ライフサイエンスコーパス: sex bias

1 our previously reported SIV vaccine-induced sex bias.

2 loped DCM or the other phenotypes, including sex bias.

3 minantly affect females, indicating a strong sex bias.

4 resent muscle damage in soleus with a strong sex bias.

5 Z chromosome, and shows other differences in sex bias.

6 well as outstanding questions regarding this sex bias.

7 rom >4,100 cancers across 21 tumor types for sex bias.

8 Deep breaths are not sex-biased.

9 show that 14-25% of the EC transcriptome is sex-biased.

10 of mortality is the propensity for it to be sex-biased.

11 are enriched for nearby and correspondingly sex-biased accessible chromatin regions, as well as sex-

12 sex bias, we demonstrate a rapid turnover of sex bias across this clade driven by sexual selection an

13 rtially migratory and that migration was not sex-biased across surveyed areas.

14 organism's environment, exhibits strikingly sex-biased activity.

15 cultural populations, we find no evidence of sex-biased admixture during the migration that spread fa

16 We demonstrate increased power to detect sex-biased admixture in African-American individuals fro

17 pproaches as well as the correlation between sex bias and expression breadth.

18 ss the island reveals that the admixture was sex biased and happened heterogeneously across Madagasca

19 d 3) a spatial coupling between regional GMV sex biases and brain expression of sex chromosome genes

20 lps; a freely adjustable sex ratio magnifies sex biases and promotes helping; and sib-mating, promisc

21 w that complex dispersal dynamics, including sex biases and strong density dependence, emerge natural

22 We prioritized 2080 genes that were sex-biased and associated with psychiatric disorders, su

23 We applied computational methods to identify sex-biased and shared molecular responses to fibrotic in

24 cross pregnancy for gene candidates that are sex-biased and stress-responsive in mice and translate t

25 However, mechanisms responsible for this sex bias are not clear.

26 n in men, but the mechanisms underlying this sex bias are unknown.

27 Sex biases are eliminated if both sexes evaluate mate av

28 ng sex difference, but the mechanisms behind sex-bias are not fully understood.

29 that X chromosome dosage contributed to this sex bias as female pDCs have an enhanced TLR7-mediated I

30 of male microglia is an important cause for sex-biased ASD.

31 systems are implicated in diverse domains of sex-biased behavior and pathology, but we lack a basic u

32 sed accessible chromatin regions, as well as sex-biased binding sites for growth hormone-regulated tr

33 ses, and potential functional corollaries of sex-biased brain anatomy in humans.

34 hese findings establish conserved aspects of sex-biased brain development in humans and mice, and she

35 d developmental abnormalities leading to 1:2 sex biases, caused by lethality of half of the male or f

36 Individual strategies were related to sex-biased changes in neuronal activation in early learn

37 matin states are thus a major determinant of sex-biased chromatin accessibility and gene expression,

38 ined by miRNA-specific regulation, including sex-biased chromatin accessibility at promoters, rather

39 ng sex-biased genes by binding to sites in a sex-biased chromatin state.

40 females, with translational implications for sex biases commonly found in midbrain DA-associated diso

41 oof of principle that when CRF is in excess, sex-biased CRF1 coupling translates into divergent cell

42 es in male and female brains, as a result of sex-biased CRF1 signaling.

43 nervous system, locomotor abnormalities, and sex-biased defects in adult craniofacial morphology.

44 in the absence of these, also by historical sex-biased demographic events or other processes.

45 (iv) Sex-biased STAT5 binding is enriched at sex-biased DHS marked as active enhancers and preferenti

46 (i) Sex-biased DHS, but not sex-biased genes, are frequently

47 tic conflict caused by ancient admixture and sex-biased differences in genomic transmission.

48 We report greater sex-biased differential expression in the pituitary as c

49 tion model to explore interactive effects of sex-biased dispersal and demographic stochasticity.

