ライフサイエンスコーパス: serum response factor

1 iption factors such as NF-kappaB, C/EBP, and serum response factor.

2 of nuclear factors of activated T cells and serum response factor.

3 ophy, likely by its direct interactions with serum response factor.

4 ing transcription factor, NF-kappaB/Rel, and serum response factor.

5 ly regulated by TGF-beta1/SMAD and myocardin/serum response factor.

6 h muscle gene expression by associating with serum response factor.

7 actin cytoskeletal dynamics, by coactivating serum response factor.

8 ering the displacement of myocardin from the serum-response factor.

9 absence of ELK1 binding partners, ERK1/2 and serum-response factor.

10 We found that Tbx1 binds serum response factor, a master regulator of muscle diff

11 scle-specific transcriptional coactivator of serum response factor, a ubiquitous transcription factor

12 lial tumours, and that, in this context, Mal/serum response factor activation is rate-limiting for tu

13 pe Galpha13, Galpha13K204A induced much less serum-response factor activation when expressed in HeLa

14 anically-induced stimuli with the control of serum response factor activity and localization through

15 buted in part to inappropriate repression of serum response factor activity in stressed hearts.

16 We found that leupaxin forms a complex with serum response factor and associates with CArG-containin

17 Conversely, the interaction between serum response factor and its co-activator myocardin was

18 The CArG box is activated by the binding of serum response factor and its coactivators, myocardin (M

19 CYA-depleted cells depended on activation of serum response factor and its cofactors, myocardial-rela

20 Serum response factor and its transcriptional cofactor M

21 rough the CArG box-binding proteins, such as serum response factor and members of the myocardin (Myoc

22 ation-associated increase in the activity of serum response factor and RhoA GTPase.

23 erentiation through the transcription factor serum response factor and the signaling effector calcine

24 sts, including that of runt-1, required SRF (serum response factor) and sos-1.

25 (cAMP response element binding factor), SRF (serum response factor), and MEF2 (myocyte enhancer facto

26 TAATC(C/T) cis-element, by interacting with serum response factor, and by increasing histone acetyla

27 ith Brg1 of the SNF/SWI complexes, recruited serum response factor, and remodeled smooth muscle targe

28 iate with the MADS box transcription factor, serum response factor, and synergistically activate tran

29 However, serum response factor appears to transiently induce cyto

30 ding sites for muscle regulatory factors and serum response factor as well as a conserved homeodomain

31 ly all smooth muscle genes are controlled by serum response factor binding sites in their promoter re

32 Both PDGF-BB and KLF4 markedly reduced serum response factor binding to CArG containing regions

33 VSMC contractile genes as well by increasing serum response factor binding to CArG-containing regions

34 nce inhibits Rho-induced gene expression via serum response factor but has no apparent effect on Rho-

35 Nuclear accumulation of the serum response factor coactivator MAL/MKL1 is controlled

36 yocardin (Myocd), a known CArG box-dependent serum response factor coactivator, participates in Smad3

37 myocardin, revealing unique roles for these serum response factor coactivators in the development of

38 lasmic/nuclear shuttling and functions as an serum response factor cofactor in the nucleus.

39 odulation of the subcellular localization of serum response factor cofactors is 1 mechanism by which

40 ex factors (TCFs; SAP-1, Elk-1, and Net) are serum response factor cofactors that share many function

41 6 can modulate the activity of the myocardin-serum-response factor complexes.

42 CC(A/T)6GG-dependent (CArG-dependent) and serum response factor-dependent (SRF-dependent) mechanis

43 otein localized to the Z disc that activates serum response factor-dependent (SRF-dependent) transcri

44 nd limits the ability of leupaxin to enhance serum response factor-dependent gene transcription.

45 gnals to the nucleus, activating a subset of serum response factor-dependent genes promoting myogenic

46 calcification through a Runx2 and myocardin-serum response factor-dependent pathway.

