ライフサイエンスコーパス: serum uric acid

1 asminogen activator inhibitor-1 antigen, and serum uric acid.

2 9 (SLC2A9), polymorphisms with variation in serum uric acid.

3 biased approach to identify loci influencing serum uric acid.

4 ations accounted for 4.3% of the variance of serum uric acid.

5 ut not meat had the lowest concentrations of serum uric acid.

6 d as the covariate responsible for rendering serum uric acid a statistically nonsignificant predictor

7 found positive genetic correlations between serum uric acid and BMI z score (rhoG = 0.45, P = 0.002)

8 nd specific association between the level of serum uric acid and cardiovascular morbidity and mortali

9 Quantitative traits, including serum uric acid and creatinine, also showed a moderate l

10 enous blood was taken for the measurement of serum uric acid and glycosylated haemoglobin (HbA1C).

11 In addition, genetic correlations between serum uric acid and other cardiovascular risk factors, s

12 ), 3000-m running time, serum triglycerides, serum uric acid and waist circumference (WC) were correl

13 mechanism for SLC2A9-mediated modulation of serum uric acid, and detail a bioinformatic approach for

14 ne of serum urea nitrogen, serum creatinine, serum uric acid, and serum phosphorus; and faster rate o

15 Elevated concentrations of serum uric acid are associated with increased risk of go

16 Levels of serum uric acid are known to be highly heritable, and mu

17 t actions exert a meaningful effect to lower serum uric acid by ~0.6 to 1.5 mg/dL and to reduce the r

18 model experiments demonstrate that increased serum uric acid causes increased BP that initially is re

19 Human serum uric acid concentration (SUA) is a complex trait.

20 ent an opinion on the nature of link between serum uric acid concentration and the risk for cardiovas

21 of causality arguments, one can start using serum uric acid concentration as an inexpensive cardiova

22 to test our hypothesis that the reduction in serum uric acid concentration induced by sevelamer would

23 cificity, 0.99; LR, 13 [95% CI, 3.1-53]) and serum uric acid concentration of 5.5 mg/dL or lower (sen

24 lopurinol intolerance or refractoriness, and serum uric acid concentration of 8.0 mg/dL or greater.

25 c uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared

26 this study was to investigate differences in serum uric acid concentrations between meat eaters, fish

27 In both men and women, serum uric acid concentrations differed significantly by

28 In women, serum uric acid concentrations were slightly higher in v

29 netic variation in SLC2A9 is associated with serum uric acid concentrations, an important biomarker o

30 A9, that explain 1.7-5.3% of the variance in serum uric acid concentrations, following a genome-wide

31 nsporters and their strong associations with serum uric acid concentrations, GLUT9 and ABCG2 appeared

32 s associated with a significant reduction in serum uric acid concentrations.

33 the effects of vitamin C supplementation on serum uric acid concentrations.

34 ut and primates have uniquely high levels of serum uric acid due to missense mutations in the uricase

35 xcessive dietary sodium intake and increased serum uric acid during follow-up despite pharmacological

36 xcretion, the relationship between change in serum uric acid during follow-up, final left ventricular

37 systolic blood pressure, sodium intake, and serum uric acid emerged as independent and significant d

38 f single nucleotide polymorphisms (SNPs) and serum uric acid explain a small fraction of the heritabi

39 The mean level of serum uric acid for both the groups was within normal ra

40 tion between RNFL and macular thickness with serum uric acid in both the groups.

41 This first GWAS of serum uric acid in continental Africans identified three

42 Here, we performed the first GWAS for serum uric acid in continental Africans, with replicatio

43 A5 rs5438 was associated with an increase in serum uric acid in European American males.

44 Our results show that variation in serum uric acid in Hispanic children is under considerab

45 oring quantitative trait loci that influence serum uric acid in Mexican Americans using data from 644

46 er showed significantly higher level of mean serum uric acid in no diabetic retinopathy group (p = 0.

47 ith the exception of a transient increase in serum uric acid in the acadesine group.

48 ibre layer (RNFL) and macular thickness with serum uric acid in type 2 diabetic patients.

49 lowup provide evidence that higher levels of serum uric acid increase the risk of gout in a graded ma

50 ial hypertension, the prevalence of elevated serum uric acid is >90%, and preliminary clinical trial

51 nderance of data support the hypothesis that serum uric acid is a cause or exacerbating factor of hyp

52 Increased serum uric acid is associated with increased risk for fu

53 An elevated serum uric acid is associated with the development of hy

54 Serum uric acid is determined by production and the net

55 Serum uric acid is the end-product of purine metabolism

56 aim was to investigate whether variation in serum uric acid is under genetic influence and whether t

57 Whether vitamin C reduces serum uric acid is unknown.

58 atios for incident hyperuricemia (defined as serum uric acid level >/=7.0 mg/dL) according to prespec

