediate these ph

229 We find that serotonergic projections from the raphe nuclei to the ol

230 KEY POINTS: There are serotonergic projections to both the main (MOB) and the

231 ffects were observed when we manipulated the serotonergic projections to the nucleus accumbens (NAc).

232 rk that suggests the actions of ketamine and serotonergic psychedelics may converge at the dendrites,

233 Pilot studies have hinted that serotonergic psychedelics such as psilocybin may relieve

234 We present these ideas in the context of rat serotonergic raphe neurons, which fire spontaneously at

235 pvf-expressing neurons control sleep via the serotonergic raphe nuclei (RN), a hindbrain structure th

236 The serotonergic raphe nuclei (RNi) connections involve regi

237 atomical heterogeneity in populations of the serotonergic raphe nuclei of the brainstem reticular for

238 o the catecholaminergic VTA/SNc homologs and serotonergic raphe nuclei.

239 neurons suppressed downstream neurons in the serotonergic raphe nucleus and caused behavioral passivi

240 al nucleus, an additional subdivision of the serotonergic raphe obscurus nucleus, and the expansion o

241 ribed 5-HT distribution in various teleosts, serotonergic raphe subgroups in fish are not well define

242 ted toward a wake-promoting function for the serotonergic raphe.

243 However, it is unclear which specific serotonergic receptors are involved in the effects.

244 Activation of these serotonergic receptors in these neurons initiates a sign

245 n are differentially mediated by a family of serotonergic receptors with distinct activities and expr

246 ctivity downstream of upregulated excitatory serotonergic receptors, in contrast to what is seen in h

247 ord injury site relay supraspinal control of serotonergic regulation for sympathetic activity to impr

248 etermine the specific role of reestablishing serotonergic regulation of hemodynamics, we implanted se

249 integrating circulating stress hormones and serotonergic regulation of stress responses.

250 The reconstituted serotonergic regulation of sympathetic activity led to t

251 blished integrity of submidbrain circuits of serotonergic reticulospinal innervation at lumbar levels

252 xpressing neurons innervate and can activate serotonergic RN neurons.

253 neurons in mice and rats for elucidation of serotonergic roles in anxiety-like behaviors and active

254 hreats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate

255 sustained inhibition of SERT activity alters serotonergic signaling and influences platelet activatio

256 increased serotonin bioavailability promotes serotonergic signaling and modulates the expression of i

257 ctly, but appears to enhance SER-4-dependent serotonergic signaling by increasing endogenous 5-HT.

258 Genetic and pharmacologic attenuation of serotonergic signaling eliminated the effects of exposur

259 Serotonergic signaling has been implicated in the pathop

260 solation differentially affected whole-brain serotonergic signaling in resting and stress-induced con

261 atterns of sleep and wakefulness by blunting serotonergic signaling in the lateral hypothalamus.

262 iation between behavioral responsiveness and serotonergic signaling in zebrafish, which is well recog

263 in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of v

264 This shift is reflected inversely by central serotonergic signaling, a system that is implicated in n

265 ction among cannabinoid, octopaminergic, and serotonergic signaling.

266 diverse physiological pathways, most notably serotonergic signaling.

267 ion of neuromodulatory systems, particularly serotonergic signaling.

268 The serotonin transporter (SERT) terminates serotonergic signalling through the sodium- and chloride

269 signalling, rather than seeking to increase serotonergic signalling, might prove to be a more cohere

270 NOS with catecholaminergic, cholinergic, and serotonergic structures, aiming to establish accurately

271 tinct, anatomically and functionally defined serotonergic subpopulation in the DR that projects to th

272 rganization of distinct serotonergic and non-serotonergic subsystems, and will facilitate the design

273 The epidermal serotonergic synapse may have important clinical implica

274 Activation of serotonergic synapse signaling and inhibition of neurotr

275 ower lip retraction in vivo, a component of "serotonergic syndrome".

276 The serotonergic system and in particular serotonin 1A recep

277 Given the known neurochemical changes in the serotonergic system and their association with symptoms

278 The brain's serotonergic system centrally regulates several physiolo

279 nteraction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely t

280 We found that plasticity of the serotonergic system contributes to the differential vuln

281 The wide range of drugs targeting the serotonergic system could be useful to treat spasticity

282 bjective was to analyze 17 other variants in serotonergic system genes (HTR1A, HTR2A, HTR1B, HTR2C, T

283 through modulation of estrogen action on the serotonergic system in the DRN.

284 Here, we show that the serotonergic system in the vinegar fly, Drosophila melan

285 We previously reported that the serotonergic system is important for the antidepressant-

286 This study investigates how the serotonergic system modulates the initial processing of

287 ic neurons that provide strong input to this serotonergic system outside of the context of olfaction.

288 These results indicate that the serotonergic system promotes sleep in both diurnal zebra

289 robiota signal bidirectionally with the host serotonergic system to promote their fitness in the inte

290 We hypothesized that the serotonergic system, which is implicated in stress, rewa

291 opens up new treatment options targeting the serotonergic system.

292 traditionally linked to deficiencies in the serotonergic system.

293 ronment interactions in the dopaminergic and serotonergic systems during multiple stages of developme

294 tudinal changes of both the dopaminergic and serotonergic systems in seven asymptomatic 1-methyl-4-ph

295 iginate from predominantly noradrenergic and serotonergic systems.

296 the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and midbrain

297 ype identified by expression of Tac1 and the serotonergic transcription factor gene Pet1, referred to

298 ow that prostaglandin-mediated modulation of serotonergic transmission controls the affective compone

299 neuromodulatory effects of dopaminergic and serotonergic transmission in the processing of erotic ve

300 rgeted different portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (Tph2)(+) neurons