47 ilent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activ

48 The serum response factor-dependent TGFbeta1 regulation was

49 rexpression of SOCS-3 specifically increased serum response factor-driven transcriptional activity bu

50 tin polymerization-controlled coactivator of serum response factor, drives myofibroblast transition f

51 , we found that larval glia are enriched for serum response factor expression, explaining the apparen

52 the SMC marker gene promoters as well as the serum-response factor, GATA, and MEF2 enhancers.

53 ey cardiac transcription factors such as the serum response factor, Gata4, and Nkx2-5.

54 ics approach to investigate the role of SRF (serum response factor) in the serum response of fibrobla

55 ted a highly conserved CArG box, which binds serum response factor, in intron 15 of mylk1.

56 es apoptotic engulfment, and determined that serum response factor is important for MFG-E8 production

57 second transcription factor that is probably serum response factor, is located within the first intro

58 ions ablated receptor-mediated activation of serum response factor luciferase, a classic measure of G

59 ctin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cyc

60 5-HT triggered Rho-dependent serum response factor-mediated reporter activation in PA

61 Co-injection of zsrf (serum response factor) mRNA rescues the cardiac phenotyp

62 itous myocardin-related transcription factor/serum response factor (MRTF-A/SRF) transcription pathway

63 t the Myocardin-related transcription factor/Serum response factor (MRTF/SRF) pathway plays a key rol

64 The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a pr

65 Because the Nox4 promoter harbors a serum response factor/MRTF cis-element (CC(A/T)6GG box),

66 nding sites for three transcription factors, serum response factor, myelin transcription factor-1, an

67 d in vivo induces the expression of the SRF (serum response factor), myocardin, and MRTFA (myocardin-

68 R-143 were direct transcriptional targets of serum response factor, myocardin and Nkx2-5 (NK2 transcr

69 ression and promoting the association of the serum response factor-myocardin complex with VSMC contra

70 ansactivated the Bmp10 gene via binding of a serum response factor-myocardin protein complex to a non

71 tion, through signaling events targeting the serum response factor-myocardin-related transcription fa

72 gulating myocardin expression and preventing serum response factor/myocardin from associating with SM

73 muscle differentiation regulators including serum response factor, MyoD and Mef2.

74 targets of RhoA and Rac1 signaling including serum response factor, NF-kappaB, and other transcriptio

75 nscriptional activity of Stat3, NFkappaB, or serum response factor, nor the expression of the cell di

76 or three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer facto

77 stingly, FHL2 does not affect recruitment of serum response factor or Myocd, however, it inhibits rec

78 es many transcription factors, including the serum response factor partner Elk-1.

79 -SRF (myocardin-related transcription factor-serum response factor) pathway for sustained PM blebbing

80 n/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

81 iac myocyte hypertrophy is modulated by SRF (serum response factor) phosphorylation, constituting an

82 Expression of myocardin/serum response factor-regulated myofibrillar genes is ex

83 AR along with the transcription factor SRF (serum response factor), representing less than 6% of and

84 based assays, including Ca(2+) mobilization, serum response factor response element, stress fiber for

85 ownstream effector, the transcription factor serum response factor resulted in analogous developmenta

86 o and in transgenic mice increased myocardin/serum response factor signaling and increased expression

87 reased levels of cellular ATP, and increased serum response factor signaling in primary fibroblasts,

88 Foxf2 attenuated myocardin/serum response factor signaling in smooth muscle cells t

89 ent is critically dependent on a RAF/MEK/ERK/serum response factor signaling pathway and suggest that

90 f the myocardin-related transcription factor/serum response factor signaling pathway as a therapeutic

91 is essential for intestinal development and serum response factor signaling.

92 st of ID proteins and has been implicated in serum-response factor signaling.

93 RF (myocardin-related transcription factor A/serum response factor) signaling.

94 We also show that Barx2, MyoD, and serum response factor simultaneously occupy the SMA prom

95 P-response element binding protein CREB, the serum response factor SRF, and the nuclear factor of act

96 orylation of a cluster of amino acids in the serum response factor (SRF) "MADS box" alphaI coil DNA b

97 Serum response factor (SRF) activates genes involved in

98 ber et al. identify actin polymerization and serum response factor (SRF) activation as key steps link

99 Actin signaling controls serum response factor (SRF) activity via SRF interaction

100 -mediated processes, including regulation of serum response factor (SRF) activity.

