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1  in XY hermaphrodites or XY females (XY(DOM) sex reversal).
2   In severe cases, XY females develop (XYDOM sex reversal).
3 omosome 11 that protected against B6.Y (POS) sex reversal.
4 enting with campomelic dysplasia but without sex reversal.
5 ned with insufficient Sry expression, causes sex reversal.
6 vestigate the Y chromosome component of this sex reversal.
7 o the mechanism of C57BL/6J-Y(M. domesticus) sex reversal.
8 nalysis of mutations in SRY that cause human sex reversal.
9             Not all Y(DOM) chromosomes cause sex reversal.
10 ethal skeletal malformation syndrome, and XY sex reversal.
11 d the possible role of DM domain genes in 9p sex reversal.
12 omosome 9, a location implicated in human XY sex reversal.
13  overexpression of Ahch cause male-to-female sex reversal.
14 sed at high levels, but do not normally show sex reversal.
15 gene allele, Kit(W-42J), exacerbates XY(DOM) sex reversal.
16 reversal) are associated with male to female sex reversal.
17 nt (B6-Y(AKR)) or severe (B6-Y(TIR)) XY(DOM) sex reversal.
18 ences are not the underlying causes of XYDOM sex reversal.
19 tive sequence whose deletion is linked to XY sex reversal.
20 etween these mutations and severity of XYDOM sex reversal.
21 mination, transient sex reversal, and severe sex reversal.
22 of loci is necessary and sufficient to cause sex reversal.
23 , delays or blocks premature oocyte loss and sex reversal.
24 r Zelda (Zld) as a critical mediator of this sex reversal.
25  Sry expression, resulting in male-to-female sex reversal.
26 nsmitted endosymbiont causing male-to-female sex reversal.
27  ligands as mediators of ovarian failure and sex reversal.
28 ovarian failure, which, in zebrafish, causes sex reversal.
29 nd drives ovarian failure and female-to-male sex reversal.
30 % of the XY hybrids underwent male-to-female sex reversal.
31  from hypospadias to complete male-to-female sex reversal.
32 t also caused fish to undergo nondirectional sex reversal.
33 ccumulation via this pathway resulting in XY sex reversal.
34  variant human SRY associated with inherited sex reversal.
35 either gene leads to complete male-to-female sex reversal.
36  in up-regulation of Wnt4 and male-to-female sex reversal.
37 p38alpha and p38beta also exhibit XY gonadal sex reversal.
38  SRY cause XY gonadal dysgenesis and somatic sex reversal.
39 i cell differentiation during female-to-male sex reversal.
40 n an early partial block in male pathway and sex reversal.
41 m by which individuals may be sensitized for sex reversal.
42 volved, as well as how they fail in cases of sex reversal.
43 rgan culture causes male-to-female germ cell sex reversal.
44 enesis of Fgf9 in mice causes male-to-female sex reversal.
45 me previously unassigned cases of XY gonadal sex reversal.
46 deletion of Fgf9 and leads to male-to-female sex reversal.
47  Kit mutation undergo partial female-to-male sex reversal.
48 tal malformation syndrome with or without XY sex reversal.
49 h-6 mutant hermaphrodites exhibit no sign of sex reversal.
50 eletion, in itself, is insufficient to cause sex reversal.
51 n with environmental pressure for phenotypic sex reversal.
52 lic dysplasia need not be associated with XY sex reversal.
53 does not rescue their partial female-to-male sex-reversal.
54 e male program and results in male-to-female sex-reversal.
55 on and the molecular mechanisms that lead to sex-reversal.
56 d and, remarkably, are associated with human sex reversal (46, XY gonadal dysgenesis).
57                      Mutations causing human sex reversal (46, XY pure gonadal dysgenesis) are cluste
58      To identify the molecular basis for the sex reversal, a 2.7-kb region of Sry, the testis-determi
59                      DAX-1 [dosage-sensitive sex reversal, adrenal hypoplasia congenita (AHC) critica
60 e of the corepressor DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region on chro
61 protein, and a reduction in dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chr
62 steroidogenic factor 1, and dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chr
63 ory, cytochrome-P450-17A1, dosage-sensitive, sex-reversal, adrenal hypoplasia-critical region on chro
64 G35E) has been reported to cause complete XY sex reversal and adrenal insufficiency.
65 f these genes, DMRT1, lead to male-to-female sex reversal and are associated with development of gona
66 s in humans, including campomelic dysplasia, sex reversal and cancer, the mechanisms underlying SOX9
67 ddition, no correlation exists between XYDOM sex reversal and copy numbers of pSx1, a Y-repetitive se
68 as B6.Y (POS) mice, commonly undergo gonadal sex reversal and develop as phenotypic females.
69 MY-) mutants, revealed the mechanism between sex reversal and DMY in medaka, and suggested that XY(DM
70 ficiency prevents (suppresses) this dominant sex reversal and Fog2+/-Wt1-Sox9 or Ods XX animals devel
71                     Loss of AR results in XY sex reversal and mutations causing reduced AR activity l
72 not solely, responsible for dosage-sensitive sex reversal and provide a model for early events in mam
73 A direct correlation was observed between XY sex reversal and reduced expression levels of Sry and Sf
74 ently in human populations, where they cause sex reversal and Turner syndrome and predispose individu
75 uences ranging from spermatogenic failure to sex reversal and Turner syndrome.