50 Sex-biased dispersal and extra-pair mating may also have

51 between mammals and birds, mating system and sex-biased dispersal are far from perfectly associated w

52 The hypothesis that patterns of sex-biased dispersal are related to social mating system

53 behavioral differences in mating system and sex-biased dispersal between mammals and birds, mating s

54 Sex-biased dispersal created spatial clines in the sex r

55 e fine-scale spatial genetic structuring and sex-biased dispersal have important implications for the

56 elationship between social mating system and sex-biased dispersal in birds when the effects of phylog

57 f the relationship between mating system and sex-biased dispersal in mammals and birds.

58 mes and the influence of sex chromosomes and sex-biased dispersal in post-speciation gene flow.

59 ulation structure and looked for evidence of sex-biased dispersal in smooth snakes (Coronella austria

60 ) the relationship between mating system and sex-biased dispersal in these vertebrate groups has not

61 t the relationship between mating system and sex-biased dispersal is more complex than a simple contr

62 Sex-biased dispersal is usually driven by a combination

63 st experimental evidence for an influence of sex-biased dispersal on invasion velocity, highlighting

64 laboratory mesocosms to test the effects of sex-biased dispersal on range expansion, and a simulatio

65 thers maintain that any kind of lineality or sex-biased dispersal only emerged much later.

66 on [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be espec

67 , theoretical studies on mate finding and on sex-biased dispersal produce opposing predictions: in th

68 ignificant differentiation for mtDNA, but no sex-biased dispersal was detected using the microsatelli

69 Clear sex-biased dispersal was not detected based on relatedne

70 life history or behaviour (skewed sex ratio, sex-biased dispersal, and sex-specific mating behaviours

71 f male and female snakes showed evidence for sex-biased dispersal, with three of four analyses findin

72 eading-edge sex ratios, perhaps overwhelming sex-biased dispersal.

73 aphic stochasticity would weaken a signal of sex-biased dispersal.

74 ew complication in explaining the drivers of sex-biased dispersal.

75 ral populations by passive processes such as sex-biased dispersal.

76 l to diurnal activity patterns, but not with sex-biased dispersal.

77 ent STAT5 binding correlated positively with sex-biased DNase hypersensitivity and H3-K4me1 and H3-K4

78 We demonstrate how the close age- and sex-biased dyadic relationships are correlated with the

79 We tested the burden and the possible sex-biased effect of CNVs at 16p13.11 in a sample of 10,

80 with controls (OR = 2.59; p = 0.0005), and a sex-biased effect, with a significant enrichment of CNVs

81 ex ratio, one male per litter, revealing its sex-biased effect.

82 logical disorders, Alzheimer's disease has a sex-biased epidemiological profile, affecting approximat

83 al network and by the dynamics of changes in sex-biased epigenetic states.

84 By integrating sex-biased eQTLs with genome-wide association study data

85 se populations, quantifying the postcolonial sex-biased European gene flow across multiple regions.

86 Despite sex-biased eve expression, the gene networks downstream

87 transcription factor, giant (gt), we traced sex-biased eve patterning to gt dose, indicating that ea

88 specialties in which the greatest and least sex biases exist.

89 Objectives: To determine if sex bias exists in human surgical clinical research, to

90 Conclusions and Relevance: Sex bias exists in human surgical clinical research.

91 in preclinical studies, we explored whether sex bias exists in skin research.

92 That sex-biased exposure might translate to sex-specific adve

93 human brain, and we identified genes showing sex biased expression at major developmental stages (pre

94 in multiple outcrossing species with strong sex-biased expression are even more likely to be missing

95 Numerous studies have shown that genes with sex-biased expression are under- or over-represented on

96 However, most sex-biased expression arose during the mammalian radiati

97 Moreover, genes with sex-biased expression as revealed by comparing amounts i

98 s showing the same growth hormone-regulated, sex-biased expression as their mouse counterparts.