101 ly identified that the transcription factor, serum response factor (SRF) and a number of its target g

102 ntractility and motility by associating with serum response factor (SRF) and activating genes involve

103 factor-responsive transcription cofactors of serum response factor (SRF) and are activated by MAP kin

104 at Tip60alpha, Tip60beta, and Tip55 can bind serum response factor (SRF) and by transient transfectio

105 The interactions between serum response factor (SRF) and CArG elements are critic

106 ein-2 (FHL2) and FHL2-mediated inhibition of serum response factor (SRF) and extracellular signal-reg

107 ction, because it acted synergistically with serum response factor (SRF) and GATA6 to activate the SM

108 Actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator megakary

109 Serum response factor (SRF) and its coactivator, myocard

110 ecent studies have shown that interaction of serum response factor (SRF) and its numerous accessory c

111 CBF regulation, express in AD high levels of serum response factor (SRF) and myocardin (MYOCD), two i

112 required for SMC differentiation, including serum response factor (SRF) and myocardin family members

113 Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transc

114 stigated the combinatorial role of myocardin/serum response factor (SRF) and Notch signaling in the t

115 oLSD1 can interact with transcription factor serum response factor (SRF) and set the chromatin state

116 -related transcription factor A (MRTF-A) and serum response factor (SRF) and the other using the tran

117 Elk-1 and the serum response factor (SRF) are downstream transcription

118 n promoter and Elk-1 binding is dependent on serum response factor (SRF) binding to a nearby CArG box

119 romatin immunoprecipitation assays confirmed serum response factor (SRF) binding to both CArG element

120 Serum response factor (SRF) binds a 1216-fold degenerate

121 The serum response factor (SRF) binds to coactivators, such

122 or transcriptional synergy between GATA4 and serum response factor (SRF) but not other cardiac cofact

123 Myocardin is a serum response factor (SRF) co-activator that regulates

124 cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic

125 The Serum Response Factor (SRF) coactivator myocardin stimul

126 Myocardin (Myocd) is a serum response factor (SRF) coactivator that promotes SM

127 We previously reported the importance of the serum response factor (SRF) cofactor myocardin in contro

128 proteins (myocardin, MRTF-A, and MRTF-B) are serum response factor (SRF) cofactors and potent transcr

129 in-related transcription factors (MRTFs) are serum response factor (SRF) cofactors that promote a smo

130 Serum response factor (SRF) controls multiple genes gove

131 Serum response factor (SRF) controls SMC gene transcript

132 Serum response factor (SRF) controls the transcription o

133 Serum response factor (SRF) directs programs of gene exp

134 in part from TGFbeta-induced enhancement of serum response factor (SRF) DNA binding and transcriptio

135 n factors megakaryoblastic leukemia-1 (MKL1)/serum response factor (SRF) during myofibroblast differe

136 e extreme thrombocytopenia than mice lacking serum response factor (SRF) expression in the megakaryoc

137 We tested the idea that T-box factors direct serum response factor (SRF) gene activity early in devel

138 Serum response factor (SRF) has an established role in c

139 Serum response factor (SRF) homozygous-null embryos from

140 Knockdown of serum response factor (SRF) in SMCs significantly reduce

141 Here, we show that deletion of serum response factor (SRF) in specific neuronal populat

142 s, we found a potential binding site for the serum response factor (SRF) in the promoter of the ubiqu

143 transcription factors (MRTFs) co-activating serum response factor (SRF) in this process is largely u

144 The transcription factor serum response factor (SRF) interacts with its cofactor,

145 Serum response factor (SRF) is a key regulator of smooth

146 Serum response factor (Srf) is a MADS-box transcription

147 Serum response factor (SRF) is a major transcription fac

148 Serum response factor (SRF) is a prototypic transcriptio

149 Serum response factor (SRF) is a transcription factor im

150 Serum response factor (SRF) is a transcription factor re

151 Serum response factor (SRF) is a transcription factor th

152 Serum response factor (SRF) is a transcription factor th

153 The serum response factor (SRF) is a transcriptional regulat

154 Serum response factor (SRF) is a ubiquitously expressed

155 Serum response factor (SRF) is a ubiquitously expressed

156 Serum response factor (SRF) is a ubiquitously expressed

157 Serum response factor (SRF) is a widely expressed transc

158 Serum response factor (SRF) is activated by contractile

159 Serum response factor (SRF) is an essential regulator of

160 uitously expressed transcriptional regulator serum response factor (SRF) is controlled by both Ras/MA