76 Y-homologous (gametologous) regions, causing sex-reversal and infertility.
77 ed to normal testis determination, transient sex reversal, and severe sex reversal.
78 ntric chromosomes, resulting in infertility, sex reversal, and Turner syndrome.
79                                      B6-YPOS sex reversal appears to result from the incompatibility
80 jority of point mutations resulting in 46X,Y sex reversal are located within this domain.
81  chromosome Xp21 locus DSS (Dosage Sensitive Sex reversal) are associated with male to female sex rev
82 Fgf9-null gonads undergo true male-to-female sex reversal as they initiate but fail to maintain the m
83  elucidate a possible mechanism for human XY sex reversal associated with a 1p31-p35 duplication incl
84 tion-factor haploinsufficiency, including XY sex reversal associated with mutations in SOX9.
85 + mice on the FVB/N background show complete sex reversal, associated with expression of Sox9 in the
86                        C57BL/6J-T-associated sex reversal (B6-TAS) in XY mice results in ovarian deve
87          We propose that Kit(W-42J) enhances sex reversal by adversely affecting a critical step in t
88 1 actively prevents postnatal male-to-female sex reversal by blocking the activation of retinoid-sign
89      Thus, these XX animals undergo dominant sex reversal by developing into phenotypically normal, b
90  The mutation causes complete female-to-male sex reversal by inducing a male-specific expression patt
91 including genes implicated in male-to-female sex reversal, cancer and neurodegenerative disease, and
92 1, and reports for the first time a complete sex-reversal capable of achieving live birth in these mi
93  lacking Gadd45gamma also exhibit XY gonadal sex reversal caused by disruption to Sry expression.
94  RNA interference resulted in male to female sex reversal, characterized by obvious feminization of g
95 n genes is the molecular genetic analyses of sex reversal conditions (that is, XX individuals with te
96 nt Sry expression patterns, that severity of sex reversal correlates with Sry mRNA titers, and that g
97                                      Gonadal sex reversal did not alter the sexually dimorphic expres
98  SRY and SOX9 in Sertoli cells lead to human sex reversal diseases with altered male gonad developmen
99          It is currently unclear why primary sex reversal does not occur at the sex-determining stage
100     Duplication of the Xp21 dosage-sensitive sex reversal (DSS) region, which contains the Ahch locus
101 kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-det
102                                        Human sex reversal due to subtle defects in the nucleocytoplas
103                                              Sex reversal experiments establish roles for this male-b
104 ries Sxr(a) [3, 4], the Y-chromosome-derived sex-reversal factor that includes the testis determinant
105                          To investigate this sex reversal further, we used single-cell RNA-seq to exa
106 ly, the X-linked, candidate dosage-sensitive sex-reversal gene, Dax-1, antagonizes synergy between SF
107 x ratios in wild and laboratory mussels, but sex reversal has not been confirmed.
108 this locus could account for the presence of sex reversal in 100% of XX Ods/+ mice which develop as m
109 r differentiation, leading to male-to-female sex reversal in 46,XY individuals.
110 cation of acampomelic CD with male-to-female sex reversal in a fetus with a de novo balanced complex
111 esticular differentiation and female-to-male sex reversal in a manner that does not requireSry or Sox
112 h we call Mod13, protects against B6.Y (POS) sex reversal in a proportion of heterozygous animals thr
113 e which develop as males, for the absence of sex reversal in approximately 92% of XX Ods/+ mice which
114 and that its knockout induces male-to-female sex reversal in B-carrying males.
115 ing gene, Sry, suggests that exacerbation of sex reversal in B6-Y(TIR) is not due to blockade of Sry
116                                              Sex reversal in both mutants is associated with reduced
117 n of autosomal and X-linked genes that cause sex reversal in C57BL/6J (B6) mice carrying a Y chromoso
118 1 allele (Dax1-) results in complete gonadal sex reversal in C57BL/6JEi (B6) XY mice, whereas testes
119 ed whether the deletion if Wnt4 could rescue sex reversal in Fgf9 and Fgfr2 mutants.
120 eads to loss of function, as demonstrated by sex reversal in Fgfr2c(C342Y/-) mice carrying the knock-
121                           The suppression of sex reversal in Fog2 heterozygous females results from a
122                Here we report male-to-female sex reversal in mice lacking Fibroblast growth factor 9
123 tion syndrome associated with male-to-female sex reversal in most, but not all, XY individuals.
124 n mutations of EFNB1, exhibits a paradoxical sex reversal in phenotypic severity: females characteris
125          Extreme temperatures can also cause sex reversal in several amphibians and lizards with geno
126        This may explain the lack of complete sex reversal in such mutants at the sex-determining stag
127                                   Ods causes sex reversal in the absence of Sry by upregulating Sox9
128 hanism may be involved in the male-to-female sex reversal in wild populations exposed to environmenta
129          This mutation causes female to male sex reversal in XX Ods/+ mice, and a characteristic eye
130 s the male program and causes male-to-female sex reversal in XY patients.