99 Sex-biased expression characterized 247 liver lincRNAs,

100 identified several OR transcripts displaying sex-biased expression in adults, as well as larval-enric

101 A total of 37% of all genes exhibit sex-biased expression in at least one tissue.

102 Genes with sex-biased expression in Drosophila are thought to under

103 We report tissue-specific and sex-biased expression in genes commonly investigated whe

104 rattlesnake to establish baseline levels of sex-biased expression in homomorphic sex chromosomes, an

105 To address this problem, we measured sex-biased expression in multiple Drosophila species and

106 We give examples of genes where sex-biased expression is both disease-relevant and likel

107 Sex-biased expression is explained by miRNA-specific reg

108 ormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat l

109 cific chromatin states appear not to explain sex-biased expression of genes.

110 osage compensation raises the possibility of sex-biased expression of key developmental genes, such a

111 ces between males and females arise from the sex-biased expression of nearly identical genomes can re

112 We find that Dsx regulates sex-biased expression predominantly in males, that Dsx's

113 bustness of the pattern to Gene Ontology and sex-biased expression suggest that partly recessive bene

114 Additionally, genes with sex-biased expression tend to be narrowly expressed in a

115 alleles to one sex, whereas ratites evolved sex-biased expression to confine the product of a sexual

116 Sex-biased expression was pervasive in floral tissue, bu

117 ary, Nasonia accomplish a striking degree of sex-biased expression without sex chromosomes or epigene

118 Populus balsamifera to assess the extent of sex-biased expression, and tested whether sex-biased gen

119 ome is the result of selection on genes with sex-biased expression, narrowly expressed genes, or some

120 identified hundreds of genes with conserved sex-biased expression-findings that, combined with genom

121 ors that should be considered when analyzing sex-biased expression.

122 and evaluated ASD risk genes for evidence of sex-biased expression.

123 % of expressed genes displayed significantly sex-biased expression.

124 viding for direct and indirect regulation of sex-biased expression.

125 e-sensitive aneuploid effects also influence sex-biased expression.

126 but also find autosomal genes with potential sex bias (females, CDK13, ITPR1; males, CHD8, MBD5, SYNG

127 or protection from autoimmunity, creating a sex bias for autoimmune diseases.

128 Furthermore, a sex bias for severe sequelae from coxsackievirus infecti

129 strains, C and C57BL/6J (B), demonstrated a sex bias for susceptibility.

130 ver, levels of gene expression are generally sex-biased for all sex-linked genes relative to autosome

131 the X chromosome has acquired a paradoxical sex-biased function by redistributing gene contents [5,

132 o distinct co-expression networks, and shows sex-biased gene expression and exon usage.

133 m manipulation disproportionately influences sex-biased gene expression but show that the direction o

134 modifications accompanied these cGH-induced sex-biased gene expression changes.

135 test the links between sexual selection and sex-biased gene expression evolution in a comparative fr

136 Our results support a scenario in which sex-biased gene expression evolved during the evolution

137 We found that sex-biased gene expression has evolved in autosomal and

138 Separate sexes and sex-biased gene expression have repeatedly evolved in an

139 Here, we review our current knowledge of sex-biased gene expression in both model and nonmodel or

140 pidly evolved new gene networks and impacted sex-biased gene expression in Drosophila.

141 iver and WAT indicates that RSL1 accentuates sex-biased gene expression in liver but greatly diminish

142 sex-differential chromatin accessibility and sex-biased gene expression in mouse liver.

143 The presence of sex-biased gene expression in tissues other than the and

144 Such studies have revealed that sex-biased gene expression is abundant in many species,

145 ally conspicuous than in animals, studies of sex-biased gene expression may provide a quantitative me

146 hanges cannot explain the extensive level of sex-biased gene expression observed.

147 males and females are likely rooted from the sex-biased gene expression regulation during brain devel

148 Sexual dimorphism depends on sex-biased gene expression, but the contributions of mic

149 ences gene expression, including patterns in sex-biased gene expression.

150 h as dosage compensation, also may influence sex-biased gene expression.

151 on, whereas other sex-specific signals cause sex-biased gene expression.

152 and transcriptional dimorphism, often termed sex-biased gene expression.