161 The serum response factor (SRF) is essential for embryonic d

162 element (SRE)-mediated gene expression, and serum response factor (SRF) is indispensable for SRE-med

163 We demonstrate that serum response factor (SRF) is induced by both platelet-

164 Serum response factor (SRF) is known to be important for

165 Here, we show that serum response factor (Srf) is needed for optimal SC-med

166 Our conditional serum response factor (SRF) knockout, Srf (Cko), in the

167 ER alpha binding sites, constitutively bound serum response factor (SRF) mediates estrogen stimulatio

168 Serum response factor (SRF) mediates immediate early gen

169 Network analysis revealed that the serum response factor (SRF) network is highly affected.

170 tion of the FHL2 gene, mediated by action of serum response factor (SRF) on its proximal promoter.

171 Several genes encoding proteins of the serum response factor (SRF) pathway are located on 5q.

172 in-related cotranscription factor-A (MRTF-A)/serum response factor (SRF) pathway.

173 ly among actomyosin genes, especially in the serum response factor (SRF) pathway.

174 Serum response factor (SRF) plays a central role in regu

175 n in vascular smooth muscle cells (VSMCs) by serum response factor (SRF) plays a crucial role in vasc

176 The transcription factor serum response factor (SRF) plays an important role in t

177 Serum response factor (SRF) recruits members of two fami

178 genomic approaches, we provide evidence that serum response factor (SRF) regulates both general and c

179 Serum response factor (SRF) regulates genes involved in

180 Serum response factor (SRF) regulates transcription of i

181 yocardin-related transcription factor (MRTF)-serum response factor (SRF) regulatory axis within stria

182 Using a serum response factor (SRF) response element reporter-dr

183 have shown that neuron-specific deletion of serum response factor (SRF) results in deficits in tange

184 p38 mitogen-activated protein kinase (MAPK) serum response factor (SRF) signaling via the TRPC6 prom

185 ith multiple actin regulators and to promote serum response factor (SRF) signalling has raised the qu

186 n is an extraordinarily powerful cofactor of serum response factor (SRF) that stimulates expression o

187 og, NKX2.5, NKX3.1 acts synergistically with serum response factor (SRF) to activate expression from

188 ors (TCFs) act with the transcription factor serum response factor (SRF) to activate mitogen-induced

189 of TNF-alpha-induced NF-kappaB and myocardin/serum response factor (SRF) to convey hypertrophy signal

190 e to actin polymerization and cooperate with serum response factor (Srf) to regulate the expression o

191 22alpha promoter by hindering the binding of serum response factor (SRF) to the proximal CArG box.

192 n state dictates the interaction between the serum response factor (SRF) transcription factor and one

193 1) is a myocardin-related coactivator of the serum response factor (SRF) transcription factor, which

194 aryoblast leukemia 1 (MKL1), an activator of serum response factor (SRF) transcriptional activity, pr

195 Serum response factor (SRF) was predicted as a transcrip

196 Serum response factor (SRF) was recently shown to bind a

197 In this study, we have shown that serum response factor (SRF), a common transcriptional fa

198 in embryos with cardiac-specific ablation of serum response factor (SRF), a direct transcriptional re

199 Here we report that murine serum response factor (SRF), a gene regulator linked to

200 of MRTFs to the nucleus where they activate serum response factor (SRF), a regulator of actin and ot

201 These changes are largely controlled by the serum response factor (SRF), a transcription factor that

202 d lamellipodin share the ability to activate serum response factor (SRF), a transcription factor that

203 tal actin signals physically associates with serum response factor (SRF), activating a subset of SRF-