59 was associated with a 0.24-mg/dL increase in serum uric acid level (P = 1.37 x 10(-80)) and a 1.75-fo

60 her the mechanism of association of elevated serum uric acid level (SUA) with cardiovascular disease

61 Current evidence supports use of serum uric acid level as a biomarker for diagnosis of es

62 ol fractions, and plasma glucose levels, the serum uric acid level continued to predict the risk of d

63 l protein intake was not associated with the serum uric acid level in multivariate analyses (P = 0.74

64 The serum uric acid level increased with increasing total me

65 ney function and cohort; therefore, elevated serum uric acid level is a modest, independent risk fact

66 Elevated serum uric acid level is associated with obesity, insuli

67 ubjects who were aged 25 to 74 years and had serum uric acid level measurements at baseline.

68 rt at least once every other day had a lower serum uric acid level than did those who did not consume

69 med milk 1 or more times per day had a lower serum uric acid level than did those who did not drink m

70 in children, presenting the possibility for serum uric acid level to serve as a biomarker for diagno

71 nce was 1664+/-81 dyne x s x cm(-5), average serum uric acid level was 7.5+/-0.35 mg/dL, and average

72 In men, after adjustment for age, elevated serum uric acid level was not associated with increased

73 Among patients with chronic gout, elevated serum uric acid level, and allopurinol intolerance or re

74 orter height, family history of ESRD, higher serum uric acid level, and lower measured GFR.

75 ds have long been suspected of affecting the serum uric acid level, but few data are available to sup

76 d kidneys, reduced oxidative stress, lowered serum uric acid level, reduced glomerular hyperfiltratio

77 For each 1-mg/dl increase in the serum uric acid level, there was a 39% increase in the r

78 Baseline characteristics, including serum uric acid level, were similar among treated and un

79 onsumption was inversely associated with the serum uric acid level.

80 r-treated stage 1 essential hypertension and serum uric acid levels > or = 6 mg/dL.

81 me of interest was hyperuricemia, defined as serum uric acid levels >/=6 mg/dL.

82 ft ventricular ejection fraction </=40%, and serum uric acid levels >/=9.5 mg/dL to receive allopurin

83 In a multivariable analysis, serum uric acid levels (all P<0.005) and diastolic blood

84 Rs2231142 was significantly associated with serum uric acid levels (P = 2.37 x 10(-67), P = 3.98 x 1

85 cebo and the allopurinol groups had baseline serum uric acid levels (SDs) of 8.7 (1.6) mg/dl and 8.3

86 (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, an

87 e shed new light on the genes which regulate serum uric acid levels and susceptibility to gout.

88 ent data on lifestyle factors that influence serum uric acid levels and the risk of gout and attempts

89 sweetened soda and orange juice can increase serum uric acid levels and, thus, the risk of gout, but

90 ogical studies have suggested that increased serum uric acid levels are a risk factor for cardiovascu

91 Serum uric acid levels are an independent predictor of d

92 from the breakdown of purines, and elevated serum uric acid levels are associated with higher risk o

93 Reductions in serum uric acid levels are clinically relevant.

94 Epidemiologic studies suggest that serum uric acid levels are heritable.

95 Our data suggest that increased serum uric acid levels are independently and significant

96 After adjusting for age, the difference in serum uric acid levels as compared with no intake increa

97 Increased serum uric acid levels had a positive relationship to ca

98 Serum uric acid levels have been linked to many ageing i

99 tudy was to evaluate the prognostic value of serum uric acid levels in a large cohort of men and wome

100 the relationship between dietary factors and serum uric acid levels in a nationally representative sa

101 , allopurinol effectively and safely lowered serum uric acid levels in adults with stage 3 CKD and as

102 stroke incidences or mortalities related to serum uric acid levels in adults.

103 Pegloticase is an enzyme used to reduce serum uric acid levels in patients with chronic, treatme

104 systolic blood pressure, triglycerides, and serum uric acid levels in the CsA reduction group.

105 n mice and non-human primates and normalized serum uric acid levels in uricase-deficient mice.

106 Serum uric acid levels increased with increasing beer or

107 or women per 1,000 person-years according to serum uric acid levels of <5.0, 5.0-5.9, 6.0-6.9, 7.0-7.

108 tcomes was limited to patients with baseline serum uric acid levels of 8 mg/dL or less.

109 n Survey suggested that these factors affect serum uric acid levels parallel to the direction of risk

110 effect of individual alcoholic beverages on serum uric acid levels varies substantially: beer confer

111 ention to minidose aspirin and its effect on serum uric acid levels was addressed.

112 ation of stroke incidence and mortality with serum uric acid levels were calculated.

113 Serum uric acid levels were determined in all patients s

114 disease in both men and women increased when serum uric acid levels were in the highest quartile comp

115 ight heart catheterization was performed and serum uric acid levels were measured in all patients.