153 In addition, various degrees of sex-biased gene flow exhibiting disproportionately highe

154 computer simulations we propose that altered sex-biased gene regulation from standing genetic variati

155 ng that sex biases in expression may reflect sex-biased gene regulatory structures.

156 Thus, the temporal, sex-biased gene responses to persistent GH stimulation a

157 rofile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas.

158 , these analyses reveal an important role of sex biased genes in brain development and neurodevelopme

159 However, there are little overlap of sex-biased genes among the major developmental stages, a

160 Sex-biased genes are enriched in transcriptional process

161 opening and STAT5, but not BCL6, regulating sex-biased genes by binding to sites in a sex-biased chr

162 h contributes to a nonrandom distribution of sex-biased genes compared to the remainder of the genome

163 Sex-biased genes did not exhibit elevated rates of prote

164 We find that sex-biased genes do change in expression but, contrary t

165 of sex-biased expression, and tested whether sex-biased genes exhibit elevated rates of protein evolu

166 tion of dynamic expression regulation of the sex-biased genes in the brain during development.

167 tion-scale RNA sequencing data, we show that sex-biased genes in the Drosophila brain are highly enri

168 s and constraints governing the evolution of sex-biased genes in the somatic tissues of Drosophila ar

169 l expression can be achieved for hundreds of sex-biased genes simply based on the GH input signal pat

170 Sex-biased genes were clustered by chromatin environment

171 active enhancers and preferentially targets sex-biased genes with sex-differences in local chromatin

172 (i) Sex-biased DHS, but not sex-biased genes, are frequently characterized by sex-di

173 Sex-biased genes, especially those with male-biased expr

174 e the genomic and evolutionary properties of sex-biased genes.

175 utionary forces that govern the evolution of sex-biased genes.

176 e chromosomal locations and the evolution of sex-biased genes.

177 al constraint on the expression evolution of sex-biased genes.

178 (n > 2,000), we find that the spatial map of sex-biased GMV in humans is highly reproducible (r > 0.8

179 ctivating) marks, correlated negatively with sex-biased H3-K27me3 (repressive) marks, and was associa

180 Second, we found no correlation between sex-biased host mortalities and sex-biased parasite prev

181 l common variants largely do not explain the sex bias in ADHD prevalence.

182 Our findings identify a natural sex bias in appendage regenerative capacity and indicate

183 the principal mechanism underlying the male sex bias in ASD.

184 mit moth dispersal and whether there was any sex bias in attraction to light.

185 -estradiol is crucial in the pathogenesis of sex bias in cancer and autoimmunity.

186 ase-hypersensitive sites (DHS) classified by sex bias in chromatin accessibility and enhancer modific

187 esented within a social group (when there is sex bias in dispersal and/or variance in reproductive su

188 ate-finding difficulties can select for less sex bias in dispersal when mate finding occurs after dis

189 and IL-6 may act synergistically to promote sex bias in experimental DILI by reducing Tregs.

190 or appearance can facilitate a considerable sex bias in fossil and modern collections, on a previous

191 An established sex bias in HIV pathogenesis is linked to immune respons

192 ulating the spatial pattern of dysbiosis and sex bias in IBD.

193 las (TCGA) and reveal divergent patterns for sex bias in immune features across multiple cancer types

194 Numerous studies have reported sex bias in infectious diseases, with bias direction dep

195 Sex bias in innate defense against Staphylococcus aureus

196 s as drivers of sex differences, that female sex bias in MC-associated diseases is evident in prepube

197 ling mechanisms are involved in establishing sex bias in neurodevelopmental disorders.

198 standing the mechanism(s) driving the innate sex bias in neutrophil bactericidal capacity could ident

199 However, the mechanism(s) driving this sex bias in neutrophil killing have not been reported.

200 ever, a possible molecular mechanism for the sex bias in physiological adaptation to oxidative stress

201 ot differ by sex, as evidenced by absence of sex bias in programmed death receptor-1 and responses to

202 izophrenia and autism, which often exhibit a sex bias in rates of presentation, age of onset, and sym

203 ex bias observed in human disease.IMPORTANCE Sex bias in severe sequelae from enteric viral infection

204 odevelopmental disorders, which often have a sex bias in severity and prevalence.