131  from 129Sl/SvImJ provide protection against sex reversal in XYPOS mice of the C57BL/6J.129-YPOS stra
132 rom 129Sl/SvImJ essentially protects against sex reversal in XYPOS mice.
133 e in humans, referred to as dosage-sensitive sex reversal, in which XY individuals carrying duplicati
134 ating that the reported sensitivity of B6 to sex reversal is consistent with a higher expression of a
135                          We propose that Ods sex reversal is due to the Dct promoter element interact
136 A/2J (D2) and (B6xD2)F1 XY mice; (2) B6-DAX1 sex reversal is inherited as a complex trait that includ
137                              M64I-associated sex reversal is instead caused by the impaired function
138 , strongly suggesting that the cause of this sex reversal is not the Sry protein itself, but rather t
139           We hypothesize that male-to-female sex reversal may be connected to a different development
140                                       Using "sex-reversal" mouse models with varying sex chromosome c
141 mportance, we have investigated a C-terminal sex-reversal mutation (R133W, position 78 of the HMG box
142                                              Sex-reversal mutations in human SRY cluster within its h
143  original discovery that SRY deletions cause sex reversal, mutations in half of the 20 human SOX gene
144                     The GATA4/FOG2-dependent sex reversal observed in the transgenic XX gonads has to
145                              Whether gonadal sex reversal occurs depends on genetic background (i.e.,
146                                     Complete sex reversal occurs, however, when the transgene is test
147                                   By genetic sex reversal of a specific gut region, we induced female
148 e epigenetic marks within the SDR and caused sex reversal of genetic females into phenotypic males.
149 TRIM28 is required to prevent female-to-male sex reversal of the mouse ovary after birth.
150 l factor(s) from the XY embryo contribute to sex reversal of the XX twin.
151 n of Kdm6bb_tv1, but not Kdm6bb_tv2, induced sex reversal of XX females into pseudo-males.
152  of Bdtra and doublesex (Bddsx), and induced sex reversal of XY individuals into phenotypic females.
153 ome, craniosynostosis with XY male-to-female sex reversal or CSR.
154 bryos could be rescued by transgene-mediated sex reversal or testosterone administration.
155          Our data reveal that the B6.Y (POS) sex reversal phenomenon is genetically complex and the e
156 onal ZNRF3 exhibit a highly variable gonadal sex reversal phenotype in the fetal period, characterise
157 lling molecule WNT4 has been associated with sex reversal phenotypes in mammals.
158 murine Wnt-4, is a strong candidate gene for sex-reversal phenotypes in humans.
159 ne containing the Y chromosome gene Sry This sex-reversal provided clear experimental proof that Sry
160 lly leads to masculinization (female-to-male sex reversal), resulting in neomales.
161       However, only a partial female-to-male sex reversal results from disruption of these ovary-prom
162 A titers, and that genetic correction of the sex reversal results in the upregulation of Sry expressi
163 human disorder characterized by autosomal XY sex reversal, severe skeletal malformations and several
164 rders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficien
165 pathways of sexual development could explain sex reversal, sterility, and the development of intersex
166                Mutation, co-transfection and sex-reversal studies all point to a feedforward, self-re
167  is an ideal model for sex determination and sex reversal, such as XY phenotypically female patients
168 be associated with gonadal dysgenesis and XY sex reversal, suggesting that this region contains one o
169 RY gene are associated with a male-to-female sex reversal syndrome in humans and other mammalian spec
170 ily, is a gene that may be responsible for a sex-reversal syndrome in humans, referred to as dosage-s
171  for the 129 region had a lower incidence of sex reversal than XYPOS adults homozygous for the B6 reg
172 his phenomenon is termed temperature-induced sex reversal (TISR).
173 ions of gonadal hormones, we induced gonadal sex reversal to alter the hormonal environment of the de
174 owever, in B6-Y(TIR), Kit(W-42J) exacerbated sex reversal to such an extent that almost all XY progen
175 wever, none were unequivocally linked to the sex-reversal trait.
176 racterization of genes implicated in gonadal sex reversal, Turner syndrome, graft rejection and sperm
177                               Female to male sex reversal was achieved in an emerging agricultural in
178 o produce partial XY sex reversal while full sex reversal was attained in mutants containing a hypomo
179                          The exacerbation of sex reversal was not linked to retardation of early feta
180                  Using cell-specific genetic sex reversal, we find that this switch reflects an inher
181 i cells in the mouse testis, in experimental sex reversal when fetal ovaries are grafted to adult kid
182 r the FVB-derived allele strongly favors Ods sex reversal, whereas homozygosity for the A/J-derived a
183  gonads was sufficient to produce partial XY sex reversal while full sex reversal was attained in mut
184 evelopment of VSDs in individuals with 46,XX sex reversal with dysgenesis of kidney, adrenals and lun
185 a Cys342Tyr substitution displays XY gonadal sex reversal with variable expressivity.
186 range from testicular hypoplasia to complete sex reversal, with most Fgf9(-/-) XY reproductive system

 
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