ライフサイエンスコーパス: seryl-tRNA

1 al corruption of translation, consumption of seryl-tRNA(Ala) by MurM may represent a first line of de

2 can incorporate seryl groups from mischarged Seryl-tRNA(Ala)(UGC) into cell wall precursors with exqu

3 s not present upstream of either copy of the seryl-tRNA(CAG) gene in eight other laboratory strains o

4 (which we designate beta) 9bp upstream of a seryl-tRNA(CAG) gene in the genome of Candida albicans.

5 There are two copies of the seryl-tRNA(CAG) gene, one on each homologue of chromosom

6 e searched for unique structural features in seryl-tRNA(CAG), which translates the leucine CUG codon

7 d that the role of this enzyme is to provide seryl-tRNA for the valanimycin biosynthetic pathway.

8 s of investigations to elucidate the role of seryl-tRNA in valanimycin biosynthesis.

9 nticodons are aminoacylated with serine, the seryl-tRNA is converted to selenocysteyl-tRNA and the la

10 Its biosynthesis from seryl-tRNA(Sec) has been established for bacteria, but t

11 ated that MJ0158 lacked affinity for E. coli seryl-tRNA(Sec) or M. jannaschii seryl-tRNA(Sec), and ne

12 se and demonstrated that the enzyme converts seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec) that could c

13 Bacterial selenocysteine synthase converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) for selenop

14 enocysteine synthase converted both types of seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

15 for E. coli seryl-tRNA(Sec) or M. jannaschii seryl-tRNA(Sec), and neither substrate was directly conv

16 cifically phosphorylated the seryl moiety on seryl-tRNA[Ser]Sec and, in addition, had a requirement f

17 Using the ACC domain of seryl tRNA synthetase (SRS-ACC) as a scaffold for protei

18 oding a flavin monooxygenase (vlmH, vlmR), a seryl tRNA synthetase gene (vlmL ) and seven genes of un

19 ryo-EM structures of the human mitochondrial seryl-tRNA synthetase (mSerRS) in complex with mtRNA(Ser

20 By positional cloning, we isolated seryl-tRNA synthetase (sars) as the gene affected by the

21 One example is the UNE-S domain, appended to seryl-tRNA synthetase (SerRS) in species that developed

22 cent studies suggested an essential role for seryl-tRNA synthetase (SerRS) in vascular development.

23 ix substrates revealed that Escherichia coli seryl-tRNA synthetase (SerRS) recognizes the 1--72 throu

24 During vascular development, seryl-tRNA synthetase (SerRS) regulates angiogenesis thr

25 utotrophicum contain a structurally uncommon seryl-tRNA synthetase (SerRS) sequence and lack an open

26 Unexpectedly, overexpression of seryl-tRNA synthetase (SerRS) suppresses primary tumor g

27 ires three steps: serylation of tRNA(Sec) by seryl-tRNA synthetase (SerRS), phosphorylation of Ser-tR

28 f Sec-specific tRNA (tRNA(Sec)) catalyzed by seryl-tRNA synthetase (SerRS)-is unclear.

29 erved that BMAA is not a substrate for human seryl-tRNA synthetase (SerRS).

30 First seryl-tRNA synthetase acylates tRNA(Sec) with serine to

31 d-coil base provided by Thermus thermophilus seryl-tRNA synthetase and tested these chimeric construc

32 c) is initially aminoacylated with serine by seryl-tRNA synthetase and the resulting seryl moiety is

33 Seryl-tRNA synthetase induced migration of CCR3-transfec

34 s SB-217452, has been found to be the active seryl-tRNA synthetase inhibitor component of albomycin d

35 The Km of Sec tRNA and serine tRNA for seryl-tRNA synthetase is 6.67 and 9.45 nM, respectively.

36 ed protein that interacts with mitochondrial seryl-tRNA synthetase, as well as with mt-tRNAs containi

37 ass II enzymes, aspartyl-tRNA synthetase and seryl-tRNA synthetase, do not edit any of the amino acid

38 thase SelA converts Ser-tRNA(Sec), formed by seryl-tRNA synthetase, to Sec-tRNA(Sec).

39 nce of a gene (vlmL) that encodes a class II seryl-tRNA synthetase.

40 ucture of tRNA(Ser) and Thermus thermophilus seryl-tRNA synthetase.

41 a seryl-thioribosyl pyrimidine that targets seryl-tRNA synthetase.

42 rising the long helical arm of the bacterial seryl tRNA synthetases (SRS).

43 genes encoding proteins that are similar to seryl-tRNA synthetases (SerRSs).

44 e Escherichia coli and Staphylococcus aureus seryl-tRNA synthetases in complex with aminoacyl adenyla

45 In contrast, both archaeal and bacterial seryl-tRNA synthetases were able to charge both archaeal

46 nhibitors that selectively inhibit bacterial seryl-tRNA synthetases with greater than 2 orders of mag

47 tRNA was found in rooster liver, and a minor seryl-tRNA that decoded the nonsense UGA was detected in

48 ivity that phosphorylated a minor species of seryl-tRNA to form phosphoseryl-tRNA was found in rooste

49 lyzes the transfer of the seryl residue from seryl-tRNA to the hydroxyl group of isobutylhydroxylamin

50 phosphoseryl-tRNA and the minor UGA-decoding seryl-tRNA were subsequently identified as selenocystein

51 mL in valanimycin biosynthesis is to produce seryl-tRNA, which is then utilized for a subsequent step