204 distintegrin and metalloprotease family 10), serum response factor (SRF), and insulin-like growth fac

205 r-related, locus 5 (NKX2-5), T-box 5 (TBX5), serum response factor (SRF), and myocyte-enhancer factor

206 the c-fos cellular oncogene is regulated by serum response factor (SRF), and Tax is known to induce

207 iscernible CArG motifs, the binding site for serum response factor (SRF), and we show that the enhanc

208 the activity-dependent transcription factor, serum response factor (SRF), as a novel upstream mediato

209 ether myocardin, a SMC-selective cofactor of serum response factor (SRF), contributed to Ang II-induc

210 response element binding protein (CREB) and serum response factor (SRF), in mediating this induction

211 the stimulus-dependent transcription factor, serum response factor (SRF), in neural precursor cells (

212 ile gene transcription factors myocardin and serum response factor (SRF), independent of mammalian ta

213 (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased in DCM porcine

214 diated by the MADS-box transcription factor, serum response factor (SRF), its actin-binding myocardin

215 Ablation of KLF3, known to interact with serum response factor (SRF), or SRF itself, results in f

216 the stimulus-dependent transcription factor, serum response factor (SRF), plays a critical role in re

217 TEAD1 competes with myocardin for binding to serum response factor (SRF), resulting in disruption of

218 ecific depletion of the transcription factor Serum Response Factor (SRF), suffer from loss of BBB int

219 cription factor-A (MRTF-A), a coactivator of serum response factor (SRF), we discovered a muscle-enri

220 ripts is the nodal transcriptional regulator serum response factor (SRF), whereas another is calcineu

221 ir differentiation state can be regulated by serum response factor (SRF), which activates genes invol

222 via RhoA, conveys androgen-responsiveness to serum response factor (SRF), which controls aggressive C

223 n factor that functions as a coactivator for serum response factor (SRF), which controls genes involv

224 of smooth muscle (SM) cells is controlled by serum response factor (SRF), which drives the expression

225 ocardin is a transcriptional co-activator of serum response factor (Srf), which is a key regulator of

226 fferentiation is mediated by the activity of serum response factor (SRF), which is tightly controlled

227 RTFs) MRTF-A and MRTF-B are coactivators for serum response factor (SRF), which regulates genes invol

228 (SMCs) is regulated, in part, by an intronic serum response factor (SRF)-binding CArG element.

229 Myocardin, a serum response factor (SRF)-dependent cofactor, is a pot

230 transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program requi

231 l activation in response to mitogens through serum response factor (SRF)-dependent recruitment of Elk

232 Forskolin also significantly inhibited serum response factor (SRF)-dependent reporter gene (SRE

233 Overexpression of MKL1 transactivates serum response factor (SRF)-dependent SMC-restricted tra

234 Here we report that Galphaz signals inhibit serum response factor (SRF)-dependent transcription.

235 e second is a cryptic degron adjacent to the serum response factor (SRF)-interaction domain that mark

236 cription factors (MRTFs) are coactivators of serum response factor (SRF)-mediated gene expression.

237 ellular F-actin/G-actin levels also regulate serum response factor (SRF)-mediated gene regulation, su

238 induce activation of Rho GTPase, leading to serum response factor (SRF)-mediated gene transcription

239 yocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription

240 Serum response factor (SRF)-mediated transcription contr

241 uced nuclear actin polymerization results in serum response factor (SRF)-mediated transcription throu

242 tiation, we screened for TGF-beta1 and MYOCD/serum response factor (SRF)-regulated TSPANs in VSMC by

243 on of MAL, which deregulates the activity of serum response factor (SRF).

244 riptional level via the transcription factor serum response factor (SRF).

245 identified PTPLa as a new target gene of the serum response factor (SRF).

246 tain a CArG box, which is a binding site for serum response factor (SRF).

247 Fos-dependent activator protein-1 (AP-1) via serum response factor (SRF).

248 vel synergistic interaction between KLF3 and serum response factor (SRF).

249 ponse element binding protein (CREB) and the serum response factor (SRF).

250 enes (IEG) involves the transcription factor serum response factor (SRF).