205 Sex bias in susceptibility to autoimmune diseases is evi

206 skin and soft tissue infections (SSTIs), yet sex bias in susceptibility to S. aureus SSTI has not bee

207 Here, we have revealed a sex bias in the efficiency of clinically relevant LT bio

208 ty of HSV-1 0DeltaNLS and uncover a probable sex bias in the induction of IFN-alpha/beta in the corne

209 contributions of CR3, C3, and ROS to innate sex bias in the neutrophil response to S. aureus Given t

210 The sex bias in urine testing is not clinically supported an

211 Sex bias in variability was trait-dependent.

212 verse symptomatology of this disease and the sex bias in vulnerability.

213 vide a possible explanation for the observed sex biases in COVID-19, and provide an important basis f

214 uences, and provide evidence suggesting that sex biases in expression may reflect sex-biased gene reg

215 lead to tissue-specific Y-Chromosome-driven sex biases in expression of critical, dosage-sensitive r

216 We surmise that conserved sex biases in expression of genes otherwise operating eq

217 demonstrate that escape from XCI results in sex biases in gene expression, establishing incomplete X

218 identifying several traits with significant sex biases in genetic susceptibilities.

219 appeal of dominance-style leaders; and (iii) sex biases in leadership emergence in modern society.

220 gnificant mechanistic implications regarding sex biases in NDDs.

221 host and pathogen genetic data can identify sex biases in pathogen spatial spread, which may be a wi

222 pmental disorders (NDDs), many of which show sex biases in prevalence, onset and/or severity.

223 ences-have established: 1) highly consistent sex biases in regional gray matter volume (GMV) involvin

224 mbined with cellular aging processes promote sex biases in stress dysregulation.

225 and highlight new avenues for research into sex biases in stress-related disorders.

226 ximate factors from SDD, including a lack of sex-bias in LDD, suggest that LDD may be more common tha

227 Cell-type enrichment analysis showed sex-bias in proportion of specific cell types.

228 s and found evidence for different levels of sex-bias in these areas: the strongest male-bias was obs

229 These include sex-biases in coding and non-coding cancer drivers, muta

230 We test the hypothesis that sex-biases in infection are related to variation in mult

231 ood, yet highly relevant to health given the sex-biased incidence of many diseases(4).

232 chronic oxidative stress show a significant sex bias, including neurodegenerative diseases, cancer,

233 in SRB - (1) 'frail males' and (2) adaptive sex-biased investment theory (Trivers-Willard).

234 In mouse, but not opossum and chicken, sex bias is coordinated across tissues such that autosom

235 The etiology of this sex bias is far from known, but pivotal for understandin

236 men, although the mechanistic basis for this sex bias is not well understood.

237 ent in males; however, the etiology for this sex bias is not well understood.

238 The basis for this sex bias lies in the X chromosome, which contains many i

239 The sex-biased lincRNA genes are enriched for nearby and cor

240 tors implicated in growth hormone-regulated, sex-biased liver gene expression, leading to the followi

241 s assigned a physiological role, accentuates sex-biased liver gene expression, most dramatically for

242 and many inflammatory diseases present in a sex-biased manner.

243 ng the molecular mechanisms controlling this sex bias may reveal novel targets to promote host innate

244 change over adolescence--with relevance for sex-biased mental disorders emerging in youth.

245 rough both severe population bottlenecks and sex-biased migration.

246 analyses uncovered numerous cases of somatic sex-biased miRNA expression, with the largest proportion

247 Sex-biased miRNAs also targeted genes related to Wnt and

248 parts, which could partially account for the sex-biased molecular pathology observed in this dataset.

249 l. applied a pan-cancer analysis to identify sex-biased molecular signatures and revealed two sex-eff

250 whereas the other shows much more extensive sex-biased molecular signatures.