116 At the end of the study period, serum uric acid levels were significantly reduced in the

117 We evaluated whether lowering serum uric acid levels with allopurinol improves endothe

118 umans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crys

119 athologies, including myocardial infarction, serum uric acid levels, mean platelet volume, aortic roo

120 and renal function plays a critical role in serum uric acid levels.

121 etween intakes of beer, liquor, and wine and serum uric acid levels.

122 eas moderate wine drinking does not increase serum uric acid levels.

123 ity and therefore may promote a reduction in serum uric acid levels.

124 g sustained enzyme activity and reduction in serum uric acid levels.

125 id reabsorption, and thereby, could increase serum uric acid levels.

126 harm in patients with less severely elevated serum uric acid levels.

127 y in metabolic phenotypes, such as increased serum uric acid levels.

128 itors prevent glucose reabsorption and lower serum uric acid levels.

129 lood cell count, blood glucose, D-dimer, and serum uric acid levels; and were more likely to have met

130 ral lines of evidence suggest that increased serum uric acid may be a significant modifiable risk fac

131 ial evidence suggests that agents that lower serum uric acid may lower BP in this select population.

132 Serum uric acid may serve as a valuable biomarker to tar

133 From episodic, longitudinal sequences of serum uric acid measurements in 4368 individuals we prod

134 e lowest to the highest quartile of baseline serum uric acid, net mean changes (95% confidence interv

135 .37; 95% CI 1.06, 1.76; p = 0.015), elevated serum uric acid (OR 3.55; 95% CI 1.03, 12.27; p = 0.045)

136 -6.15, p < 0.001), hyperuricemia (per 1mg/dl serum uric acid; OR = 1.35, 95% CI = 1.12-1.62, p < 0.01

137 In multivariate analysis, serum uric acid (P = 0.001), estimated glomerular filtra

138 d with gallstone risk in US adult women, and serum uric acid played a mediating role.

139 s negatively related to blood urea nitrogen, serum uric acid, proteinuria, and supernatant IL-4; wher

140 pharmacologic and nonpharmacologic means of serum uric acid reduction prior to clinical use as a the

141 gh the investigations are still preliminary, serum uric acid represents a possible new and intriguing

142 moking status, body mass index, haemoglobin, serum uric acid, serum albumin, albuminuria, and C react

143 Serum uric acid showed a poor correlation with RNFL and

144 Compared with placebo, allopurinol lowered serum uric acid significantly but did not improve endoth

145 The link between serum uric acid (SUA) and the risk of venous thromboembo

146 ers of endothelial dysfunction, specifically serum uric acid (SUA) and urine albumin excretion (UAE),

147 Oxypurinol reduced serum uric acid (SUA) by approximately 2 mg/dl (p < 0.00

148 Serum uric acid (SUA) is the end product of purine metab

149 Serum uric acid (SUA) level is associated with vascular

150 Elevated serum uric acid (SUA) level may contribute to endothelia

151 s of SLC2A9/GLUT9 were associated with lower serum uric acid (SUA) levels and the effects were strong

152 Increased serum uric acid (SUA) levels cause gout and are associat

153 Elevated levels of serum uric acid (SUA) were considered to be risk factors

154 Empagliflozin reduces serum uric acid (SUA), but the relevance of this effect

155 atients initiating treatment for an elevated serum uric acid (SUA), the SUA normalized or improved in

156 500 mg/day of vitamin C for 2 months reduces serum uric acid, suggesting that vitamin C might be bene

157 s with MS have significantly lower levels of serum uric acid than controls.

158 We found serum uric acid to be significantly heritable [h(2) +/-

159 The relationship between serum uric acid (UA) and outcomes after acute ischemic s

160 Serum uric acid (UA) could be a valid prognostic marker

161 In 10 CHF patients with normal serum uric acid (UA) levels (315+/-42 micromol/L) and 9

162 Elevated serum uric acid (UA) levels strongly reflect and may eve

163 tative trait loci with measurable effects on serum uric acid variability.

164 ; CB: 159.4 ng/mL; P = 0.028), and increased serum uric acid (WA: 341.4 mumol/L; CB: 330 mumol/L; P =

165 Mean baseline serum uric acid was 5.9 +/- 1.5 mg/dl, mean baseline ser

166 Serum uric acid was first noted to be associated with in

167 Serum uric acid was found to exhibit significant heritab

168 Serum uric acid was higher in SCT (7.3 1.0 mg/dL) compar

169 Serum uric acid was measured in 3315 patients of the Lud

170 Serum uric acid was measured in 7,968 men at the baselin

171 The mean serum uric acid was significantly higher in patient with

172 The association between rs2231142 and serum uric acid was significantly stronger in men, postm

173 , it is not known whether the association of serum uric acid with SLC2A9 polymorphisms manifests in c

174 t mean changes (95% confidence intervals) in serum uric acid with vitamin C supplementation were -0.4