251 romotes muscle differentiation by activating serum response factor (SRF).

252 L, a coactivator of the transcription factor serum response factor (SRF).

253 roteins are transcriptional coactivators for serum response factor (SRF).

254 igration, and myogenesis by associating with serum response factor (SRF).

255 ac and smooth muscle-specific coactivator of serum response factor (SRF).

256 wound healing/angiogenesis--is regulated by serum response factor (Srf).

257 muscle-specific transcriptional cofactor for serum response factor (SRF).

258 nteract with class I bHLH factors as well as serum response factor (SRF).

259 holipase Cbeta2 by Rac3 and signaling to the serum response factor (SRF).

260 rG boxes, which represent a binding site for serum response factor (SRF).

261 ctor for the ubiquitous transcription factor serum response factor (SRF).

262 nhances myoblast proliferation by repressing serum response factor (SRF).

263 array of muscle-specific genes controlled by serum response factor (SRF).

264 is regulated by RhoA-dependent activation of serum response factor (SRF).

265 n promoter required co-expressed full-length serum response factor (SRF).

266 tor (MRTF), a transcriptional coactivator of serum response factor (SRF).

267 , a co-activator of the transcription factor serum response factor (SRF).

268 marker expression and promoter activity in a serum response factor (SRF)/CArG box-dependent manner.

269 ll-restricted genes governed directly by the serum response factor (SRF)/myocardin (MYOCD) transcript

270 The serum response factor (SRF)/myocardin complex binds to C

271 ptional control by the transcription factor, serum response factor (SRF); however, the mechanisms dyn

272 SMA) is mediated by the transcription factor serum-response factor (SRF) along with its co-activator,

273 Serum-response factor (SRF) is an obligatory transcripti

274 (MRTFs), through their interaction with the serum-response factor (SRF) on CArG box regulatory eleme

275 hypertrophy via activation of Rho-dependent serum-response factor (SRF) signaling.

276 ion corresponded with elevated expression of serum-response factor (SRF), a master regulator of mitog

277 In addition, PKN increased the activities of serum-response factor (SRF), GATA, and MEF2-dependent en

278 nscription factor (MRTF)-A, a coactivator of serum-response factor (SRF), known to promote fibroblast

279 A/MAL/MKL1/BSAC) regulates the expression of serum-response factor (SRF)-dependent target genes in re

280 ), which directly binds actin and stimulates serum-response factor (SRF)-dependent transcription.

281 Megakaryoblastic leukemia (MKL)/serum-response factor (SRF)-mediated gene transcription

282 tion with myocyte-enhancing factor (MEF2) or serum-response factor (SRF).

283 genes are enriched for binding sites of the serum-response factor (SRF).

284 GATA-6 did not interfere with the serum-response factor-stimulated promoter activity but b

285 mechanism for fine tuning the expression of serum response factor target genes in a gene-specific ma

286 Thus, Arc is the first target of serum response factor that functions at synapses to medi

287 nteracts with Pico, and, Mal, a cofactor for serum response factor that responds to changes in G:F ac

288 transcriptional coactivators cooperate with serum response factor to activate smooth muscle gene exp

289 f transcriptional coactivators that bind the serum-response factor to activate gene expression progra

290 binding of the sequence-specific factor Srf (serum response factor) to Egr1 regulatory sites is depen

291 in the context of cardiac hypertrophy, where serum response factor transactivation is a key event nec

292 of dilated cardiomyopathy (DCM) triggered by Serum Response Factor transcription factor depletion in

293 ers cofilin phosphorylation, F-actin levels, serum response factor transcriptional activity and colla

294 Serum response factor transcriptional activity is contro

295 143/145 was dependent upon the myocardin and serum response factor transcriptional switch as well as

296 ular smooth muscle phenotype is regulated by serum response factor, which is itself regulated in part

297 This element binds serum response factor, which is recruited by synaptic ac

298 tors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiov

299 ption factor A (MRTF-A), is a coactivator of serum response factor, which regulates transcription of

300 ced stress fiber formation and activation of serum response factor without affecting Smad signaling.