251 We propose that to understand causes of sex-biased mortalities, more complex analyses are needed

252 f this more vulnerable sex in expectation of sex-biased mortality.

253 hromosome population datasets emphasizes the sex-biased nature of recent demographic transitions in E

254 Studies have linked sex-biased neurodevelopmental disorders, including autis

255 ss during pregnancy predisposes offspring to sex-biased neurodevelopmental disorders, including schiz

256 et and penetrance of disease, abrogating the sex bias normally seen in the NOD model.

257 With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon.

258 ine and should be considered in light of the sex bias observed in human disease.IMPORTANCE Sex bias i

259 response, specifically in the context of the sex bias observed in susceptibility to infectious and au

260 Sex bias occurrence of HCC associated with EGFR was conf

261 Sex bias occurrence was conserved in our model, with mal

262 dy provides evidence for the role of EGFR in sex bias occurrences of liver cancer and as the driver m

263 not affect the time of onset, incidence, or sex bias of type 1 diabetes in NOD/ShiLtJ mice.

264 nes of these neuronal pathways may cause the sex-bias of psychiatric disorders.

265 e regulatory network and its contribution to sex-bias of psychiatric disorders.

266 We did not find sex-bias or an effect of population density in LDD dista

267 Although several of these domains are sex biased, our fundamental understanding of cerebellar

268 maternal stress exposure that may relate to sex-biased outcomes in neurodevelopment.

269 tion between sex-biased host mortalities and sex-biased parasite prevalence.

270 evels of African ancestry, consistent with a sex-biased pattern of gene flow with an excess of Europe

271 ly controlled at least in part by genes with sex-biased patterns of expression.

272 ch varied in density, genetic diversity, and sex-biased philopatry.

273 uently in males than females, a dramatically sex-biased prevalence that suggests the involvement of s

274 rently contradictory evidence on the role of sex-biased processes in human evolutionary history and s

275 ther than piggybacking of intronic miRNAs on sex-biased protein-coding genes.

276 ons, and further specifying their timing and sex-biases, provides potent new research targets for bas

277 driver lines, in most cases with a parental sex bias related to Cre expression in sperm or oocytes.

278 and the underlying molecular basis for this sex bias remains unclear.

279 male and female affected persons without any sex bias, replicating recent findings, though the author

280 n of histone H3 at K27 (H3K27me3) is a major sex-biased repressive mark at highly female-biased but n

281 putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden o

282 1 to Gs-independent signaling pathways, this sex-biased signaling is proposed to result in distinct c

283 of clinically actionable genes (60/114) show sex-biased signatures.

284 (iv) Sex-biased STAT5 binding is enriched at sex-biased DHS m

285 males and persistent in females-regulate the sex-biased, STAT5-dependent expression of hundreds of ge

286 tion between sex-dependent STAT5 binding and sex-biased target gene expression.

287 CRISPR technology offers a new approach for sex bias that could be incorporated within gene-drive de

288 iod of multiple generations, with a level of sex bias that excludes a pulse migration during a single

289 suggested that 17beta-estradiol may enhance sex bias through IL-6 induction, which subsequently disc

290 The degree of sex bias to SARS-CoV infection increased with advancing

291 remain viable, though flightless, and show a sex bias towards maleness.

292 n, for example when using mixed controls for sex-biased traits.

293 The sex-biased transmission of the Z and its hemizygosity in

294 Recently we reported a vaccine-induced sex bias: vaccinated female but not male rhesus macaques

295 Importantly, this sex bias was mediated by a sex-specific response to the

296 Through ancestral reconstruction of sex bias, we demonstrate a rapid turnover of sex bias ac

297 To identify molecular correlates of this sex bias, we investigated molecular pathology in females

298 ously found that the CRF1 receptor (CRF1) is sex biased whereby coupling to its GTP-binding protein,

299 We again report a vaccine-induced sex bias, with female rhesus macaques but not males disp

300 neuroinflammatory pain disorders, exhibit a sex bias, with females at increase risk.